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Redirecting the immune response towards immunoprotective domains of a DNABII protein resolves experimental otitis media.

Novotny LA, Goodman SD, Bakaletz LO.

NPJ Vaccines. 2019 Oct 14;4:43. doi: 10.1038/s41541-019-0137-1. eCollection 2019.


Expression of the NTHI Type IV Pilus is Stimulated by Co-culture with Host Respiratory Tract Epithelial Cells.

Mokrzan EM, Johnson TJ, Bakaletz LO.

Infect Immun. 2019 Sep 23. pii: IAI.00704-19. doi: 10.1128/IAI.00704-19. [Epub ahead of print]


In Silico Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae In Vivo.

Brown JR, Jurcisek J, Lakhani V, Snedden A, Ray WC, Mokrzan EM, Bakaletz LO, Das J.

mSphere. 2019 Jul 31;4(4). pii: e00254-19. doi: 10.1128/mSphere.00254-19.


Antibodies against the DNABII protein integration host factor (IHF) inhibit sinus implant biofilms.

Martyn L, Sethia R, Chon R, Novotny L, Goodman SD, Elmaraghy C, Bakaletz LO.

Laryngoscope. 2019 Jul 17. doi: 10.1002/lary.28188. [Epub ahead of print]


A Protein E-PilA Fusion Protein Shows Vaccine Potential against Nontypeable Haemophilus influenzae in Mice and Chinchillas.

Ysebaert C, Denoël P, Weynants V, Bakaletz LO, Novotny LA, Godfroid F, Hermand P.

Infect Immun. 2019 Jul 23;87(8). pii: e00345-19. doi: 10.1128/IAI.00345-19. Print 2019 Aug.


Identification of essential biofilm proteins in middle ear fluids of otitis media with effusion patients.

Barron CL, Kamel-Abusalha LB, Sethia R, Goodman SD, Elmaraghy CA, Bakaletz LO.

Laryngoscope. 2019 Apr 25. doi: 10.1002/lary.28011. [Epub ahead of print]


Biofilm biology and vaccine strategies for otitis media due to nontypeable Haemophilus influenzae.

Novotny LA, Brockman KL, Mokrzan EM, Jurcisek JA, Bakaletz LO.

J Pediatr Infect Dis. 2019 Feb;14(2):69-77. doi: 10.1055/s-0038-1660818. Epub 2018 Jul 6.


High-Depth RNA-Seq Data Sets for Studying Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae.

Atack JM, Bakaletz LO, Jennings MP.

Microbiol Resour Announc. 2019 Jan 10;8(2). pii: e01500-18. doi: 10.1128/MRA.01500-18. eCollection 2019 Jan.


Antibodies against the Majority Subunit (PilA) of the Type IV Pilus of Nontypeable Haemophilus influenzae Disperse Moraxella catarrhalis from a Dual-Species Biofilm.

Mokrzan EM, Novotny LA, Brockman KL, Bakaletz LO.

MBio. 2018 Dec 11;9(6). pii: e02423-18. doi: 10.1128/mBio.02423-18.


Closed Complete Genome Sequences of Two Nontypeable Haemophilus influenzae Strains Containing Novel modA Alleles from the Sputum of Patients with Chronic Obstructive Pulmonary Disease.

Atack JM, Murphy TF, Bakaletz LO, Seib KL, Jennings MP.

Microbiol Resour Announc. 2018 Jul 19;7(2). pii: e00821-18. doi: 10.1128/MRA.00821-18. eCollection 2018 Jul.


First Otitis Media and Pneumococcal Conjugate Vaccine Serotypes in Infants.

Dagan R, Pelton S, Bakaletz L, Cohen R.

Pediatr Infect Dis J. 2018 Dec;37(12):e351-e352. doi: 10.1097/INF.0000000000002030. No abstract available.


Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease.

Blakeway LV, Tan A, Lappan R, Ariff A, Pickering JL, Peacock CS, Blyth CC, Kahler CM, Chang BJ, Lehmann D, Kirkham LS, Murphy TF, Jennings MP, Bakaletz LO, Atack JM, Peak IR, Seib KL.

Genome Biol Evol. 2018 Nov 1;10(11):2932-2946. doi: 10.1093/gbe/evy226.


Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae.

