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Items: 1 to 50 of 64

1.

ATR inhibition sensitizes HPV- and HPV+ head and neck squamous cell carcinoma to cisplatin.

Leonard BC, Lee ED, Bhola NE, Li H, Sogaard KK, Bakkenist CJ, Grandis JR, Johnson DE.

Oral Oncol. 2019 Aug;95:35-42. doi: 10.1016/j.oraloncology.2019.05.028. Epub 2019 Jun 6.

PMID:
31345392
2.

Dormant origin signaling during unperturbed replication.

Moiseeva TN, Bakkenist CJ.

DNA Repair (Amst). 2019 Jul 8:102655. doi: 10.1016/j.dnarep.2019.102655. [Epub ahead of print] Review.

PMID:
31311769
3.

IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell.

Shao L, Hou W, Scharping NE, Vendetti FP, Srivastava R, Roy CN, Menk AV, Wang Y, Chauvin JM, Karukonda P, Thorne SH, Hornung V, Zarour HM, Bakkenist CJ, Delgoffe GM, Sarkar SN.

Cancer Immunol Res. 2019 Aug;7(8):1258-1266. doi: 10.1158/2326-6066.CIR-18-0711. Epub 2019 Jun 25.

PMID:
31239318
4.

An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication.

Moiseeva TN, Yin Y, Calderon MJ, Qian C, Schamus-Haynes S, Sugitani N, Osmanbeyoglu HU, Rothenberg E, Watkins SC, Bakkenist CJ.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13374-13383. doi: 10.1073/pnas.1903418116. Epub 2019 Jun 17.

5.

Quantitative analysis of ATM phosphorylation in lymphocytes.

Bakkenist CJ, Czambel RK, Lin Y, Yates NA, Zeng X, Shogan J, Schmitz JC.

DNA Repair (Amst). 2019 Jun 4;80:1-7. doi: 10.1016/j.dnarep.2019.06.002. [Epub ahead of print]

PMID:
31176958
6.

The neonatal Fc receptor is a pan-echovirus receptor.

Morosky S, Wells AI, Lemon K, Evans AS, Schamus S, Bakkenist CJ, Coyne CB.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3758-3763. doi: 10.1073/pnas.1817341116. Epub 2019 Feb 11.

7.

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA.

Menolfi D, Jiang W, Lee BJ, Moiseeva T, Shao Z, Estes V, Frattini MG, Bakkenist CJ, Zha S.

Nat Commun. 2018 Dec 17;9(1):5351. doi: 10.1038/s41467-018-07798-3.

8.

ATM Is Required for the Repair of Oxaliplatin-Induced DNA Damage in Colorectal Cancer.

Bakkenist CJ, Lee JJ, Schmitz JC.

Clin Colorectal Cancer. 2018 Dec;17(4):255-257. doi: 10.1016/j.clcc.2018.09.001. Epub 2018 Sep 13. No abstract available.

9.

Regulation of the initiation of DNA replication in human cells.

Moiseeva TN, Bakkenist CJ.

DNA Repair (Amst). 2018 Dec;72:99-106. doi: 10.1016/j.dnarep.2018.09.003. Epub 2018 Sep 12. Review.

PMID:
30266203
10.

ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation.

Vendetti FP, Karukonda P, Clump DA, Teo T, Lalonde R, Nugent K, Ballew M, Kiesel BF, Beumer JH, Sarkar SN, Conrads TP, O'Connor MJ, Ferris RL, Tran PT, Delgoffe GM, Bakkenist CJ.

J Clin Invest. 2018 Aug 31;128(9):3926-3940. doi: 10.1172/JCI96519. Epub 2018 Aug 13.

11.

Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromosome rearrangements.

Evdokimova VN, Gandhi M, Nikitski AV, Bakkenist CJ, Nikiforov YE.

Oncotarget. 2018 Feb 7;9(17):13612-13622. doi: 10.18632/oncotarget.24434. eCollection 2018 Mar 2.

12.

Role of Immunotherapy in Head and Neck Cancer.

Ling DC, Bakkenist CJ, Ferris RL, Clump DA.

Semin Radiat Oncol. 2018 Jan;28(1):12-16. doi: 10.1016/j.semradonc.2017.08.009. Review.

PMID:
29173750
13.

ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1.

Moiseeva T, Hood B, Schamus S, O'Connor MJ, Conrads TP, Bakkenist CJ.

Nat Commun. 2017 Nov 9;8(1):1392. doi: 10.1038/s41467-017-01401-x.

14.

LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma.

Kiesel BF, Scemama J, Parise RA, Villaruz L, Iffland A, Doyle A, Ivy P, Chu E, Bakkenist CJ, Beumer JH.

J Pharm Biomed Anal. 2017 Nov 30;146:244-250. doi: 10.1016/j.jpba.2017.08.037. Epub 2017 Aug 31.

15.

RAD-ADAPT: Software for modelling clonogenic assay data in radiation biology.

Zhang Y, Hu K, Beumer JH, Bakkenist CJ, D'Argenio DZ.

