Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 107

1.

Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders.

Tessadori F, Roessler HI, Savelberg SMC, Chocron S, Kamel SM, Duran KJ, van Haelst MM, van Haaften G, Bakkers J.

Dis Model Mech. 2018 Oct 18;11(10). pii: dmm035469. doi: 10.1242/dmm.035469.

2.

Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis.

van Opbergen CJM, Koopman CD, Kok BJM, Knöpfel T, Renninger SL, Orger MB, Vos MA, van Veen TAB, Bakkers J, de Boer TP.

Theranostics. 2018 Sep 9;8(17):4750-4764. doi: 10.7150/thno.26108. eCollection 2018.

3.

GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay.

Rumping L, Tessadori F, Pouwels PJ, Vringer E, Wijnen JP, Bhogal AA, Savelberg SM, Duran KJ, Bakkers MJ, Ramos RJ, Schellekens PA, Kroes HY, Klomp DW, Black GC, Taylor RL, Bakkers JP, Prinsen HC, Knaap MS, Dansen TB, Rehmann H, Zwartkruis FJ, Houwen RH, Haaften G, Verhoeven-Duif NM, Jans JJ, Hasselt PM.

Hum Mol Genet. 2018 Sep 18. doi: 10.1093/hmg/ddy330. [Epub ahead of print]

PMID:
30239721
4.

Shaping up with morphogen gradients.

Garric L, Bakkers J.

Nat Cell Biol. 2018 Sep;20(9):998-999. doi: 10.1038/s41556-018-0168-2. No abstract available.

PMID:
30061679
5.
6.

On the Evolution of the Cardiac Pacemaker.

Burkhard S, van Eif V, Garric L, Christoffels VM, Bakkers J.

J Cardiovasc Dev Dis. 2017 Apr 27;4(2). pii: E4. doi: 10.3390/jcdd4020004. Review.

7.

Variants in members of the cadherin-catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome.

Kievit A, Tessadori F, Douben H, Jordens I, Maurice M, Hoogeboom J, Hennekam R, Nampoothiri S, Kayserili H, Castori M, Whiteford M, Motter C, Melver C, Cunningham M, Hing A, Kokitsu-Nakata NM, Vendramini-Pittoli S, Richieri-Costa A, Baas AF, Breugem CC, Duran K, Massink M, Derksen PWB, van IJcken WFJ, van Unen L, Santos-Simarro F, Lapunzina P, Gil-da Silva Lopes VL, Lustosa-Mendes E, Krall M, Slavotinek A, Martinez-Glez V, Bakkers J, van Gassen KLI, de Klein A, van den Boogaard MH, van Haaften G.

Eur J Hum Genet. 2018 Feb;26(2):210-219. doi: 10.1038/s41431-017-0010-5. Epub 2018 Jan 18.

PMID:
29348693
8.

Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis.

Laarman MD, Vermunt MW, Kleinloog R, de Boer-Bergsma JJ, Brain Bank N, Rinkel GJE, Creyghton MP, Mokry M, Bakkers J, Ruigrok YM.

Stroke. 2018 Feb;49(2):447-453. doi: 10.1161/STROKEAHA.117.018557. Epub 2018 Jan 4.

PMID:
29301971
9.

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

Sala L, van Meer BJ, Tertoolen LGJ, Bakkers J, Bellin M, Davis RP, Denning C, Dieben MAE, Eschenhagen T, Giacomelli E, Grandela C, Hansen A, Holman ER, Jongbloed MRM, Kamel SM, Koopman CD, Lachaud Q, Mannhardt I, Mol MPH, Mosqueira D, Orlova VV, Passier R, Ribeiro MC, Saleem U, Smith GL, Burton FL, Mummery CL.

Circ Res. 2018 Feb 2;122(3):e5-e16. doi: 10.1161/CIRCRESAHA.117.312067. Epub 2017 Dec 27. Review.

10.

Twists and turns.

Noël ES, Bakkers J.

Elife. 2017 Nov 28;6. pii: e32709. doi: 10.7554/eLife.32709.

11.

Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control.

