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The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster.

Bashiri G, Grove TL, Hegde SS, Lagautriere T, Gerfen GJ, Almo SC, Squire CJ, Blanchard JS, Baker EN.

J Biol Chem. 2019 Aug 30;294(35):13158-13170. doi: 10.1074/jbc.RA119.009498. Epub 2019 Jul 16.


Findable Accessible Interoperable Re-usable (FAIR) diffraction data are coming to protein crystallography.

Helliwell JR, Minor W, Weiss MS, Garman EF, Read RJ, Newman J, van Raaij MJ, Hajdu J, Baker EN.

J Appl Crystallogr. 2019 Apr 30;52(Pt 3):495-497. doi: 10.1107/S1600576719005922. eCollection 2019 Jun 1.


Findable Accessible Interoperable Re-usable (FAIR) diffraction data are coming to protein crystallography.

Helliwell JR, Minor W, Weiss MS, Garman EF, Read RJ, Newman J, van Raaij MJ, Hajdu J, Baker EN.

IUCrJ. 2019 Apr 30;6(Pt 3):341-343. doi: 10.1107/S2052252519005918. eCollection 2019 May 1.


Findable Accessible Interoperable Re-usable (FAIR) diffraction data are coming to protein crystallography.

Helliwell JR, Minor W, Weiss MS, Garman EF, Read RJ, Newman J, van Raaij MJ, Hajdu J, Baker EN.

Acta Crystallogr D Struct Biol. 2019 May 1;75(Pt 5):455-457. doi: 10.1107/S2059798319004844. Epub 2019 Apr 29. No abstract available.


Findable Accessible Interoperable Re-usable (FAIR) diffraction data are coming to protein crystallography.

Helliwell JR, Minor W, Weiss MS, Garman EF, Read RJ, Newman J, van Raaij MJ, Hajdu J, Baker EN.

Acta Crystallogr F Struct Biol Commun. 2019 May 1;75(Pt 5):321-323. doi: 10.1107/S2053230X19005909. Epub 2019 Apr 30. No abstract available.


A revised biosynthetic pathway for the cofactor F420 in prokaryotes.

Bashiri G, Antoney J, Jirgis ENM, Shah MV, Ney B, Copp J, Stuteley SM, Sreebhavan S, Palmer B, Middleditch M, Tokuriki N, Greening C, Scott C, Baker EN, Jackson CJ.

Nat Commun. 2019 Apr 5;10(1):1558. doi: 10.1038/s41467-019-09534-x.


Group A Streptococcus T Antigens Have a Highly Conserved Structure Concealed under a Heterogeneous Surface That Has Implications for Vaccine Design.

Young PG, Raynes JM, Loh JM, Proft T, Baker EN, Moreland NJ.

Infect Immun. 2019 May 21;87(6). pii: e00205-19. doi: 10.1128/IAI.00205-19. Print 2019 Jun.


Why conferences matter - musings from a crystallographic meeting.

Baker EN.

IUCrJ. 2019 Feb 21;6(Pt 2):152-153. doi: 10.1107/S2052252519002215. eCollection 2019 Mar 1.


Crystallography and the development of therapeutic medicines.

Baker EN.

IUCrJ. 2018 Feb 26;5(Pt 2):118-119. doi: 10.1107/S2052252518002555. eCollection 2018 Mar 1.


Protein adhesins as vaccine antigens for Group A Streptococcus.

Raynes JM, Young PG, Proft T, Williamson DA, Baker EN, Moreland NJ.

Pathog Dis. 2018 Mar 1;76(2). doi: 10.1093/femspd/fty016. Review.


Stress control for a well-structured life.

Goldstone DC, Baker EN.

J Biol Chem. 2018 Apr 20;293(16):5806-5807. doi: 10.1074/jbc.H118.002699.


Datasets, processing and refinement details for Mtb-AnPRT: inhibitor structures with various space groups.

