Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 24

1.

TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps.

Yi J, Balagopalan L, Nguyen T, McIntire KM, Samelson LE.

Nat Commun. 2019 Jan 17;10(1):277. doi: 10.1038/s41467-018-08064-2.

2.

Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation.

Manna A, Zhao H, Wada J, Balagopalan L, Tagad HD, Appella E, Schuck P, Samelson LE.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11914-E11923. doi: 10.1073/pnas.1817142115. Epub 2018 Dec 3.

3.

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation.

Balagopalan L, Yi J, Nguyen T, McIntire KM, Harned AS, Narayan K, Samelson LE.

Nat Commun. 2018 May 22;9(1):2013. doi: 10.1038/s41467-018-04419-x.

4.

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance.

Palmer DC, Guittard GC, Franco Z, Crompton JG, Eil RL, Patel SJ, Ji Y, Van Panhuys N, Klebanoff CA, Sukumar M, Clever D, Chichura A, Roychoudhuri R, Varma R, Wang E, Gattinoni L, Marincola FM, Balagopalan L, Samelson LE, Restifo NP.

J Exp Med. 2015 Nov 16;212(12):2095-113. doi: 10.1084/jem.20150304. Epub 2015 Nov 2.

5.

The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters.

Balagopalan L, Kortum RL, Coussens NP, Barr VA, Samelson LE.

J Biol Chem. 2015 Oct 30;290(44):26422-9. doi: 10.1074/jbc.R115.665869. Epub 2015 Sep 9. Review.

6.

Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.

Rodriguez-Peña AB, Gomez-Rodriguez J, Kortum RL, Palmer DC, Yu Z, Guittard GC, Wohlfert EA, Silver PB, Misplon JA, Sommers CL, Feigenbaum L, Epstein SL, Caspi RR, Belkaid Y, Restifo NP, Samelson LE, Balagopalan L.

Gene Ther. 2015 Oct;22(10):781-92. doi: 10.1038/gt.2015.48. Epub 2015 Jun 18.

7.

Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.

Guittard G, Kortum RL, Balagopalan L, Çuburu N, Nguyen P, Sommers CL, Samelson LE.

Eur J Immunol. 2015 Aug;45(8):2389-95. doi: 10.1002/eji.201445226. Epub 2015 Jun 5.

8.

Cytoskeletal forces during signaling activation in Jurkat T-cells.

Hui KL, Balagopalan L, Samelson LE, Upadhyaya A.

Mol Biol Cell. 2015 Feb 15;26(4):685-95. doi: 10.1091/mbc.E14-03-0830. Epub 2014 Dec 17.

9.

The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.

Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.

Sci Signal. 2013 Nov 12;6(301):ra99. doi: 10.1126/scisignal.2004494.

10.

Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.

Coussens NP, Hayashi R, Brown PH, Balagopalan L, Balbo A, Akpan I, Houtman JC, Barr VA, Schuck P, Appella E, Samelson LE.

Mol Cell Biol. 2013 Nov;33(21):4140-51. doi: 10.1128/MCB.00410-13. Epub 2013 Aug 26.

11.

Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling.

Balagopalan L, Barr VA, Kortum RL, Park AK, Samelson LE.

J Immunol. 2013 Apr 15;190(8):3849-53. doi: 10.4049/jimmunol.1202760. Epub 2013 Mar 13.

12.

Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation.

Kunii N, Zhao Y, Jiang S, Liu X, Scholler J, Balagopalan L, Samelson LE, Milone MC, June CH.

Hum Gene Ther. 2013 Jan;24(1):27-37. doi: 10.1089/hum.2012.130. Epub 2012 Nov 6.

13.

Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor.

Sherman E, Barr V, Manley S, Patterson G, Balagopalan L, Akpan I, Regan CK, Merrill RK, Sommers CL, Lippincott-Schwartz J, Samelson LE.

Immunity. 2011 Nov 23;35(5):705-20. doi: 10.1016/j.immuni.2011.10.004. Epub 2011 Nov 4.

14.

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.

Balagopalan L, Ashwell BA, Bernot KM, Akpan IO, Quasba N, Barr VA, Samelson LE.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2885-90. doi: 10.1073/pnas.1007098108. Epub 2011 Jan 31.

15.

Imaging techniques for assaying lymphocyte activation in action.

Balagopalan L, Sherman E, Barr VA, Samelson LE.

Nat Rev Immunol. 2011 Jan;11(1):21-33. doi: 10.1038/nri2903. Review.

16.

The LAT story: a tale of cooperativity, coordination, and choreography.

Balagopalan L, Coussens NP, Sherman E, Samelson LE, Sommers CL.

Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a005512. doi: 10.1101/cshperspect.a005512. Epub 2010 Jul 7. Review.

17.

Endocytic events in TCR signaling: focus on adapters in microclusters.

Balagopalan L, Barr VA, Samelson LE.

Immunol Rev. 2009 Nov;232(1):84-98. doi: 10.1111/j.1600-065X.2009.00840.x. Review.

18.

Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.

Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE.

Mol Biol Cell. 2008 Jul;19(7):2802-17. doi: 10.1091/mbc.E08-02-0146. Epub 2008 Apr 30.

19.

c-Cbl-mediated regulation of LAT-nucleated signaling complexes.

Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, Samelson LE.

Mol Cell Biol. 2007 Dec;27(24):8622-36. Epub 2007 Oct 15.

21.

T-cell antigen receptor-induced signaling complexes: internalization via a cholesterol-dependent endocytic pathway.

Barr VA, Balagopalan L, Barda-Saad M, Polishchuk R, Boukari H, Bunnell SC, Bernot KM, Toda Y, Nossal R, Samelson LE.

Traffic. 2006 Sep;7(9):1143-62.

22.

Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila.

Presgraves DC, Balagopalan L, Abmayr SM, Orr HA.

Nature. 2003 Jun 12;423(6941):715-9.

PMID:
12802326
23.

Cell and molecular biology of myoblast fusion.

Abmayr SM, Balagopalan L, Galletta BJ, Hong SJ.

Int Rev Cytol. 2003;225:33-89. Review.

PMID:
12696590
24.

Supplemental Content

Loading ...
Support Center