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Items: 1 to 50 of 209

1.

PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines.

Wang K, Huynh N, Wang X, Pajic M, Parkin A, Man J, Baldwin GS, Nikfarjam M, He H.

Am J Transl Res. 2019 Jun 15;11(6):3353-3364. eCollection 2019.

2.

Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associated with downregulation of p21-activated kinases in pancreatic cancer.

Wang K, Baldwin GS, Nikfarjam M, He H.

Am J Physiol Gastrointest Liver Physiol. 2019 May 1;316(5):G632-G640. doi: 10.1152/ajpgi.00344.2018. Epub 2019 Mar 7.

PMID:
30844294
3.

Preconditioning against renal ischaemia reperfusion injury: the failure to translate to the clinic.

O'Kane D, Baldwin GS, Bolton DM, Ischia JJ, Patel O.

J Nephrol. 2019 Aug;32(4):539-547. doi: 10.1007/s40620-019-00582-6. Epub 2019 Jan 11. Review.

PMID:
30635875
4.

Structural basis for recognition and repair of the 3'-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis.

Silhan J, Zhao Q, Boura E, Thomson H, Förster A, Tang CM, Freemont PS, Baldwin GS.

Nucleic Acids Res. 2018 Dec 14;46(22):11980-11989. doi: 10.1093/nar/gky934.

5.

Redox Kinetics of the Amyloid-β-Cu Complex and Its Biological Implications.

Girvan P, Teng X, Brooks NJ, Baldwin GS, Ying L.

Biochemistry. 2018 Oct 30;57(43):6228-6233. doi: 10.1021/acs.biochem.8b00133. Epub 2018 Oct 12.

6.

p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation.

Wang K, Baldwin GS, Nikfarjam M, He H.

World J Gastroenterol. 2018 Sep 7;24(33):3709-3723. doi: 10.3748/wjg.v24.i33.3709. Review.

7.

Zinc preconditioning protects against renal ischaemia reperfusion injury in a preclinical sheep large animal model.

O'Kane D, Gibson L, May CN, du Plessis J, Shulkes A, Baldwin GS, Bolton D, Ischia J, Patel O.

Biometals. 2018 Oct;31(5):821-834. doi: 10.1007/s10534-018-0125-3. Epub 2018 Jul 4.

PMID:
29974287
8.

Zinc ion dyshomeostasis increases resistance of prostate cancer cells to oxidative stress via upregulation of HIF1α.

Wetherell D, Baldwin GS, Shulkes A, Bolton D, Ischia J, Patel O.

Oncotarget. 2018 Jan 3;9(9):8463-8477. doi: 10.18632/oncotarget.23893. eCollection 2018 Feb 2.

9.

Oral trivalent bismuth ions decrease, and trivalent indium or ruthenium ions increase, intestinal tumor burden in ApcΔ14/+ mice.

Laval M, Dumesny C, Eutick M, Baldwin GS, Marshall KM.

Metallomics. 2018 Jan 24;10(1):194-200. doi: 10.1039/c7mt00272f.

PMID:
29296993
10.

Complexes of gastrin with In3+, Ru3+ or Ga3+ ions are not recognised by the cholecystokinin 2 receptor.

Laval M, Marshall KM, Sachinidis J, Scott A, Eutick M, Baldwin GS.

J Biol Inorg Chem. 2017 Oct;22(7):999-1006. doi: 10.1007/s00775-017-1478-8. Epub 2017 Jul 12.

PMID:
28702751
11.

Protective effect of zinc preconditioning against renal ischemia reperfusion injury is dose dependent.

Rao K, Sethi K, Ischia J, Gibson L, Galea L, Xiao L, Yim M, Chang M, Papa N, Bolton D, Shulkes A, Baldwin GS, Patel O.

PLoS One. 2017 Jul 7;12(7):e0180028. doi: 10.1371/journal.pone.0180028. eCollection 2017.

12.

Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis.

Huynh N, Wang K, Yim M, Dumesny CJ, Sandrin MS, Baldwin GS, Nikfarjam M, He H.

BMC Cancer. 2017 Jun 19;17(1):431. doi: 10.1186/s12885-017-3432-0.

13.

