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Items: 28

1.

A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier.

Hart EM, Mitchell AM, Konovalova A, Grabowicz M, Sheng J, Han X, Rodriguez-Rivera FP, Schwaid AG, Malinverni JC, Balibar CJ, Bodea S, Si Q, Wang H, Homsher MF, Painter RE, Ogawa AK, Sutterlin H, Roemer T, Black TA, Rothman DM, Walker SS, Silhavy TJ.

Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 201912345. doi: 10.1073/pnas.1912345116. [Epub ahead of print]

PMID:
31591200
2.

In vitro studies evaluating the activity of imipenem in combination with relebactam against Pseudomonas aeruginosa.

Young K, Painter RE, Raghoobar SL, Hairston NN, Racine F, Wisniewski D, Balibar CJ, Villafania A, Zhang R, Sahm DF, Blizzard T, Murgolo N, Hammond ML, Motyl MR.

BMC Microbiol. 2019 Jul 4;19(1):150. doi: 10.1186/s12866-019-1522-7.

3.

Inhibitor of intramembrane protease RseP blocks the σE response causing lethal accumulation of unfolded outer membrane proteins.

Konovalova A, Grabowicz M, Balibar CJ, Malinverni JC, Painter RE, Riley D, Mann PA, Wang H, Garlisi CG, Sherborne B, Rigel NW, Ricci DP, Black TA, Roemer T, Silhavy TJ, Walker SS.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6614-E6621. doi: 10.1073/pnas.1806107115. Epub 2018 Jun 25.

4.

Validation and Development of an Escherichia coli Riboflavin Pathway Phenotypic Screen Hit as a Small-Molecule Ligand of the Flavin Mononucleotide Riboswitch.

Balibar CJ, Villafania A, Barbieri CM, Murgolo N, Roemer T, Wang H, Howe JA.

Methods Mol Biol. 2018;1787:19-40. doi: 10.1007/978-1-4939-7847-2_2.

PMID:
29736707
5.

Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.

Moreau RJ, Skepper CK, Appleton BA, Blechschmidt A, Balibar CJ, Benton BM, Drumm JE 3rd, Feng BY, Geng M, Li C, Lindvall MK, Lingel A, Lu Y, Mamo M, Mergo W, Polyakov V, Smith TM, Takeoka K, Uehara K, Wang L, Wei JR, Weiss AH, Xie L, Xu W, Zhang Q, de Vicente J.

J Med Chem. 2018 Apr 26;61(8):3309-3324. doi: 10.1021/acs.jmedchem.7b01691. Epub 2018 Apr 9.

PMID:
29498517
6.

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.

Lee SH, Wang H, Labroli M, Koseoglu S, Zuck P, Mayhood T, Gill C, Mann P, Sher X, Ha S, Yang SW, Mandal M, Yang C, Liang L, Tan Z, Tawa P, Hou Y, Kuvelkar R, DeVito K, Wen X, Xiao J, Batchlett M, Balibar CJ, Liu J, Xiao J, Murgolo N, Garlisi CG, Sheth PR, Flattery A, Su J, Tan C, Roemer T.

Sci Transl Med. 2016 Mar 9;8(329):329ra32. doi: 10.1126/scitranslmed.aad7364.

PMID:
26962156
7.

Mutant Alleles of lptD Increase the Permeability of Pseudomonas aeruginosa and Define Determinants of Intrinsic Resistance to Antibiotics.

Balibar CJ, Grabowicz M.

Antimicrob Agents Chemother. 2015 Nov 23;60(2):845-54. doi: 10.1128/AAC.01747-15. Print 2016 Feb.

8.

Yeast: a microbe with macro-implications to antimicrobial drug discovery.

Balibar CJ, Roemer T.

Brief Funct Genomics. 2016 Mar;15(2):147-54. doi: 10.1093/bfgp/elv038. Epub 2015 Oct 5. Review.

PMID:
26443612
9.

Selective small-molecule inhibition of an RNA structural element.

Howe JA, Wang H, Fischmann TO, Balibar CJ, Xiao L, Galgoci AM, Malinverni JC, Mayhood T, Villafania A, Nahvi A, Murgolo N, Barbieri CM, Mann PA, Carr D, Xia E, Zuck P, Riley D, Painter RE, Walker SS, Sherborne B, de Jesus R, Pan W, Plotkin MA, Wu J, Rindgen D, Cummings J, Garlisi CG, Zhang R, Sheth PR, Gill CJ, Tang H, Roemer T.

Nature. 2015 Oct 29;526(7575):672-7. doi: 10.1038/nature15542. Epub 2015 Sep 30.

PMID:
26416753
10.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

11.

