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Six gene and TH2 signature expression in endobronchial biopsies of participants with asthma.

Sánchez-Ovando S, Baines KJ, Barker D, Wark PA, Simpson JL.

Immun Inflamm Dis. 2020 Mar;8(1):40-49. doi: 10.1002/iid3.282. Epub 2020 Jan 5.


Antiviral Inflammation during Early Pregnancy Reduces Placental and Fetal Growth Trajectories.

Baines KJ, Rampersaud AM, Hillier DM, Jeyarajah MJ, Grafham GK, Eastabrook G, Lacefield JC, Renaud SJ.

J Immunol. 2020 Feb 1;204(3):694-706. doi: 10.4049/jimmunol.1900888. Epub 2019 Dec 27.


Blood Neutrophils In COPD But Not Asthma Exhibit A Primed Phenotype With Downregulated CD62L Expression.

Lokwani R, Wark PA, Baines KJ, Fricker M, Barker D, Simpson JL.

Int J Chron Obstruct Pulmon Dis. 2019 Nov 15;14:2517-2525. doi: 10.2147/COPD.S222486. eCollection 2019.


Sputum transcriptomics implicates increased p38 signalling activity in severe asthma.

Baines KJ, Fricker M, McDonald VM, Simpson JL, Wood LG, Wark PAB, Macdonald HE, Reid A, Gibson PG.

Respirology. 2019 Dec 6. doi: 10.1111/resp.13749. [Epub ahead of print]


Targeting Treatable Traits in Severe Asthma: A Randomised Controlled Trial.

McDonald VM, Clark VL, Cordova-Rivera L, Wark PAB, Baines KJ, Gibson PG.

Eur Respir J. 2019 Dec 5. pii: 1901509. doi: 10.1183/13993003.01509-2019. [Epub ahead of print]


Soluble fibre supplementation with and without a probiotic in adults with asthma: A 7-day randomised, double blind, three way cross-over trial.

McLoughlin R, Berthon BS, Rogers GB, Baines KJ, Leong LEX, Gibson PG, Williams EJ, Wood LG.

EBioMedicine. 2019 Aug;46:473-485. doi: 10.1016/j.ebiom.2019.07.048. Epub 2019 Jul 31.


The Emerging Role of Neutrophil Extracellular Traps in Respiratory Disease.

Twaddell SH, Baines KJ, Grainge C, Gibson PG.

Chest. 2019 Oct;156(4):774-782. doi: 10.1016/j.chest.2019.06.012. Epub 2019 Jun 29. Review.


Dysregulation of sputum columnar epithelial cells and products in distinct asthma phenotypes.

Qin L, Gibson PG, Simpson JL, Baines KJ, McDonald VM, Wood LG, Powell H, Fricker M.

Clin Exp Allergy. 2019 Nov;49(11):1418-1428. doi: 10.1111/cea.13452. Epub 2019 Aug 6.


Hypersegmented airway neutrophils and its association with reduced lung function in adults with obstructive airway disease: an exploratory study.

Lokwani R, Wark PAB, Baines KJ, Barker D, Simpson JL.

BMJ Open. 2019 Jan 28;9(1):e024330. doi: 10.1136/bmjopen-2018-024330.


A sputum 6-gene signature predicts future exacerbations of poorly controlled asthma.

Fricker M, Gibson PG, Powell H, Simpson JL, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Marks GB, Baraket M, Baines KJ.

J Allergy Clin Immunol. 2019 Jul;144(1):51-60.e11. doi: 10.1016/j.jaci.2018.12.1020. Epub 2019 Jan 22.


Galectin-3 enhances monocyte-derived macrophage efferocytosis of apoptotic granulocytes in asthma.

Erriah M, Pabreja K, Fricker M, Baines KJ, Donnelly LE, Bylund J, Karlsson A, Simpson JL.

Respir Res. 2019 Jan 3;20(1):1. doi: 10.1186/s12931-018-0967-9.


Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD.

Baines KJ, Wright TK, Gibson PG, Powell H, Hansbro PM, Simpson JL.

ERJ Open Res. 2018 Nov 5;4(4). pii: 00031-2018. doi: 10.1183/23120541.00031-2018. eCollection 2018 Oct.


Saturated fatty acids, obesity, and the nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in asthmatic patients.