Brockman KL, Azzari PN, Branstool MT, Atack JM, Schulz BL, Jen FE, Jennings MP, Bakaletz LO.

MBio. 2018 Sep 18;9(5). pii: e01682-18. doi: 10.1128/mBio.01682-18.


Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses.

Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Kopp BT, Amer AO, McCoy K, Bakaletz LO, Partida-Sanchez S.

J Immunol. 2018 Oct 1;201(7):2016-2027. doi: 10.4049/jimmunol.1800076. Epub 2018 Aug 17.


The HMW2 adhesin of non-typeable Haemophilus influenzae is a human-adapted lectin that mediates high-affinity binding to 2-6 linked N-acetylneuraminic acid glycans.

Atack JM, Day CJ, Poole J, Brockman KL, Bakaletz LO, Barenkamp SJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):1103-1107. doi: 10.1016/j.bbrc.2018.06.126. Epub 2018 Jun 27.


Skin Microbiota in Obese Women at Risk for Surgical Site Infection After Cesarean Delivery.

Rood KM, Buhimschi IA, Jurcisek JA, Summerfield TL, Zhao G, Ackerman WE, Wang W, Rumpf RW, Thung SF, Bakaletz LO, Buhimschi CS.

Sci Rep. 2018 Jun 8;8(1):8756. doi: 10.1038/s41598-018-27134-5.


Nontypeable Haemophilus influenzae (NTHi).

Bakaletz LO, Novotny LA.

Trends Microbiol. 2018 Aug;26(8):727-728. doi: 10.1016/j.tim.2018.05.001. Epub 2018 May 21.


Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies.

Atack JM, Tan A, Bakaletz LO, Jennings MP, Seib KL.

Trends Microbiol. 2018 Aug;26(8):715-726. doi: 10.1016/j.tim.2018.01.008. Epub 2018 Feb 13. Review.


Targeting the HUβ Protein Prevents Porphyromonas gingivalis from Entering into Preexisting Biofilms.

Rocco CJ, Bakaletz LO, Goodman SD.

J Bacteriol. 2018 May 9;200(11). pii: e00790-17. doi: 10.1128/JB.00790-17. Print 2018 Jun 1.


Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable Haemophilus influenzae.

Das J, Mokrzan E, Lakhani V, Rosas L, Jurcisek JA, Ray WC, Bakaletz LO.

MBio. 2017 Dec 19;8(6). pii: e01466-17. doi: 10.1128/mBio.01466-17.


The DNABII family of proteins is comprised of the only nucleoid associated proteins required for nontypeable Haemophilus influenzae biofilm structure.

Devaraj A, Buzzo J, Rocco CJ, Bakaletz LO, Goodman SD.

Microbiologyopen. 2018 Jun;7(3):e00563. doi: 10.1002/mbo3.563. Epub 2017 Dec 12.


Nontypeable Haemophilus influenzae releases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery.

Jurcisek JA, Brockman KL, Novotny LA, Goodman SD, Bakaletz LO.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6632-E6641. doi: 10.1073/pnas.1705508114. Epub 2017 Jul 10.


The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils.

Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO.

Sci Rep. 2017 Jun 9;7(1):3161. doi: 10.1038/s41598-017-03552-9.


Impact of protein D-containing pneumococcal conjugate vaccines on non-typeable Haemophilus influenzae acute otitis media and carriage.

Clarke C, Bakaletz LO, Ruiz-Guiñazú J, Borys D, Mrkvan T.

Expert Rev Vaccines. 2017 Jul;16(7):1-14. doi: 10.1080/14760584.2017.1333905. Epub 2017 Jun 7. Review.


Complete Genome Sequence of Moraxella catarrhalis Strain CCRI-195ME, Isolated from the Middle Ear.

Tan A, Blakeway LV, Bakaletz LO, Boitano M, Clark TA, Korlach J, Jennings MP, Peak IR, Seib KL.

Genome Announc. 2017 May 25;5(21). pii: e00384-17. doi: 10.1128/genomeA.00384-17.


Enhanced Probiotic Potential of Lactobacillus reuteri When Delivered as a Biofilm on Dextranomer Microspheres That Contain Beneficial Cargo.

Navarro JB, Mashburn-Warren L, Bakaletz LO, Bailey MT, Goodman SD.

