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Formation of a Secretion Competent Protein Complex by a Dynamic Wrap-around Binding Mechanism.

Gupta AA, Reinartz I, Karunanithy G, Spilotros A, Jonna VR, Hofer A, Svergun DI, Baldwin AJ, Schug A, Wolf-Watz M.

J Mol Biol. 2018 Jul 15. pii: S0022-2836(18)30442-X. doi: 10.1016/j.jmb.2018.07.014. [Epub ahead of print]


Mollie Lentaigne, the nurse who drew McIndoe's Guinea pigs: Exploring the role of a medical artist at the Queen Victoria Hospital, 1940-1945.

Baldwin AJ.

J Plast Reconstr Aesthet Surg. 2018 Apr 16. pii: S1748-6815(18)30130-X. doi: 10.1016/j.bjps.2018.04.011. [Epub ahead of print]


Comparison of the characteristics of retinal hemorrhages in abusive head trauma versus normal vaginal delivery.

Kim SY, Morgan LA, Baldwin AJ, Suh DW.

J AAPOS. 2018 Apr;22(2):139-144. doi: 10.1016/j.jaapos.2017.12.006. Epub 2018 Mar 14.


Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions.

Hochberg GKA, Shepherd DA, Marklund EG, Santhanagoplan I, Degiacomi MT, Laganowsky A, Allison TM, Basha E, Marty MT, Galpin MR, Struwe WB, Baldwin AJ, Vierling E, Benesch JLP.

Science. 2018 Feb 23;359(6378):930-935. doi: 10.1126/science.aam7229.


Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum.

Cocorocchio M, Baldwin AJ, Stewart B, Kim L, Harwood AJ, Thompson CRL, Andrews PLR, Williams RSB.

Dis Model Mech. 2018 Jan 29;11(1). pii: dmm032375. doi: 10.1242/dmm.032375.


Selective Radical Trifluoromethylation of Native Residues in Proteins.

Imiołek M, Karunanithy G, Ng WL, Baldwin AJ, Gouverneur V, Davis BG.

J Am Chem Soc. 2018 Feb 7;140(5):1568-1571. doi: 10.1021/jacs.7b10230. Epub 2018 Jan 22.


Accommodating Protein Dynamics in the Modeling of Chemical Crosslinks.

Degiacomi MT, Schmidt C, Baldwin AJ, Benesch JLP.

Structure. 2017 Nov 7;25(11):1751-1757.e5. doi: 10.1016/j.str.2017.08.015. Epub 2017 Sep 28.


Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation.

Brady JP, Farber PJ, Sekhar A, Lin YH, Huang R, Bah A, Nott TJ, Chan HS, Baldwin AJ, Forman-Kay JD, Kay LE.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8194-E8203. doi: 10.1073/pnas.1706197114. Epub 2017 Sep 11.


Automatic Assignment of Methyl-NMR Spectra of Supramolecular Machines Using Graph Theory.

Pritišanac I, Degiacomi MT, Alderson TR, Carneiro MG, Ab E, Siegal G, Baldwin AJ.

J Am Chem Soc. 2017 Jul 19;139(28):9523-9533. doi: 10.1021/jacs.6b11358. Epub 2017 Jul 10.


Proline isomerization in the C-terminal region of HSP27.

Alderson TR, Benesch JLP, Baldwin AJ.

Cell Stress Chaperones. 2017 Jul;22(4):639-651. doi: 10.1007/s12192-017-0791-z. Epub 2017 May 25.


Monitoring the Disassembly of Virus-like Particles by 19F-NMR.

Leung RLC, Robinson MDM, Ajabali AAA, Karunanithy G, Lyons B, Raj R, Raoufmoghaddam S, Mohammed S, Claridge TDW, Baldwin AJ, Davis BG.

J Am Chem Soc. 2017 Apr 19;139(15):5277-5280. doi: 10.1021/jacs.6b11040. Epub 2017 Apr 7.


Reliability of inertial sensors in the assessment of patients with vestibular disorders: a feasibility study.

Sankarpandi SK, Baldwin AJ, Ray J, Mazzà C.

BMC Ear Nose Throat Disord. 2017 Feb 2;17:1. doi: 10.1186/s12901-017-0034-z. eCollection 2017.