Wood LG, Li Q, Scott HA, Rutting S, Berthon BS, Gibson PG, Hansbro PM, Williams E, Horvat J, Simpson JL, Young P, Oliver BG, Baines KJ.

J Allergy Clin Immunol. 2019 Jan;143(1):305-315. doi: 10.1016/j.jaci.2018.04.037. Epub 2018 May 30.


Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis.

Chen AC, Tran HB, Xi Y, Yerkovich ST, Baines KJ, Pizzutto SJ, Carroll M, Robertson AAB, Cooper MA, Schroder K, Simpson JL, Gibson PG, Hodge G, Masters IB, Buntain HM, Petsky HL, Prime SJ, Chang AB, Hodge S, Upham JW.

ERJ Open Res. 2018 Mar 23;4(1). pii: 00130-2017. doi: 10.1183/23120541.00130-2017. eCollection 2018 Jan.


Airway cells from protracted bacterial bronchitis and bronchiectasis share similar gene expression profiles.

Chen AC, Pena OM, Nel HJ, Yerkovich ST, Chang AB, Baines KJ, Gibson PG, Petsky HL, Pizzutto SJ, Hodge S, Masters IB, Buntain HL, Upham JW.

Pediatr Pulmonol. 2018 May;53(5):575-582. doi: 10.1002/ppul.23984. Epub 2018 Mar 24.


Advancing the management of obstructive airways diseases through translational research.

Porsbjerg C, Sverrild A, Baines KJ, Searles A, Maltby S, Foster PS, Brightling C, Gibson PG.

Clin Exp Allergy. 2018 May;48(5):493-501. doi: 10.1111/cea.13112. Epub 2018 Mar 13. Review.


Obese asthmatics are characterized by altered adipose tissue macrophage activation.

Periyalil HA, Wood LG, Wright TA, Karihaloo C, Starkey MR, Miu AS, Baines KJ, Hansbro PM, Gibson PG.

Clin Exp Allergy. 2018 Jun;48(6):641-649. doi: 10.1111/cea.13109. Epub 2018 Mar 23.


Cytokine responses to two common respiratory pathogens in children are dependent on interleukin-1β.

Chen AC, Xi Y, Carroll M, Petsky HL, Gardiner SJ, Pizzutto SJ, Yerkovich ST, Baines KJ, Gibson PG, Hodge S, Masters IB, Buntain HM, Chang AB, Upham JW.

ERJ Open Res. 2017 Oct 2;3(4). pii: 00025-2017. doi: 10.1183/23120541.00025-2017. eCollection 2017 Oct.


Sputum colour can identify patients with neutrophilic inflammation in asthma.

Pabreja K, Gibson P, Lochrin AJ, Wood L, Baines KJ, Simpson JL.

BMJ Open Respir Res. 2017 Oct 9;4(1):e000236. doi: 10.1136/bmjresp-2017-000236. eCollection 2017.


Short-chain fatty acids, prebiotics, synbiotics, and systemic inflammation: a systematic review and meta-analysis.

McLoughlin RF, Berthon BS, Jensen ME, Baines KJ, Wood LG.

Am J Clin Nutr. 2017 Sep 1;106(3):930-945. doi: 10.3945/ajcn.117.156265.


A sputum gene expression signature predicts oral corticosteroid response in asthma.

Berthon BS, Gibson PG, Wood LG, MacDonald-Wicks LK, Baines KJ.

Eur Respir J. 2017 Jun 29;49(6). pii: 1700180. doi: 10.1183/13993003.00180-2017. Print 2017 Jun.


MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD.

Hsu AC, Dua K, Starkey MR, Haw TJ, Nair PM, Nichol K, Zammit N, Grey ST, Baines KJ, Foster PS, Hansbro PM, Wark PA.

JCI Insight. 2017 Apr 6;2(7):e90443. doi: 10.1172/jci.insight.90443.


Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.

Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, Mayall JR, Ali MK, Starkey MR, Hansbro NG, Hirota JA, Wood LG, Simpson JL, Knight DA, Wark PA, Gibson PG, O'Neill LAJ, Cooper MA, Horvat JC, Hansbro PM.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297. doi: 10.1164/rccm.201609-1830OC.


Airway gene expression of IL-1 pathway mediators predicts exacerbation risk in obstructive airway disease.

