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Items: 37


Microfluidic Cell Culture Platforms to Capture Hepatic Physiology and Complex Cellular Interactions.

Bale SS, Borenstein JT.

Drug Metab Dispos. 2018 Nov;46(11):1638-1646. doi: 10.1124/dmd.118.083055. Epub 2018 Aug 16.


Multi-omic network-based interrogation of rat liver metabolism following gastric bypass surgery featuring SWATH proteomics.

Sridharan GV, D'Alessandro M, Bale SS, Bhagat V, Gagnon H, Asara JM, Uygun K, Yarmush ML, Saeidi N.

Technology (Singap World Sci). 2017 Sep;5(3):139-184. doi: 10.1142/S233954781750008X. Epub 2017 Sep 26.


Metabolomic Modularity Analysis (MMA) to Quantify Human Liver Perfusion Dynamics.

Sridharan GV, Bruinsma BG, Bale SS, Swaminathan A, Saeidi N, Yarmush ML, Uygun K.

Metabolites. 2017 Nov 13;7(4). pii: E58. doi: 10.3390/metabo7040058.


A microfluidic in-line ELISA for measuring secreted protein under perfusion.

Luan Q, Cahoon S, Wu A, Bale SS, Yarmush M, Bhushan A.

Biomed Microdevices. 2017 Nov 11;19(4):101. doi: 10.1007/s10544-017-0244-6.


Exposure to human immunodeficiency virus/hepatitis C virus in hepatic and stellate cell lines reveals cooperative profibrotic transcriptional activation between viruses and cell types.

Salloum S, Holmes JA, Jindal R, Bale SS, Brisac C, Alatrakchi N, Lidofsky A, Kruger AJ, Fusco DN, Luther J, Schaefer EA, Lin W, Yarmush ML, Chung RT.

Hepatology. 2016 Dec;64(6):1951-1968. doi: 10.1002/hep.28766. Epub 2016 Oct 5.


Isolation and co-culture of rat parenchymal and non-parenchymal liver cells to evaluate cellular interactions and response.

Bale SS, Geerts S, Jindal R, Yarmush ML.

Sci Rep. 2016 May 4;6:25329. doi: 10.1038/srep25329.


Emerging In Vitro Liver Technologies for Drug Metabolism and Inter-Organ Interactions.

Bale SS, Moore L, Yarmush M, Jindal R.

Tissue Eng Part B Rev. 2016 Oct;22(5):383-394. Epub 2016 Jun 1. Review.


A novel low-volume two-chamber microfabricated platform for evaluating drug metabolism and toxicity.

Bale SS, Sridharan GV, Golberg I, Prodanov L, McCarty WJ, Usta OB, Jindal R, Yarmush ML.

Technology (Singap World Sci). 2015 Dec;3(4):155-162. Epub 2015 Apr 21.


Layer-by-layer Collagen Deposition in Microfluidic Devices for Microtissue Stabilization.

McCarty WJ, Prodanov L, Bale SS, Bhushan A, Jindal R, Yarmush ML, Usta OB.

J Vis Exp. 2015 Sep 29;(103). doi: 10.3791/53078.


Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability.

Luther J, Garber JJ, Khalili H, Dave M, Bale SS, Jindal R, Motola DL, Luther S, Bohr S, Jeoung SW, Deshpande V, Singh G, Turner JR, Yarmush ML, Chung RT, Patel SJ.

Cell Mol Gastroenterol Hepatol. 2015 Mar;1(2):222-232.


Long-term maintenance of a microfluidic 3D human liver sinusoid.

Prodanov L, Jindal R, Bale SS, Hegde M, McCarty WJ, Golberg I, Bhushan A, Yarmush ML, Usta OB.

Biotechnol Bioeng. 2016 Jan;113(1):241-6. doi: 10.1002/bit.25700. Epub 2015 Aug 26.


Engineered Trehalose Permeable to Mammalian Cells.

