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Items: 20


Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.

Wang C, Najm R, Xu Q, Jeong DE, Walker D, Balestra ME, Yoon SY, Yuan H, Li G, Miller ZA, Miller BL, Malloy MJ, Huang Y.

Nat Med. 2018 May;24(5):647-657. doi: 10.1038/s41591-018-0004-z. Epub 2018 Apr 9.


Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells.

Fong H, Wang C, Knoferle J, Walker D, Balestra ME, Tong LM, Leung L, Ring KL, Seeley WW, Karydas A, Kshirsagar MA, Boxer AL, Kosik KS, Miller BL, Huang Y.

Stem Cell Reports. 2013 Aug 29;1(3):226-34. doi: 10.1016/j.stemcr.2013.08.001. eCollection 2013.


Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.

Ring KL, Tong LM, Balestra ME, Javier R, Andrews-Zwilling Y, Li G, Walker D, Zhang WR, Kreitzer AC, Huang Y.

Cell Stem Cell. 2012 Jul 6;11(1):100-9. doi: 10.1016/j.stem.2012.05.018. Epub 2012 Jun 7.


Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.

Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW.

J Biol Chem. 2012 Feb 17;287(8):5253-66. doi: 10.1074/jbc.M111.276162. Epub 2011 Dec 12.


Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.

Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, Freedman S, Weisgraber KH, Mahley RW, Huang Y.

J Biol Chem. 2011 May 13;286(19):17217-26. doi: 10.1074/jbc.M110.217380. Epub 2011 Mar 18.


Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS.

Xu Q, Walker D, Bernardo A, Brodbeck J, Balestra ME, Huang Y.

J Neurosci. 2008 Feb 6;28(6):1452-9. doi: 10.1523/JNEUROSCI.3253-07.2008.


Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.

Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1343-6. doi: 10.1073/pnas.0709906104. Epub 2008 Jan 22.


Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.

Chang S, ran Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18694-9. Epub 2005 Dec 12.


Regulatable liver expression of the rabbit apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1 (APOBEC-1) in mice lacking endogenous APOBEC-1 leads to aberrant hyperediting.

Hersberger M, Patarroyo-White S, Qian X, Arnold KS, Rohrer L, Balestra ME, Innerarity TL.

Biochem J. 2003 Jan 15;369(Pt 2):255-62.


DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women.

Ludwig EH, Mahley RW, Palaoglu E, Ozbayrakçi S, Balestra ME, Borecki IB, Innerarity TL, Farese RV Jr.

Clin Genet. 2002 Jul;62(1):68-73.


Effect of arginine 172 on the binding of apolipoprotein E to the low density lipoprotein receptor.

Morrow JA, Arnold KS, Dong J, Balestra ME, Innerarity TL, Weisgraber KH.

J Biol Chem. 2000 Jan 28;275(4):2576-80.


Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.

Qian X, Balestra ME, Yamanaka S, Borén J, Lee I, Innerarity TL.

Arterioscler Thromb Vasc Biol. 1998 Jun;18(6):1013-20.


Differences in receptor binding of LDL subfractions.

Campos H, Arnold KS, Balestra ME, Innerarity TL, Krauss RM.

Arterioscler Thromb Vasc Biol. 1996 Jun;16(6):794-801.


Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.

Yamanaka S, Balestra ME, Ferrell LD, Fan J, Arnold KS, Taylor S, Taylor JM, Innerarity TL.

Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8483-7.


Isolation of allele-specific, receptor-binding-defective low density lipoproteins from familial defective apolipoprotein B-100 subjects.

Arnold KS, Balestra ME, Krauss RM, Curtiss LK, Young SG, Innerarity TL.

J Lipid Res. 1994 Aug;35(8):1469-76.


Characterization of apolipoprotein B mRNA editing from rabbit intestine.

Garcia ZC, Poksay KS, Boström K, Johnson DF, Balestra ME, Shechter I, Innerarity TL.

Arterioscler Thromb. 1992 Feb;12(2):172-9.


Apolipoprotein B gene mutations in Austrian subjects with heart disease and their kindred.

Friedl W, Ludwig EH, Balestra ME, Arnold KS, Paulweber B, Sandhofer F, McCarthy BJ, Innerarity TL.

Arterioscler Thromb. 1991 Mar-Apr;11(2):371-8.

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