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Items: 1 to 50 of 340

1.

Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites.

Matralis AN, Malik A, Penzo M, Moreno I, Almela MJ, Camino I, Crespo B, Saadeddin A, Ghidelli-Disse S, Rueda L, Calderon F, Osborne SA, Drewes G, Böesche M, Fernández-Álvaro E, Martin Hernando JI, Baker DA.

J Med Chem. 2019 Oct 24;62(20):9217-9235. doi: 10.1021/acs.jmedchem.9b01099. Epub 2019 Oct 14.

2.

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.

Large JM, Birchall K, Bouloc NS, Merritt AT, Smiljanic-Hurley E, Tsagris DJ, Wheldon MC, Ansell KH, Coombs PJ, Kettleborough CA, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA.

Bioorg Med Chem Lett. 2019 Oct 1;29(19):126610. doi: 10.1016/j.bmcl.2019.08.014. Epub 2019 Aug 9.

3.

Antimalarial activity of primaquine operates via a two-step biochemical relay.

Camarda G, Jirawatcharadech P, Priestley RS, Saif A, March S, Wong MHL, Leung S, Miller AB, Baker DA, Alano P, Paine MJI, Bhatia SN, O'Neill PM, Ward SA, Biagini GA.

Nat Commun. 2019 Jul 19;10(1):3226. doi: 10.1038/s41467-019-11239-0.

4.

MHC genotyping from rhesus macaque exome sequences.

Caskey JR, Wiseman RW, Karl JA, Baker DA, Lee T, Maddox RJ, Raveendran M, Harris RA, Hu J, Muzny DM, Rogers J, O'Connor DH.

Immunogenetics. 2019 Sep;71(8-9):531-544. doi: 10.1007/s00251-019-01125-w. Epub 2019 Jul 18.

PMID:
31321455
5.

Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.

El Bakkouri M, Kouidmi I, Wernimont AK, Amani M, Hutchinson A, Loppnau P, Kim JJ, Flueck C, Walker JR, Seitova A, Senisterra G, Kakihara Y, Kim C, Blackman MJ, Calmettes C, Baker DA, Hui R.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14164-14173. doi: 10.1073/pnas.1905558116. Epub 2019 Jun 25.

6.

Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research.

Mohring F, Hart MN, Rawlinson TA, Henrici R, Charleston JA, Diez Benavente E, Patel A, Hall J, Almond N, Campino S, Clark TG, Sutherland CJ, Baker DA, Draper SJ, Moon RW.

Elife. 2019 Jun 17;8. pii: e45829. doi: 10.7554/eLife.45829.

7.

An analysis of large structural variation in global Plasmodium falciparum isolates identifies a novel duplication of the chloroquine resistance associated gene.

Ravenhall M, Benavente ED, Sutherland CJ, Baker DA, Campino S, Clark TG.

Sci Rep. 2019 Jun 4;9(1):8287. doi: 10.1038/s41598-019-44599-0.

8.

Caregiving for children through conflict and displacement: a pilot study testing the feasibility of delivering and evaluating a light touch parenting intervention for caregivers in the West Bank.

El-Khani A, Maalouf W, Baker DA, Zahra N, Noubani A, Cartwright K.

Int J Psychol. 2019 May 30. doi: 10.1002/ijop.12591. [Epub ahead of print]

PMID:
31144308
9.

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery.

Patel A, Perrin AJ, Flynn HR, Bisson C, Withers-Martinez C, Treeck M, Flueck C, Nicastro G, Martin SR, Ramos A, Gilberger TW, Snijders AP, Blackman MJ, Baker DA.

PLoS Biol. 2019 May 10;17(5):e3000264. doi: 10.1371/journal.pbio.3000264. eCollection 2019 May.

10.

High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites.

Penzo M, de Las Heras-Dueña L, Mata-Cantero L, Diaz-Hernandez B, Vazquez-Muñiz MJ, Ghidelli-Disse S, Drewes G, Fernandez-Alvaro E, Baker DA.