The role of interfacial lipids in stabilizing membrane protein oligomers.

Gupta K, Donlan JAC, Hopper JTS, Uzdavinys P, Landreh M, Struwe WB, Drew D, Baldwin AJ, Stansfeld PJ, Robinson CV.

Nature. 2017 Jan 19;541(7637):421-424. doi: 10.1038/nature20820. Epub 2017 Jan 11.


Polyglycine Acts as a Rejection Signal for Protein Transport at the Chloroplast Envelope.

Endow JK, Rocha AG, Baldwin AJ, Roston RL, Yamaguchi T, Kamikubo H, Inoue K.

PLoS One. 2016 Dec 9;11(12):e0167802. doi: 10.1371/journal.pone.0167802. eCollection 2016.


Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity.

Wright TH, Bower BJ, Chalker JM, Bernardes GJ, Wiewiora R, Ng WL, Raj R, Faulkner S, Vallée MR, Phanumartwiwath A, Coleman OD, Thézénas ML, Khan M, Galan SR, Lercher L, Schombs MW, Gerstberger S, Palm-Espling ME, Baldwin AJ, Kessler BM, Claridge TD, Mohammed S, Davis BG.

Science. 2016 Nov 4;354(6312). pii: aag1465. Epub 2016 Sep 22.


Determination of an optimally sensitive and specific chemical exchange saturation transfer MRI quantification metric in relevant biological phantoms.

Ray KJ, Larkin JR, Tee YK, Khrapitchev AA, Karunanithy G, Barber M, Baldwin AJ, Chappell MA, Sibson NR.

NMR Biomed. 2016 Nov;29(11):1624-1633. doi: 10.1002/nbm.3614. Epub 2016 Sep 30.


Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters.

Nott TJ, Craggs TD, Baldwin AJ.

Nat Chem. 2016 Jun;8(6):569-75. doi: 10.1038/nchem.2519. Epub 2016 May 16.


Harnessing NMR relaxation interference effects to characterise supramolecular assemblies.

Karunanithy G, Cnossen A, Müller H, Peeks MD, Rees NH, Claridge TD, Anderson HL, Baldwin AJ.

Chem Commun (Camb). 2016 Jun 14;52(47):7450-3. doi: 10.1039/c6cc02544g. Epub 2016 Apr 28.


Aflibercept for neovascular age-related macular degeneration.

Sarwar S, Clearfield E, Soliman MK, Sadiq MA, Baldwin AJ, Hanout M, Agarwal A, Sepah YJ, Do DV, Nguyen QD.

Cochrane Database Syst Rev. 2016 Feb 8;2:CD011346. doi: 10.1002/14651858.CD011346.pub2. Review.


Quantifying the stabilizing effects of protein-ligand interactions in the gas phase.

Allison TM, Reading E, Liko I, Baldwin AJ, Laganowsky A, Robinson CV.

Nat Commun. 2015 Oct 6;6:8551. doi: 10.1038/ncomms9551.


In-frame amber stop codon replacement mutagenesis for the directed evolution of proteins containing non-canonical amino acids: identification of residues open to bio-orthogonal modification.

Arpino JA, Baldwin AJ, McGarrity AR, Tippmann EM, Jones DD.

PLoS One. 2015 May 26;10(5):e0127504. doi: 10.1371/journal.pone.0127504. eCollection 2015.


Investigating the mechanisms of amylolysis of starch granules by solution-state NMR.

Baldwin AJ, Egan DL, Warren FJ, Barker PD, Dobson CM, Butterworth PJ, Ellis PR.

Biomacromolecules. 2015 May 11;16(5):1614-21. doi: 10.1021/acs.biomac.5b00190. Epub 2015 Apr 14.


Collision cross sections for structural proteomics.

Marklund EG, Degiacomi MT, Robinson CV, Baldwin AJ, Benesch JL.

Structure. 2015 Apr 7;23(4):791-9. doi: 10.1016/j.str.2015.02.010. Epub 2015 Mar 19.


Bayesian deconvolution of mass and ion mobility spectra: from binary interactions to polydisperse ensembles.

Marty MT, Baldwin AJ, Marklund EG, Hochberg GK, Benesch JL, Robinson CV.

