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Items: 1 to 50 of 123

1.

Metformin Inhibits the Type 1 IFN Response in Human CD4+ T Cells.

Titov AA, Baker HV, Brusko TM, Sobel ES, Morel L.

J Immunol. 2019 Jul 15;203(2):338-348. doi: 10.4049/jimmunol.1801651. Epub 2019 Jun 3.

PMID:
31160534
2.

Prospective Validation of a Transcriptomic Metric in Severe Trauma.

Raymond SL, Hawkins RB, Wang Z, Mira JC, Stortz JA, Han F, Lanz JD, Hennessy LV, Brumback BA, Baker HV, Efron PA, Brakenridge SC, Xiao W, Tompkins RG, Cuschieri J, Moore FA, Maier RV, Moldawer LL.

Ann Surg. 2019 Jan 24. doi: 10.1097/SLA.0000000000003204. [Epub ahead of print]

PMID:
30688688
3.

Impact of toll-like receptor 4 stimulation on human neonatal neutrophil spontaneous migration, transcriptomics, and cytokine production.

Raymond SL, Hawkins RB, Murphy TJ, Rincon JC, Stortz JA, López MC, Ungaro R, Ellett F, Baker HV, Wynn JL, Moldawer LL, Irimia D, Larson SD.

J Mol Med (Berl). 2018 Jul;96(7):673-684. doi: 10.1007/s00109-018-1646-5. Epub 2018 May 28.

4.

Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.

Efron PA, Mohr AM, Bihorac A, Horiguchi H, Hollen MK, Segal MS, Baker HV, Leeuwenburgh C, Moldawer LL, Moore FA, Brakenridge SC.

Surgery. 2018 Aug;164(2):178-184. doi: 10.1016/j.surg.2018.04.011. Epub 2018 May 26. Review.

PMID:
29807651
5.

Hyperacute Monocyte Gene Response Patterns Are Associated With Lower Extremity Vein Bypass Graft Failure.

Rehfuss JP, DeSart KM, Rozowsky JM, O'Malley KA, Moldawer LL, Baker HV, Wang Y, Wu R, Nelson PR, Berceli SA.

Circ Genom Precis Med. 2018 Mar;11(3):e001970. doi: 10.1161/CIRCGEN.117.001970.

6.

Unique transcriptomic response to sepsis is observed among patients of different age groups.

Raymond SL, López MC, Baker HV, Larson SD, Efron PA, Sweeney TE, Khatri P, Moldawer LL, Wynn JL.

PLoS One. 2017 Sep 8;12(9):e0184159. doi: 10.1371/journal.pone.0184159. eCollection 2017.

7.

Neutrophil chemotaxis and transcriptomics in term and preterm neonates.

Raymond SL, Mathias BJ, Murphy TJ, Rincon JC, López MC, Ungaro R, Ellett F, Jorgensen J, Wynn JL, Baker HV, Moldawer LL, Irimia D, Larson SD.

Transl Res. 2017 Dec;190:4-15. doi: 10.1016/j.trsl.2017.08.003. Epub 2017 Sep 1.

8.

The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two Level-One Trauma Centers.

Mira JC, Cuschieri J, Ozrazgat-Baslanti T, Wang Z, Ghita GL, Loftus TJ, Stortz JA, Raymond SL, Lanz JD, Hennessy LV, Brumback B, Efron PA, Baker HV, Moore FA, Maier RV, Moldawer LL, Brakenridge SC.

Crit Care Med. 2017 Dec;45(12):1989-1996. doi: 10.1097/CCM.0000000000002697.

9.

Formation of Aza-ortho-quinone Methides Under Room Temperature Conditions: Cs2CO3 Effect.

Walden DM, Jaworski AA, Johnston RC, Hovey MT, Baker HV, Meyer MP, Scheidt KA, Cheong PH.

J Org Chem. 2017 Jul 21;82(14):7183-7189. doi: 10.1021/acs.joc.7b00697. Epub 2017 Jul 7.

PMID:
28649838
10.

Validation of the Sepsis MetaScore for Diagnosis of Neonatal Sepsis.

Sweeney TE, Wynn JL, Cernada M, Serna E, Wong HR, Baker HV, Vento M, Khatri P.

