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Effective glucose metabolism maintains low intracellular glucose in airway epithelial cells after exposure to hyperglycemia.

Bearham J, Garnett JP, Schroeder V, Biggart MGS, Baines DL.

Am J Physiol Cell Physiol. 2019 Nov 1;317(5):C983-C992. doi: 10.1152/ajpcell.00193.2019. Epub 2019 Aug 21.


Metformin attenuates the effect of Staphylococcus aureus on airway tight junctions by increasing PKCζ-mediated phosphorylation of occludin.

Kalsi KK, Garnett JP, Patkee W, Weekes A, Dockrell ME, Baker EH, Baines DL.

J Cell Mol Med. 2019 Jan;23(1):317-327. doi: 10.1111/jcmm.13929. Epub 2018 Nov 18.


Differential Effect of LPS on Glucose, Lactate and Inflammatory Markers in the Lungs of Normal and Diabetic Mice.

Holmberg CN, Åstrand A, Wingren C, Garnett JP, Mayer G, Taylor JD, Baker EH, Baines DL.

J Pulm Respir Med. 2017 May 11;2017(1). pii: PROA-101.


TEMPORARY REMOVAL: The Frontier Framework (and its eight Frontier Archetypes): A new conceptual approach to representing staff and patient well-being in health systems.

Baines DL.

Soc Sci Med. 2018 Jul;208:98-106. doi: 10.1016/j.socscimed.2018.04.043. Epub 2018 May 4. No abstract available.


Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung.

Tagalakis AD, Munye MM, Ivanova R, Chen H, Smith CM, Aldossary AM, Rosa LZ, Moulding D, Barnes JL, Kafetzis KN, Jones SA, Baines DL, Moss GWJ, O'Callaghan C, McAnulty RJ, Hart SL.

Thorax. 2018 Sep;73(9):847-856. doi: 10.1136/thoraxjnl-2017-210670. Epub 2018 May 10.


Economic evaluation of prescribing conventional and newer oral anticoagulants in older adults.

Hasan SS, Kow CS, Curley LE, Baines DL, Babar ZU.

Expert Rev Pharmacoecon Outcomes Res. 2018 Aug;18(4):371-377. doi: 10.1080/14737167.2018.1474101. Epub 2018 May 9. Review.


Airway Glucose Homeostasis: A New Target in the Prevention and Treatment of Pulmonary Infection.

Baker EH, Baines DL.

Chest. 2018 Feb;153(2):507-514. doi: 10.1016/j.chest.2017.05.031. Epub 2017 Jun 10. Review.


Dapagliflozin-lowered blood glucose reduces respiratory Pseudomonas aeruginosa infection in diabetic mice.

Åstrand A, Wingren C, Benjamin A, Tregoning JS, Garnett JP, Groves H, Gill S, Orogo-Wenn M, Lundqvist AJ, Walters D, Smith DM, Taylor JD, Baker EH, Baines DL.

Br J Pharmacol. 2017 May;174(9):836-847. doi: 10.1111/bph.13741. Epub 2017 Mar 9.


The impact of injuries on health service resource use and costs in primary and secondary care in the English NHS.

Kellezi B, Baines DL, Coupland C, Beckett K, Barnes J, Sleney J, Christie N, Kendrick D.

J Public Health (Oxf). 2016 Dec 2;38(4):e464-e471. doi: 10.1093/pubmed/fdv173. No abstract available.


BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity.

Munye MM, Shoemark A, Hirst RA, Delhove JM, Sharp TV, McKay TR, O'Callaghan C, Baines DL, Howe SJ, Hart SL.

Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L258-L267. doi: 10.1152/ajplung.00471.2016. Epub 2016 Dec 15.


Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion.

Garnett JP, Kalsi KK, Sobotta M, Bearham J, Carr G, Powell J, Brodlie M, Ward C, Tarran R, Baines DL.

Sci Rep. 2016 Nov 29;6:37955. doi: 10.1038/srep37955.


Increased airway glucose increases airway bacterial load in hyperglycaemia.

Gill SK, Hui K, Farne H, Garnett JP, Baines DL, Moore LS, Holmes AH, Filloux A, Tregoning JS.

Sci Rep. 2016 Jun 8;6:27636. doi: 10.1038/srep27636.


Metformin prevents the effects of Pseudomonas aeruginosa on airway epithelial tight junctions and restricts hyperglycaemia-induced bacterial growth.

Patkee WR, Carr G, Baker EH, Baines DL, Garnett JP.

J Cell Mol Med. 2016 Apr;20(4):758-64. doi: 10.1111/jcmm.12784. Epub 2016 Feb 2.


Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model.

Zuckermann AM, La Ragione RM, Baines DL, Williams RS.