Anal Chem. 2015 Apr 21;87(8):4370-6. doi: 10.1021/acs.analchem.5b00140. Epub 2015 Apr 1.


Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles.

Nott TJ, Petsalaki E, Farber P, Jervis D, Fussner E, Plochowietz A, Craggs TD, Bazett-Jones DP, Pawson T, Forman-Kay JD, Baldwin AJ.

Mol Cell. 2015 Mar 5;57(5):936-947. doi: 10.1016/j.molcel.2015.01.013.


Directed evolution of GFP with non-natural amino acids identifies residues for augmenting and photoswitching fluorescence.

Reddington SC, Baldwin AJ, Thompson R, Brancale A, Tippmann EM, Jones DD.

Chem Sci. 2015 Feb 1;6(2):1159-1166. doi: 10.1039/c4sc02827a. Epub 2014 Nov 7.


Transposon-based approaches for generating novel molecular diversity during directed evolution.

Jones DD, Arpino JA, Baldwin AJ, Edmundson MC.

Methods Mol Biol. 2014;1179:159-72. doi: 10.1007/978-1-4939-1053-3_11.


Membrane proteins bind lipids selectively to modulate their structure and function.

Laganowsky A, Reading E, Allison TM, Ulmschneider MB, Degiacomi MT, Baldwin AJ, Robinson CV.

Nature. 2014 Jun 5;510(7503):172-175. doi: 10.1038/nature13419.


An exact solution for R2,eff in CPMG experiments in the case of two site chemical exchange.

Baldwin AJ.

J Magn Reson. 2014 Jul;244:114-24. doi: 10.1016/j.jmr.2014.02.023. Epub 2014 Apr 13.


The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity.

Hochberg GK, Ecroyd H, Liu C, Cox D, Cascio D, Sawaya MR, Collier MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JL, Laganowsky A.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):E1562-70. doi: 10.1073/pnas.1322673111. Epub 2014 Apr 7.


The significance of the Dewar valence photoisomer as a UV radiation-induced DNA photoproduct in marine microbial communities.

Meador JA, Baldwin AJ, Pakulski JD, Jeffrey WH, Mitchell DL, Douki T.

Environ Microbiol. 2014 Jun;16(6):1808-20. doi: 10.1111/1462-2920.12414. Epub 2014 Mar 5.


C-terminal interactions mediate the quaternary dynamics of αB-crystallin.

Hilton GR, Hochberg GK, Laganowsky A, McGinnigle SI, Baldwin AJ, Benesch JL.

Philos Trans R Soc Lond B Biol Sci. 2013 Mar 25;368(1617):20110405. doi: 10.1098/rstb.2011.0405. Print 2013 May 5.


An R(1ρ) expression for a spin in chemical exchange between two sites with unequal transverse relaxation rates.

Baldwin AJ, Kay LE.

J Biomol NMR. 2013 Feb;55(2):211-8. doi: 10.1007/s10858-012-9694-6. Epub 2013 Jan 23.


Probing dynamic conformations of the high-molecular-weight αB-crystallin heat shock protein ensemble by NMR spectroscopy.

Baldwin AJ, Walsh P, Hansen DF, Hilton GR, Benesch JL, Sharpe S, Kay LE.

J Am Chem Soc. 2012 Sep 19;134(37):15343-50. Epub 2012 Sep 7.


Use of X-ray micro tomography to study the microstructure of loose-packed and compacted milk powders.

Chawanji AS, Baldwin AJ, Brisson G, Webster E.

J Microsc. 2012 Oct;248(1):49-57. doi: 10.1111/j.1365-2818.2012.03649.x. Epub 2012 Aug 17.


Structural biology: Dynamic binding.

Baldwin AJ, Kay LE.

Nature. 2012 Aug 9;488(7410):165-6. doi: 10.1038/488165a. No abstract available.


Dissecting heterogeneous molecular chaperone complexes using a mass spectrum deconvolution approach.

Stengel F, Baldwin AJ, Bush MF, Hilton GR, Lioe H, Basha E, Jaya N, Vierling E, Benesch JL.

Chem Biol. 2012 May 25;19(5):599-607. doi: 10.1016/j.chembiol.2012.04.007.


