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Characterization of Glyceollins as Novel Aryl Hydrocarbon Receptor Ligands and Their Role in Cell Migration.

Pham TH, Lecomte S, Le Guevel R, Lardenois A, Evrard B, Chalmel F, Ferriere F, Balaguer P, Efstathiou T, Pakdel F.

Int J Mol Sci. 2020 Feb 18;21(4). pii: E1368. doi: 10.3390/ijms21041368.


Nuclear receptors are the major targets of endocrine disrupting chemicals.

Toporova L, Balaguer P.

Mol Cell Endocrinol. 2020 Feb 15;502:110665. doi: 10.1016/j.mce.2019.110665. Epub 2019 Nov 21. Review.


Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations.

le Maire A, Teyssier C, Balaguer P, Bourguet W, Germain P.

Cells. 2019 Nov 5;8(11). pii: E1392. doi: 10.3390/cells8111392.


Towards symmetry driven and nature inspired UV filter design.

Horbury MD, Holt EL, Mouterde LMM, Balaguer P, Cebrián J, Blasco L, Allais F, Stavros VG.

Nat Commun. 2019 Oct 18;10(1):4748. doi: 10.1038/s41467-019-12719-z.


Differential activity of BPA, BPAF and BPC on zebrafish estrogen receptors in vitro and in vivo.

Pinto C, Hao R, Grimaldi M, Thrikawala S, Boulahtouf A, Aït-Aïssa S, Brion F, Gustafsson JÅ, Balaguer P, Bondesson M.

Toxicol Appl Pharmacol. 2019 Oct 1;380:114709. doi: 10.1016/j.taap.2019.114709. Epub 2019 Aug 12.


Insights into the activation mechanism of human estrogen-related receptor γ by environmental endocrine disruptors.

Thouennon E, Delfosse V, Bailly R, Blanc P, Boulahtouf A, Grimaldi M, Barducci A, Bourguet W, Balaguer P.

Cell Mol Life Sci. 2019 Dec;76(23):4769-4781. doi: 10.1007/s00018-019-03129-x. Epub 2019 May 24.


Preparation of Renewable Epoxy-Amine Resins With Tunable Thermo-Mechanical Properties, Wettability and Degradation Abilities From Lignocellulose- and Plant Oils-Derived Components.

Hollande L, Do Marcolino I, Balaguer P, Domenek S, Gross RA, Allais F.

Front Chem. 2019 Mar 27;7:159. doi: 10.3389/fchem.2019.00159. eCollection 2019.


Functional profiling of bisphenols for nuclear receptors.

Grimaldi M, Boulahtouf A, Toporova L, Balaguer P.

Toxicology. 2019 May 15;420:39-45. doi: 10.1016/j.tox.2019.04.003. Epub 2019 Apr 2.


In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts.

Alameh G, Emptoz-Bonneton A, Rolland de Ravel M, Matera EL, Mappus E, Balaguer P, Rocheblave L, Lomberget T, Dumontet C, Le Borgne M, Pugeat M, Grenot C, Cuilleron CY.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):684-691. doi: 10.1080/14756366.2019.1575825.


A Cell Model Suitable for a High-Throughput Screening of Inhibitors of the Wnt/β-Catenin Pathway.

Grimaldi M, Boulahtouf A, Prévostel C, Thierry A, Balaguer P, Blache P.

Front Pharmacol. 2018 Oct 11;9:1160. doi: 10.3389/fphar.2018.01160. eCollection 2018.


Functional and Structural Study of the Amino Acid Substitution in a Novel Familial Androgen Receptor Mutation (W752G) Responsible for Complete Androgen Insensitivity Syndrome.

Paris F, Boulahtouf A, Kalfa N, Guibal MP, Gaspari L, Servant N, Bourguet W, Sultan C, Balaguer P.

Sex Dev. 2018 Aug 1. doi: 10.1159/000491114. [Epub ahead of print]


Imidazo[2,1-b]benzothiazol Derivatives as Potential Allosteric Inhibitors of the Glucocorticoid Receptor.