Tessadori F, Giltay JC, Hurst JA, Massink MP, Duran K, Vos HR, van Es RM; Deciphering Developmental Disorders Study, Scott RH, van Gassen KLI, Bakkers J, van Haaften G.

Nat Genet. 2017 Nov;49(11):1642-1646. doi: 10.1038/ng.3956. Epub 2017 Sep 18.

PMID:
28920961
12.

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.

De Angelis JE, Lagendijk AK, Chen H, Tromp A, Bower NI, Tunny KA, Brooks AJ, Bakkers J, Francois M, Yap AS, Simons C, Wicking C, Hogan BM, Smith KA.

Dev Cell. 2017 Feb 27;40(4):421. doi: 10.1016/j.devcel.2017.02.005. No abstract available.

13.

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.

De Angelis JE, Lagendijk AK, Chen H, Tromp A, Bower NI, Tunny KA, Brooks AJ, Bakkers J, Francois M, Yap AS, Simons C, Wicking C, Hogan BM, Smith KA.

Dev Cell. 2017 Jan 23;40(2):123-136. doi: 10.1016/j.devcel.2016.12.017.

14.

Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity.

Josifova DJ, Monroe GR, Tessadori F, de Graaff E, van der Zwaag B, Mehta SG; DDD Study, Harakalova M, Duran KJ, Savelberg SM, Nijman IJ, Jungbluth H, Hoogenraad CC, Bakkers J, Knoers NV, Firth HV, Beales PL, van Haaften G, van Haelst MM.

Hum Mol Genet. 2016 Jun 1;25(11):2158-2167. Epub 2016 Mar 22.

PMID:
27005418
15.

αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish.

Han MK, Hoijman E, Nöel E, Garric L, Bakkers J, de Rooij J.

Biol Open. 2016 Oct 15;5(10):1461-1472. doi: 10.1242/bio.021378.

16.

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.

Lodder EM, De Nittis P, Koopman CD, Wiszniewski W, Moura de Souza CF, Lahrouchi N, Guex N, Napolioni V, Tessadori F, Beekman L, Nannenberg EA, Boualla L, Blom NA, de Graaff W, Kamermans M, Cocciadiferro D, Malerba N, Mandriani B, Coban Akdemir ZH, Fish RJ, Eldomery MK, Ratbi I, Wilde AAM, de Boer T, Simonds WF, Neerman-Arbez M, Sutton VR, Kok F, Lupski JR, Reymond A, Bezzina CR, Bakkers J, Merla G.

Am J Hum Genet. 2016 Sep 1;99(3):786. doi: 10.1016/j.ajhg.2016.08.011. Epub 2016 Sep 1. No abstract available.

17.

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.

Lodder EM, De Nittis P, Koopman CD, Wiszniewski W, Moura de Souza CF, Lahrouchi N, Guex N, Napolioni V, Tessadori F, Beekman L, Nannenberg EA, Boualla L, Blom NA, de Graaff W, Kamermans M, Cocciadiferro D, Malerba N, Mandriani B, Akdemir ZHC, Fish RJ, Eldomery MK, Ratbi I, Wilde AAM, de Boer T, Simonds WF, Neerman-Arbez M, Sutton VR, Kok F, Lupski JR, Reymond A, Bezzina CR, Bakkers J, Merla G.

Am J Hum Genet. 2016 Sep 1;99(3):704-710. doi: 10.1016/j.ajhg.2016.06.025. Epub 2016 Aug 11. Erratum in: Am J Hum Genet. 2016 Sep 1;99(3):786.

18.

Tomo-seq: A method to obtain genome-wide expression data with spatial resolution.

Kruse F, Junker JP, van Oudenaarden A, Bakkers J.

Methods Cell Biol. 2016;135:299-307. doi: 10.1016/bs.mcb.2016.01.006. Epub 2016 Feb 26.

PMID:
27443932
19.

Rare novel variants in the ZIC3 gene cause X-linked heterotaxy.