Sci Rep. 2019 May 7;9(1):7005. doi: 10.1038/s41598-019-42801-x.

11.

Metabolomic identification of diagnostic serum-based biomarkers for advanced stage melanoma.

Bayci AWL, Baker DA, Somerset AE, Turkoglu O, Hothem Z, Callahan RE, Mandal R, Han B, Bjorndahl T, Wishart D, Bahado-Singh R, Graham SF, Keidan R.

Metabolomics. 2018 Aug 3;14(8):105. doi: 10.1007/s11306-018-1398-9.

PMID:
30830422
12.

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion.

Flueck C, Drought LG, Jones A, Patel A, Perrin AJ, Walker EM, Nofal SD, Snijders AP, Blackman MJ, Baker DA.

PLoS Biol. 2019 Feb 22;17(2):e3000154. doi: 10.1371/journal.pbio.3000154. eCollection 2019 Feb.

13.

Progesterone effects on vaginal cytokines in women with a history of preterm birth.

Garry DJ, Baker DA, Persad MD, Peresleni T, Kocis C, Demishev M.

PLoS One. 2018 Dec 31;13(12):e0209346. doi: 10.1371/journal.pone.0209346. eCollection 2018.

14.

Self-compassion and depression, anxiety, and resilience in adults with epilepsy.

Baker DA, Caswell HL, Eccles FJR.

Epilepsy Behav. 2019 Jan;90:154-161. doi: 10.1016/j.yebeh.2018.11.025. Epub 2018 Dec 14.

PMID:
30557784
15.

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.

Large JM, Birchall K, Bouloc NS, Merritt AT, Smiljanic-Hurley E, Tsagris DJ, Wheldon MC, Ansell KH, Coombs PJ, Kettleborough CA, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA.

Bioorg Med Chem Lett. 2019 Feb 1;29(3):509-514. doi: 10.1016/j.bmcl.2018.11.039. Epub 2018 Nov 20.

16.

Subclinical Infection of Macaques and Baboons with A Baboon Simarterivirus.

Buechler C, Semler M, Baker DA, Newman C, Cornish JP, Chavez D, Guerra B, Lanford R, Brasky K, Kuhn JH, Johnson RF, O'Connor DH, Bailey AL.

Viruses. 2018 Dec 10;10(12). pii: E701. doi: 10.3390/v10120701.

17.

Enhanced CRFR1-Dependent Regulation of a Ventral Tegmental Area to Prelimbic Cortex Projection Establishes Susceptibility to Stress-Induced Cocaine Seeking.

Vranjkovic O, Van Newenhizen EC, Nordness ME, Blacktop JM, Urbanik LA, Mathy JC, McReynolds JR, Miller AM, Doncheck EM, Kloehn TM, Stinnett GS, Gerndt CH, Ketchesin KD, Baker DA, Seasholtz AF, Mantsch JR.

J Neurosci. 2018 Dec 12;38(50):10657-10671. doi: 10.1523/JNEUROSCI.2080-18.2018. Epub 2018 Oct 24.

18.

Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development.

Benavente ED, Oresegun DR, de Sessions PF, Walker EM, Roper C, Dombrowski JG, de Souza RM, Marinho CRF, Sutherland CJ, Hibberd ML, Mohareb F, Baker DA, Clark TG, Campino S.

Sci Rep. 2018 Oct 18;8(1):15429. doi: 10.1038/s41598-018-33767-3.

19.

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites.

Fang H, Gomes AR, Klages N, Pino P, Maco B, Walker EM, Zenonos ZA, Angrisano F, Baum J, Doerig C, Baker DA, Billker O, Brochet M.

Nat Commun. 2018 Oct 12;9(1):4248. doi: 10.1038/s41467-018-06733-w.

20.

Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).

Tsagris DJ, Birchall K, Bouloc N, Large JM, Merritt A, Smiljanic-Hurley E, Wheldon M, Ansell KH, Kettleborough C, Whalley D, Stewart LB, Bowyer PW, Baker DA, Osborne SA.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3168-3173. doi: 10.1016/j.bmcl.2018.08.028. Epub 2018 Aug 27.