DNA Repair (Amst). 2017 Apr;52:24-30. doi: 10.1016/j.dnarep.2017.02.004. Epub 2017 Feb 20.

16.

LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma.

Kiesel BF, Shogan JC, Rachid M, Parise RA, Vendetti FP, Bakkenist CJ, Beumer JH.

J Pharm Biomed Anal. 2017 May 10;138:158-165. doi: 10.1016/j.jpba.2017.01.055. Epub 2017 Feb 4.

17.

Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation.

Vendetti FP, Leibowitz BJ, Barnes J, Schamus S, Kiesel BF, Abberbock S, Conrads T, Clump DA, Cadogan E, O'Connor MJ, Yu J, Beumer JH, Bakkenist CJ.

Sci Rep. 2017 Feb 1;7:41892. doi: 10.1038/srep41892.

18.

ATM protein is deficient in over 40% of lung adenocarcinomas.

Villaruz LC, Jones H, Dacic S, Abberbock S, Kurland BF, Stabile LP, Siegfried JM, Conrads TP, Smith NR, O'Connor MJ, Pierce AJ, Bakkenist CJ.

Oncotarget. 2016 Sep 6;7(36):57714-57725. doi: 10.18632/oncotarget.9757.

19.

Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.

Moiseeva TN, Gamper AM, Hood BL, Conrads TP, Bakkenist CJ.

DNA Repair (Amst). 2016 Jul;43:9-17. doi: 10.1016/j.dnarep.2016.04.007. Epub 2016 May 7.

20.

ATM serine-1981 phosphorylation is a plausible biomarker.

Bakkenist CJ, Beumer JH, Schmitz JC.

Cell Cycle. 2015;14(20):3207-8. doi: 10.1080/15384101.2015.1084205. No abstract available.

21.

The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.

Vendetti FP, Lau A, Schamus S, Conrads TP, O'Connor MJ, Bakkenist CJ.

Oncotarget. 2015 Dec 29;6(42):44289-305. doi: 10.18632/oncotarget.6247.

22.

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma.

Beumer JH, Fu KY, Anyang BN, Siegfried JM, Bakkenist CJ.

BMC Cancer. 2015 Oct 5;15:649. doi: 10.1186/s12885-015-1649-3.

23.

Chromatin perturbations during the DNA damage response in higher eukaryotes.

Bakkenist CJ, Kastan MB.

DNA Repair (Amst). 2015 Dec;36:8-12. doi: 10.1016/j.dnarep.2015.09.002. Epub 2015 Sep 9. Review.

24.

A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells.

Bakkenist CJ, Czambel RK, Hershberger PA, Tawbi H, Beumer JH, Schmitz JC.

Oncoscience. 2015 May 14;2(5):542-54. eCollection 2015.

25.

Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells.

Teng PN, Bateman NW, Darcy KM, Hamilton CA, Maxwell GL, Bakkenist CJ, Conrads TP.

Gynecol Oncol. 2015 Mar;136(3):554-61. doi: 10.1016/j.ygyno.2014.12.035. Epub 2015 Jan 2.

26.

Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase.

Forero A, Giacobbi NS, McCormick KD, Gjoerup OV, Bakkenist CJ, Pipas JM, Sarkar SN.

J Immunol. 2014 Jun 15;192(12):5933-42. doi: 10.4049/jimmunol.1303470. Epub 2014 May 5.

27.

Erratum: Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation: erratum.

Uttam S, Bista RK, Staton K, Alexandrov S, Choi S, Bakkenist CJ, Hartman DJ, Brand RE, Liu Y.

Biomed Opt Express. 2013 Oct 14;4(11):2491. eCollection 2013.

28.

Stoichiometry of ubiquitin-binding proteins directs DSB repair.

Bakkenist CJ, Vaziri C.

Cell Cycle. 2013 Dec 15;12(24):3716-7. doi: 10.4161/cc.26963. Epub 2013 Oct 28. No abstract available.

29.

Brd4 shields chromatin from ATM kinase signaling storms.

Choi S, Bakkenist CJ.

Sci Signal. 2013 Sep 17;6(293):pe30. doi: 10.1126/scisignal.2004622. Review.

30.

ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.

Gamper AM, Rofougaran R, Watkins SC, Greenberger JS, Beumer JH, Bakkenist CJ.

Nucleic Acids Res. 2013 Dec;41(22):10334-44. doi: 10.1093/nar/gkt833. Epub 2013 Sep 14.

31.

Radiation therapy induces the DNA damage response in peripheral blood.

Bakkenist CJ, Czambel RK, Clump DA, Greenberger JS, Beumer JH, Schmitz JC.

Oncotarget. 2013 Aug;4(8):1143-8.

32.

Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation.

Uttam S, Bista RK, Staton K, Alexandrov S, Choi S, Bakkenist CJ, Hartman DJ, Brand RE, Liu Y.

Biomed Opt Express. 2013 Apr 1;4(4):596-613. doi: 10.1364/BOE.4.000596. Epub 2013 Mar 22. Erratum in: Biomed Opt Express. 2013 Oct 14;4(11):2491.

33.

