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Targeted High Resolution LC/MS3 Adductomics Method for the Characterization of Endogenous DNA Damage.

Carrà A, Guidolin V, Dator RP, Upadhyaya P, Kassie F, Villalta PW, Balbo S.

Front Chem. 2019 Oct 24;7:658. doi: 10.3389/fchem.2019.00658. eCollection 2019.


Fragmentation Spectra Prediction and DNA Adducts Structural Determination.

Carrà A, Macaluso V, Villalta PW, Spezia R, Balbo S.

J Am Soc Mass Spectrom. 2019 Nov 6. doi: 10.1007/s13361-019-02348-7. [Epub ahead of print]


Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring.

Teleken JL, Gomes ECZ, Marmentini C, Moi MB, Ribeiro RA, Balbo SL, Amorim EMP, Bonfleur ML.

J Dev Orig Health Dis. 2019 Jul 16:1-8. doi: 10.1017/S2040174419000382. [Epub ahead of print]


Reactivity of an Unusual Amidase May Explain Colibactin's DNA Cross-Linking Activity.

Jiang Y, Stornetta A, Villalta PW, Wilson MR, Boudreau PD, Zha L, Balbo S, Balskus EP.

J Am Chem Soc. 2019 Jul 24;141(29):11489-11496. doi: 10.1021/jacs.9b02453. Epub 2019 Jul 11.


Alcohol Effects on Colon Epithelium are Time-Dependent.

Bishehsari F, Zhang L, Voigt RM, Maltby N, Semsarieh B, Zorub E, Shaikh M, Wilber S, Armstrong AR, Mirbagheri SS, Preite NZ, Song P, Stornetta A, Balbo S, Forsyth CB, Keshavarzian A.

Alcohol Clin Exp Res. 2019 Sep;43(9):1898-1908. doi: 10.1111/acer.14141. Epub 2019 Jul 22.


Bioanalytical and Mass Spectrometric Methods for Aldehyde Profiling in Biological Fluids.

Dator RP, Solivio MJ, Villalta PW, Balbo S.

Toxics. 2019 Jun 4;7(2). pii: E32. doi: 10.3390/toxics7020032. Review.


The Bile Acid TUDCA Improves Beta-Cell Mass and Reduces Insulin Degradation in Mice With Early-Stage of Type-1 Diabetes.

Bronczek GA, Vettorazzi JF, Soares GM, Kurauti MA, Santos C, Bonfim MF, Carneiro EM, Balbo SL, Boschero AC, Costa Júnior JM.

Front Physiol. 2019 May 15;10:561. doi: 10.3389/fphys.2019.00561. eCollection 2019.


Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde.

Sobh A, Loguinov A, Stornetta A, Balbo S, Tagmount A, Zhang L, Vulpe CD.

Toxicol Sci. 2019 May 1;169(1):235-245. doi: 10.1093/toxsci/kfz037.


Maternal Roux-en-Y gastric bypass impairs insulin action and endocrine pancreatic function in male F1 offspring.

Pietrobon CB, Bertasso IM, Ribeiro RA, Alegre-Maller ACP, Lubaczeuski C, Boschero AC, Araújo ACF, Balbo SL, Bonfleur ML.

Eur J Nutr. 2019 Apr 13. doi: 10.1007/s00394-019-01968-9. [Epub ahead of print]


The human gut bacterial genotoxin colibactin alkylates DNA.

Wilson MR, Jiang Y, Villalta PW, Stornetta A, Boudreau PD, Carrá A, Brennan CA, Chun E, Ngo L, Samson LD, Engelward BP, Garrett WS, Balbo S, Balskus EP.

Science. 2019 Feb 15;363(6428). pii: eaar7785. doi: 10.1126/science.aar7785.


Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N'-Nitrosonornicotine.

Li Y, Ma B, Cao Q, Balbo S, Zhao L, Upadhyaya P, Hecht SS.

Chem Res Toxicol. 2019 Apr 15;32(4):773-783. doi: 10.1021/acs.chemrestox.9b00007. Epub 2019 Feb 26.


Analysis of Acrolein-Derived 1, N2-Propanodeoxyguanosine Adducts in Human Lung DNA from Smokers and Nonsmokers.

Yang J, Balbo S, Villalta PW, Hecht SS.

Chem Res Toxicol. 2019 Feb 18;32(2):318-325. doi: 10.1021/acs.chemrestox.8b00326. Epub 2019 Jan 30.


The Wild West of E-Cigarettes.

Balbo S, Stepanov I.

