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Items: 1 to 50 of 118

1.

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.

Honkoop H, de Bakker DE, Aharonov A, Kruse F, Shakked A, Nguyen PD, de Heus C, Garric L, Muraro MJ, Shoffner A, Tessadori F, Peterson JC, Noort W, Bertozzi A, Weidinger G, Posthuma G, Grun D, van der Laarse WJ, Klumperman J, Jaspers RT, Poss KD, van Oudenaarden A, Tzahor E, Bakkers J.

Elife. 2019 Dec 23;8. pii: e50163. doi: 10.7554/eLife.50163. [Epub ahead of print]

2.

A de novo variant in the human HIST1H4J gene causes a syndrome analogous to the HIST1H4C-associated neurodevelopmental disorder.

Tessadori F, Rehman AU, Giltay JC, Xia F, Streff H, Duran K, Bakkers J, Lalani SR, van Haaften G.

Eur J Hum Genet. 2019 Dec 5. doi: 10.1038/s41431-019-0552-9. [Epub ahead of print]

PMID:
31804630
3.

Pyridox(am)ine 5'-phosphate oxidase (PNPO) deficiency in zebrafish results in fatal seizures and metabolic aberrations.

Ciapaite J, Albersen M, Savelberg SMC, Bosma M, Tessadori F, Gerrits J, Lansu N, Zwakenberg S, Bakkers JPW, Zwartkruis FJT, van Haaften G, Jans JJ, Verhoeven-Duif NM.

Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165607. doi: 10.1016/j.bbadis.2019.165607. Epub 2019 Nov 21.

4.

ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9.

Smeland MF, McClenaghan C, Roessler HI, Savelberg S, Hansen GÅM, Hjellnes H, Arntzen KA, Müller KI, Dybesland AR, Harter T, Sala-Rabanal M, Emfinger CH, Huang Y, Singareddy SS, Gunn J, Wozniak DF, Kovacs A, Massink M, Tessadori F, Kamel SM, Bakkers J, Remedi MS, Van Ghelue M, Nichols CG, van Haaften G.

Nat Commun. 2019 Oct 1;10(1):4457. doi: 10.1038/s41467-019-12428-7.

5.

Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation.

van den Boogaard M, van Weerd JH, Bawazeer AC, Hooijkaas IB, van de Werken HJG, Tessadori F, de Laat W, Barnett P, Bakkers J, Christoffels VM.

Cell Rep. 2019 Sep 3;28(10):2704-2714.e5. doi: 10.1016/j.celrep.2019.08.007.

6.

Assessment of the Most Optimal Control Tissue for Intracranial Aneurysm Gene Expression Studies.

Laarman MD, Kleinloog R, Bakker MK, Rinkel GJE, Bakkers J, Ruigrok YM.

Stroke. 2019 Oct;50(10):2933-2936. doi: 10.1161/STROKEAHA.119.024881. Epub 2019 Aug 20.

PMID:
31426730
7.

Conserved NPPB+ Border Zone Switches From MEF2- to AP-1-Driven Gene Program.

van Duijvenboden K, de Bakker DEM, Man JCK, Janssen R, Günthel M, Hill MC, Hooijkaas IB, van der Made I, van der Kraak PH, Vink A, Creemers EE, Martin JF, Barnett P, Bakkers J, Christoffels VM.

Circulation. 2019 Sep 9;140(10):864-879. doi: 10.1161/CIRCULATIONAHA.118.038944. Epub 2019 Jul 1.

PMID:
31259610
8.

Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I K,ACh).

Veerman CC, Mengarelli I, Koopman CD, Wilders R, van Amersfoorth SC, Bakker D, Wolswinkel R, Hababa M, de Boer TP, Guan K, Milnes J, Lodder EM, Bakkers J, Verkerk AO, Bezzina CR.

Dis Model Mech. 2019 Jul 9;12(7). pii: dmm037994. doi: 10.1242/dmm.037994.

9.

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm-Associated Regions to Potential Candidate Genes.

Laarman MD, Geeven G, Barnett P; Netherlands Brain Bank, Rinkel GJE, de Laat W, Ruigrok YM, Bakkers J.

J Am Heart Assoc. 2019 May 7;8(9):e011201. doi: 10.1161/JAHA.118.011201.

10.

Identification of human D lactate dehydrogenase deficiency.

