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Items: 1 to 50 of 209

1.

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome.

Sieben CJ, Jeganathan KB, Nelson GG, Sturmlechner I, Zhang C, van Deursen WH, Bakker B, Foijer F, Li H, Baker DJ, van Deursen JM.

J Clin Invest. 2019 Nov 18. pii: 126863. doi: 10.1172/JCI126863. [Epub ahead of print]

2.

PulseNet and the Changing Paradigm of Laboratory-Based Surveillance for Foodborne Diseases.

Kubota KA, Wolfgang WJ, Baker DJ, Boxrud D, Turner L, Trees E, Carleton HA, Gerner-Smidt P.

Public Health Rep. 2019 Nov/Dec;134(2_suppl):22S-28S. doi: 10.1177/0033354919881650.

PMID:
31682558
3.

Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL.

Zhang Y, Gundelach J, Lindquist LD, Baker DJ, van Deursen J, Bram RJ.

PLoS One. 2019 Oct 29;14(10):e0224172. doi: 10.1371/journal.pone.0224172. eCollection 2019.

4.

Cellular Senescence and the Immune System in Cancer.

Prieto LI, Baker DJ.

Gerontology. 2019;65(5):505-512. doi: 10.1159/000500683. Epub 2019 Jun 18. Review.

5.

Pak2 kinase promotes cellular senescence and organismal aging.

Lee JS, Mo Y, Gan H, Burgess RJ, Baker DJ, van Deursen JM, Zhang Z.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13311-13319. doi: 10.1073/pnas.1903847116. Epub 2019 Jun 17.

PMID:
31209047
6.

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction.

Iegre J, Brear P, Baker DJ, Tan YS, Atkinson EL, Sore HF, O' Donovan DH, Verma CS, Hyvönen M, Spring DR.

Chem Sci. 2019 Apr 12;10(19):5056-5063. doi: 10.1039/c9sc00798a. eCollection 2019 May 21.

7.

The power to detect regional declines in common bird populations using continental monitoring data.

Baker DJ, Clarke RH, McGeoch MA.

Ecol Appl. 2019 Jul;29(5):e01918. doi: 10.1002/eap.1918. Epub 2019 Jun 4.

PMID:
31162764
8.

Vaspin promotes insulin sensitivity of elderly muscle and is upregulated in obesity.

Nicholson T, Church C, Tsintzas K, Jones R, Breen L, Davis ET, Baker DJ, Jones SW.

J Endocrinol. 2019 Feb 1. pii: JOE-18-0528.R3. doi: 10.1530/JOE-18-0528. [Epub ahead of print]

PMID:
30721136
9.

Cellular Identification and Quantification of Senescence-Associated β-Galactosidase Activity In Vivo.

Childs BG, Bussian TJ, Baker DJ.

Methods Mol Biol. 2019;1896:31-38. doi: 10.1007/978-1-4939-8931-7_4.

10.

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.

Bussian TJ, Aziz A, Meyer CF, Swenson BL, van Deursen JM, Baker DJ.

Nature. 2018 Oct;562(7728):578-582. doi: 10.1038/s41586-018-0543-y. Epub 2018 Sep 19.

11.

Conserving the abundance of nonthreatened species.

Baker DJ, Garnett ST, O'Connor J, Ehmke G, Clarke RH, Woinarski JCZ, McGeoch MA.

Conserv Biol. 2019 Apr;33(2):319-328. doi: 10.1111/cobi.13197. Epub 2018 Oct 24.

PMID:
30047186
12.

The role of adipokines in skeletal muscle inflammation and insulin sensitivity.

Nicholson T, Church C, Baker DJ, Jones SW.

J Inflamm (Lond). 2018 May 9;15:9. doi: 10.1186/s12950-018-0185-8. eCollection 2018. Review.

13.

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives.

Baker DJ, Petersen RC.

J Clin Invest. 2018 Apr 2;128(4):1208-1216. doi: 10.1172/JCI95145. Epub 2018 Feb 19. Review.

14.

Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans.

Yousefzadeh MJ, Schafer MJ, Noren Hooten N, Atkinson EJ, Evans MK, Baker DJ, Quarles EK, Robbins PD, Ladiges WC, LeBrasseur NK, Niedernhofer LJ.

Aging Cell. 2018 Apr;17(2). doi: 10.1111/acel.12706. Epub 2017 Dec 31.