Evans GL, Furkert DP, Abermil N, Kundu P, de Lange KM, Parker EJ, Brimble MA, Baker EN, Lott JS.

Data Brief. 2017 Oct 31;15:1019-1029. doi: 10.1016/j.dib.2017.10.051. eCollection 2017 Dec.


Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design.

Evans GL, Furkert DP, Abermil N, Kundu P, de Lange KM, Parker EJ, Brimble MA, Baker EN, Lott JS.

Biochim Biophys Acta Proteins Proteom. 2018 Feb;1866(2):264-274. doi: 10.1016/j.bbapap.2017.08.018. Epub 2017 Aug 26.


Mechanistic insights into F420-dependent glucose-6-phosphate dehydrogenase using isotope effects and substrate inhibition studies.

Oyugi MA, Bashiri G, Baker EN, Johnson-Winters K.

Biochim Biophys Acta Proteins Proteom. 2018 Feb;1866(2):387-395. doi: 10.1016/j.bbapap.2017.08.001. Epub 2017 Aug 12.


Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas.

Gerth ML, Liu Y, Jiao W, Zhang XX, Baker EN, Lott JS, Rainey PB, Johnston JM.

Proteins. 2017 Aug;85(8):1580-1588. doi: 10.1002/prot.25303. Epub 2017 Apr 25.


Data archiving and availability in an era of open science.

Baker EN.

IUCrJ. 2017 Jan 1;4(Pt 1):1-2. doi: 10.1107/S2052252516020340. eCollection 2017 Jan 1.


Mass spectral determination of phosphopantetheinylation specificity for carrier proteins in Mycobacterium tuberculosis.

Jung J, Bashiri G, Johnston JM, Baker EN.

FEBS Open Bio. 2016 Oct 24;6(12):1220-1226. doi: 10.1002/2211-5463.12140. eCollection 2016 Dec.


Engineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability.

Kwon H, Young PG, Squire CJ, Baker EN.

Sci Rep. 2017 Feb 16;7:42753. doi: 10.1038/srep42753.


Harnessing ester bond chemistry for protein ligation.

Young PG, Yosaatmadja Y, Harris PW, Leung IK, Baker EN, Squire CJ.

Chem Commun (Camb). 2017 Jan 26;53(9):1502-1505. doi: 10.1039/c6cc09899a.


Using X-Ray Crystallography to Simplify and Accelerate Biologics Drug Development.

Brader ML, Baker EN, Dunn MF, Laue TM, Carpenter JF.

J Pharm Sci. 2017 Feb;106(2):477-494. doi: 10.1016/j.xphs.2016.10.017. Epub 2016 Nov 23. Review.


Serological Evidence of Immune Priming by Group A Streptococci in Patients with Acute Rheumatic Fever.

Raynes JM, Frost HR, Williamson DA, Young PG, Baker EN, Steemson JD, Loh JM, Proft T, Dunbar PR, Atatoa Carr PE, Bell A, Moreland NJ.

Front Microbiol. 2016 Jul 22;7:1119. doi: 10.3389/fmicb.2016.01119. eCollection 2016.


Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.

Jirgis EN, Bashiri G, Bulloch EM, Johnston JM, Baker EN.

Structure. 2016 Jul 6;24(7):1167-77. doi: 10.1016/j.str.2016.04.018. Epub 2016 Jun 9.


Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily.

Yeung H, Squire CJ, Yosaatmadja Y, Panjikar S, López G, Molina A, Baker EN, Harris PW, Brimble MA.

Angew Chem Int Ed Engl. 2016 Jul 4;55(28):7930-3. doi: 10.1002/anie.201602719. Epub 2016 May 4.


Widening the reach of structural biology.

Baker EN.

IUCrJ. 2016 Feb 25;3(Pt 2):84-5. doi: 10.1107/S2052252516002438. eCollection 2016 Mar 1.