J Pediatric Infect Dis Soc. 2018 May 15;7(2):129-135. doi: 10.1093/jpids/pix021.

11.

LPS Stimulation of Cord Blood Reveals a Newborn-Specific Neutrophil Transcriptomic Response and Cytokine Production.

Mathias B, Mira JC, Rehfuss JP, Rincon JC, Ungaro R, Nacionales DC, Lopez MC, Baker HV, Moldawer LL, Larson SD.

Shock. 2017 May;47(5):606-614. doi: 10.1097/SHK.0000000000000800.

12.

Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice.

Han C, Ding D, Lopez MC, Manohar S, Zhang Y, Kim MJ, Park HJ, White K, Kim YH, Linser P, Tanokura M, Leeuwenburgh C, Baker HV, Salvi RJ, Someya S.

J Neurosci. 2016 Nov 2;36(44):11308-11319.

13.

Gene Expression Patterns in Peripheral Blood Leukocytes in Patients with Recurrent Ciguatera Fish Poisoning: Preliminary Studies.

Lopez MC, Ungaro RF, Baker HV, Moldawer LL, Robertson A, Abbott M, Roberts SM, Grattan LM, Morris JG Jr.

Harmful Algae. 2016 Jul;57(B):35-38.

14.

Gene expression patterns in peripheral blood leukocytes in patients with recurrent ciguatera fish poisoning: Preliminary studies.

Lopez MC, Ungaro RF, Baker HV, Moldawer LL, Robertson A, Abbott M, Roberts SM, Grattan LM, Morris JG Jr.

Harmful Algae. 2016 Jul;57(Pt B):35-38. doi: 10.1016/j.hal.2016.03.009. Epub 2016 Aug 30.

PMID:
28918889
15.

Histological chorioamnionitis shapes the neonatal transcriptomic immune response.

Weitkamp JH, Guthrie SO, Wong HR, Moldawer LL, Baker HV, Wynn JL.

Early Hum Dev. 2016 Jul;98:1-6. doi: 10.1016/j.earlhumdev.2016.06.001. Epub 2016 Jun 16.

16.

Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock.

Lopez MC, Efron PA, Ozrazgat-Baslanti T, Zhang J, Cuschieri J, Maier RV, Minei JP, Baker HV, Moore FA, Moldawer LL, Brakenridge SC.

J Trauma Acute Care Surg. 2016 Sep;81(3):478-85. doi: 10.1097/TA.0000000000001113.

17.

Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis.

Chen S, Fisher RC, Signs S, Molina LA, Shenoy AK, Lopez MC, Baker HV, Koomen JM, Chen Y, Gittleman H, Barnholtz-Sloan J, Berg A, Appelman HD, Huang EH.

Oncotarget. 2016 Jun 8;8(31):50476-50488. doi: 10.18632/oncotarget.9919. eCollection 2017 Aug 1.

18.

Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium.

Armfield BA, Seifert AW, Zheng Z, Merton EM, Rock JR, Lopez MC, Baker HV, Cohn MJ.

J Urol. 2016 Oct;196(4):1295-302. doi: 10.1016/j.juro.2016.04.091. Epub 2016 May 9.

19.

Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.

Wynn JL, Wilson CS, Hawiger J, Scumpia PO, Marshall AF, Liu JH, Zharkikh I, Wong HR, Lahni P, Benjamin JT, Plosa EJ, Weitkamp JH, Sherwood ER, Moldawer LL, Ungaro R, Baker HV, Lopez MC, McElroy SJ, Colliou N, Mohamadzadeh M, Moore DJ.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2627-35. doi: 10.1073/pnas.1515793113. Epub 2016 Apr 25.

20.

A Comparative Analysis of Gene Expression Profiles during Skin Regeneration in Mus and Acomys.

Brant JO, Lopez MC, Baker HV, Barbazuk WB, Maden M.

PLoS One. 2015 Nov 25;10(11):e0142931. doi: 10.1371/journal.pone.0142931. eCollection 2015.

21.

Patterns of gene expression among murine models of hemorrhagic shock/trauma and sepsis.