Kibdelomycin is a bactericidal broad-spectrum aerobic antibacterial agent.

Singh SB, Dayananth P, Balibar CJ, Garlisi CG, Lu J, Kishii R, Takei M, Fukuda Y, Ha S, Young K.

Antimicrob Agents Chemother. 2015;59(6):3474-81. doi: 10.1128/AAC.00382-15. Epub 2015 Apr 6.

12.

Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG.

Mann PA, Müller A, Xiao L, Pereira PM, Yang C, Ho Lee S, Wang H, Trzeciak J, Schneeweis J, Dos Santos MM, Murgolo N, She X, Gill C, Balibar CJ, Labroli M, Su J, Flattery A, Sherborne B, Maier R, Tan CM, Black T, Onder K, Kargman S, Monsma FJ Jr, Pinho MG, Schneider T, Roemer T.

ACS Chem Biol. 2013 Nov 15;8(11):2442-51. doi: 10.1021/cb400487f. Epub 2013 Sep 5.

PMID:
23957438
13.

Elongation factor P is dispensable in Escherichia coli and Pseudomonas aeruginosa.

Balibar CJ, Iwanowicz D, Dean CR.

Curr Microbiol. 2013 Sep;67(3):293-9. doi: 10.1007/s00284-013-0363-0. Epub 2013 Apr 17.

PMID:
23591475
14.

Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa.

Balibar CJ, Hollis-Symynkywicz MF, Tao J.

J Bacteriol. 2011 Jul;193(13):3304-12. doi: 10.1128/JB.00334-11. Epub 2011 May 6.

15.

cwrA, a gene that specifically responds to cell wall damage in Staphylococcus aureus.

Balibar CJ, Shen X, McGuire D, Yu D, McKenney D, Tao J.

Microbiology. 2010 May;156(Pt 5):1372-83. doi: 10.1099/mic.0.036129-0. Epub 2010 Feb 18.

PMID:
20167623
16.

Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A.

Cotton JL, Tao J, Balibar CJ.

Biochemistry. 2009 Feb 10;48(5):1025-35. doi: 10.1021/bi801844c.

PMID:
19138128
17.

The mevalonate pathway of Staphylococcus aureus.

Balibar CJ, Shen X, Tao J.

J Bacteriol. 2009 Feb;191(3):851-61. doi: 10.1128/JB.01357-08. Epub 2008 Nov 21.

18.

The violacein biosynthetic enzyme VioE shares a fold with lipoprotein transporter proteins.

Ryan KS, Balibar CJ, Turo KE, Walsh CT, Drennan CL.

J Biol Chem. 2008 Mar 7;283(10):6467-75. doi: 10.1074/jbc.M708573200. Epub 2008 Jan 2.

19.

From thioesters to amides and back: condensation domain reversibility in the biosynthesis of vibriobactin.

Balibar CJ, Walsh CT.

Chembiochem. 2008 Jan 4;9(1):42-5. No abstract available.

PMID:
18022888
20.

Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation.

Balibar CJ, Howard-Jones AR, Walsh CT.

Nat Chem Biol. 2007 Sep;3(9):584-92. Epub 2007 Aug 12.

PMID:
17704773
21.

Covalent CouN7 enzyme intermediate for acyl group shuttling in aminocoumarin biosynthesis.

Balibar CJ, Garneau-Tsodikova S, Walsh CT.

Chem Biol. 2007 Jun;14(6):679-90.

22.

Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7.

Fridman M, Balibar CJ, Lupoli T, Kahne D, Walsh CT, Garneau-Tsodikova S.

Biochemistry. 2007 Jul 17;46(28):8462-71. Epub 2007 Jun 20.

PMID:
17580964
23.

In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum.

Balibar CJ, Walsh CT.

Biochemistry. 2006 Dec 26;45(51):15444-57. Epub 2006 Dec 19.

PMID:
17176066
24.
25.

Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry.

Hicks LM, Balibar CJ, Walsh CT, Kelleher NL, Hillson NJ.

Biophys J. 2006 Oct 1;91(7):2609-19. Epub 2006 Jun 30.

26.

Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.

Cramer RA Jr, Gamcsik MP, Brooking RM, Najvar LK, Kirkpatrick WR, Patterson TF, Balibar CJ, Graybill JR, Perfect JR, Abraham SN, Steinbach WJ.

Eukaryot Cell. 2006 Jun;5(6):972-80.

27.

Generation of D amino acid residues in assembly of arthrofactin by dual condensation/epimerization domains.

Balibar CJ, Vaillancourt FH, Walsh CT.

Chem Biol. 2005 Nov;12(11):1189-200.

28.

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