Paulussen AD, Steyls A, Vanoevelen J, van Tienen FH, Krapels IP, Claes GR, Chocron S, Velter C, Tan-Sindhunata GM, Lundin C, Valenzuela I, Nagy B, Bache I, Maroun LL, Avela K, Brunner HG, Smeets HJ, Bakkers J, van den Wijngaard A.

Eur J Hum Genet. 2016 Dec;24(12):1783-1791. doi: 10.1038/ejhg.2016.91. Epub 2016 Jul 13.

20.

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2.

San B, Chrispijn ND, Wittkopp N, van Heeringen SJ, Lagendijk AK, Aben M, Bakkers J, Ketting RF, Kamminga LM.

Sci Rep. 2016 May 5;6:24658. doi: 10.1038/srep24658.

21.

Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration.

Wu CC, Kruse F, Vasudevarao MD, Junker JP, Zebrowski DC, Fischer K, Noël ES, Grün D, Berezikov E, Engel FB, van Oudenaarden A, Weidinger G, Bakkers J.

Dev Cell. 2016 Jan 11;36(1):36-49. doi: 10.1016/j.devcel.2015.12.010. Epub 2015 Dec 31.

22.

A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function.

Noël ES, Momenah TS, Al-Dagriri K, Al-Suwaid A, Al-Shahrani S, Jiang H, Willekers S, Oostveen YY, Chocron S, Postma AV, Bhuiyan ZA, Bakkers J.

Hum Mutat. 2016 Feb;37(2):194-200. doi: 10.1002/humu.22928. Epub 2015 Dec 2.

PMID:
26531781
23.

Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes.

Marchegiani S, Davis T, Tessadori F, van Haaften G, Brancati F, Hoischen A, Huang H, Valkanas E, Pusey B, Schanze D, Venselaar H, Vulto-van Silfhout AT, Wolfe LA, Tifft CJ, Zerfas PM, Zambruno G, Kariminejad A, Sabbagh-Kermani F, Lee J, Tsokos MG, Lee CC, Ferraz V, da Silva EM, Stevens CA, Roche N, Bartsch O, Farndon P, Bermejo-Sanchez E, Brooks BP, Maduro V, Dallapiccola B, Ramos FJ, Chung HY, Le Caignec C, Martins F, Jacyk WK, Mazzanti L, Brunner HG, Bakkers J, Lin S, Malicdan MC, Boerkoel CF, Gahl WA, de Vries BB, van Haelst MM, Zenker M, Markello TC.

Am J Hum Genet. 2015 Jul 2;97(1):99-110. doi: 10.1016/j.ajhg.2015.05.017. Epub 2015 Jun 25.

24.

Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies.

Ramspacher C, Steed E, Boselli F, Ferreira R, Faggianelli N, Roth S, Spiegelhalter C, Messaddeq N, Trinh L, Liebling M, Chacko N, Tessadori F, Bakkers J, Laporte J, Hnia K, Vermot J.

Cell Rep. 2015 Jun 16;11(10):1564-76. doi: 10.1016/j.celrep.2015.05.010. Epub 2015 Jun 4.

25.

Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling.

Strate I, Tessadori F, Bakkers J.

Development. 2015 May 15;142(10):1767-76. doi: 10.1242/dev.113894.

26.

Nodal signaling range is regulated by proprotein convertase-mediated maturation.

Tessadori F, Noël ES, Rens EG, Magliozzi R, Evers-van Gogh IJ, Guardavaccaro D, Merks RM, Bakkers J.

Dev Cell. 2015 Mar 9;32(5):631-9. doi: 10.1016/j.devcel.2014.12.014. Epub 2015 Feb 12.

27.

Animal and in silico models for the study of sarcomeric cardiomyopathies.

Duncker DJ, Bakkers J, Brundel BJ, Robbins J, Tardiff JC, Carrier L.

Cardiovasc Res. 2015 Apr 1;105(4):439-48. doi: 10.1093/cvr/cvv006. Epub 2015 Jan 18. Review.

28.

Genome-wide RNA Tomography in the zebrafish embryo.