Synthesis and structural insight into ESX-1 Substrate Protein C, an immunodominant Mycobacterium tuberculosis-secreted antigen.

Son SJ, Harris PW, Squire CJ, Baker EN, Brimble MA.

Biopolymers. 2016 May;106(3):267-74. doi: 10.1002/bip.22838.


Structure of the ectodomain of the electron transporter Rv2874 from Mycobacterium tuberculosis reveals a thioredoxin-like domain combined with a carbohydrate-binding module.

Goldstone DC, Metcalf P, Baker EN.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):40-8. doi: 10.1107/S2059798315021488. Epub 2016 Jan 1.


Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization.

Ting YT, Harris PW, Batot G, Brimble MA, Baker EN, Young PG.

IUCrJ. 2016 Jan 1;3(Pt 1):10-9. doi: 10.1107/S2052252515019971. eCollection 2016 Jan 1.


Elongation of the Poly-γ-glutamate Tail of F420 Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis.

Bashiri G, Rehan AM, Sreebhavan S, Baker HM, Baker EN, Squire CJ.

J Biol Chem. 2016 Mar 25;291(13):6882-94. doi: 10.1074/jbc.M115.689026. Epub 2016 Feb 9.


The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.

Ho NA, Dawes SS, Crowe AM, Casabon I, Gao C, Kendall SL, Baker EN, Eltis LD, Lott JS.

J Biol Chem. 2016 Apr 1;291(14):7256-66. doi: 10.1074/jbc.M115.707760. Epub 2016 Feb 8.


PdxH proteins of mycobacteria are typical members of the classical pyridoxine/pyridoxamine 5'-phosphate oxidase family.

Ankisettypalli K, Cheng JJ, Baker EN, Bashiri G.

FEBS Lett. 2016 Feb;590(4):453-60. doi: 10.1002/1873-3468.12080. Epub 2016 Feb 15.


Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex.

Bashiri G, Johnston JM, Evans GL, Bulloch EM, Goldstone DC, Jirgis EN, Kleinboelting S, Castell A, Ramsay RJ, Manos-Turvey A, Payne RJ, Lott JS, Baker EN.

Acta Crystallogr D Biol Crystallogr. 2015 Nov;71(Pt 11):2297-308. doi: 10.1107/S1399004715017216. Epub 2015 Oct 31.


Self-generated covalent cross-links in the cell-surface adhesins of Gram-positive bacteria.

Baker EN, Squire CJ, Young PG.

Biochem Soc Trans. 2015 Oct;43(5):787-94. doi: 10.1042/BST20150066. Review.


Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.

Cookson TV, Evans GL, Castell A, Baker EN, Lott JS, Parker EJ.

Biochemistry. 2015 Oct 6;54(39):6082-92. doi: 10.1021/acs.biochem.5b00612.


Corrigendum: Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.

Evans GL, Gamage SA, Bulloch EM, Baker EN, Denny WA, Lott JS.

Chembiochem. 2015 Mar 23;16(5):706. doi: 10.1002/cbic.201500098. Epub 2015 Mar 11. No abstract available.


Convergent weaponry in a biological arms race.

Baker EN, Young PG.

Elife. 2015 Jun 11;4. doi: 10.7554/eLife.08710.


Complex Formation between Two Biosynthetic Enzymes Modifies the Allosteric Regulatory Properties of Both: AN EXAMPLE OF MOLECULAR SYMBIOSIS.

Blackmore NJ, Nazmi AR, Hutton RD, Webby MN, Baker EN, Jameson GB, Parker EJ.

J Biol Chem. 2015 Jul 17;290(29):18187-98. doi: 10.1074/jbc.M115.638700. Epub 2015 Jun 1.


Biological crystallography: new methods, new challenges.

Baker EN.

IUCrJ. 2015 Feb 26;2(Pt 2):155-6. doi: 10.1107/S2052252515003541. eCollection 2015 Mar 1.