Chem Res Toxicol. 2018 Sep 17;31(9):823-824. doi: 10.1021/acs.chemrestox.8b00214. Epub 2018 Sep 6.


Tobacco biomarkers and genetic/epigenetic analysis to investigate ethnic/racial differences in lung cancer risk among smokers.

Murphy SE, Park SL, Balbo S, Haiman CA, Hatsukami DK, Patel Y, Peterson LA, Stepanov I, Stram DO, Tretyakova N, Hecht SS, Le Marchand L.

NPJ Precis Oncol. 2018 Aug 22;2:17. doi: 10.1038/s41698-018-0057-y. eCollection 2018. Review.


In Vivo Stable-Isotope Labeling and Mass-Spectrometry-Based Metabolic Profiling of a Potent Tobacco-Specific Carcinogen in Rats.

Dator R, von Weymarn LB, Villalta PW, Hooyman CJ, Maertens LA, Upadhyaya P, Murphy SE, Balbo S.

Anal Chem. 2018 Oct 16;90(20):11863-11872. doi: 10.1021/acs.analchem.8b01881. Epub 2018 Oct 4.


Duodeno-jejunal bypass restores β-cell hypersecretion and islet hypertrophy in western diet obese rats.

Mendes MC, Bonfleur ML, Ribeiro RA, Lubaczeuski C, Fêo AFJ, Vargas R, Carneiro EM, Boschero AC, Araujo ACF, Balbo SL.

Endocrine. 2018 Jun;60(3):407-414. doi: 10.1007/s12020-018-1578-4. Epub 2018 Mar 19.


Correction: Alessia Stornetta et al. Alcohol-Derived Acetaldehyde Exposure in the Oral Cavity. Cancers 2018, 10, 20.

Stornetta A, Guidolin V, Balbo S.

Cancers (Basel). 2018 Mar 16;10(3). pii: E74. doi: 10.3390/cancers10030074.


Alcohol-Derived Acetaldehyde Exposure in the Oral Cavity.

Stornetta A, Guidolin V, Balbo S.

Cancers (Basel). 2018 Jan 14;10(1). pii: E20. doi: 10.3390/cancers10010020. Review. Erratum in: Cancers (Basel). 2018 Mar 16;10 (3):.


Life-long Maternal Cafeteria Diet Promotes Tissue-Specific Morphological Changes in Male Offspring Adult Rats.

Santos CDS, Balbo SL, Guimarães ATB, Sagae SC, Negretti F, Grassiolli S.

An Acad Bras Cienc. 2017 Oct-Dec;89(4):2887-2900. doi: 10.1590/0001-3765201720170316.


Liver steatosis in hypothalamic obese rats improves after duodeno-jejunal bypass by reduction in de novo lipogenesis pathway.

Soares GM, Cantelli KR, Balbo SL, Ribeiro RA, Alegre-Maller ACP, Barbosa-Sampaio HC, Boschero AC, Araújo ACF, Bonfleur ML.

Life Sci. 2017 Nov 1;188:68-75. doi: 10.1016/j.lfs.2017.08.035. Epub 2017 Sep 1.


Investigation of the presence in human urine of mercapturic acids derived from phenanthrene, a representative polycyclic aromatic hydrocarbon.

Cheng G, Zarth AT, Upadhyaya P, Villalta PW, Balbo S, Hecht SS.

Chem Biol Interact. 2017 Aug 25;274:80-88. doi: 10.1016/j.cbi.2017.07.005. Epub 2017 Jul 8.


Duodenal-jejunal bypass normalizes pancreatic islet proliferation rate and function but not hepatic steatosis in hypothalamic obese rats.

Cantelli KR, Soares GM, Ribeiro RA, Balbo SL, Lubaczeuski C, Boschero AC, Araújo AC, Bonfleur ML.

Braz J Med Biol Res. 2017 Mar 30;50(5):e5858. doi: 10.1590/1414-431X20175858.


Effects of duodenal-jejunal bypass on structure of diaphragm in western diet obese rats.

Ulsenheimer BH, Confortim HD, Jeronimo LC, Centenaro LA, Guimarães AT, Bonfleur ML, Balbo SL, Matheus SM, Torrejais MM.

Acta Cir Bras. 2017 Jan;32(1):1-13. doi: 10.1590/s0102-865020170101.


DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A.

Stornetta A, Villalta PW, Gossner F, Wilson WR, Balbo S, Sturla SJ.

Chem Res Toxicol. 2017 Mar 20;30(3):830-839. doi: 10.1021/acs.chemrestox.6b00412. Epub 2017 Feb 19.