Junker JP, Noël ES, Guryev V, Peterson KA, Shah G, Huisken J, McMahon AP, Berezikov E, Bakkers J, van Oudenaarden A.

Cell. 2014 Oct 23;159(3):662-75. doi: 10.1016/j.cell.2014.09.038.

29.

GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish.

Jiménez-Amilburu V, Jong-Raadsen S, Bakkers J, Spaink HP, Marín-Juez R.

J Endocrinol. 2015 Jan;224(1):1-15. doi: 10.1530/JOE-14-0539. Epub 2014 Oct 17.

PMID:
25326603
30.

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm.

Chetaille P, Preuss C, Burkhard S, Côté JM, Houde C, Castilloux J, Piché J, Gosset N, Leclerc S, Wünnemann F, Thibeault M, Gagnon C, Galli A, Tuck E, Hickson GR, El Amine N, Boufaied I, Lemyre E, de Santa Barbara P, Faure S, Jonzon A, Cameron M, Dietz HC, Gallo-McFarlane E, Benson DW, Moreau C, Labuda D; FORGE Canada Consortium, Zhan SH, Shen Y, Jomphe M, Jones SJ, Bakkers J, Andelfinger G.

Nat Genet. 2014 Nov;46(11):1245-9. doi: 10.1038/ng.3113. Epub 2014 Oct 5.

PMID:
25282101
31.

Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish.

Bonetti M, Paardekooper Overman J, Tessadori F, Noël E, Bakkers J, den Hertog J.

Development. 2014 May;141(9):1961-70. doi: 10.1242/dev.106310. Epub 2014 Apr 9.

32.

A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality.

Noël ES, Verhoeven M, Lagendijk AK, Tessadori F, Smith K, Choorapoikayil S, den Hertog J, Bakkers J.

Nat Commun. 2013;4:2754. doi: 10.1038/ncomms3754.

PMID:
24212328
33.

On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling.

Goudarzi M, Strate I, Paksa A, Lagendijk AK, Bakkers J, Raz E.

Nat Genet. 2013 Nov;45(11):1264-5. doi: 10.1038/ng.2793. No abstract available.

PMID:
24165724
34.

Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis.

Mugoni V, Postel R, Catanzaro V, De Luca E, Turco E, Digilio G, Silengo L, Murphy MP, Medana C, Stainier DY, Bakkers J, Santoro MM.

Cell. 2013 Jan 31;152(3):504-18. doi: 10.1016/j.cell.2013.01.013.

35.

Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation.

Lagendijk AK, Szabó A, Merks RM, Bakkers J.

Trends Cardiovasc Med. 2013 Jul;23(5):135-42. doi: 10.1016/j.tcm.2012.10.002. Epub 2013 Jan 5. Review.

PMID:
23295082
36.

Revealing details: whole mount microRNA in situ hybridization protocol for zebrafish embryos and adult tissues.

Lagendijk AK, Moulton JD, Bakkers J.

Biol Open. 2012 Jun 15;1(6):566-9. doi: 10.1242/bio.2012810. Epub 2012 Apr 11.

37.

Structural brain changes in migraine.

Palm-Meinders IH, Koppen H, Terwindt GM, Launer LJ, Konishi J, Moonen JM, Bakkers JT, Hofman PA, van Lew B, Middelkoop HA, van Buchem MA, Ferrari MD, Kruit MC.

JAMA. 2012 Nov 14;308(18):1889-97. doi: 10.1001/jama.2012.14276.

38.

Identification and functional characterization of cardiac pacemaker cells in zebrafish.

Tessadori F, van Weerd JH, Burkhard SB, Verkerk AO, de Pater E, Boukens BJ, Vink A, Christoffels VM, Bakkers J.

PLoS One. 2012;7(10):e47644. doi: 10.1371/journal.pone.0047644. Epub 2012 Oct 16.

39.

UDP-glucose dehydrogenase polymorphisms from patients with congenital heart valve defects disrupt enzyme stability and quaternary assembly.

Hyde AS, Farmer EL, Easley KE, van Lammeren K, Christoffels VM, Barycki JJ, Bakkers J, Simpson MA.