Front Microbiol. 2017 Mar 27;8:489. doi: 10.3389/fmicb.2017.00489. eCollection 2017.


Transcutaneous Immunization with a Band-Aid Prevents Experimental Otitis Media in a Polymicrobial Model.

Novotny LA, Clements JD, Goodman SD, Bakaletz LO.

Clin Vaccine Immunol. 2017 Jun 5;24(6). pii: e00563-16. doi: 10.1128/CVI.00563-16. Print 2017 Jun.


Panel 6: Vaccines.

Pettigrew MM, Alderson MR, Bakaletz LO, Barenkamp SJ, Hakansson AP, Mason KM, Nokso-Koivisto J, Patel J, Pelton SI, Murphy TF.

Otolaryngol Head Neck Surg. 2017 Apr;156(4_suppl):S76-S87. doi: 10.1177/0194599816632178. Review.


Viral-bacterial co-infections in the respiratory tract.

Bakaletz LO.

Curr Opin Microbiol. 2017 Feb;35:30-35. doi: 10.1016/j.mib.2016.11.003. Epub 2016 Dec 7. Review.


Identification of biofilms in post-tympanostomy tube otorrhea.

Idicula WK, Jurcisek JA, Cass ND, Ali S, Goodman SD, Elmaraghy CA, Jatana KR, Bakaletz LO.

Laryngoscope. 2016 Aug;126(8):1946-51. doi: 10.1002/lary.25826. Epub 2016 Jan 4.


Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo.

Novotny LA, Jurcisek JA, Goodman SD, Bakaletz LO.

EBioMedicine. 2016 Aug;10:33-44. doi: 10.1016/j.ebiom.2016.06.022. Epub 2016 Jun 16.


ModA2 Phasevarion Switching in Nontypeable Haemophilus influenzae Increases the Severity of Experimental Otitis Media.

Brockman KL, Jurcisek JA, Atack JM, Srikhanta YN, Jennings MP, Bakaletz LO.

J Infect Dis. 2016 Sep 1;214(5):817-24. doi: 10.1093/infdis/jiw243. Epub 2016 Jun 10.


The Chinchilla Research Resource Database: resource for an otolaryngology disease model.

Shimoyama M, Smith JR, De Pons J, Tutaj M, Khampang P, Hong W, Erbe CB, Ehrlich GD, Bakaletz LO, Kerschner JE.

Database (Oxford). 2016 May 12;2016. pii: baw073. doi: 10.1093/database/baw073. Print 2016.


What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention.

Gunn JS, Bakaletz LO, Wozniak DJ.

J Biol Chem. 2016 Jun 10;291(24):12538-46. doi: 10.1074/jbc.R115.707547. Epub 2016 Apr 21. Review.


Type IV Pilus Expression Is Upregulated in Nontypeable Haemophilus influenzae Biofilms Formed at the Temperature of the Human Nasopharynx.

Mokrzan EM, Ward MO, Bakaletz LO.

J Bacteriol. 2016 Sep 9;198(19):2619-30. doi: 10.1128/JB.01022-15. Print 2016 Oct 1.


Prevention of early episodes of otitis media by pneumococcal vaccines might reduce progression to complex disease.

Dagan R, Pelton S, Bakaletz L, Cohen R.

Lancet Infect Dis. 2016 Apr;16(4):480-92. doi: 10.1016/S1473-3099(15)00549-6. Review.


Natural antigenic differences in the functionally equivalent extracellular DNABII proteins of bacterial biofilms provide a means for targeted biofilm therapeutics.

Rocco CJ, Davey ME, Bakaletz LO, Goodman SD.

Mol Oral Microbiol. 2017 Apr;32(2):118-130. doi: 10.1111/omi.12157. Epub 2016 Apr 25.


A bacterial-biofilm-induced oral osteolytic infection can be successfully treated by immuno-targeting an extracellular nucleoid-associated protein.

Freire MO, Devaraj A, Young A, Navarro JB, Downey JS, Chen C, Bakaletz LO, Zadeh HH, Goodman SD.

Mol Oral Microbiol. 2017 Feb;32(1):74-88. doi: 10.1111/omi.12155. Epub 2016 Apr 5.


