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Items: 1 to 50 of 61

1.

Synthesis, physicochemical and biological evaluation of tacrine derivative labeled with technetium-99m and gallium-68 as a prospective diagnostic tool for early diagnosis of Alzheimer's disease.

Gniazdowska E, Koźmiński P, Halik P, Bajda M, Czarnecka K, Mikiciuk-Olasik E, Masłowska K, Rogulski Z, Cheda Ł, Kilian K, Szymański P.

Bioorg Chem. 2019 Jul 20;91:103136. doi: 10.1016/j.bioorg.2019.103136. [Epub ahead of print]

PMID:
31374521
2.

Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives.

Jończyk J, Lodarski K, Staszewski M, Godyń J, Zaręba P, Soukup O, Janockova J, Korabecny J, Sałat K, Malikowska-Racia N, Hebda M, Szałaj N, Filipek B, Walczyński K, Malawska B, Bajda M.

Bioorg Chem. 2019 Sep;90:103084. doi: 10.1016/j.bioorg.2019.103084. Epub 2019 Jun 26.

PMID:
31271942
3.

EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer.

Viswanadhapalli S, Luo Y, Sareddy GR, Santhamma B, Zhou M, Li M, Ma S, Sonavane R, Pratap UP, Altwegg KA, Li X, Chang A, Chávez-Riveros A, Dileep KV, Zhang KYJ, Pan X, Murali R, Bajda M, Raj GV, Brenner AJ, Manthati V, Rao MK, Tekmal RR, Nair HB, Nickisch KJ, Vadlamudi RK.

Mol Cancer Ther. 2019 Aug;18(8):1341-1354. doi: 10.1158/1535-7163.MCT-18-1258. Epub 2019 May 29.

PMID:
31142661
4.

Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer's Disease.

Czarnecka K, Girek M, Kręcisz P, Skibiński R, Łątka K, Jończyk J, Bajda M, Kabziński J, Majsterek I, Szymczyk P, Szymański P.

Int J Mol Sci. 2019 Jan 24;20(3). pii: E498. doi: 10.3390/ijms20030498.

5.

Identification of 1,2,4-triazoles as new thymidine phosphorylase inhibitors: Future anti-tumor drugs.

Shahzad SA, Yar M, Khan ZA, Shahzadi L, Naqvi SAR, Mahmood A, Ullah S, Shaikh AJ, Sherazi TA, Bale AT, Kukułowicz J, Bajda M.

Bioorg Chem. 2019 Apr;85:209-220. doi: 10.1016/j.bioorg.2019.01.005. Epub 2019 Jan 4.

PMID:
30634096
6.

Characteristics of metabolic stability and the cell permeability of 2-pyrimidinyl-piperazinyl-alkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione with antidepressant- and anxiolytic-like activities.

Zagórska A, Partyka A, Bucki A, Kołaczkowski M, Jastrzębska-Więsek M, Czopek A, Siwek A, Głuch-Lutwin M, Bednarski M, Bajda M, Jończyk J, Piska K, Koczurkiewicz P, Wesołowska A, Pawłowski M.

Chem Biol Drug Des. 2019 Apr;93(4):511-521. doi: 10.1111/cbdd.13442. Epub 2018 Dec 4.

PMID:
30422400
7.

4-tert-Pentylphenoxyalkyl derivatives - Histamine H3 receptor ligands and monoamine oxidase B inhibitors.

Łażewska D, Olejarz-Maciej A, Kaleta M, Bajda M, Siwek A, Karcz T, Doroz-Płonka A, Cichoń U, Kuder K, Kieć-Kononowicz K.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3596-3600. doi: 10.1016/j.bmcl.2018.10.048. Epub 2018 Oct 31.

PMID:
30404719
8.

Determination of ligand efficiency indices in a group of 7H-purine-2,6-dione derivatives with psychotropic activity using micellar electrokinetic chromatography.

Bajda M, Chłoń-Rzepa G, Żmudzki P, Czopek A, Stanisz-Wallis K, Łątka K, Pawłowski M, Zagórska A.

Electrophoresis. 2018 Oct;39(19):2446-2453. doi: 10.1002/elps.201800156. Epub 2018 Aug 7.