Mira JC, Szpila BE, Nacionales DC, Lopez MC, Gentile LF, Mathias BJ, Vanzant EL, Ungaro R, Holden D, Rosenthal MD, Rincon J, Verdugo PT, Larson SD, Moore FA, Brakenridge SC, Mohr AM, Baker HV, Moldawer LL, Efron PA.

Physiol Genomics. 2016 Feb;48(2):135-44. doi: 10.1152/physiolgenomics.00072.2015. Epub 2015 Nov 17.

22.

A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged.

Nacionales DC, Szpila B, Ungaro R, Lopez MC, Zhang J, Gentile LF, Cuenca AL, Vanzant E, Mathias B, Jyot J, Westerveld D, Bihorac A, Joseph A, Mohr A, Duckworth LV, Moore FA, Baker HV, Leeuwenburgh C, Moldawer LL, Brakenridge S, Efron PA.

J Immunol. 2015 Sep 1;195(5):2396-407. doi: 10.4049/jimmunol.1500984. Epub 2015 Aug 5.

23.

Postnatal Age Is a Critical Determinant of the Neonatal Host Response to Sepsis.

Wynn JL, Guthrie SO, Wong HR, Lahni P, Ungaro R, Lopez MC, Baker HV, Moldawer LL.

Mol Med. 2015 Jun 2;21:496-504. doi: 10.2119/molmed.2015.00064.

24.

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.

Fuhrman CA, Yeh WI, Seay HR, Saikumar Lakshmi P, Chopra G, Zhang L, Perry DJ, McClymont SA, Yadav M, Lopez MC, Baker HV, Zhang Y, Li Y, Whitley M, von Schack D, Atkinson MA, Bluestone JA, Brusko TM.

J Immunol. 2015 Jul 1;195(1):145-55. doi: 10.4049/jimmunol.1402381. Epub 2015 May 20.

25.

Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.

Vanzant EL, Hilton RE, Lopez CM, Zhang J, Ungaro RF, Gentile LF, Szpila BE, Maier RV, Cuschieri J, Bihorac A, Leeuwenburgh C, Moore FA, Baker HV, Moldawer LL, Brakenridge SC, Efron PA; Inflammation and Host Response to Injury Investigators.

Crit Care. 2015 Mar 4;19:77. doi: 10.1186/s13054-015-0788-x.

26.

A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets.

Gao R, Cao C, Zhang M, Lopez MC, Yan Y, Chen Z, Mitani Y, Zhang L, Zajac-Kaye M, Liu B, Wu L, Renne R, Baker HV, El-Naggar A, Kaye FJ.

Oncotarget. 2014 Dec 30;5(24):12528-42.

27.

A mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-dependent transcriptional program controls activation of the early growth response 1 (EGR1) gene during amino acid limitation.

Shan J, Balasubramanian MN, Donelan W, Fu L, Hayner J, Lopez MC, Baker HV, Kilberg MS.

J Biol Chem. 2014 Aug 29;289(35):24665-79. doi: 10.1074/jbc.M114.565028. Epub 2014 Jul 15.

28.

Host responses to sepsis vary in different low-lethality murine models.

Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Szpila BE, Cuenca AG, Joseph A, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA.

PLoS One. 2014 May 1;9(5):e94404. doi: 10.1371/journal.pone.0094404. eCollection 2014.

29.

Protective immunity and defects in the neonatal and elderly immune response to sepsis.

Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Cuenca AG, Ungaro R, Szpila BE, Larson S, Joseph A, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA.

J Immunol. 2014 Apr 1;192(7):3156-65. doi: 10.4049/jimmunol.1301726. Epub 2014 Mar 3.

30.

A better understanding of why murine models of trauma do not recapitulate the human syndrome.

Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Cuenca AG, Ungaro R, Baslanti TO, McKinley BA, Bihorac A, Cuschieri J, Maier RV, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA.

Crit Care Med. 2014 Jun;42(6):1406-13. doi: 10.1097/CCM.0000000000000222.

31.

Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma.

Vanzant EL, Lopez CM, Ozrazgat-Baslanti T, Ungaro R, Davis R, Cuenca AG, Gentile LF, Nacionales DC, Cuenca AL, Bihorac A, Leeuwenburgh C, Lanz J, Baker HV, McKinley B, Moldawer LL, Moore FA, Efron PA.