Abazari A, Meimetis LG, Budin G, Bale SS, Weissleder R, Toner M.

PLoS One. 2015 Jun 26;10(6):e0130323. doi: 10.1371/journal.pone.0130323. eCollection 2015.


Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells.

Bohr S, Patel SJ, Vasko R, Shen K, Iracheta-Vellve A, Lee J, Bale SS, Chakraborty N, Brines M, Cerami A, Berthiaume F, Yarmush ML.

J Mol Med (Berl). 2015 Feb;93(2):199-210. doi: 10.1007/s00109-014-1218-2. Epub 2014 Nov 6.


Long-term coculture strategies for primary hepatocytes and liver sinusoidal endothelial cells.

Bale SS, Golberg I, Jindal R, McCarty WJ, Luitje M, Hegde M, Bhushan A, Usta OB, Yarmush ML.

Tissue Eng Part C Methods. 2015 Apr;21(4):413-22. doi: 10.1089/ten.TEC.2014.0152. Epub 2014 Nov 6.


A novel ultrathin collagen nanolayer assembly for 3-D microtissue engineering: Layer-by-layer collagen deposition for long-term stable microfluidic hepatocyte culture.

McCarty WJ, Usta OB, Luitje M, Bale SS, Bhushan A, Hegde M, Golberg I, Jindal R, Yarmush ML.

Technology (Singap World Sci). 2014 Mar;2(1):67-74.


Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform.

Hegde M, Jindal R, Bhushan A, Bale SS, McCarty WJ, Golberg I, Usta OB, Yarmush ML.

Lab Chip. 2014 Jun 21;14(12):2033-9. doi: 10.1039/c4lc00071d. Epub 2014 Apr 28.


In vitro platforms for evaluating liver toxicity.

Bale SS, Vernetti L, Senutovitch N, Jindal R, Hegde M, Gough A, McCarty WJ, Bakan A, Bhushan A, Shun TY, Golberg I, DeBiasio R, Usta BO, Taylor DL, Yarmush ML.

Exp Biol Med (Maywood). 2014 Sep;239(9):1180-1191. doi: 10.1177/1535370214531872. Epub 2014 Apr 24. Review.


Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans.

Bhushan A, Senutovitch N, Bale SS, McCarty WJ, Hegde M, Jindal R, Golberg I, Berk Usta O, Yarmush ML, Vernetti L, Gough A, Bakan A, Shun TY, DeBiasio R, Lansing Taylor D.

Stem Cell Res Ther. 2013;4 Suppl 1:S16. doi: 10.1186/scrt377. Epub 2013 Dec 20. Review.


Disorganized collagen scaffold interferes with fibroblast mediated deposition of organized extracellular matrix in vitro.

Saeidi N, Guo X, Hutcheon AE, Sander EA, Bale SS, Melotti SA, Zieske JD, Trinkaus-Randall V, Ruberti JW.

Biotechnol Bioeng. 2012 Oct;109(10):2683-98. doi: 10.1002/bit.24533. Epub 2012 May 4.


Ex vivo gene delivery to hepatocytes: techniques, challenges, and underlying mechanisms.

Gao S, Seker E, Casali M, Wang F, Bale SS, Price GM, Yarmush ML.

Ann Biomed Eng. 2012 Sep;40(9):1851-61. doi: 10.1007/s10439-012-0555-y. Epub 2012 Apr 7.


Particles and microfluidics merged: perspectives of highly sensitive diagnostic detection.

Konry T, Bale SS, Bhushan A, Shen K, Seker E, Polyak B, Yarmush M.

Mikrochim Acta. 2012 Feb;176(3-4):251-269.


Polyphenolic glycosides and aglycones utilize opposing pathways to selectively remodel and inactivate toxic oligomers of amyloid ╬▓.

Ladiwala AR, Mora-Pale M, Lin JC, Bale SS, Fishman ZS, Dordick JS, Tessier PM.