A High Resolution/Accurate Mass (HRAM) Data-Dependent MS3 Neutral Loss Screening, Classification, and Relative Quantitation Methodology for Carbonyl Compounds in Saliva.

Dator R, Carrà A, Maertens L, Guidolin V, Villalta PW, Balbo S.

J Am Soc Mass Spectrom. 2017 Apr;28(4):608-618. doi: 10.1007/s13361-016-1521-y. Epub 2016 Oct 26.


The Aryl Hydrocarbon Receptor is a Repressor of Inflammation-associated Colorectal Tumorigenesis in Mouse.

Díaz-Díaz CJ, Ronnekleiv-Kelly SM, Nukaya M, Geiger PG, Balbo S, Dator R, Megna BW, Carney PR, Bradfield CA, Kennedy GD.

Ann Surg. 2016 Sep;264(3):429-36. doi: 10.1097/SLA.0000000000001874.


Vagotomy diminishes obesity in cafeteria rats by decreasing cholinergic potentiation of insulin release.

Balbo SL, Ribeiro RA, Mendes MC, Lubaczeuski C, Maller AC, Carneiro EM, Bonfleur ML.

J Physiol Biochem. 2016 Dec;72(4):625-633. Epub 2016 Jun 28.


Benefits of L-alanine or L-arginine supplementation against adiposity and glucose intolerance in monosodium glutamate-induced obesity.

Araujo TR, Freitas IN, Vettorazzi JF, Batista TM, Santos-Silva JC, Bonfleur ML, Balbo SL, Boschero AC, Carneiro EM, Ribeiro RA.

Eur J Nutr. 2017 Sep;56(6):2069-2080. doi: 10.1007/s00394-016-1245-6. Epub 2016 Jun 17.


Increased levels of the acetaldehyde-derived DNA adduct N 2-ethyldeoxyguanosine in oral mucosa DNA from Rhesus monkeys exposed to alcohol.

Balbo S, Juanes RC, Khariwala S, Baker EJ, Daunais JB, Grant KA.

Mutagenesis. 2016 Sep;31(5):553-8. doi: 10.1093/mutage/gew016. Epub 2016 Apr 7.


Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis.

Khammanivong A, Anandharaj A, Qian X, Song JM, Upadhyaya P, Balbo S, Bandyopadhyay D, Dickerson EB, Hecht SS, Kassie F.

Mol Carcinog. 2016 Dec;55(12):2168-2182. doi: 10.1002/mc.22459. Epub 2016 Jan 19.


Taurine supplementation regulates Iκ-Bα protein expression in adipose tissue and serum IL-4 and TNF-α concentrations in MSG obesity.

Caetano LC, Bonfleur ML, Ribeiro RA, Nardelli TR, Lubaczeuski C, do Nascimento da Silva J, Carneiro EM, Balbo SL.

Eur J Nutr. 2017 Mar;56(2):705-713. doi: 10.1007/s00394-015-1114-8. Epub 2015 Nov 30.


Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS(3) Adductomic Approach.

Stornetta A, Villalta PW, Hecht SS, Sturla SJ, Balbo S.

Anal Chem. 2015 Dec 1;87(23):11706-13. doi: 10.1021/acs.analchem.5b02759. Epub 2015 Nov 10.


[Blockade of AT1 receptor of Angiotensin II reduces the number of antral follicles in female rats with obesity induced by cafeteria diet].

Sagae SC, Gobo CG, Paz ED, Menegotto JB, Yamashita PK, Franci CR, Balbo SL.

Rev Bras Ginecol Obstet. 2015 Jul;37(7):302-7. doi: 10.1590/S0100-720320150005352. Portuguese.


Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine.

Bonfleur ML, Borck PC, Ribeiro RA, Caetano LC, Soares GM, Carneiro EM, Balbo SL.

Life Sci. 2015 Aug 15;135:15-21. doi: 10.1016/j.lfs.2015.05.019. Epub 2015 Jun 17.


Influence of low-level laser therapy on vertical jump in sedentary individuals.

Kakihata CM, Malanotte JA, Higa JY, Errero TK, Balbo SL, Bertolini GR.

Einstein (Sao Paulo). 2015 Jan-Mar;13(1):41-6. doi: 10.1590/S1679-45082015AO3243. English, Portuguese.


Vagotomy ameliorates islet morphofunction and body metabolic homeostasis in MSG-obese rats.

Lubaczeuski C, Balbo SL, Ribeiro RA, Vettorazzi JF, Santos-Silva JC, Carneiro EM, Bonfleur ML.