PMID:
30051931
9.

Novel carbamate derivatives as selective butyrylcholinesterase inhibitors.

Bajda M, Łątka K, Hebda M, Jończyk J, Malawska B.

Bioorg Chem. 2018 Aug;78:29-38. doi: 10.1016/j.bioorg.2018.03.003. Epub 2018 Mar 3.

PMID:
29529519
10.

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents.

Panek D, Więckowska A, Pasieka A, Godyń J, Jończyk J, Bajda M, Knez D, Gobec S, Malawska B.

Molecules. 2018 Feb 7;23(2). pii: E347. doi: 10.3390/molecules23020347.

11.

Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment.

Czarnecka K, Chufarova N, Halczuk K, Maciejewska K, Girek M, Skibiński R, Jończyk J, Bajda M, Kabziński J, Majsterek I, Szymański P.

Eur J Med Chem. 2018 Feb 10;145:760-769. doi: 10.1016/j.ejmech.2018.01.014. Epub 2018 Jan 9.

PMID:
29353726
12.

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.

Panek D, Więckowska A, Jończyk J, Godyń J, Bajda M, Wichur T, Pasieka A, Knez D, Pišlar A, Korabecny J, Soukup O, Sepsova V, Sabaté R, Kos J, Gobec S, Malawska B.

ACS Chem Neurosci. 2018 May 16;9(5):1074-1094. doi: 10.1021/acschemneuro.7b00461. Epub 2018 Feb 1.

PMID:
29345897
13.

New cyclopentaquinoline hybrids with multifunctional capacities for the treatment of Alzheimer's disease.

Czarnecka K, Girek M, Maciejewska K, Skibiński R, Jończyk J, Bajda M, Kabziński J, Sołowiej P, Majsterek I, Szymański P.

J Enzyme Inhib Med Chem. 2017 Dec;33(1):158-170. doi: 10.1080/14756366.2017.1406485. Erratum in: J Enzyme Inhib Med Chem. 2018 Dec;33(1):558-559.

14.

Novel pyridine-2,4,6-tricarbohydrazide thiourea compounds as small key organic molecules for the potential treatment of type-2 diabetes mellitus: In vitro studies against yeast α- and β-glucosidase and in silico molecular modeling.

Rehman TU, Riaz S, Khan IU, Ashraf M, Bajda M, Gawalska A, Yar M.

Arch Pharm (Weinheim). 2018 Jan;351(1). doi: 10.1002/ardp.201700236. Epub 2017 Dec 1.

PMID:
29194730
15.

Hybrid approach to structure modeling of the histamine H3 receptor: Multi-level assessment as a tool for model verification.

Jończyk J, Malawska B, Bajda M.

PLoS One. 2017 Oct 5;12(10):e0186108. doi: 10.1371/journal.pone.0186108. eCollection 2017.

16.

Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer's disease treatment.

Czarnecka K, Szymański P, Girek M, Mikiciuk-Olasik E, Skibiński R, Kabziński J, Majsterek I, Malawska B, Jończyk J, Bajda M.

Bioorg Chem. 2017 Jun;72:315-322. doi: 10.1016/j.bioorg.2017.05.003. Epub 2017 May 5.

PMID:
28501648
17.

Lipophilic properties of anti-Alzheimer's agents determined by micellar electrokinetic chromatography and reversed-phase thin-layer chromatography.

Godyń J, Hebda M, Więckowska A, Więckowski K, Malawska B, Bajda M.

Electrophoresis. 2017 May;38(9-10):1268-1275. doi: 10.1002/elps.201600473. Epub 2017 Mar 15.

PMID:
28169440
18.

Synthesis, physicochemical and biological studies of technetium-99m labeled tacrine derivative as a diagnostic tool for evaluation of cholinesterase level.

Gniazdowska E, Koźmiński P, Wasek M, Bajda M, Sikora J, Mikiciuk-Olasik E, Szymański P.

Bioorg Med Chem. 2017 Feb 1;25(3):912-920. doi: 10.1016/j.bmc.2016.12.004. Epub 2016 Dec 7.

PMID:
27998671
19.

Computational approach for the assessment of inhibitory potency against beta-amyloid aggregation.

Bajda M, Filipek S.