Progastrin: a potential predictive marker of liver metastasis in colorectal cancer.

Westwood DA, Patel O, Christophi C, Shulkes A, Baldwin GS.

Int J Colorectal Dis. 2017 Jul;32(7):1061-1064. doi: 10.1007/s00384-017-2822-8. Epub 2017 Apr 21.

PMID:
28432443
14.

Inhibition of group 1 p21-activated kinases suppresses pancreatic stellate cell activation and increases survival of mice with pancreatic cancer.

Yeo D, Phillips P, Baldwin GS, He H, Nikfarjam M.

Int J Cancer. 2017 May 1;140(9):2101-2111. doi: 10.1002/ijc.30615. Epub 2017 Feb 7.

15.

Zinc Ions Mediate Gastrin Expression, Proliferation, and Migration Downstream of the Cholecystokinin-2 Receptor.

Chang M, Xiao L, Shulkes A, Baldwin GS, Patel O.

Endocrinology. 2016 Dec;157(12):4706-4719. Epub 2016 Oct 31.

PMID:
27797597
16.

BASIC: A Simple and Accurate Modular DNA Assembly Method.

Storch M, Casini A, Mackrow B, Ellis T, Baldwin GS.

Methods Mol Biol. 2017;1472:79-91. doi: 10.1007/978-1-4939-6343-0_6.

PMID:
27671933
17.

Glaucarubinone Combined with Gemcitabine Improves Pancreatic Cancer Survival in an Immunocompetent Orthotopic Murine Model.

Yeo D, Huynh N, Beutler JA, Baldwin GS, He H, Nikfarjam M.

J Invest Surg. 2016 Dec;29(6):366-372. Epub 2016 Mar 30.

PMID:
27027695
18.

FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine.

Yeo D, He H, Patel O, Lowy AM, Baldwin GS, Nikfarjam M.

BMC Cancer. 2016 Jan 16;16:24. doi: 10.1186/s12885-016-2057-z.

19.

Tyrosine modification increases the affinity of gastrin for ferric ions.

Baldwin GS, Sims I.

Springerplus. 2015 Dec 24;4:815. doi: 10.1186/s40064-015-1622-2. eCollection 2015.

20.

Retro-inverso forms of gastrin5-12 are as biologically active as glycine-extended gastrin in vitro but not in vivo.

Marshall KM, Laval M, Sims I, Shulkes A, Baldwin GS.

Peptides. 2015 Dec;74:16-22. doi: 10.1016/j.peptides.2015.09.012. Epub 2015 Oct 22.

PMID:
26471904
21.

High Affinity Binding of Indium and Ruthenium Ions by Gastrins.

Baldwin GS, George GN, Pushie MJ.

PLoS One. 2015 Oct 12;10(10):e0140126. doi: 10.1371/journal.pone.0140126. eCollection 2015.

22.

Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo.

Marshall KM, Laval M, Estacio O, Hudson DF, Kalitsis P, Shulkes A, Baldwin GS, Patel O.

Metallomics. 2015 Oct;7(10):1390-8. doi: 10.1039/c5mt00147a. Epub 2015 Sep 25.

PMID:
26404630
23.

Bricks and blueprints: methods and standards for DNA assembly.

Casini A, Storch M, Baldwin GS, Ellis T.

Nat Rev Mol Cell Biol. 2015 Sep;16(9):568-76. doi: 10.1038/nrm4014. Epub 2015 Jun 17. Review.

24.

The role of p21-activated kinases in pancreatic cancer.

Yeo D, He H, Baldwin GS, Nikfarjam M.

Pancreas. 2015 Apr;44(3):363-9. doi: 10.1097/MPA.0000000000000276. Review.

PMID:
25760284
25.

BASIC: A New Biopart Assembly Standard for Idempotent Cloning Provides Accurate, Single-Tier DNA Assembly for Synthetic Biology.

Storch M, Casini A, Mackrow B, Fleming T, Trewhitt H, Ellis T, Baldwin GS.

ACS Synth Biol. 2015 Jul 17;4(7):781-7. doi: 10.1021/sb500356d. Epub 2015 Apr 16.

26.

HIF1α expression under normoxia in prostate cancer--which pathways to target?