15.

The small molecule CLP257 does not modify activity of the K+-Cl- co-transporter KCC2 but does potentiate GABAA receptor activity.

Cardarelli RA, Jones K, Pisella LI, Wobst HJ, McWilliams LJ, Sharpe PM, Burnham MP, Baker DJ, Chudotvorova I, Guyot J, Silayeva L, Morrow DH, Dekker N, Zicha S, Davies PA, Holenz J, Duggan ME, Dunlop J, Mather RJ, Wang Q, Medina I, Brandon NJ, Deeb TZ, Moss SJ.

Nat Med. 2017 Dec 7;23(12):1394-1396. doi: 10.1038/nm.4442. No abstract available.

PMID:
29216042
16.

Molecular architecture of potassium chloride co-transporter KCC2.

Agez M, Schultz P, Medina I, Baker DJ, Burnham MP, Cardarelli RA, Conway LC, Garnier K, Geschwindner S, Gunnarsson A, McCall EJ, Frechard A, Audebert S, Deeb TZ, Moss SJ, Brandon NJ, Wang Q, Dekker N, Jawhari A.

Sci Rep. 2017 Nov 28;7(1):16452. doi: 10.1038/s41598-017-15739-1.

17.

Advancing Global Precision Medicine: An Overview of Genomic Testing and Counseling Services in Malaysia.

Balasopoulou A, Mooy FM, Baker DJ, Mitropoulou C, Skoufas E, Bulgiba A, Katsila T, Patrinos GP.

OMICS. 2017 Dec;21(12):733-740. doi: 10.1089/omi.2017.0136. Epub 2017 Nov 27. Review.

PMID:
29173101
18.

Development and characterisation of a novel glucagon like peptide-1 receptor antibody.

Biggs EK, Liang L, Naylor J, Madalli S, Collier R, Coghlan MP, Baker DJ, Hornigold DC, Ravn P, Reimann F, Gribble FM.

Diabetologia. 2018 Mar;61(3):711-721. doi: 10.1007/s00125-017-4491-0. Epub 2017 Nov 9.

19.

N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation.

Conway LC, Cardarelli RA, Moore YE, Jones K, McWilliams LJ, Baker DJ, Burnham MP, Bürli RW, Wang Q, Brandon NJ, Moss SJ, Deeb TZ.

J Biol Chem. 2017 Dec 29;292(52):21253-21263. doi: 10.1074/jbc.M117.817841. Epub 2017 Nov 1.

20.

The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment.

Brown A, Pospiech J, Eiwen K, Baker DJ, Moehrle B, Sakk V, Nattamai K, Vogel M, Grigoryan A, Geiger H.

Stem Cell Reports. 2017 Nov 14;9(5):1359-1368. doi: 10.1016/j.stemcr.2017.09.017. Epub 2017 Oct 19.

21.

Gut check on diabesity: leveraging gut mechanisms for the treatment of type 2 diabetes and obesity.

Will S, Hornigold DC, Baker DJ, Coghlan MP, Mesquita M, Trevaskis JL, Naylor J.

Curr Opin Pharmacol. 2017 Dec;37:10-15. doi: 10.1016/j.coph.2017.07.010. Epub 2017 Aug 10. Review.

PMID:
28802873
22.

Senescent cells: an emerging target for diseases of ageing.

Childs BG, Gluscevic M, Baker DJ, Laberge RM, Marquess D, Dananberg J, van Deursen JM.

Nat Rev Drug Discov. 2017 Oct;16(10):718-735. doi: 10.1038/nrd.2017.116. Epub 2017 Jul 21. Review.

23.

Biphasic Modeling of Mitochondrial Metabolism Dysregulation during Aging.

Baker DJ, Peleg S.

Trends Biochem Sci. 2017 Sep;42(9):702-711. doi: 10.1016/j.tibs.2017.06.005. Epub 2017 Jun 29. Review.

24.

Perception of Leitmotives in Richard Wagner's Der Ring des Nibelungen.

Baker DJ, Müllensiefen D.

Front Psychol. 2017 May 4;8:662. doi: 10.3389/fpsyg.2017.00662. eCollection 2017.

25.

Age-associated changes in the blood-brain barrier: comparative studies in human and mouse.