21.

The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress.

Perrin AJ, Collins CR, Russell MRG, Collinson LM, Baker DA, Blackman MJ.

MBio. 2018 Jul 3;9(4). pii: e00905-18. doi: 10.1128/mBio.00905-18.

22.

Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites.

Meerstein-Kessel L, van der Lee R, Stone W, Lanke K, Baker DA, Alano P, Silvestrini F, Janse CJ, Khan SM, van de Vegte-Bolmer M, Graumans W, Siebelink-Stoter R, Kooij TWA, Marti M, Drakeley C, Campo JJ, van Dam TJP, Sauerwein R, Bousema T, Huynen MA.

Sci Rep. 2018 Jan 11;8(1):410. doi: 10.1038/s41598-017-18840-7.

23.

Cyclic nucleotide signalling in malaria parasites.

Baker DA, Drought LG, Flueck C, Nofal SD, Patel A, Penzo M, Walker EM.

Open Biol. 2017 Dec;7(12). pii: 170213. doi: 10.1098/rsob.170213. Review.

24.

Control of endothelial cell tube formation by Notch ligand intracellular domain interactions with activator protein 1 (AP-1).

Forghany Z, Robertson F, Lundby A, Olsen JV, Baker DA.

J Biol Chem. 2018 Jan 26;293(4):1229-1242. doi: 10.1074/jbc.M117.819045. Epub 2017 Dec 1.

25.

Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesis.

van IJzendoorn DGP, Forghany Z, Liebelt F, Vertegaal AC, Jochemsen AG, Bovée JVMG, Szuhai K, Baker DA.

J Biol Chem. 2017 Dec 29;292(52):21282-21290. doi: 10.1074/jbc.C117.815845. Epub 2017 Nov 17.

26.

Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex.

McReynolds JR, Doncheck EM, Li Y, Vranjkovic O, Graf EN, Ogasawara D, Cravatt BF, Baker DA, Liu QS, Hillard CJ, Mantsch JR.

Biol Psychiatry. 2018 Jul 15;84(2):85-94. doi: 10.1016/j.biopsych.2017.09.024. Epub 2017 Oct 6.

27.

Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions.

Swaminathan V, Kalappurakkal JM, Mehta SB, Nordenfelt P, Moore TI, Koga N, Baker DA, Oldenbourg R, Tani T, Mayor S, Springer TA, Waterman CM.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10648-10653. doi: 10.1073/pnas.1701136114.

28.

Utility of matrix reasoning as an embedded performance validity indicator in pediatric mild traumatic brain injury.

Sussman ZW, Peterson RL, Connery AK, Baker DA, Kirkwood MW.

Appl Neuropsychol Child. 2019 Jan-Mar;8(1):70-75. doi: 10.1080/21622965.2017.1382359. Epub 2017 Oct 23.

PMID:
29058467
29.

Corticosterone regulates both naturally occurring and cocaine-induced dopamine signaling by selectively decreasing dopamine uptake.

Wheeler DS, Ebben AL, Kurtoglu B, Lovell ME, Bohn AT, Jasek IA, Baker DA, Mantsch JR, Gasser PJ, Wheeler RA.

Eur J Neurosci. 2017 Nov;46(10):2638-2646. doi: 10.1111/ejn.13730. Epub 2017 Nov 6.

30.

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

Baker DA, Stewart LB, Large JM, Bowyer PW, Ansell KH, Jiménez-Díaz MB, El Bakkouri M, Birchall K, Dechering KJ, Bouloc NS, Coombs PJ, Whalley D, Harding DJ, Smiljanic-Hurley E, Wheldon MC, Walker EM, Dessens JT, Lafuente MJ, Sanz LM, Gamo FJ, Ferrer SB, Hui R, Bousema T, Angulo-Barturén I, Merritt AT, Croft SL, Gutteridge WE, Kettleborough CA, Osborne SA.