J Trauma Acute Care Surg. 2014 Jan;76(1):21-9; discussion 29-30. doi: 10.1097/TA.0b013e3182ab1ab5.

32.

Aged mice are unable to mount an effective myeloid response to sepsis.

Nacionales DC, Gentile LF, Vanzant E, Lopez MC, Cuenca A, Cuenca AG, Ungaro R, Li Y, Baslanti TO, Bihorac A, Moore FA, Baker HV, Leeuwenburgh C, Moldawer LL, Efron PA.

J Immunol. 2014 Jan 15;192(2):612-22. doi: 10.4049/jimmunol.1302109. Epub 2013 Dec 13.

33.

Genomic responses in mouse models poorly mimic human inflammatory diseases.

Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, Finnerty CC, López CM, Honari S, Moore EE, Minei JP, Cuschieri J, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Jeschke MG, Klein MB, Gamelli RL, Gibran NS, Brownstein BH, Miller-Graziano C, Calvano SE, Mason PH, Cobb JP, Rahme LG, Lowry SF, Maier RV, Moldawer LL, Herndon DN, Davis RW, Xiao W, Tompkins RG; Inflammation and Host Response to Injury, Large Scale Collaborative Research Program.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3507-12. doi: 10.1073/pnas.1222878110. Epub 2013 Feb 11.

34.

Identification and description of a novel murine model for polytrauma and shock.

Gentile LF, Nacionales DC, Cuenca AG, Armbruster M, Ungaro RF, Abouhamze AS, Lopez C, Baker HV, Moore FA, Ang DN, Efron PA.

Crit Care Med. 2013 Apr;41(4):1075-85. doi: 10.1097/CCM.0b013e318275d1f9.

35.

Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients.

Cuenca AG, Gentile LF, Lopez MC, Ungaro R, Liu H, Xiao W, Seok J, Mindrinos MN, Ang D, Baslanti TO, Bihorac A, Efron PA, Cuschieri J, Warren HS, Tompkins RG, Maier RV, Baker HV, Moldawer LL; Inflammation and Host Response to Injury Collaborative Research Program.

Crit Care Med. 2013 May;41(5):1175-85. doi: 10.1097/CCM.0b013e318277131c.

36.

Transcriptomic analysis of PNN- and ESRP1-regulated alternative pre-mRNA splicing in human corneal epithelial cells.

Joo JH, Correia GP, Li JL, Lopez MC, Baker HV, Sugrue SP.

Invest Ophthalmol Vis Sci. 2013 Jan 23;54(1):697-707. doi: 10.1167/iovs.12-10695.

37.

A genomic analysis of Clostridium difficile infections in blunt trauma patients.

Efron PA, Liu H, Lottenberg L, Cuenca AG, Gentile LF, Miggins MV, Bihorac A, Baker HV, Moore FA, Moldawer LL, Ang DN.

J Trauma Acute Care Surg. 2013 Jan;74(1):334-8. doi: 10.1097/TA.0b013e3182789426.

38.

Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocytes.

Chauncey KM, Lopez MC, Sidhu G, Szarowicz SE, Baker HV, Quinn C, Southwick FS.

BMC Immunol. 2012 Jul 2;13:33. doi: 10.1186/1471-2172-13-33.

39.

Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor γ.

Perry DJ, Yin Y, Telarico T, Baker HV, Dozmorov I, Perl A, Morel L.

J Immunol. 2012 Jul 15;189(2):793-803. doi: 10.4049/jimmunol.1200411. Epub 2012 Jun 18.

40.

Partitioning transcript variation in Drosophila: abundance, isoforms, and alleles.

Yang Y, Graze RM, Walts BM, Lopez CM, Baker HV, Wayne ML, Nuzhdin SV, McIntyre LM.

G3 (Bethesda). 2011 Nov;1(6):427-36. doi: 10.1534/g3.111.000596. Epub 2011 Nov 1.

41.

Severe injury is associated with insulin resistance, endoplasmic reticulum stress response, and unfolded protein response.

Jeschke MG, Finnerty CC, Herndon DN, Song J, Boehning D, Tompkins RG, Baker HV, Gauglitz GG.

Ann Surg. 2012 Feb;255(2):370-8. doi: 10.1097/SLA.0b013e31823e76e7.