Goodall EF, Wang C, Simpson JE, Baker DJ, Drew DR, Heath PR, Saffrey MJ, Romero IA, Wharton SB.

Neuropathol Appl Neurobiol. 2018 Apr;44(3):328-340. doi: 10.1111/nan.12408. Epub 2017 May 29. Erratum in: Neuropathol Appl Neurobiol. 2018 Dec;44(7):747-748.

26.

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH.

Nat Med. 2017 Jun;23(6):775-781. doi: 10.1038/nm.4324. Epub 2017 Apr 24.

27.

Oncogenic senescence: a multi-functional perspective.

Baker DJ, Alimirah F, van Deursen JM, Campisi J, Hildesheim J.

Oncotarget. 2017 Apr 18;8(16):27661-27672. doi: 10.18632/oncotarget.15742.

28.

Age-related decline in BubR1 impairs adult hippocampal neurogenesis.

Yang Z, Jun H, Choi CI, Yoo KH, Cho CH, Hussaini SMQ, Simmons AJ, Kim S, van Deursen JM, Baker DJ, Jang MH.

Aging Cell. 2017 Jun;16(3):598-601. doi: 10.1111/acel.12594. Epub 2017 Apr 6.

29.

LMWH in IVF - Biomarkers and benefits.

Fishel S, Baker DJ, Greer IA.

Thromb Res. 2017 Mar;151 Suppl 1:S65-S69. doi: 10.1016/S0049-3848(17)30071-3. Review.

PMID:
28262239
30.

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism.

Flores RR, Clauson CL, Cho J, Lee BC, McGowan SJ, Baker DJ, Niedernhofer LJ, Robbins PD.

Aging Cell. 2017 Jun;16(3):480-487. doi: 10.1111/acel.12571. Epub 2017 Feb 23.

31.

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.

Maskey RS, Flatten KS, Sieben CJ, Peterson KL, Baker DJ, Nam HJ, Kim MS, Smyrk TC, Kojima Y, Machida Y, Santiago A, van Deursen JM, Kaufmann SH, Machida YJ.

Nucleic Acids Res. 2017 May 5;45(8):4564-4576. doi: 10.1093/nar/gkx107.

32.

Cellular senescence in renal ageing and disease.

Sturmlechner I, Durik M, Sieben CJ, Baker DJ, van Deursen JM.

Nat Rev Nephrol. 2017 Feb;13(2):77-89. doi: 10.1038/nrneph.2016.183. Epub 2016 Dec 28. Review.

PMID:
28029153
33.

The progeroid gene BubR1 regulates axon myelination and motor function.

Choi CI, Yoo KH, Hussaini SM, Jeon BT, Welby J, Gan H, Scarisbrick IA, Zhang Z, Baker DJ, van Deursen JM, Rodriguez M, Jang MH.

Aging (Albany NY). 2016 Sep 12;8(11):2667-2688. doi: 10.18632/aging.101032.

34.

Senescent intimal foam cells are deleterious at all stages of atherosclerosis.

Childs BG, Baker DJ, Wijshake T, Conover CA, Campisi J, van Deursen JM.

Science. 2016 Oct 28;354(6311):472-477. Epub 2016 Oct 27.

35.

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.

Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, van Deursen WH, Hamada N, Naylor RM, Becker NA, Davies BA, van Ree JH, Mer G, Shapiro VS, Maher LJ 3rd, Katzmann DJ, van Deursen JM.

Science. 2016 Sep 30;353(6307):1549-1552.

36.

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer.

Weaver RL, Limzerwala JF, Naylor RM, Jeganathan KB, Baker DJ, van Deursen JM.

Elife. 2016 Aug 16;5. pii: e16620. doi: 10.7554/eLife.16620.

37.

Use of CRISPR/Cas9-engineered INS-1 pancreatic β cells to define the pharmacology of dual GIPR/GLP-1R agonists.

Naylor J, Suckow AT, Seth A, Baker DJ, Sermadiras I, Ravn P, Howes R, Li J, Snaith MR, Coghlan MP, Hornigold DC.

Biochem J. 2016 Sep 15;473(18):2881-91. doi: 10.1042/BCJ20160476. Epub 2016 Jul 15.

PMID:
27422784
38.

Implementation of Salmonella serotype determination using pulsed-field gel electrophoresis in a state public health laboratory.