Christodoulou MS, Dapiaggi F, Ghiringhelli F, Pieraccini S, Sironi M, Lucafò M, Curci D, Decorti G, Stocco G, Chirumamilla CS, Vanden Berghe W, Balaguer P, Michel BY, Burger A, Beccalli EM, Passarella D, Martinet N.

ACS Med Chem Lett. 2018 Feb 26;9(4):339-344. doi: 10.1021/acsmedchemlett.7b00527. eCollection 2018 Apr 12.


Analysis of endocrine activity in drinking water, surface water and treated wastewater from six countries.

Leusch FDL, Neale PA, Arnal C, Aneck-Hahn NH, Balaguer P, Bruchet A, Escher BI, Esperanza M, Grimaldi M, Leroy G, Scheurer M, Schlichting R, Schriks M, Hebert A.

Water Res. 2018 Aug 1;139:10-18. doi: 10.1016/j.watres.2018.03.056. Epub 2018 Mar 27.


Structural and functional evidences for the interactions between nuclear hormone receptors and endocrine disruptors at low doses.

Balaguer P, Delfosse V, Grimaldi M, Bourguet W.

C R Biol. 2017 Sep - Oct;340(9-10):414-420. doi: 10.1016/j.crvi.2017.08.002.


In vitro and in vivo estrogenic activity of BPA, BPF and BPS in zebrafish-specific assays.

Le Fol V, Aït-Aïssa S, Sonavane M, Porcher JM, Balaguer P, Cravedi JP, Zalko D, Brion F.

Ecotoxicol Environ Saf. 2017 Aug;142:150-156. doi: 10.1016/j.ecoenv.2017.04.009. Epub 2017 Apr 11.


Syringaresinol: A Renewable and Safer Alternative to Bisphenol A for Epoxy-Amine Resins.

Janvier M, Hollande L, Jaufurally AS, Pernes M, Ménard R, Grimaldi M, Beaugrand J, Balaguer P, Ducrot PH, Allais F.

ChemSusChem. 2017 Feb 22;10(4):738-746. doi: 10.1002/cssc.201601595. Epub 2017 Feb 7.


A consolidated method for screening the endocrine activity of drinking water.

Chevolleau S, Debrauwer L, Stroheker T, Viglino L, Mourahib I, Meireles MH, Grimaldi M, Balaguer P, di Gioia L.

Food Chem. 2016 Dec 15;213:274-283. doi: 10.1016/j.foodchem.2016.06.089. Epub 2016 Jun 25.


Functionalized Mesoporous Silica Nanoparticle with Antioxidants as a New Carrier That Generates Lower Oxidative Stress Impact on Cells.

Ebabe Elle R, Rahmani S, Lauret C, Morena M, Bidel LP, Boulahtouf A, Balaguer P, Cristol JP, Durand JO, Charnay C, Badia E.

Mol Pharm. 2016 Aug 1;13(8):2647-60. doi: 10.1021/acs.molpharmaceut.6b00190. Epub 2016 Jul 1.


Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes.

Rasmussen MK, Balaguer P, Ekstrand B, Daujat-Chavanieu M, Gerbal-Chaloin S.

PLoS One. 2016 May 3;11(5):e0154629. doi: 10.1371/journal.pone.0154629. eCollection 2016.


[The association makes the poison: new perspective on the cocktail effect of xenobiotics and drug interactions].

Delfosse V, Balaguer P, Bourguet W.

Med Sci (Paris). 2016 Apr;32(4):326-8. doi: 10.1051/medsci/20163204005. Epub 2016 May 2. French. No abstract available.


Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors.

Lapierre M, Linares A, Dalvai M, Duraffourd C, Bonnet S, Boulahtouf A, Rodriguez C, Jalaguier S, Assou S, Orsetti B, Balaguer P, Maudelonde T, Blache P, Bystricky K, Boulle N, Cavaillès V.

Oncotarget. 2016 Apr 12;7(15):19693-708. doi: 10.18632/oncotarget.7564.


Molecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds.

Khallouki F, de Medina P, Caze-Subra S, Bystricky K, Balaguer P, Poirot M, Silvente-Poirot S.

Front Oncol. 2016 Jan 5;5:287. doi: 10.3389/fonc.2015.00287. eCollection 2015.


Lxr regulates lipid metabolic and visual perception pathways during zebrafish development.

Pinto CL, Kalasekar SM, McCollum CW, Riu A, Jonsson P, Lopez J, Swindell EC, Bouhlatouf A, Balaguer P, Bondesson M, Gustafsson JÅ.

Mol Cell Endocrinol. 2016 Jan 5;419:29-43. doi: 10.1016/j.mce.2015.09.030. Epub 2015 Sep 30.


Development of a molecular recognition based approach for multi-residue extraction of estrogenic endocrine disruptors from biological fluids coupled to liquid chromatography-tandem mass spectrometry measurement.

Bousoumah R, Antignac JP, Camel V, Grimaldi M, Balaguer P, Courant F, Bichon E, Morvan ML, Le Bizec B.

Anal Bioanal Chem. 2015 Nov;407(29):8713-23. doi: 10.1007/s00216-015-9024-4. Epub 2015 Sep 21.


Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.

Delfosse V, Dendele B, Huet T, Grimaldi M, Boulahtouf A, Gerbal-Chaloin S, Beucher B, Roecklin D, Muller C, Rahmani R, Cavaillès V, Daujat-Chavanieu M, Vivat V, Pascussi JM, Balaguer P, Bourguet W.

Nat Commun. 2015 Sep 3;6:8089. doi: 10.1038/ncomms9089.


Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.

Briolotti P, Chaloin L, Balaguer P, Da Silva F, Tománková V, Pascussi JM, Duret C, Fabre JM, Ramos J, Klieber S, Maurel P, Daujat-Chavanieu M, Gerbal-Chaloin S.

Toxicol Sci. 2015 Nov;148(1):261-75. doi: 10.1093/toxsci/kfv177. Epub 2015 Aug 10.


Effect of tamoxifen and fulvestrant long-term treatments on ROS production and (pro/anti)-oxidant enzymes mRNA levels in a MCF-7-derived breast cancer cell line.

Badia E, Morena M, Lauret C, Boulahtouf A, Boulle N, Cavaillès V, Balaguer P, Cristol JP.

Breast Cancer. 2016 Sep;23(5):692-700. doi: 10.1007/s12282-015-0626-7. Epub 2015 Jul 21.


Reporter cell lines to evaluate the selectivity of chemicals for human and zebrafish estrogen and peroxysome proliferator activated γ receptors.

Grimaldi M, Boulahtouf A, Delfosse V, Thouennon E, Bourguet W, Balaguer P.

Front Neurosci. 2015 Jun 9;9:212. doi: 10.3389/fnins.2015.00212. eCollection 2015. Review.


Reporter Cell Lines for the Characterization of the Interactions between Human Nuclear Receptors and Endocrine Disruptors.

Grimaldi M, Boulahtouf A, Delfosse V, Thouennon E, Bourguet W, Balaguer P.

Front Endocrinol (Lausanne). 2015 May 11;6:62. doi: 10.3389/fendo.2015.00062. eCollection 2015. Review.


Molecular action of norgestimate: new developments.

Paris F, Balaguer P, Rimbault F, Gaspari L, Sultan C.

Gynecol Endocrinol. 2015 Jun;31(6):487-90. doi: 10.3109/09513590.2015.1016904. Epub 2015 May 13.


Cell-specific biotransformation of benzophenone-2 and bisphenol-s in zebrafish and human in vitro models used for toxicity and estrogenicity screening.

Le Fol V, Aït-Aïssa S, Cabaton N, Dolo L, Grimaldi M, Balaguer P, Perdu E, Debrauwer L, Brion F, Zalko D.

Environ Sci Technol. 2015 Mar 17;49(6):3860-8. doi: 10.1021/es505302c. Epub 2015 Mar 2.