J Biol Chem. 2012 Sep 21;287(39):32708-16. Epub 2012 Jul 18.

40.

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.

van den Boogaard M, Wong LY, Tessadori F, Bakker ML, Dreizehnter LK, Wakker V, Bezzina CR, 't Hoen PA, Bakkers J, Barnett P, Christoffels VM.

J Clin Invest. 2012 Jul;122(7):2519-30. doi: 10.1172/JCI62613. Epub 2012 Jun 18.

41.

Identification and regulation of a molecular module for bleb-based cell motility.

Goudarzi M, Banisch TU, Mobin MB, Maghelli N, Tarbashevich K, Strate I, van den Berg J, Blaser H, Bandemer S, Paluch E, Bakkers J, Tolić-Nørrelykke IM, Raz E.

Dev Cell. 2012 Jul 17;23(1):210-8. doi: 10.1016/j.devcel.2012.05.007. Epub 2012 Jun 14.

42.

Bmp signaling exerts opposite effects on cardiac differentiation.

de Pater E, Ciampricotti M, Priller F, Veerkamp J, Strate I, Smith K, Lagendijk AK, Schilling TF, Herzog W, Abdelilah-Seyfried S, Hammerschmidt M, Bakkers J.

Circ Res. 2012 Feb 17;110(4):578-87. doi: 10.1161/CIRCRESAHA.111.261172. Epub 2012 Jan 12.

43.

Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish.

Smith KA, Noël E, Thurlings I, Rehmann H, Chocron S, Bakkers J.

PLoS Genet. 2011 Sep;7(9):e1002289. doi: 10.1371/journal.pgen.1002289. Epub 2011 Sep 29.

44.

Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development.

Smith KA, Lagendijk AK, Courtney AD, Chen H, Paterson S, Hogan BM, Wicking C, Bakkers J.

Development. 2011 Oct;138(19):4193-8. doi: 10.1242/dev.065375.

45.

MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production.

Lagendijk AK, Goumans MJ, Burkhard SB, Bakkers J.

Circ Res. 2011 Sep 2;109(6):649-57. doi: 10.1161/CIRCRESAHA.111.247635. Epub 2011 Jul 21.

PMID:
21778427
46.

Macrophage development from HSCs requires PU.1-coordinated microRNA expression.

Ghani S, Riemke P, Schönheit J, Lenze D, Stumm J, Hoogenkamp M, Lagendijk A, Heinz S, Bonifer C, Bakkers J, Abdelilah-Seyfried S, Hummel M, Rosenbauer F.

Blood. 2011 Aug 25;118(8):2275-84. doi: 10.1182/blood-2011-02-335141. Epub 2011 Jul 5.

47.

The indicating FTA elute cartridge a solid sample carrier to detect high-risk HPV and high-grade cervical lesions.

de Bie RP, Schmeink CE, Bakkers JM, Snijders PJ, Quint WG, Massuger LF, Bekkers RL, Melchers WJ.

J Mol Diagn. 2011 Jul;13(4):371-6. doi: 10.1016/j.jmoldx.2011.02.003. Epub 2011 Apr 29.

48.

Zebrafish as a model to study cardiac development and human cardiac disease.

Bakkers J.

Cardiovasc Res. 2011 Jul 15;91(2):279-88. doi: 10.1093/cvr/cvr098. Epub 2011 May 19. Review.

49.

Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2.

Verhoeven MC, Haase C, Christoffels VM, Weidinger G, Bakkers J.

Birth Defects Res A Clin Mol Teratol. 2011 Jun;91(6):435-40. doi: 10.1002/bdra.20804. Epub 2011 Apr 28.

PMID:
21567896
50.

Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43.

Boogerd CJ, Wong LY, van den Boogaard M, Bakker ML, Tessadori F, Bakkers J, 't Hoen PA, Moorman AF, Christoffels VM, Barnett P.

Cell Mol Life Sci. 2011 Dec;68(23):3949-61. doi: 10.1007/s00018-011-0693-7. Epub 2011 May 3.

Supplemental Content

Loading ...
Support Center