Bopp DJ, Baker DJ, Thompson L, Saylors A, Root TP, Armstrong L, Mitchell K, Dumas NB, Musser KA.

Diagn Microbiol Infect Dis. 2016 Aug;85(4):416-8. doi: 10.1016/j.diagmicrobio.2016.04.023. Epub 2016 May 5.

PMID:
27220605
39.

Genomic Resolution of Outbreak-Associated Legionella pneumophila Serogroup 1 Isolates from New York State.

Raphael BH, Baker DJ, Nazarian E, Lapierre P, Bopp D, Kozak-Muiznieks NA, Morrison SS, Lucas CE, Mercante JW, Musser KA, Winchell JM.

Appl Environ Microbiol. 2016 May 31;82(12):3582-3590. doi: 10.1128/AEM.00362-16. Print 2016 Jun 15.

40.

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK.

Diabetes. 2016 Jun;65(6):1606-15. doi: 10.2337/db15-0291. Epub 2016 Mar 16.

41.

Choice of baseline climate data impacts projected species' responses to climate change.

Baker DJ, Hartley AJ, Butchart SH, Willis SG.

Glob Chang Biol. 2016 Jul;22(7):2392-404. doi: 10.1111/gcb.13273. Epub 2016 Apr 19.

PMID:
26950769
42.

Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown.

Yamazaki Y, Baker DJ, Tachibana M, Liu CC, van Deursen JM, Brott TG, Bu G, Kanekiyo T.

Stroke. 2016 Apr;47(4):1068-77. doi: 10.1161/STROKEAHA.115.010835. Epub 2016 Feb 16.

43.

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.

Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM.

Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3.

44.

Cellular senescence in aging and age-related disease: from mechanisms to therapy.

Childs BG, Durik M, Baker DJ, van Deursen JM.

Nat Med. 2015 Dec;21(12):1424-35. doi: 10.1038/nm.4000. Review.

45.

Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis.

Baker DJ, Blackburn DJ, Keatinge M, Sokhi D, Viskaitis P, Heath PR, Ferraiuolo L, Kirby J, Shaw PJ.

Front Cell Neurosci. 2015 Oct 15;9:410. doi: 10.3389/fncel.2015.00410. eCollection 2015.

46.

Geographical variation in species' population responses to changes in temperature and precipitation.

Pearce-Higgins JW, Ockendon N, Baker DJ, Carr J, White EC, Almond RE, Amano T, Bertram E, Bradbury RB, Bradley C, Butchart SH, Doswald N, Foden W, Gill DJ, Green RE, Sutherland WJ, Tanner EV.

Proc Biol Sci. 2015 Nov 7;282(1818):20151561. doi: 10.1098/rspb.2015.1561.

47.

Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization.

D'Amato G, Holgate ST, Pawankar R, Ledford DK, Cecchi L, Al-Ahmad M, Al-Enezi F, Al-Muhsen S, Ansotegui I, Baena-Cagnani CE, Baker DJ, Bayram H, Bergmann KC, Boulet LP, Buters JT, D'Amato M, Dorsano S, Douwes J, Finlay SE, Garrasi D, Gómez M, Haahtela T, Halwani R, Hassani Y, Mahboub B, Marks G, Michelozzi P, Montagni M, Nunes C, Oh JJ, Popov TA, Portnoy J, Ridolo E, Rosário N, Rottem M, Sánchez-Borges M, Sibanda E, Sienra-Monge JJ, Vitale C, Annesi-Maesano I.

World Allergy Organ J. 2015 Jul 14;8(1):25. doi: 10.1186/s40413-015-0073-0. eCollection 2015.

48.

Spartan deficiency causes genomic instability and progeroid phenotypes.

Maskey RS, Kim MS, Baker DJ, Childs B, Malureanu LA, Jeganathan KB, Machida Y, van Deursen JM, Machida YJ.

Nat Commun. 2014 Dec 11;5:5744. doi: 10.1038/ncomms6744.

49.

Senescence and apoptosis: dueling or complementary cell fates?

Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM.

EMBO Rep. 2014 Nov;15(11):1139-53. doi: 10.15252/embr.201439245. Epub 2014 Oct 13. Review.

50.

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.

North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA.

EMBO J. 2014 Jul 1;33(13):1438-53. doi: 10.15252/embj.201386907. Epub 2014 May 12.

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