Ranasinghe WK, Baldwin GS, Bolton D, Shulkes A, Ischia J, Patel O.

J Urol. 2015 Mar;193(3):763-70. doi: 10.1016/j.juro.2014.10.085. Epub 2014 Oct 19. Review.

PMID:
25444956
27.

Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and β-catenin via a p-21 activated kinase 1-dependent pathway.

Huynh N, Beutler JA, Shulkes A, Baldwin GS, He H.

Biochim Biophys Acta. 2015 Jan;1853(1):157-65. doi: 10.1016/j.bbamcr.2014.10.013. Epub 2014 Oct 22.

28.

Increased gastrin gene expression provides a physiological advantage to mice under hypoxic conditions.

Laval M, Baldwin GS, Shulkes A, Marshall KM.

Am J Physiol Gastrointest Liver Physiol. 2015 Jan 15;308(2):G76-84. doi: 10.1152/ajpgi.00344.2014. Epub 2014 Nov 13.

29.

Analysis of DNA binding and nucleotide flipping kinetics using two-color two-photon fluorescence lifetime imaging microscopy.

Robinson T, Valluri P, Kennedy G, Sardini A, Dunsby C, Neil MA, Baldwin GS, French PM, de Mello AJ.

Anal Chem. 2014 Nov 4;86(21):10732-40. doi: 10.1021/ac502732s. Epub 2014 Oct 20.

30.

Identification of binding sites for C-terminal pro-gastrin-releasing peptide (GRP)-derived peptides in renal cell carcinoma: a potential target for future therapy.

Ischia J, Patel O, Sethi K, Nordlund MS, Bolton D, Shulkes A, Baldwin GS.

BJU Int. 2015 May;115(5):829-38. doi: 10.1111/bju.12886. Epub 2015 Jan 26.

31.

Gastrin mediates resistance to hypoxia-induced cell death in xenografts of the human colorectal cancer cell line LoVo.

Westwood DA, Patel O, Baldwin GS.

Biochim Biophys Acta. 2014 Nov;1843(11):2471-80. doi: 10.1016/j.bbamcr.2014.06.016. Epub 2014 Jul 3.

32.

Normoxic regulation of HIF-1α in prostate cancer.

Ranasinghe WK, Baldwin GS, Shulkes A, Bolton D, Patel O.

Nat Rev Urol. 2014 Jul;11(7):419. doi: 10.1038/nrurol.2013.110-c2. Epub 2014 Jul 1. No abstract available.

PMID:
24980197
33.

Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells.

Huynh N, Liu KH, Yim M, Shulkes A, Baldwin GS, He H.

Physiol Rep. 2014 Jun 24;2(6). pii: e12048. doi: 10.14814/phy2.12048. Print 2014 Jun 1.

34.

R2oDNA designer: computational design of biologically neutral synthetic DNA sequences.

Casini A, Christodoulou G, Freemont PS, Baldwin GS, Ellis T, MacDonald JT.

ACS Synth Biol. 2014 Aug 15;3(8):525-8. doi: 10.1021/sb4001323. Epub 2014 Feb 11.

PMID:
24933158
35.

Expression and function of gastrin-releasing peptide (GRP) in normal and cancerous urological tissues.

Ischia J, Patel O, Bolton D, Shulkes A, Baldwin GS.

BJU Int. 2014 Mar;113 Suppl 2:40-7. doi: 10.1111/bju.12594. Review.

36.

Circulating gastrin concentrations in patients at increased risk of developing colorectal carcinoma.

Paterson AC, Macrae FA, Pizzey C, Baldwin GS, Shulkes A.

J Gastroenterol Hepatol. 2014 Mar;29(3):480-6.

PMID:
24716212
37.

Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases.

Yeo D, Huynh N, Beutler JA, Christophi C, Shulkes A, Baldwin GS, Nikfarjam M, He H.

Cancer Lett. 2014 May 1;346(2):264-72. doi: 10.1016/j.canlet.2014.01.001. Epub 2014 Jan 31.

PMID:
24491405
38.

Zinc ions upregulate the hormone gastrin via an E-box motif in the proximal gastrin promoter.

Xiao L, Kovac S, Chang M, Shulkes A, Baldwin GS, Patel O.