Nat Commun. 2017 Sep 5;8(1):430. doi: 10.1038/s41467-017-00572-x.

31.

Creation and Execution of a Novel Anesthesia Perioperative Care Service at a Veterans Affairs Hospital.

Alvis BD, King AB, Pandharipande PP, Weavind LM, Avila K, Leisy PJ, Ajmal M, McHugh M, Keegan KA, Baker DA, Walia A, Hughes CG.

Anesth Analg. 2017 Nov;125(5):1526-1531. doi: 10.1213/ANE.0000000000001930.

PMID:
28632542
32.

Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony.

Ganter M, Goldberg JM, Dvorin JD, Paulo JA, King JG, Tripathi AK, Paul AS, Yang J, Coppens I, Jiang RH, Elsworth B, Baker DA, Dinglasan RR, Gygi SP, Duraisingh MT.

Nat Microbiol. 2017 Mar 6;2:17038. doi: 10.1038/nmicrobiol.2017.38. No abstract available.

PMID:
28263306
33.

Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony.

Ganter M, Goldberg JM, Dvorin JD, Paulo JA, King JG, Tripathi AK, Paul AS, Yang J, Coppens I, Jiang RH, Elsworth B, Baker DA, Dinglasan RR, Gygi SP, Duraisingh MT.

Nat Microbiol. 2017 Feb 17;2:17017. doi: 10.1038/nmicrobiol.2017.17. Erratum in: Nat Microbiol. 2017 Mar 06;2:17038.

34.

The Relationship Between Online Social Networking and Depression: A Systematic Review of Quantitative Studies.

Baker DA, Algorta GP.

Cyberpsychol Behav Soc Netw. 2016 Nov;19(11):638-648. Epub 2016 Oct 12. Review.

PMID:
27732062
35.

Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3.

McReynolds JR, Taylor A, Vranjkovic O, Ambrosius T, Derricks O, Nino B, Kurtoglu B, Wheeler RA, Baker DA, Gasser PJ, Mantsch JR.

Neuropsychopharmacology. 2017 Feb;42(3):757-765. doi: 10.1038/npp.2016.187. Epub 2016 Sep 8.

36.

Pituitary Adenylate-Cyclase Activating Polypeptide Regulates Hunger- and Palatability-Induced Binge Eating.

Hurley MM, Maunze B, Block ME, Frenkel MM, Reilly MJ, Kim E, Chen Y, Li Y, Baker DA, Liu QS, Choi S.

Front Neurosci. 2016 Aug 22;10:383. doi: 10.3389/fnins.2016.00383. eCollection 2016.

37.

The Role of Neuropsychological Evaluation in the Clinical Management of Concussion.

Connery AK, Peterson RL, Baker DA, Randolph C, Kirkwood MW.

Phys Med Rehabil Clin N Am. 2016 May;27(2):475-86. doi: 10.1016/j.pmr.2015.12.001. Epub 2016 Feb 22. Review.

PMID:
27154857
38.

The impact of pediatric neuropsychological consultation in mild traumatic brain injury: a model for providing feedback after invalid performance.

Connery AK, Peterson RL, Baker DA, Kirkwood MW.

Clin Neuropsychol. 2016 May;30(4):579-98. doi: 10.1080/13854046.2016.1177596. Epub 2016 May 3.

PMID:
27142647
39.

Genomic variation in two gametocyte non-producing Plasmodium falciparum clonal lines.

Campino S, Benavente ED, Assefa S, Thompson E, Drought LG, Taylor CJ, Gorvett Z, Carret CK, Flueck C, Ivens AC, Kwiatkowski DP, Alano P, Baker DA, Clark TG.

Malar J. 2016 Apr 21;15:229. doi: 10.1186/s12936-016-1254-1.

40.

N-acetylcysteine decreases binge eating in a rodent model.

Hurley MM, Resch JM, Maunze B, Frenkel MM, Baker DA, Choi S.

Int J Obes (Lond). 2016 Jul;40(7):1183-6. doi: 10.1038/ijo.2016.31. Epub 2016 Feb 15.