Homologous chromosomes move and rapidly initiate contact at the sites of double-strand breaks in genes in G₀-phase human cells.

Gandhi M, Evdokimova VN, Cuenco KT, Bakkenist CJ, Nikiforov YE.

Cell Cycle. 2013 Feb 15;12(4):547-52. doi: 10.4161/cc.23754. Epub 2013 Jan 31.

34.

Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress.

Qian W, Choi S, Gibson GA, Watkins SC, Bakkenist CJ, Van Houten B.

J Cell Sci. 2012 Dec 1;125(Pt 23):5745-57. doi: 10.1242/jcs.109769. Epub 2012 Sep 26.

35.

Quantitative proteomics reveal ATM kinase-dependent exchange in DNA damage response complexes.

Choi S, Srivas R, Fu KY, Hood BL, Dost B, Gibson GA, Watkins SC, Van Houten B, Bandeira N, Conrads TP, Ideker T, Bakkenist CJ.

J Proteome Res. 2012 Oct 5;11(10):4983-91. doi: 10.1021/pr3005524. Epub 2012 Sep 18.

36.

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.

Yamamoto K, Wang Y, Jiang W, Liu X, Dubois RL, Lin CS, Ludwig T, Bakkenist CJ, Zha S.

J Cell Biol. 2012 Aug 6;198(3):305-13. doi: 10.1083/jcb.201204098.

37.

Homologous chromosomes make contact at the sites of double-strand breaks in genes in somatic G0/G1-phase human cells.

Gandhi M, Evdokimova VN, T Cuenco K, Nikiforova MN, Kelly LM, Stringer JR, Bakkenist CJ, Nikiforov YE.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9454-9. doi: 10.1073/pnas.1205759109. Epub 2012 May 29.

38.

ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.

Gamper AM, Choi S, Matsumoto Y, Banerjee D, Tomkinson AE, Bakkenist CJ.

J Biol Chem. 2012 Apr 6;287(15):12445-54. doi: 10.1074/jbc.M112.352310. Epub 2012 Feb 23.

39.

GS-nitroxide (JP4-039)-mediated radioprotection of human Fanconi anemia cell lines.

Bernard ME, Kim H, Berhane H, Epperly MW, Franicola D, Zhang X, Houghton F, Shields D, Wang H, Bakkenist CJ, Frantz MC, Forbeck EM, Goff JP, Wipf P, Greenberger JS.

Radiat Res. 2011 Nov;176(5):603-12. Epub 2011 Sep 22.

40.

CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.

Choi S, Toledo LI, Fernandez-Capetillo O, Bakkenist CJ.

DNA Repair (Amst). 2011 Oct 10;10(10):1000-1; author reply 1002. doi: 10.1016/j.dnarep.2011.07.013. Epub 2011 Aug 23. No abstract available.

41.

Quantification of nanoscale nuclear refractive index changes during the cell cycle.

Bista RK, Uttam S, Wang P, Staton K, Choi S, Bakkenist CJ, Hartman DJ, Brand RE, Liu Y.

J Biomed Opt. 2011 Jul;16(7):070503. doi: 10.1117/1.3597723.

43.
44.

Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange.

White JS, Choi S, Bakkenist CJ.

Sci Signal. 2010 Jun 1;3(124):ra44. doi: 10.1126/scisignal.2000758.

45.

HDAC2 promotes eIF4E sumoylation and activates mRNA translation gene specifically.

Xu X, Vatsyayan J, Gao C, Bakkenist CJ, Hu J.

J Biol Chem. 2010 Jun 11;285(24):18139-43. doi: 10.1074/jbc.C110.131599. Epub 2010 Apr 26.

46.

Sumoylation of eIF4E activates mRNA translation.

Xu X, Vatsyayan J, Gao C, Bakkenist CJ, Hu J.

EMBO Rep. 2010 Apr;11(4):299-304. doi: 10.1038/embor.2010.18. Epub 2010 Mar 12.

47.

Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation.

Goff JP, Shields DS, Seki M, Choi S, Epperly MW, Dixon T, Wang H, Bakkenist CJ, Dertinger SD, Torous DK, Wittschieben J, Wood RD, Greenberger JS.

Radiat Res. 2009 Aug;172(2):165-74. doi: 10.1667/RR1598.1.

48.

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity.

White JS, Choi S, Bakkenist CJ.

Cell Cycle. 2008 May 1;7(9):1277-84. Epub 2008 Mar 18.

PMID:
18418045
49.

Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma.

Parikh RA, White JS, Huang X, Schoppy DW, Baysal BE, Baskaran R, Bakkenist CJ, Saunders WS, Hsu LC, Romkes M, Gollin SM.

Genes Chromosomes Cancer. 2007 Aug;46(8):761-75.

PMID:
17492757
50.

ATM activation in normal human tissues and testicular cancer.

Bartkova J, Bakkenist CJ, Rajpert-De Meyts E, Skakkebaek NE, Sehested M, Lukas J, Kastan MB, Bartek J.

Cell Cycle. 2005 Jun;4(6):838-45. Epub 2005 Jun 13.

PMID:
15846060

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