Braz J Med Biol Res. 2015 May;48(5):447-57. doi: 10.1590/1414-431X20144340. Epub 2015 Feb 24.


Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease.

Zabala V, Tong M, Yu R, Ramirez T, Yalcin EB, Balbo S, Silbermann E, Deochand C, Nunez K, Hecht S, de la Monte SM.

Alcohol Alcohol. 2015 Mar;50(2):118-31. doi: 10.1093/alcalc/agu083. Epub 2015 Jan 24.


Implications of acetaldehyde-derived DNA adducts for understanding alcohol-related carcinogenesis.

Balbo S, Brooks PJ.

Adv Exp Med Biol. 2015;815:71-88. doi: 10.1007/978-3-319-09614-8_5. Review.


Intranasal delivery of liposomal indole-3-carbinol improves its pulmonary bioavailability.

Song JM, Kirtane AR, Upadhyaya P, Qian X, Balbo S, Teferi F, Panyam J, Kassie F.

Int J Pharm. 2014 Dec 30;477(1-2):96-101. doi: 10.1016/j.ijpharm.2014.10.018. Epub 2014 Oct 11.


Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats.

Balbo S, Johnson CS, Kovi RC, James-Yi SA, O'Sullivan MG, Wang M, Le CT, Khariwala SS, Upadhyaya P, Hecht SS.

Carcinogenesis. 2014 Dec;35(12):2798-806. doi: 10.1093/carcin/bgu204. Epub 2014 Sep 30.


Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats.

Ebertz CE, Bonfleur ML, Bertasso IM, Mendes MC, Lubaczeuski C, Araujo AC, Paes AM, de Amorim EM, Balbo SL.

Acta Cir Bras. 2014 Sep;29(9):609-14.


Duodenal-jejunal bypass restores insulin action and βeta-cell function in hypothalamic-obese rats.

Bonfleur ML, Ribeiro RA, Pavanello A, Soster R, Lubaczeuski C, Cezar Faria Araujo A, Boschero AC, Balbo SL.

Obes Surg. 2015 Apr;25(4):656-65. doi: 10.1007/s11695-014-1427-3.


Analysis of a malondialdehyde-deoxyguanosine adduct in human leukocyte DNA by liquid chromatography nanoelectrospray-high-resolution tandem mass spectrometry.

Ma B, Villalta PW, Balbo S, Stepanov I.

Chem Res Toxicol. 2014 Oct 20;27(10):1829-36. doi: 10.1021/tx5002699. Epub 2014 Sep 15.


Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice.

Narayanapillai SC, Balbo S, Leitzman P, Grill AE, Upadhyaya P, Shaik AA, Zhou B, O'Sullivan MG, Peterson LA, Lu J, Hecht SS, Xing C.

Carcinogenesis. 2014 Oct;35(10):2365-72. doi: 10.1093/carcin/bgu149. Epub 2014 Jul 22.


Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors.

Kennedy GD, Nukaya M, Moran SM, Glover E, Weinberg S, Balbo S, Hecht SS, Pitot HC, Drinkwater NR, Bradfield CA.

Toxicol Sci. 2014 Jul;140(1):135-43. doi: 10.1093/toxsci/kfu065. Epub 2014 Apr 9.


Analysis of the benzene oxide-DNA adduct 7-phenylguanine by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry-parallel reaction monitoring: application to DNA from exposed mice and humans.

Zarth AT, Cheng G, Zhang Z, Wang M, Villalta PW, Balbo S, Hecht SS.

Chem Biol Interact. 2014 May 25;215:40-5. doi: 10.1016/j.cbi.2014.03.002. Epub 2014 Mar 13.


Physical exercise introduced after weaning enhances pancreatic islet responsiveness to glucose and potentiating agents in adult MSG-obese rats.

Ribeiro RA, Bonfleur ML, Vanzela EC, Zotti AI, Scomparin DX, Boschero AC, Balbo SL.

Horm Metab Res. 2014 Aug;46(9):609-14. doi: 10.1055/s-0034-1368705. Epub 2014 Feb 19.


DNA adductomics.

Balbo S, Turesky RJ, Villalta PW.

Chem Res Toxicol. 2014 Mar 17;27(3):356-66. doi: 10.1021/tx4004352. Epub 2014 Feb 25. Review.


Application of a high-resolution mass-spectrometry-based DNA adductomics approach for identification of DNA adducts in complex mixtures.

Balbo S, Hecht SS, Upadhyaya P, Villalta PW.

Anal Chem. 2014 Feb 4;86(3):1744-52. doi: 10.1021/ac403565m. Epub 2014 Jan 21.

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