A structural perspective on nuclear receptors as targets of environmental compounds.

Delfosse V, Maire AL, Balaguer P, Bourguet W.

Acta Pharmacol Sin. 2015 Jan;36(1):88-101. doi: 10.1038/aps.2014.133. Epub 2014 Dec 15. Review.


Evidence of ERalpha and ERbeta selectivity and partial estrogen agonism in traditional Chinese medicine.

Tiosano D, Paris F, Grimaldi M, Georgescu V, Servant N, Hochberg Z, Balaguer P, Sultan C.

Reprod Biol Endocrinol. 2014 Oct 10;12:97. doi: 10.1186/1477-7827-12-97.


Structural and functional profiling of environmental ligands for estrogen receptors.

Delfosse V, Grimaldi M, Cavaillès V, Balaguer P, Bourguet W.

Environ Health Perspect. 2014 Dec;122(12):1306-13. doi: 10.1289/ehp.1408453. Epub 2014 Sep 26.


Selectivity of natural, synthetic and environmental estrogens for zebrafish estrogen receptors.

Pinto C, Grimaldi M, Boulahtouf A, Pakdel F, Brion F, Aït-Aïssa S, Cavaillès V, Bourguet W, Gustafsson JA, Bondesson M, Balaguer P.

Toxicol Appl Pharmacol. 2014 Oct 1;280(1):60-9. doi: 10.1016/j.taap.2014.07.020. Epub 2014 Aug 8.


Estrogen-related receptor γ is an in vivo receptor of bisphenol A.

Tohmé M, Prud'homme SM, Boulahtouf A, Samarut E, Brunet F, Bernard L, Bourguet W, Gibert Y, Balaguer P, Laudet V.

FASEB J. 2014 Jul;28(7):3124-33. doi: 10.1096/fj.13-240465. Epub 2014 Apr 17.


Halogenated bisphenol-A analogs act as obesogens in zebrafish larvae (Danio rerio).

Riu A, McCollum CW, Pinto CL, Grimaldi M, Hillenweck A, Perdu E, Zalko D, Bernard L, Laudet V, Balaguer P, Bondesson M, Gustafsson JA.

Toxicol Sci. 2014 May;139(1):48-58. doi: 10.1093/toxsci/kfu036. Epub 2014 Mar 3.


Nuclear receptor profiling of bisphenol-A and its halogenated analogues.

Delfosse V, Grimaldi M, le Maire A, Bourguet W, Balaguer P.

Vitam Horm. 2014;94:229-51. doi: 10.1016/B978-0-12-800095-3.00009-2. Review.


Benchmarking organic micropollutants in wastewater, recycled water and drinking water with in vitro bioassays.

Escher BI, Allinson M, Altenburger R, Bain PA, Balaguer P, Busch W, Crago J, Denslow ND, Dopp E, Hilscherova K, Humpage AR, Kumar A, Grimaldi M, Jayasinghe BS, Jarosova B, Jia A, Makarov S, Maruya KA, Medvedev A, Mehinto AC, Mendez JE, Poulsen A, Prochazka E, Richard J, Schifferli A, Schlenk D, Scholz S, Shiraishi F, Snyder S, Su G, Tang JY, van der Burg B, van der Linden SC, Werner I, Westerheide SD, Wong CK, Yang M, Yeung BH, Zhang X, Leusch FD.

Environ Sci Technol. 2014;48(3):1940-56. doi: 10.1021/es403899t. Epub 2013 Dec 26.


Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent.

Mazaud-Guittot S, Nicolas Nicolaz C, Desdoits-Lethimonier C, Coiffec I, Ben Maamar M, Balaguer P, Kristensen DM, Chevrier C, Lavoué V, Poulain P, Dejucq-Rainsford N, Jégou B.

J Clin Endocrinol Metab. 2013 Nov;98(11):E1757-67. doi: 10.1210/jc.2013-2531. Epub 2013 Sep 12.


Negative regulation of estrogen signaling by ERβ and RIP140 in ovarian cancer cells.