Intercellular adhesion molecule 1 serves as a primary cognate receptor for the Type IV pilus of nontypeable Haemophilus influenzae.

Novotny LA, Bakaletz LO.

Cell Microbiol. 2016 Aug;18(8):1043-55. doi: 10.1111/cmi.12575. Epub 2016 Feb 26.


A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae.

Atack JM, Srikhanta YN, Fox KL, Jurcisek JA, Brockman KL, Clark TA, Boitano M, Power PM, Jen FE, McEwan AG, Grimmond SM, Smith AL, Barenkamp SJ, Korlach J, Bakaletz LO, Jennings MP.

Nat Commun. 2015 Jul 28;6:7828. doi: 10.1038/ncomms8828.


Therapeutic Transcutaneous Immunization with a Band-Aid Vaccine Resolves Experimental Otitis Media.

Novotny LA, Clements JD, Bakaletz LO.

Clin Vaccine Immunol. 2015 Aug;22(8):867-74. doi: 10.1128/CVI.00090-15. Epub 2015 May 27.


DNABII proteins play a central role in UPEC biofilm structure.

Devaraj A, Justice SS, Bakaletz LO, Goodman SD.

Mol Microbiol. 2015 Jun;96(6):1119-35. doi: 10.1111/mmi.12994. Epub 2015 Apr 16.


Selection and Counterselection of Hia Expression Reveals a Key Role for Phase-Variable Expression of Hia in Infection Caused by Nontypeable Haemophilus influenzae.

Atack JM, Winter LE, Jurcisek JA, Bakaletz LO, Barenkamp SJ, Jennings MP.

J Infect Dis. 2015 Aug 15;212(4):645-53. doi: 10.1093/infdis/jiv103. Epub 2015 Feb 23.


Antibodies against the majority subunit of type IV Pili disperse nontypeable Haemophilus influenzae biofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media.

Novotny LA, Jurcisek JA, Ward MO Jr, Jordan ZB, Goodman SD, Bakaletz LO.

Mol Microbiol. 2015 Apr;96(2):276-92. doi: 10.1111/mmi.12934. Epub 2015 Feb 15.


Role of the nuclease of nontypeable Haemophilus influenzae in dispersal of organisms from biofilms.

Cho C, Chande A, Gakhar L, Bakaletz LO, Jurcisek JA, Ketterer M, Shao J, Gotoh K, Foster E, Hunt J, O'Brien E, Apicella MA.

Infect Immun. 2015 Mar;83(3):950-7. doi: 10.1128/IAI.02601-14. Epub 2014 Dec 29.


ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media.

Blakeway LV, Power PM, Jen FE, Worboys SR, Boitano M, Clark TA, Korlach J, Bakaletz LO, Jennings MP, Peak IR, Seib KL.

FASEB J. 2014 Dec;28(12):5197-207. doi: 10.1096/fj.14-256578. Epub 2014 Sep 2.


Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms.

Brockson ME, Novotny LA, Mokrzan EM, Malhotra S, Jurcisek JA, Akbar R, Devaraj A, Goodman SD, Bakaletz LO.

Mol Microbiol. 2014 Sep;93(6):1246-58. doi: 10.1111/mmi.12735. Epub 2014 Aug 19.


Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children.

Jones EA, Kananurak A, Bevins CL, Hollox EJ, Bakaletz LO.

PLoS One. 2014 May 27;9(5):e98269. doi: 10.1371/journal.pone.0098269. eCollection 2014.


Selection for phase variation of LOS biosynthetic genes frequently occurs in progression of non-typeable Haemophilus influenzae infection from the nasopharynx to the middle ear of human patients.

Fox KL, Atack JM, Srikhanta YN, Eckert A, Novotny LA, Bakaletz LO, Jennings MP.

PLoS One. 2014 Feb 28;9(2):e90505. doi: 10.1371/journal.pone.0090505. eCollection 2014.


D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes resistance to antimicrobial peptides and polymorphonuclear leukocyte-mediated killing.

Taneja NK, Ganguly T, Bakaletz LO, Nelson KJ, Dubey P, Poole LB, Deora R.

J Bacteriol. 2013 Nov;195(22):5102-11. doi: 10.1128/JB.00510-13. Epub 2013 Sep 6.

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