Bioorg Med Chem Lett. 2017 Jan 15;27(2):212-216. doi: 10.1016/j.bmcl.2016.11.072. Epub 2016 Nov 24.

PMID:
27914799
20.

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.

Panek D, Więckowska A, Wichur T, Bajda M, Godyń J, Jończyk J, Mika K, Janockova J, Soukup O, Knez D, Korabecny J, Gobec S, Malawska B.

Eur J Med Chem. 2017 Jan 5;125:676-695. doi: 10.1016/j.ejmech.2016.09.078. Epub 2016 Sep 26.

PMID:
27721153
21.

Organocatalyzed Novel Synthetic Methodology for Highly Functionalized Piperidines as Potent α-Glucosidase Inhibitors.

Farooq A, Shahazadi L, Bajda M, Ullah N, Rauf A, Shahzad SA, Khan AF, Ashraf M, Yar M.

Arch Pharm (Weinheim). 2016 Sep;349(9):724-32. doi: 10.1002/ardp.201600045. Epub 2016 Aug 4.

PMID:
27489132
22.

Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.

Łażewska D, Jończyk J, Bajda M, Szałaj N, Więckowska A, Panek D, Moore C, Kuder K, Malawska B, Kieć-Kononowicz K.

Bioorg Med Chem Lett. 2016 Aug 15;26(16):4140-5. doi: 10.1016/j.bmcl.2016.04.054. Epub 2016 Apr 20.

PMID:
27445168
23.

Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta.

Hebda M, Bajda M, Więckowska A, Szałaj N, Pasieka A, Panek D, Godyń J, Wichur T, Knez D, Gobec S, Malawska B.

Molecules. 2016 Mar 26;21(4):410. doi: 10.3390/molecules21040410.

24.

A Hybrid Approach to Structure and Function Modeling of G Protein-Coupled Receptors.

Latek D, Bajda M, Filipek S.

J Chem Inf Model. 2016 Apr 25;56(4):630-41. doi: 10.1021/acs.jcim.5b00451. Epub 2016 Mar 29.

PMID:
26978043
25.

SEARCH FOR POTENTIAL CHOLINESTERASE INHIBITORS FROM THE ZINC DATABASE BY VIRTUAL SCREENING METHOD.

Bajda M, Panek D, Hebda M, Więckowska A, Guzior N, Malawska B.

Acta Pol Pharm. 2015 Jul-Aug;72(4):737-45.

26.

REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY STUDY OF LIPOPHILICITY OF IMIDAZO[2,1-F]THEOPHYLLINE DERIVATIVES.

Zagórska A, Czopek A, Pełka K, Bajda M, Stanisz-Wallis K, Pawłowski M.

Acta Pol Pharm. 2015 Jul-Aug;72(4):663-9.

27.

Novel biphenyl bis-sulfonamides as acetyl and butyrylcholinesterase inhibitors: Synthesis, biological evaluation and molecular modeling studies.

Mutahir S, Jończyk J, Bajda M, Khan IU, Khan MA, Ullah N, Ashraf M, Qurat-ul-Ain, Riaz S, Hussain S, Yar M.

Bioorg Chem. 2016 Feb;64:13-20. doi: 10.1016/j.bioorg.2015.11.002. Epub 2015 Nov 10.

PMID:
26595185
28.

Natural Larval Diet Differently Influences the Pattern of Developmental Changes in DNA 5-Methylcytosine Levels in Apis mellifera Queens as Compared with Workers and Drones.

Strachecka A, Olszewski K, Bajda M, Demetraki-Paleolog J.

Biochemistry (Mosc). 2015 Aug;80(8):1019-25. doi: 10.1134/S0006297915080076.

29.

Pyridine sulfonamide as a small key organic molecule for the potential treatment of type-II diabetes mellitus and Alzheimer's disease: In vitro studies against yeast α-glucosidase, acetylcholinesterase and butyrylcholinesterase.

Riaz S, Khan IU, Bajda M, Ashraf M, Qurat-Ul-Ain, Shaukat A, Rehman TU, Mutahir S, Hussain S, Mustafa G, Yar M.

Bioorg Chem. 2015 Dec;63:64-71. doi: 10.1016/j.bioorg.2015.09.008. Epub 2015 Sep 30.