Docquier A, Garcia A, Savatier J, Boulahtouf A, Bonnet S, Bellet V, Busson M, Margeat E, Jalaguier S, Royer C, Balaguer P, Cavaillès V.

Mol Endocrinol. 2013 Sep;27(9):1429-41. doi: 10.1210/me.2012-1351. Epub 2013 Jul 24.


In vitro study on the agonistic and antagonistic activities of bisphenol-S and other bisphenol-A congeners and derivatives via nuclear receptors.

Molina-Molina JM, Amaya E, Grimaldi M, Sáenz JM, Real M, Fernández MF, Balaguer P, Olea N.

Toxicol Appl Pharmacol. 2013 Oct 1;272(1):127-36. doi: 10.1016/j.taap.2013.05.015. Epub 2013 May 25.


AhR- and NF-κB-dependent induction of interleukin-6 by co-exposure to the environmental contaminant benzanthracene and the cytokine tumor necrosis factor-α in human mammary MCF-7 cells.

Kolasa E, Houlbert N, Balaguer P, Fardel O.

Chem Biol Interact. 2013 Apr 25;203(2):391-400. doi: 10.1016/j.cbi.2013.01.005. Epub 2013 Feb 8.


Effect-directed analysis of endocrine-disrupting compounds in multi-contaminated sediment: identification of novel ligands of estrogen and pregnane X receptors.

Creusot N, Budzinski H, Balaguer P, Kinani S, Porcher JM, Aït-Aïssa S.

Anal Bioanal Chem. 2013 Mar;405(8):2553-66. doi: 10.1007/s00216-013-6708-5. Epub 2013 Jan 26.


[Towards bisphenols without hormonal effects].

Balaguer P, Delfosse V, Grimaldi M, Bourguet W.

Med Sci (Paris). 2013 Jan;29(1):14-7. doi: 10.1051/medsci/2013291004. Epub 2013 Jan 25. French. No abstract available.


Characterization of endocrine disruptors from a complex matrix using estrogen receptor affinity columns and high performance liquid chromatography-high resolution mass spectrometry.

Jondeau-Cabaton A, Soucasse A, Jamin EL, Creusot N, Grimaldi M, Jouanin I, Aït-Aïssa S, Balaguer P, Debrauwer L, Zalko D.

Environ Sci Pollut Res Int. 2013 May;20(5):2705-20. doi: 10.1007/s11356-012-1458-z. Epub 2013 Jan 15.


Distribution of steroid- and dioxin-like activities between sediments, POCIS and SPMD in a French river subject to mixed pressures.

Creusot N, Tapie N, Piccini B, Balaguer P, Porcher JM, Budzinski H, Aït-Aïssa S.

Environ Sci Pollut Res Int. 2013 May;20(5):2784-94. doi: 10.1007/s11356-012-1452-5. Epub 2013 Jan 11.


Potential role of estrogen receptor beta as a tumor suppressor of epithelial ovarian cancer.

Bossard C, Busson M, Vindrieux D, Gaudin F, Machelon V, Brigitte M, Jacquard C, Pillon A, Balaguer P, Balabanian K, Lazennec G.

PLoS One. 2012;7(9):e44787. doi: 10.1371/journal.pone.0044787. Epub 2012 Sep 6. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/480acc26-456b-4e06-8cb6-2834bd6f5553.


Chemical and toxicological assessment of a full-scale biosolid compost.

Patureau D, Delgenes N, Muller M, Dagnino S, Lhoutellier C, Delgenes JP, Balaguer P, Hernandez-Raquet G.

Environ Toxicol Chem. 2012 Dec;31(12):2748-56. doi: 10.1002/etc.2002. Epub 2012 Oct 17.


Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes.

Delfosse V, Grimaldi M, Pons JL, Boulahtouf A, le Maire A, Cavailles V, Labesse G, Bourguet W, Balaguer P.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14930-5. doi: 10.1073/pnas.1203574109. Epub 2012 Aug 27.

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