Monroe GR, van Eerde AM, Tessadori F, Duran KJ, Savelberg SMC, van Alfen JC, Terhal PA, van der Crabben SN, Lichtenbelt KD, Fuchs SA, Gerrits J, van Roosmalen MJ, van Gassen KL, van Aalderen M, Koot BG, Oostendorp M, Duran M, Visser G, de Koning TJ, Calì F, Bosco P, Geleijns K, de Sain-van der Velden MGM, Knoers NV, Bakkers J, Verhoeven-Duif NM, van Haaften G, Jans JJ.

Nat Commun. 2019 Apr 1;10(1):1477. doi: 10.1038/s41467-019-09458-6.

11.

Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development.

Chrispijn ND, Elurbe DM, Mickoleit M, Aben M, de Bakker DEM, Andralojc KM, Huisken J, Bakkers J, Kamminga LM.

Sci Rep. 2019 Mar 13;9(1):4327. doi: 10.1038/s41598-019-40867-1.

12.

Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders.

Tessadori F, Roessler HI, Savelberg SMC, Chocron S, Kamel SM, Duran KJ, van Haelst MM, van Haaften G, Bakkers J.

Dis Model Mech. 2018 Oct 18;11(10). pii: dmm035469. doi: 10.1242/dmm.035469.

13.

Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis.

van Opbergen CJM, Koopman CD, Kok BJM, Knöpfel T, Renninger SL, Orger MB, Vos MA, van Veen TAB, Bakkers J, de Boer TP.

Theranostics. 2018 Sep 9;8(17):4750-4764. doi: 10.7150/thno.26108. eCollection 2018.

14.

GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay.

Rumping L, Tessadori F, Pouwels PJW, Vringer E, Wijnen JP, Bhogal AA, Savelberg SMC, Duran KJ, Bakkers MJG, Ramos RJJ, Schellekens PAW, Kroes HY, Klomp DWJ, Black GCM, Taylor RL, Bakkers JPW, Prinsen HCMT, van der Knaap MS, Dansen TB, Rehmann H, Zwartkruis FJT, Houwen RHJ, van Haaften G, Verhoeven-Duif NM, Jans JJM, van Hasselt PM.

Hum Mol Genet. 2019 Jan 1;28(1):96-104. doi: 10.1093/hmg/ddy330.

PMID:
30239721
15.

Shaping up with morphogen gradients.

Garric L, Bakkers J.

Nat Cell Biol. 2018 Sep;20(9):998-999. doi: 10.1038/s41556-018-0168-2. No abstract available.

PMID:
30061679
16.
17.

On the Evolution of the Cardiac Pacemaker.

Burkhard S, van Eif V, Garric L, Christoffels VM, Bakkers J.

J Cardiovasc Dev Dis. 2017 Apr 27;4(2). pii: E4. doi: 10.3390/jcdd4020004. Review.

18.

Variants in members of the cadherin-catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome.

Kievit A, Tessadori F, Douben H, Jordens I, Maurice M, Hoogeboom J, Hennekam R, Nampoothiri S, Kayserili H, Castori M, Whiteford M, Motter C, Melver C, Cunningham M, Hing A, Kokitsu-Nakata NM, Vendramini-Pittoli S, Richieri-Costa A, Baas AF, Breugem CC, Duran K, Massink M, Derksen PWB, van IJcken WFJ, van Unen L, Santos-Simarro F, Lapunzina P, Gil-da Silva Lopes VL, Lustosa-Mendes E, Krall M, Slavotinek A, Martinez-Glez V, Bakkers J, van Gassen KLI, de Klein A, van den Boogaard MH, van Haaften G.

Eur J Hum Genet. 2018 Feb;26(2):210-219. doi: 10.1038/s41431-017-0010-5. Epub 2018 Jan 18.

19.

Intracranial Aneurysm-Associated Single-Nucleotide Polymorphisms Alter Regulatory DNA in the Human Circle of Willis.

Laarman MD, Vermunt MW, Kleinloog R, de Boer-Bergsma JJ, Brain Bank N, Rinkel GJE, Creyghton MP, Mokry M, Bakkers J, Ruigrok YM.

Stroke. 2018 Feb;49(2):447-453. doi: 10.1161/STROKEAHA.117.018557. Epub 2018 Jan 4.

PMID:
29301971
20.