41.

Pituitary Adenylate cyclase-activating polypeptide orchestrates neuronal regulation of the astrocytic glutamate-releasing mechanism system xc (.).

Kong L, Albano R, Madayag A, Raddatz N, Mantsch JR, Choi S, Lobner D, Baker DA.

J Neurochem. 2016 May;137(3):384-93. doi: 10.1111/jnc.13566. Epub 2016 Mar 1.

42.

Parent satisfaction with neuropsychological consultation after pediatric mild traumatic brain injury.

Kirkwood MW, Peterson RL, Baker DA, Connery AK.

Child Neuropsychol. 2017 Apr;23(3):273-283. doi: 10.1080/09297049.2015.1130219. Epub 2016 Jan 7.

PMID:
26739699
43.

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development.

Green JL, Moon RW, Whalley D, Bowyer PW, Wallace C, Rochani A, Nageshan RK, Howell SA, Grainger M, Jones HM, Ansell KH, Chapman TM, Taylor DL, Osborne SA, Baker DA, Tatu U, Holder AA.

Antimicrob Agents Chemother. 2015 Dec 28;60(3):1464-75. doi: 10.1128/AAC.01748-15.

44.

Antagonism of GABA-B but not GABA-A receptors in the VTA prevents stress- and intra-VTA CRF-induced reinstatement of extinguished cocaine seeking in rats.

Blacktop JM, Vranjkovic O, Mayer M, Van Hoof M, Baker DA, Mantsch JR.

Neuropharmacology. 2016 Mar;102:197-206. doi: 10.1016/j.neuropharm.2015.11.013. Epub 2015 Nov 17.

45.

A Pilot Study Investigating Neuropsychological Consultation as an Intervention for Persistent Postconcussive Symptoms in a Pediatric Sample.

Kirkwood MW, Peterson RL, Connery AK, Baker DA, Forster J.

J Pediatr. 2016 Feb;169:244-9.e1. doi: 10.1016/j.jpeds.2015.10.014. Epub 2015 Nov 2.

PMID:
26541427
46.

CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats.

McReynolds JR, Doncheck EM, Vranjkovic O, Ganzman GS, Baker DA, Hillard CJ, Mantsch JR.

Psychopharmacology (Berl). 2016 Jan;233(1):99-109. doi: 10.1007/s00213-015-4092-x. Epub 2015 Oct 12.

47.

Making sense of research on the neuroimage bias.

Baker DA, Ware JM, Schweitzer NJ, Risko EF.

Public Underst Sci. 2017 Feb;26(2):251-258. doi: 10.1177/0963662515604975. Epub 2016 Aug 3.

PMID:
26386020
48.

Preinjury Emotional-Behavioral Functioning of Children With Lingering Problems After Mild Traumatic Brain Injury.

Peterson RL, Connery AK, Baker DA, Kirkwood MW.

J Neuropsychiatry Clin Neurosci. 2015 Fall;27(4):280-6. doi: 10.1176/appi.neuropsych.14120373. Epub 2015 Aug 10.

PMID:
26258490
49.

Phosphoantigen Burst upon Plasmodium falciparum Schizont Rupture Can Distantly Activate Vγ9Vδ2 T Cells.

Guenot M, Loizon S, Howard J, Costa G, Baker DA, Mohabeer SY, Troye-Blomberg M, Moreau JF, Déchanet-Merville J, Mercereau-Puijalon O, Mamani-Matsuda M, Behr C.

Infect Immun. 2015 Oct;83(10):3816-24. doi: 10.1128/IAI.00446-15. Epub 2015 Jul 13.

50.

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion.

Alam MM, Solyakov L, Bottrill AR, Flueck C, Siddiqui FA, Singh S, Mistry S, Viskaduraki M, Lee K, Hopp CS, Chitnis CE, Doerig C, Moon RW, Green JL, Holder AA, Baker DA, Tobin AB.

Nat Commun. 2015 Jul 7;6:7285. doi: 10.1038/ncomms8285.

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