Baines KJ, Fu JJ, McDonald VM, Gibson PG.

Int J Chron Obstruct Pulmon Dis. 2017 Feb 8;12:541-550. doi: 10.2147/COPD.S119443. eCollection 2017.


Effects of an Encapsulated Fruit and Vegetable Juice Concentrate on Obesity-Induced Systemic Inflammation: A Randomised Controlled Trial.

Williams EJ, Baines KJ, Berthon BS, Wood LG.

Nutrients. 2017 Feb 8;9(2). pii: E116. doi: 10.3390/nu9020116.


Transcription Factors That Regulate Trophoblast Development and Function.

Baines KJ, Renaud SJ.

Prog Mol Biol Transl Sci. 2017;145:39-88. doi: 10.1016/bs.pmbts.2016.12.003. Epub 2017 Jan 16. Review.


Soluble Fibre Meal Challenge Reduces Airway Inflammation and Expression of GPR43 and GPR41 in Asthma.

Halnes I, Baines KJ, Berthon BS, MacDonald-Wicks LK, Gibson PG, Wood LG.

Nutrients. 2017 Jan 10;9(1). pii: E57. doi: 10.3390/nu9010057.


Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD.

Negewo NA, McDonald VM, Baines KJ, Wark PA, Simpson JL, Jones PW, Gibson PG.

Int J Chron Obstruct Pulmon Dis. 2016 Jul 1;11:1495-504. doi: 10.2147/COPD.S100338. eCollection 2016.


A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro.

Tang FS, Hansbro PM, Burgess JK, Ammit AJ, Baines KJ, Oliver BG.

Thorax. 2016 Nov;71(11):1039-1049. doi: 10.1136/thoraxjnl-2015-207781. Epub 2016 Jun 10.


TNF-α and Macrophages Are Critical for Respiratory Syncytial Virus-Induced Exacerbations in a Mouse Model of Allergic Airways Disease.

Nguyen TH, Maltby S, Simpson JL, Eyers F, Baines KJ, Gibson PG, Foster PS, Yang M.

J Immunol. 2016 May 1;196(9):3547-58. doi: 10.4049/jimmunol.1502339. Epub 2016 Apr 1.


Is Alveolar Macrophage Phagocytic Dysfunction in Children With Protracted Bacterial Bronchitis a Forerunner to Bronchiectasis?

Hodge S, Upham JW, Pizzutto S, Petsky HL, Yerkovich S, Baines KJ, Gibson P, Simpson JL, Buntain H, Chen ACH, Hodge G, Chang AB.

Chest. 2016 Feb;149(2):508-515. doi: 10.1016/j.chest.2015.10.066.


Neutrophil extracellular traps are associated with inflammation in chronic airway disease.

Wright TK, Gibson PG, Simpson JL, McDonald VM, Wood LG, Baines KJ.

Respirology. 2016 Apr;21(3):467-75. doi: 10.1111/resp.12730. Epub 2016 Jan 25.


COPD is characterized by increased detection of Haemophilus influenzae, Streptococcus pneumoniae and a deficiency of Bacillus species.

Simpson JL, Baines KJ, Horvat JC, Essilfie AT, Brown AC, Tooze M, McDonald VM, Gibson PG, Hansbro PM.

Respirology. 2016 May;21(4):697-704. doi: 10.1111/resp.12734. Epub 2016 Jan 18.


Increased asthma and adipose tissue inflammatory gene expression with obesity and Inuit migration to a western country.

Backer V, Baines KJ, Powell H, Porsbjerg C, Gibson PG.

Respir Med. 2016 Feb;111:8-15. doi: 10.1016/j.rmed.2015.12.003. Epub 2015 Dec 19.


Changes in Expression of Genes Regulating Airway Inflammation Following a High-Fat Mixed Meal in Asthmatics.

Li Q, Baines KJ, Gibson PG, Wood LG.

Nutrients. 2016 Jan 7;8(1). pii: E30. doi: 10.3390/nu8010030.


Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma.

Wang G, Baines KJ, Fu JJ, Wood LG, Simpson JL, McDonald VM, Cowan DC, Taylor DR, Cowan JO, Gibson PG.

Eur Respir J. 2016 Apr;47(4):1123-33. doi: 10.1183/13993003.01098-2015. Epub 2015 Dec 23.