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

Sala L, van Meer BJ, Tertoolen LGJ, Bakkers J, Bellin M, Davis RP, Denning C, Dieben MAE, Eschenhagen T, Giacomelli E, Grandela C, Hansen A, Holman ER, Jongbloed MRM, Kamel SM, Koopman CD, Lachaud Q, Mannhardt I, Mol MPH, Mosqueira D, Orlova VV, Passier R, Ribeiro MC, Saleem U, Smith GL, Burton FL, Mummery CL.

Circ Res. 2018 Feb 2;122(3):e5-e16. doi: 10.1161/CIRCRESAHA.117.312067. Epub 2017 Dec 27. Review.

21.

Twists and turns.

Noël ES, Bakkers J.

Elife. 2017 Nov 28;6. pii: e32709. doi: 10.7554/eLife.32709.

22.

Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control.

Tessadori F, Giltay JC, Hurst JA, Massink MP, Duran K, Vos HR, van Es RM; Deciphering Developmental Disorders Study, Scott RH, van Gassen KLI, Bakkers J, van Haaften G.

Nat Genet. 2017 Nov;49(11):1642-1646. doi: 10.1038/ng.3956. Epub 2017 Sep 18.

PMID:
28920961
23.

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.

De Angelis JE, Lagendijk AK, Chen H, Tromp A, Bower NI, Tunny KA, Brooks AJ, Bakkers J, Francois M, Yap AS, Simons C, Wicking C, Hogan BM, Smith KA.

Dev Cell. 2017 Feb 27;40(4):421. doi: 10.1016/j.devcel.2017.02.005. No abstract available.

24.

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.

De Angelis JE, Lagendijk AK, Chen H, Tromp A, Bower NI, Tunny KA, Brooks AJ, Bakkers J, Francois M, Yap AS, Simons C, Wicking C, Hogan BM, Smith KA.

Dev Cell. 2017 Jan 23;40(2):123-136. doi: 10.1016/j.devcel.2016.12.017.

25.

Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity.

Josifova DJ, Monroe GR, Tessadori F, de Graaff E, van der Zwaag B, Mehta SG; DDD Study, Harakalova M, Duran KJ, Savelberg SM, Nijman IJ, Jungbluth H, Hoogenraad CC, Bakkers J, Knoers NV, Firth HV, Beales PL, van Haaften G, van Haelst MM.

Hum Mol Genet. 2016 Jun 1;25(11):2158-2167. Epub 2016 Mar 22.

PMID:
27005418
26.

αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish.

Han MK, Hoijman E, Nöel E, Garric L, Bakkers J, de Rooij J.

Biol Open. 2016 Oct 15;5(10):1461-1472. doi: 10.1242/bio.021378.

27.

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.

Lodder EM, De Nittis P, Koopman CD, Wiszniewski W, Moura de Souza CF, Lahrouchi N, Guex N, Napolioni V, Tessadori F, Beekman L, Nannenberg EA, Boualla L, Blom NA, de Graaff W, Kamermans M, Cocciadiferro D, Malerba N, Mandriani B, Coban Akdemir ZH, Fish RJ, Eldomery MK, Ratbi I, Wilde AAM, de Boer T, Simonds WF, Neerman-Arbez M, Sutton VR, Kok F, Lupski JR, Reymond A, Bezzina CR, Bakkers J, Merla G.

Am J Hum Genet. 2016 Sep 1;99(3):786. doi: 10.1016/j.ajhg.2016.08.011. Epub 2016 Sep 1. No abstract available.

28.

GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.

Lodder EM, De Nittis P, Koopman CD, Wiszniewski W, Moura de Souza CF, Lahrouchi N, Guex N, Napolioni V, Tessadori F, Beekman L, Nannenberg EA, Boualla L, Blom NA, de Graaff W, Kamermans M, Cocciadiferro D, Malerba N, Mandriani B, Akdemir ZHC, Fish RJ, Eldomery MK, Ratbi I, Wilde AAM, de Boer T, Simonds WF, Neerman-Arbez M, Sutton VR, Kok F, Lupski JR, Reymond A, Bezzina CR, Bakkers J, Merla G.

Am J Hum Genet. 2016 Sep 1;99(3):704-710. doi: 10.1016/j.ajhg.2016.06.025. Epub 2016 Aug 11. Erratum in: Am J Hum Genet. 2016 Sep 1;99(3):786.

29.