PMID:
26451651
30.

Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.

Bajda M, Jończyk J, Malawska B, Czarnecka K, Girek M, Olszewska P, Sikora J, Mikiciuk-Olasik E, Skibiński R, Gumieniczek A, Szymański P.

Bioorg Med Chem. 2015 Sep 1;23(17):5610-8. doi: 10.1016/j.bmc.2015.07.029. Epub 2015 Jul 21.

PMID:
26242241
31.

Design and synthesis of new barbituric- and thiobarbituric acid derivatives as potent urease inhibitors: Structure activity relationship and molecular modeling studies.

Rauf A, Shahzad S, Bajda M, Yar M, Ahmed F, Hussain N, Akhtar MN, Khan A, Jończyk J.

Bioorg Med Chem. 2015 Sep 1;23(17):6049-58. doi: 10.1016/j.bmc.2015.05.038. Epub 2015 Jun 3.

PMID:
26081763
32.

Multiple Ligands Targeting Cholinesterases and β-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore.

Szałaj N, Bajda M, Dudek K, Brus B, Gobec S, Malawska B.

Arch Pharm (Weinheim). 2015 Aug;348(8):556-63. doi: 10.1002/ardp.201500117. Epub 2015 May 29.

PMID:
26032855
33.

Synthesis, thymidine phosphorylase inhibition and molecular modeling studies of 1,3,4-oxadiazole-2-thione derivatives.

Shahzad SA, Yar M, Bajda M, Shahzadi L, Khan ZA, Naqvi SA, Mutahir S, Mahmood N, Khan KM.

Bioorg Chem. 2015 Jun;60:37-41. doi: 10.1016/j.bioorg.2015.04.003. Epub 2015 Apr 20.

PMID:
25920005
34.

Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.

Więckowska A, Więckowski K, Bajda M, Brus B, Sałat K, Czerwińska P, Gobec S, Filipek B, Malawska B.

Bioorg Med Chem. 2015 May 15;23(10):2445-57. doi: 10.1016/j.bmc.2015.03.051. Epub 2015 Mar 27.

PMID:
25868744
35.

Study of early stages of amyloid Aβ13-23 formation using molecular dynamics simulation in implicit environments.

Bajda M, Filipek S.

Comput Biol Chem. 2015 Jun;56:13-8. doi: 10.1016/j.compbiolchem.2015.02.014. Epub 2015 Feb 25.

PMID:
25749181
36.

Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.

Guzior N, Bajda M, Rakoczy J, Brus B, Gobec S, Malawska B.

Bioorg Med Chem. 2015 Apr 1;23(7):1629-37. doi: 10.1016/j.bmc.2015.01.045. Epub 2015 Feb 9.

PMID:
25707322
37.

Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties.

Guzior N, Bajda M, Skrok M, Kurpiewska K, Lewiński K, Brus B, Pišlar A, Kos J, Gobec S, Malawska B.

Eur J Med Chem. 2015 Mar 6;92:738-49. doi: 10.1016/j.ejmech.2015.01.027. Epub 2015 Jan 13.

PMID:
25621991
38.

Unexpectedly strong effect of caffeine on the vitality of western honeybees (Apis mellifera).

Strachecka A, Krauze M, Olszewski K, Borsuk G, Paleolog J, Merska M, Chobotow J, Bajda M, Grzywnowicz K.

Biochemistry (Mosc). 2014 Nov;79(11):1192-201. doi: 10.1134/S0006297914110066.

39.

Organocatalyzed solvent free an efficient novel synthesis of 2,4,5-trisubstituted imidazoles for α-glucosidase inhibition to treat diabetes.

Yar M, Bajda M, Shahzad S, Ullah N, Gilani MA, Ashraf M, Rauf A, Shaukat A.

Bioorg Chem. 2015 Feb;58:65-71. doi: 10.1016/j.bioorg.2014.11.006. Epub 2014 Nov 21.

PMID:
25462626
40.

Novel synthesis of dihydropyrimidines for α-glucosidase inhibition to treat type 2 diabetes: in vitro biological evaluation and in silico docking.