42.

A genomic storm in critically injured humans.

Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, Hayden DL, Hennessy L, Moore EE, Minei JP, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Brownstein BH, Mason PH, Baker HV, Finnerty CC, Jeschke MG, López MC, Klein MB, Gamelli RL, Gibran NS, Arnoldo B, Xu W, Zhang Y, Calvano SE, McDonald-Smith GP, Schoenfeld DA, Storey JD, Cobb JP, Warren HS, Moldawer LL, Herndon DN, Lowry SF, Maier RV, Davis RW, Tompkins RG; Inflammation and Host Response to Injury Large-Scale Collaborative Research Program.

J Exp Med. 2011 Dec 19;208(13):2581-90. doi: 10.1084/jem.20111354. Epub 2011 Nov 21.

43.

Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage.

Warner EA, Kotz KT, Ungaro RF, Abouhamze AS, Lopez MC, Cuenca AG, Kelly-Scumpia KM, Moreno C, O'Malley KA, Lanz JD, Baker HV, Martin LC, Toner M, Tompkins RG, Efron PA, Moldawer LL.

Lab Invest. 2011 Dec;91(12):1787-95. doi: 10.1038/labinvest.2011.94. Epub 2011 Sep 19.

44.

Polymicrobial periodontal pathogen transcriptomes in calvarial bone and soft tissue.

Bakthavatchalu V, Meka A, Mans JJ, Sathishkumar S, Lopez MC, Bhattacharyya I, Boyce BF, Baker HV, Lamont RJ, Ebersole JL, Kesavalu L.

Mol Oral Microbiol. 2011 Oct;26(5):303-20. doi: 10.1111/j.2041-1014.2011.00619.x. Epub 2011 Jul 19.

45.

Detection of altered extracellular matrix in surface layers of unstable carotid plaque: an optical spectroscopy, birefringence and microarray genetic analysis.

Korol RM, Canham PB, Liu L, Viswanathan K, Ferguson GG, Hammond RR, Finlay HM, Baker HV, Lopez C, Lucas AR.

Photochem Photobiol. 2011 Sep-Oct;87(5):1164-72. doi: 10.1111/j.1751-1097.2011.00960.x. Epub 2011 Jul 28.

PMID:
21699546
46.

Gene expression changes in the human diaphragm after cardiothoracic surgery.

Huang TT, Deoghare HV, Smith BK, Beaver TM, Baker HV, Mehinto AC, Martin AD.

J Thorac Cardiovasc Surg. 2011 Nov;142(5):1214-22, 1222.e1-20. doi: 10.1016/j.jtcvs.2011.02.025. Epub 2011 Apr 3.

47.

Transcriptome analysis of LuxS-deficient Streptococcus mutans grown in biofilms.

Wen ZT, Nguyen AH, Bitoun JP, Abranches J, Baker HV, Burne RA.

Mol Oral Microbiol. 2011 Feb;26(1):2-18. doi: 10.1111/j.2041-1014.2010.00581.x. Epub 2010 Nov 18.

48.

Roles of vaccinia virus genes E3L and K3L and host genes PKR and RNase L during intratracheal infection of C57BL/6 mice.

Rice AD, Turner PC, Embury JE, Moldawer LL, Baker HV, Moyer RW.

J Virol. 2011 Jan;85(1):550-67. doi: 10.1128/JVI.00254-10. Epub 2010 Oct 13.

49.

Tannerella forsythia infection-induced calvarial bone and soft tissue transcriptional profiles.

Bakthavatchalu V, Meka A, Sathishkumar S, Lopez MC, Bhattacharyya I, Boyce BF, Mans JJ, Lamont RJ, Baker HV, Ebersole JL, Kesavalu L.

Mol Oral Microbiol. 2010 Oct;25(5):317-30. doi: 10.1111/j.2041-1014.2010.00583.x.

50.

Role of the ATM-checkpoint kinase 2 pathway in CDT-mediated apoptosis of gingival epithelial cells.

Alaoui-El-Azher M, Mans JJ, Baker HV, Chen C, Progulske-Fox A, Lamont RJ, Handfield M.

PLoS One. 2010 Jul 23;5(7):e11714. doi: 10.1371/journal.pone.0011714.

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