Tomo-seq: A method to obtain genome-wide expression data with spatial resolution.

Kruse F, Junker JP, van Oudenaarden A, Bakkers J.

Methods Cell Biol. 2016;135:299-307. doi: 10.1016/bs.mcb.2016.01.006. Epub 2016 Feb 26.

PMID:
27443932
30.

Rare novel variants in the ZIC3 gene cause X-linked heterotaxy.

Paulussen AD, Steyls A, Vanoevelen J, van Tienen FH, Krapels IP, Claes GR, Chocron S, Velter C, Tan-Sindhunata GM, Lundin C, Valenzuela I, Nagy B, Bache I, Maroun LL, Avela K, Brunner HG, Smeets HJ, Bakkers J, van den Wijngaard A.

Eur J Hum Genet. 2016 Dec;24(12):1783-1791. doi: 10.1038/ejhg.2016.91. Epub 2016 Jul 13.

31.

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2.

San B, Chrispijn ND, Wittkopp N, van Heeringen SJ, Lagendijk AK, Aben M, Bakkers J, Ketting RF, Kamminga LM.

Sci Rep. 2016 May 5;6:24658. doi: 10.1038/srep24658.

32.

Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration.

Wu CC, Kruse F, Vasudevarao MD, Junker JP, Zebrowski DC, Fischer K, Noël ES, Grün D, Berezikov E, Engel FB, van Oudenaarden A, Weidinger G, Bakkers J.

Dev Cell. 2016 Jan 11;36(1):36-49. doi: 10.1016/j.devcel.2015.12.010. Epub 2015 Dec 31.

33.

A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function.

Noël ES, Momenah TS, Al-Dagriri K, Al-Suwaid A, Al-Shahrani S, Jiang H, Willekers S, Oostveen YY, Chocron S, Postma AV, Bhuiyan ZA, Bakkers J.

Hum Mutat. 2016 Feb;37(2):194-200. doi: 10.1002/humu.22928. Epub 2015 Dec 2.

PMID:
26531781
34.

Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes.

Marchegiani S, Davis T, Tessadori F, van Haaften G, Brancati F, Hoischen A, Huang H, Valkanas E, Pusey B, Schanze D, Venselaar H, Vulto-van Silfhout AT, Wolfe LA, Tifft CJ, Zerfas PM, Zambruno G, Kariminejad A, Sabbagh-Kermani F, Lee J, Tsokos MG, Lee CC, Ferraz V, da Silva EM, Stevens CA, Roche N, Bartsch O, Farndon P, Bermejo-Sanchez E, Brooks BP, Maduro V, Dallapiccola B, Ramos FJ, Chung HY, Le Caignec C, Martins F, Jacyk WK, Mazzanti L, Brunner HG, Bakkers J, Lin S, Malicdan MC, Boerkoel CF, Gahl WA, de Vries BB, van Haelst MM, Zenker M, Markello TC.

Am J Hum Genet. 2015 Jul 2;97(1):99-110. doi: 10.1016/j.ajhg.2015.05.017. Epub 2015 Jun 25.

35.

Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies.

Ramspacher C, Steed E, Boselli F, Ferreira R, Faggianelli N, Roth S, Spiegelhalter C, Messaddeq N, Trinh L, Liebling M, Chacko N, Tessadori F, Bakkers J, Laporte J, Hnia K, Vermot J.

Cell Rep. 2015 Jun 16;11(10):1564-76. doi: 10.1016/j.celrep.2015.05.010. Epub 2015 Jun 4.

36.

Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling.

Strate I, Tessadori F, Bakkers J.

Development. 2015 May 15;142(10):1767-76. doi: 10.1242/dev.113894.

37.

Nodal signaling range is regulated by proprotein convertase-mediated maturation.

Tessadori F, Noël ES, Rens EG, Magliozzi R, Evers-van Gogh IJ, Guardavaccaro D, Merks RM, Bakkers J.

Dev Cell. 2015 Mar 9;32(5):631-9. doi: 10.1016/j.devcel.2014.12.014. Epub 2015 Feb 12.

38.

Animal and in silico models for the study of sarcomeric cardiomyopathies.

Duncker DJ, Bakkers J, Brundel BJ, Robbins J, Tardiff JC, Carrier L.

Cardiovasc Res. 2015 Apr 1;105(4):439-48. doi: 10.1093/cvr/cvv006. Epub 2015 Jan 18. Review.