A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket.

Chai AF, Bulloch EM, Evans GL, Lott JS, Baker EN, Johnston JM.

Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):862-72. doi: 10.1107/S1399004715001650. Epub 2015 Mar 26.


A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography.

Bunker RD, Mandal K, Bashiri G, Chaston JJ, Pentelute BL, Lott JS, Kent SB, Baker EN.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4310-5. doi: 10.1073/pnas.1422387112. Epub 2015 Mar 23.


Expression, purification and crystallization of a membrane-associated, catalytically active type I signal peptidase from Staphylococcus aureus.

Ting YT, Batot G, Baker EN, Young PG.

Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):61-5. doi: 10.1107/S2053230X1402603X. Epub 2015 Jan 1.


Use of a "silver bullet" to resolve crystal lattice dislocation disorder: a cobalamin complex of Δ1-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis.

Lagautriere T, Bashiri G, Baker EN.

J Struct Biol. 2015 Feb;189(2):153-7. doi: 10.1016/j.jsb.2014.12.007. Epub 2014 Dec 31.


Purification, crystallization and preliminary X-ray crystallographic studies of KstR2 (ketosteroid regulatory protein) from Mycobacterium tuberculosis.

Dawes SS, Kendall SL, Baker EN, Lott JS.

Acta Crystallogr F Struct Biol Commun. 2014 Dec 1;70(Pt 12):1643-5. doi: 10.1107/S2053230X14023589. Epub 2014 Nov 14.


Crystal structure of the essential Mycobacterium tuberculosis phosphopantetheinyl transferase PptT, solved as a fusion protein with maltose binding protein.

Jung J, Bashiri G, Johnston JM, Brown AS, Ackerley DF, Baker EN.

J Struct Biol. 2014 Dec;188(3):274-8. doi: 10.1016/j.jsb.2014.10.004. Epub 2014 Oct 18.


Production of recombinant proteins in Mycobacterium smegmatis for structural and functional studies.

Bashiri G, Baker EN.

Protein Sci. 2015 Jan;24(1):1-10. doi: 10.1002/pro.2584. Epub 2014 Nov 13. Review.


Crystal structure of kiwellin, a major cell-wall protein from kiwifruit.

Hamiaux C, Maddumage R, Middleditch MJ, Prakash R, Brummell DA, Baker EN, Atkinson RG.

J Struct Biol. 2014 Sep;187(3):276-281. doi: 10.1016/j.jsb.2014.07.005. Epub 2014 Aug 2.


New perspectives in biological crystallography.

Baker EN.

IUCrJ. 2014 Feb 28;1(Pt 2):82-3. doi: 10.1107/S205225251400373X. eCollection 2014 Mar 1.


Crystal structure of PhnF, a GntR-family transcriptional regulator of phosphate transport in Mycobacterium smegmatis.

Gebhard S, Busby JN, Fritz G, Moreland NJ, Cook GM, Lott JS, Baker EN, Money VA.

J Bacteriol. 2014 Oct;196(19):3472-81. doi: 10.1128/JB.01965-14. Epub 2014 Jul 21.


Structure and activity of Streptococcus pyogenes SipA: a signal peptidase-like protein essential for pilus polymerisation.

Young PG, Proft T, Harris PW, Brimble MA, Baker EN.

PLoS One. 2014 Jun 9;9(6):e99135. doi: 10.1371/journal.pone.0099135. eCollection 2014.


Working towards a group A streptococcal vaccine: report of a collaborative Trans-Tasman workshop.

Moreland NJ, Waddington CS, Williamson DA, Sriskandan S, Smeesters PR, Proft T, Steer AC, Walker MJ, Baker EN, Baker MG, Lennon D, Dunbar R, Carapetis J, Fraser JD.

Vaccine. 2014 Jun 24;32(30):3713-20. doi: 10.1016/j.vaccine.2014.05.017. Epub 2014 May 14.


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