Altered Innate Immune Responses in Neutrophils from Patients with Well- and Suboptimally Controlled Asthma.

Tang FS, Foxley GJ, Gibson PG, Burgess JK, Baines KJ, Oliver BG.

Mediators Inflamm. 2015;2015:219374. doi: 10.1155/2015/219374. Epub 2015 Nov 18.


Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma.

Simpson JL, Daly J, Baines KJ, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Hugenholtz P, Willner D, Gibson PG.

Eur Respir J. 2016 Mar;47(3):792-800. doi: 10.1183/13993003.00405-2015. Epub 2015 Dec 2.


Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma.

Baines KJ, Wright TK, Simpson JL, McDonald VM, Wood LG, Parsons KS, Wark PA, Gibson PG.

Mediators Inflamm. 2015;2015:407271. doi: 10.1155/2015/407271. Epub 2015 Oct 19.


Differential neutrophil activation in viral infections: Enhanced TLR-7/8-mediated CXCL8 release in asthma.

Tang FS, Van Ly D, Spann K, Reading PC, Burgess JK, Hartl D, Baines KJ, Oliver BG.

Respirology. 2016 Jan;21(1):172-9. doi: 10.1111/resp.12657. Epub 2015 Oct 18.


Increased Peripheral Blood Pro-Inflammatory/Cytotoxic Lymphocytes in Children with Bronchiectasis.

Hodge G, Upham JW, Chang AB, Baines KJ, Yerkovich ST, Pizzutto SJ, Hodge S.

PLoS One. 2015 Aug 10;10(8):e0133695. doi: 10.1371/journal.pone.0133695. eCollection 2015.


Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation.

Sverrild A, Bergqvist A, Baines KJ, Porsbjerg C, Andersson CK, Thomsen SF, Hoffmann HJ, Gibson P, Erjefält JS, Backer V.

Clin Exp Allergy. 2016 Feb;46(2):288-97. doi: 10.1111/cea.12609.


Understanding Xeroderma Pigmentosum Complementation Groups Using Gene Expression Profiling after UV-Light Exposure.

Bowden NA, Beveridge NJ, Ashton KA, Baines KJ, Scott RJ.

Int J Mol Sci. 2015 Jul 14;16(7):15985-96. doi: 10.3390/ijms160715985.


Investigating the effects of arctic dietary intake on lung health.

Baines KJ, Backer V, Gibson PG, Powell H, Porsbjerg CM.

Eur J Clin Nutr. 2015 Nov;69(11):1262-6. doi: 10.1038/ejcn.2015.85. Epub 2015 May 27.


Airway IL-1β and Systemic Inflammation as Predictors of Future Exacerbation Risk in Asthma and COPD.

Fu JJ, McDonald VM, Baines KJ, Gibson PG.

Chest. 2015 Sep;148(3):618-629. doi: 10.1378/chest.14-2337.


Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β.

Gao P, Gibson PG, Baines KJ, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Zhang J, Simpson JL.

Respir Res. 2015 Jan 24;16:5. doi: 10.1186/s12931-014-0163-5.


Impaired lung function is associated with systemic inflammation and macrophage activation.

Baines KJ, Backer V, Gibson PG, Powel H, Porsbjerg CM.

Eur Respir J. 2015 Feb;45(2):557-9. doi: 10.1183/09031936.00187514. Epub 2014 Dec 10. No abstract available.


The role of biomarkers in the management of airways disease.

Baines KJ, Pavord ID, Gibson PG.

Int J Tuberc Lung Dis. 2014 Nov;18(11):1264-8. doi: 10.5588/ijtld.14.0226.


The effect of azithromycin in adults with stable neutrophilic COPD: a double blind randomised, placebo controlled trial.

Simpson JL, Powell H, Baines KJ, Milne D, Coxson HO, Hansbro PM, Gibson PG.

PLoS One. 2014 Aug 22;9(8):e105609. doi: 10.1371/journal.pone.0105609. eCollection 2014.


Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma.

Gunawardhana LP, Gibson PG, Simpson JL, Benton MC, Lea RA, Baines KJ.

Epigenetics. 2014 Sep;9(9):1302-16. doi: 10.4161/epi.33066. Epub 2014 Aug 11.

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