Yar M, Bajda M, Shahzadi L, Shahzad SA, Ahmed M, Ashraf M, Alam U, Khan IU, Khan AF.

Bioorg Chem. 2014 Jun;54:96-104. doi: 10.1016/j.bioorg.2014.05.003. Epub 2014 May 15.

PMID:
24880489
41.

Design and Synthesis of New Dual Binding Site Cholinesterase Inhibitors: in vitro Inhibition Studies with in silico Docking.

Yar M, Bajda M, Mehmood RA, Sidra LR, Ullah N, Shahzadi L, Ashraf M, Ismail T, Shahzad SA, Khan ZA, Naqvi SA, Mahmood N.

Lett Drug Des Discov. 2014 Mar;11(3):331-338.

42.

Discovery of butyrylcholinesterase inhibitors among derivatives of azaphenothiazines.

Lodarski K, Jończyk J, Guzior N, Bajda M, Gładysz J, Walczyk J, Jeleń M, Morak-Młodawska B, Pluta K, Malawska B.

J Enzyme Inhib Med Chem. 2015 Feb;30(1):98-106. doi: 10.3109/14756366.2014.889127. Epub 2014 Mar 25.

PMID:
24666296
43.

Application of computational methods for the design of BACE-1 inhibitors: validation of in silico modelling.

Bajda M, Jończyk J, Malawska B, Filipek S.

Int J Mol Sci. 2014 Mar 24;15(3):5128-39. doi: 10.3390/ijms15035128.

44.

Coenzyme Q10 treatments influence the lifespan and key biochemical resistance systems in the honeybee, Apis mellifera.

Strachecka A, Olszewski K, Paleolog J, Borsuk G, Bajda M, Krauze M, Merska M, Chobotow J.

Arch Insect Biochem Physiol. 2014 Jul;86(3):165-79. doi: 10.1002/arch.21159. Epub 2014 Mar 21.

PMID:
24659567
45.

Synthesis and biological evaluation of novel oxadiazole derivatives: a new class of thymidine phosphorylase inhibitors as potential anti-tumor agents.

Shahzad SA, Yar M, Bajda M, Jadoon B, Khan ZA, Naqvi SA, Shaikh AJ, Hayat K, Mahmmod A, Mahmood N, Filipek S.

Bioorg Med Chem. 2014 Feb 1;22(3):1008-15. doi: 10.1016/j.bmc.2013.12.043. Epub 2013 Dec 30.

PMID:
24411198
46.

Determination of lipophilicity of γ-butyrolactone derivatives with anticonvulsant and analgesic activity using micellar electrokinetic chromatography.

Bajda M, Guła A, Więckowski K, Malawska B.

Electrophoresis. 2013 Nov;34(20-21):3079-85. doi: 10.1002/elps.201300266. Epub 2013 Oct 3.

PMID:
24037952
47.

Structure-based search for new inhibitors of cholinesterases.

Bajda M, Więckowska A, Hebda M, Guzior N, Sotriffer CA, Malawska B.

Int J Mol Sci. 2013 Mar 11;14(3):5608-32. doi: 10.3390/ijms14035608.

48.

New tacrine analogs as acetylcholinesterase inhibitors - theoretical study with chemometric analysis.

Szymański P, Skibiński R, Inglot T, Bajda M, Jończyk J, Malawska B, Mikiciuk-Olasik E.

Molecules. 2013 Mar 4;18(3):2878-94. doi: 10.3390/molecules18032878.

49.

Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors.

Skrzypek A, Matysiak J, Niewiadomy A, Bajda M, Szymański P.

Eur J Med Chem. 2013 Apr;62:311-9. doi: 10.1016/j.ejmech.2012.12.060. Epub 2013 Jan 11.

PMID:
23376249
50.

Synthesis, biological activity and molecular modeling of 4-fluoro-N-[ω-(1,2,3,4-tetrahydroacridin-9-ylamino)-alkyl]-benzamide derivatives as cholinesterase inhibitors.

Szymański P, Markowicz M, Bajda M, Malawska B, Mikiciuk-Olasik E.

Arzneimittelforschung. 2012 Dec;62(12):655-60. doi: 10.1055/s-0032-1329963. Epub 2012 Nov 15.

PMID:
23154886

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