J Mol Endocrinol. 2013 Dec 20;52(1):29-42. doi: 10.1530/JME-13-0162. Print 2014 Feb.

PMID:
24363439
39.

Activation of Src family tyrosine kinases by ferric ions.

Baldwin GS, Lio DS, Ferrand A, Catimel B, Shehan BP, Norton RS, Cheng HC.

Biochim Biophys Acta. 2014 Mar;1844(3):487-96. doi: 10.1016/j.bbapap.2013.12.004. Epub 2013 Dec 12.

PMID:
24334106
40.

One-pot DNA construction for synthetic biology: the Modular Overlap-Directed Assembly with Linkers (MODAL) strategy.

Casini A, MacDonald JT, De Jonghe J, Christodoulou G, Freemont PS, Baldwin GS, Ellis T.

Nucleic Acids Res. 2014 Jan;42(1):e7. doi: 10.1093/nar/gkt915. Epub 2013 Oct 22.

41.

The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo.

Marshall KM, Patel O, Bramante G, Laval M, Yim M, Baldwin GS, Shulkes A.

Peptides. 2013 Aug;46:83-93. doi: 10.1016/j.peptides.2013.05.009. Epub 2013 Jun 3.

PMID:
23742999
42.

Specific DNA recognition mediated by a type IV pilin.

Cehovin A, Simpson PJ, McDowell MA, Brown DR, Noschese R, Pallett M, Brady J, Baldwin GS, Lea SM, Matthews SJ, Pelicic V.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3065-70. doi: 10.1073/pnas.1218832110. Epub 2013 Feb 5.

43.

The role of hypoxia-inducible factor 1α in determining the properties of castrate-resistant prostate cancers.

Ranasinghe WK, Xiao L, Kovac S, Chang M, Michiels C, Bolton D, Shulkes A, Baldwin GS, Patel O.

PLoS One. 2013;8(1):e54251. doi: 10.1371/journal.pone.0054251. Epub 2013 Jan 16.

44.

p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways.

Huynh N, Yim M, Chernoff J, Shulkes A, Baldwin GS, He H.

Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15;304(6):G561-7. doi: 10.1152/ajpgi.00218.2012. Epub 2013 Jan 10.

45.

p21-activated kinases and gastrointestinal cancer.

He H, Baldwin GS.

Biochim Biophys Acta. 2013 Jan;1833(1):33-9. doi: 10.1016/j.bbamcr.2012.10.015. Epub 2012 Oct 22. Review.

46.

Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.

Lu D, Silhan J, MacDonald JT, Carpenter EP, Jensen K, Tang CM, Baldwin GS, Freemont PS.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16852-7. doi: 10.1073/pnas.1206563109. Epub 2012 Oct 3.

47.

Induction of gastrin expression in gastrointestinal cells by hypoxia or cobalt is independent of hypoxia-inducible factor (HIF).

Xiao L, Kovac S, Chang M, Shulkes A, Baldwin GS, Patel O.

Endocrinology. 2012 Jul;153(7):3006-16. doi: 10.1210/en.2011-2069. Epub 2012 May 16.

48.

A network of enzymes involved in repair of oxidative DNA damage in Neisseria meningitidis.

Nagorska K, Silhan J, Li Y, Pelicic V, Freemont PS, Baldwin GS, Tang CM.

Mol Microbiol. 2012 Mar;83(5):1064-1079. doi: 10.1111/j.1365-2958.2012.07989.x. Epub 2012 Feb 15.

49.

Pro-GRP-derived peptides are expressed in colorectal cancer cells and tumors and are biologically active in vivo.

Patel O, Clyde D, Chang M, Nordlund MS, Steel R, Kemp BE, Pritchard DM, Shulkes A, Baldwin GS.

Endocrinology. 2012 Mar;153(3):1082-92. doi: 10.1210/en.2011-1875. Epub 2011 Dec 27.

PMID:
22202166
50.

Bismuth ions inhibit the biological activity of non-amidated gastrins in vivo.

Kovac S, Loh SW, Lachal S, Shulkes A, Baldwin GS.

Biochem Pharmacol. 2012 Feb 15;83(4):524-30. doi: 10.1016/j.bcp.2011.11.030. Epub 2011 Dec 8.

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