39.

Genome-wide RNA Tomography in the zebrafish embryo.

Junker JP, Noël ES, Guryev V, Peterson KA, Shah G, Huisken J, McMahon AP, Berezikov E, Bakkers J, van Oudenaarden A.

Cell. 2014 Oct 23;159(3):662-75. doi: 10.1016/j.cell.2014.09.038.

40.

GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish.

Jiménez-Amilburu V, Jong-Raadsen S, Bakkers J, Spaink HP, Marín-Juez R.

J Endocrinol. 2015 Jan;224(1):1-15. doi: 10.1530/JOE-14-0539. Epub 2014 Oct 17.

PMID:
25326603
41.

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm.

Chetaille P, Preuss C, Burkhard S, Côté JM, Houde C, Castilloux J, Piché J, Gosset N, Leclerc S, Wünnemann F, Thibeault M, Gagnon C, Galli A, Tuck E, Hickson GR, El Amine N, Boufaied I, Lemyre E, de Santa Barbara P, Faure S, Jonzon A, Cameron M, Dietz HC, Gallo-McFarlane E, Benson DW, Moreau C, Labuda D; FORGE Canada Consortium, Zhan SH, Shen Y, Jomphe M, Jones SJ, Bakkers J, Andelfinger G.

Nat Genet. 2014 Nov;46(11):1245-9. doi: 10.1038/ng.3113. Epub 2014 Oct 5.

PMID:
25282101
42.

Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish.

Bonetti M, Paardekooper Overman J, Tessadori F, Noël E, Bakkers J, den Hertog J.

Development. 2014 May;141(9):1961-70. doi: 10.1242/dev.106310. Epub 2014 Apr 9.

43.

A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality.

Noël ES, Verhoeven M, Lagendijk AK, Tessadori F, Smith K, Choorapoikayil S, den Hertog J, Bakkers J.

Nat Commun. 2013;4:2754. doi: 10.1038/ncomms3754.

PMID:
24212328
44.

On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling.

Goudarzi M, Strate I, Paksa A, Lagendijk AK, Bakkers J, Raz E.

Nat Genet. 2013 Nov;45(11):1264-5. doi: 10.1038/ng.2793. No abstract available.

PMID:
24165724
45.

Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis.

Mugoni V, Postel R, Catanzaro V, De Luca E, Turco E, Digilio G, Silengo L, Murphy MP, Medana C, Stainier DY, Bakkers J, Santoro MM.

Cell. 2013 Jan 31;152(3):504-18. doi: 10.1016/j.cell.2013.01.013.

46.

Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation.

Lagendijk AK, Szabó A, Merks RM, Bakkers J.

Trends Cardiovasc Med. 2013 Jul;23(5):135-42. doi: 10.1016/j.tcm.2012.10.002. Epub 2013 Jan 5. Review.

PMID:
23295082
47.

Revealing details: whole mount microRNA in situ hybridization protocol for zebrafish embryos and adult tissues.

Lagendijk AK, Moulton JD, Bakkers J.

Biol Open. 2012 Jun 15;1(6):566-9. doi: 10.1242/bio.2012810. Epub 2012 Apr 11.

48.

Structural brain changes in migraine.

Palm-Meinders IH, Koppen H, Terwindt GM, Launer LJ, Konishi J, Moonen JM, Bakkers JT, Hofman PA, van Lew B, Middelkoop HA, van Buchem MA, Ferrari MD, Kruit MC.

JAMA. 2012 Nov 14;308(18):1889-97. doi: 10.1001/jama.2012.14276.

49.

Identification and functional characterization of cardiac pacemaker cells in zebrafish.

Tessadori F, van Weerd JH, Burkhard SB, Verkerk AO, de Pater E, Boukens BJ, Vink A, Christoffels VM, Bakkers J.

PLoS One. 2012;7(10):e47644. doi: 10.1371/journal.pone.0047644. Epub 2012 Oct 16.

50.

UDP-glucose dehydrogenase polymorphisms from patients with congenital heart valve defects disrupt enzyme stability and quaternary assembly.

Hyde AS, Farmer EL, Easley KE, van Lammeren K, Christoffels VM, Barycki JJ, Bakkers J, Simpson MA.

J Biol Chem. 2012 Sep 21;287(39):32708-16. Epub 2012 Jul 18.

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