Small heat-shock proteins: paramedics of the cell.

Hilton GR, Lioe H, Stengel F, Baldwin AJ, Benesch JL.

Top Curr Chem. 2013;328:69-98. doi: 10.1007/128_2012_324. Review.


The morphology of decorated amyloid fibers is controlled by the conformation and position of the displayed protein.

Forman CJ, Nickson AA, Anthony-Cahill SJ, Baldwin AJ, Kaggwa G, Feber U, Sheikh K, Jarvis SP, Barker PD.

ACS Nano. 2012 Feb 28;6(2):1332-46. doi: 10.1021/nn204140a. Epub 2012 Feb 14.


The polydispersity of αB-crystallin is rationalized by an interconverting polyhedral architecture.

Baldwin AJ, Lioe H, Hilton GR, Baker LA, Rubinstein JL, Kay LE, Benesch JL.

Structure. 2011 Dec 7;19(12):1855-63. doi: 10.1016/j.str.2011.09.015.


Functional diversification of thylakoidal processing peptidases in Arabidopsis thaliana.

Hsu SC, Endow JK, Ruppel NJ, Roston RL, Baldwin AJ, Inoue K.

PLoS One. 2011;6(11):e27258. doi: 10.1371/journal.pone.0027258. Epub 2011 Nov 7.


Quaternary dynamics of αB-crystallin as a direct consequence of localised tertiary fluctuations in the C-terminus.

Baldwin AJ, Hilton GR, Lioe H, Bagnéris C, Benesch JL, Kay LE.

J Mol Biol. 2011 Oct 21;413(2):310-20. doi: 10.1016/j.jmb.2011.07.017. Epub 2011 Aug 3.


αB-crystallin polydispersity is a consequence of unbiased quaternary dynamics.

Baldwin AJ, Lioe H, Robinson CV, Kay LE, Benesch JL.

J Mol Biol. 2011 Oct 21;413(2):297-309. doi: 10.1016/j.jmb.2011.07.016. Epub 2011 Aug 3.


Metastability of native proteins and the phenomenon of amyloid formation.

Baldwin AJ, Knowles TP, Tartaglia GG, Fitzpatrick AW, Devlin GL, Shammas SL, Waudby CA, Mossuto MF, Meehan S, Gras SL, Christodoulou J, Anthony-Cahill SJ, Barker PD, Vendruscolo M, Dobson CM.

J Am Chem Soc. 2011 Sep 14;133(36):14160-3. doi: 10.1021/ja2017703. Epub 2011 Aug 19.


Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions.

Shammas SL, Knowles TP, Baldwin AJ, Macphee CE, Welland ME, Dobson CM, Devlin GL.

Biophys J. 2011 Jun 8;100(11):2783-91. doi: 10.1016/j.bpj.2011.04.039.


The quaternary organization and dynamics of the molecular chaperone HSP26 are thermally regulated.

Benesch JL, Aquilina JA, Baldwin AJ, Rekas A, Stengel F, Lindner RA, Basha E, Devlin GL, Horwitz J, Vierling E, Carver JA, Robinson CV.

Chem Biol. 2010 Sep 24;17(9):1008-17. doi: 10.1016/j.chembiol.2010.06.016.


13CHD2 methyl group probes of millisecond time scale exchange in proteins by 1H relaxation dispersion: an application to proteasome gating residue dynamics.

Baldwin AJ, Religa TL, Hansen DF, Bouvignies G, Kay LE.

J Am Chem Soc. 2010 Aug 18;132(32):10992-5. doi: 10.1021/ja104578n.


Regulation of beta-lactamase activity by remote binding of heme: functional coupling of unrelated proteins through domain insertion.

Edwards WR, Williams AJ, Morris JL, Baldwin AJ, Allemann RK, Jones DD.

Biochemistry. 2010 Aug 10;49(31):6541-9. doi: 10.1021/bi100793y.


Remnants of a 35-year-old ventriculo-atrial shunt presenting as orofacial pain.

Chiu GA, Nisar K, Shetty S, Baldwin AJ.

Ann R Coll Surg Engl. 2010 May;92(4):W15-7. doi: 10.1308/147870810X12659688851870.

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