Chembiochem. 2011 Jul 25;12(11):1749-58. doi: 10.1002/cbic.201100123. Epub 2011 Jun 10.


Kinesin I ATPase manipulates biohybrids formed from tubulin and carbon nanotubes.

Dinu CZ, Bale SS, Dordick JS.

Methods Mol Biol. 2011;743:77-93. doi: 10.1007/978-1-61779-132-1_7.


Regulation of stem cell signaling by nanoparticle-mediated intracellular protein delivery.

Shah DA, Kwon SJ, Bale SS, Banerjee A, Dordick JS, Kane RS.

Biomaterials. 2011 Apr;32(12):3210-9. doi: 10.1016/j.biomaterials.2010.11.077. Epub 2011 Feb 5.


Single-walled carbon nanotubes alter Schwann cell behavior differentially within 2D and 3D environments.

Behan BL, DeWitt DG, Bogdanowicz DR, Koppes AN, Bale SS, Thompson DM.

J Biomed Mater Res A. 2011 Jan;96(1):46-57. doi: 10.1002/jbm.a.32939. Epub 2010 Oct 14.


A GFP complementation system for monitoring and directing nanomaterial mediated protein delivery to human cellular organelles.

Bale SS, Kwon SJ, Shah DA, Kane RS, Dordick JS.

Biotechnol Bioeng. 2010 Dec 15;107(6):1040-7. doi: 10.1002/bit.22897.


Antistaphylococcal nanocomposite films based on enzyme-nanotube conjugates.

Pangule RC, Brooks SJ, Dinu CZ, Bale SS, Salmon SL, Zhu G, Metzger DW, Kane RS, Dordick JS.

ACS Nano. 2010 Jul 27;4(7):3993-4000. doi: 10.1021/nn100932t.


Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers.

Ladiwala AR, Lin JC, Bale SS, Marcelino-Cruz AM, Bhattacharya M, Dordick JS, Tessier PM.

J Biol Chem. 2010 Jul 30;285(31):24228-37. doi: 10.1074/jbc.M110.133108. Epub 2010 May 28.


Nanoparticle-mediated cytoplasmic delivery of proteins to target cellular machinery.

Bale SS, Kwon SJ, Shah DA, Banerjee A, Dordick JS, Kane RS.

ACS Nano. 2010 Mar 23;4(3):1493-500. doi: 10.1021/nn901586e.


Three-dimensional cell culture microarray for high-throughput studies of stem cell fate.

Fernandes TG, Kwon SJ, Bale SS, Lee MY, Diogo MM, Clark DS, Cabral JM, Dordick JS.

Biotechnol Bioeng. 2010 May 1;106(1):106-18. doi: 10.1002/bit.22661.


Tubulin encapsulation of carbon nanotubes into functional hybrid assemblies.

Dinu CZ, Bale SS, Zhu G, Dordick JS.

Small. 2009 Mar;5(3):310-5. doi: 10.1002/smll.200801434. No abstract available.


Nanotube-assisted protein deactivation.

Joshi A, Punyani S, Bale SS, Yang H, Borca-Tasciuc T, Kane RS.

Nat Nanotechnol. 2008 Jan;3(1):41-5. doi: 10.1038/nnano.2007.386. Epub 2007 Dec 9.


Structure, function, and stability of enzymes covalently attached to single-walled carbon nanotubes.

Asuri P, Bale SS, Pangule RC, Shah DA, Kane RS, Dordick JS.

Langmuir. 2007 Nov 20;23(24):12318-21. Epub 2007 Oct 18.


The protein-nanomaterial interface.

Asuri P, Bale SS, Karajanagi SS, Kane RS.

Curr Opin Biotechnol. 2006 Dec;17(6):562-8. Epub 2006 Oct 2. Review.


Cytological effects of kepone on Chinese hamster cells.

Bale SS.

J Hered. 1983 Mar-Apr;74(2):123-4.


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