Br J Pharmacol. 2015 Nov;172(22):5306-17. doi: 10.1111/bph.13320. Epub 2015 Oct 22.


Interaction between extracellular matrix molecules and microbial pathogens: evidence for the missing link in autoimmunity with rheumatoid arthritis as a disease model.

Sofat N, Wait R, Robertson SD, Baines DL, Baker EH.

Front Microbiol. 2015 Jan 14;5:783. doi: 10.3389/fmicb.2014.00783. eCollection 2014.


A novel fluorescent sensor protein for detecting changes in airway surface liquid glucose concentration.

Helassa N, Garnett JP, Farrant M, Khan F, Pickup JC, Hahn KM, MacNevin CJ, Tarran R, Baines DL.

Biochem J. 2014 Dec 1;464(2):213-20. doi: 10.1042/BJ20141041.


Fructose transport-deficient Staphylococcus aureus reveals important role of epithelial glucose transporters in limiting sugar-driven bacterial growth in airway surface liquid.

Garnett JP, Braun D, McCarthy AJ, Farrant MR, Baker EH, Lindsay JA, Baines DL.

Cell Mol Life Sci. 2014 Dec;71(23):4665-73. doi: 10.1007/s00018-014-1635-y. Epub 2014 May 9.


Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes.

Badshah II, Baines DL, Dockrell ME.

Front Pharmacol. 2014 Apr 21;5:71. doi: 10.3389/fphar.2014.00071. eCollection 2014.


The phosphorylation of endogenous Nedd4-2 In Na(+)-absorbing human airway epithelial cells.

Ismail NA, Baines DL, Wilson SM.

Eur J Pharmacol. 2014 Jun 5;732:32-42. doi: 10.1016/j.ejphar.2014.03.005. Epub 2014 Mar 18.


The dangers of the day of birth.

Walker KF, Cohen AL, Walker SH, Allen KM, Baines DL, Thornton JG.

BJOG. 2014 May;121(6):714-8. doi: 10.1111/1471-0528.12544. Epub 2014 Feb 13. Review.


Elevated paracellular glucose flux across cystic fibrosis airway epithelial monolayers is an important factor for Pseudomonas aeruginosa growth.

Garnett JP, Gray MA, Tarran R, Brodlie M, Ward C, Baker EH, Baines DL.

PLoS One. 2013 Oct 4;8(10):e76283. doi: 10.1371/journal.pone.0076283. eCollection 2013.


Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose.

Garnett JP, Baker EH, Naik S, Lindsay JA, Knight GM, Gill S, Tregoning JS, Baines DL.

Thorax. 2013 Sep;68(9):835-45. doi: 10.1136/thoraxjnl-2012-203178. Epub 2013 May 24.


The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes.

Yang HY, Charles RP, Hummler E, Baines DL, Isseroff RR.

J Cell Sci. 2013 May 1;126(Pt 9):1942-51. doi: 10.1242/jcs.113225. Epub 2013 Feb 27.


Sweet talk: insights into the nature and importance of glucose transport in lung epithelium.

Garnett JP, Baker EH, Baines DL.

Eur Respir J. 2012 Nov;40(5):1269-76. doi: 10.1183/09031936.00052612. Epub 2012 Aug 9. Review.


Proinflammatory mediators disrupt glucose homeostasis in airway surface liquid.

Garnett JP, Nguyen TT, Moffatt JD, Pelham ER, Kalsi KK, Baker EH, Baines DL.

J Immunol. 2012 Jul 1;189(1):373-80. doi: 10.4049/jimmunol.1200718. Epub 2012 May 23.


AMP-activated protein kinase (AMPK)-dependent and -independent pathways regulate hypoxic inhibition of transepithelial Na+ transport across human airway epithelial cells.

Tan CD, Smolenski RT, Harhun MI, Patel HK, Ahmed SG, Wanisch K, Yáñez-Muñoz RJ, Baines DL.

Br J Pharmacol. 2012 Sep;167(2):368-82. doi: 10.1111/j.1476-5381.2012.01993.x.


The gasotransmitter hydrogen sulphide decreases Na⁺ transport across pulmonary epithelial cells.

Althaus M, Urness KD, Clauss WG, Baines DL, Fronius M.

Br J Pharmacol. 2012 Jul;166(6):1946-63. doi: 10.1111/j.1476-5381.2012.01909.x.


Lipopolysaccharide modifies amiloride-sensitive Na+ transport processes across human airway cells: role of mitogen-activated protein kinases ERK 1/2 and 5.

Baines DL, Albert AP, Hazell MJ, Gambling L, Woollhead AM, Dockrell ME.

Pflugers Arch. 2010 Feb;459(3):451-63. doi: 10.1007/s00424-009-0717-4. Epub 2009 Oct 13.


Glucose homeostasis across human airway epithelial cell monolayers: role of diffusion, transport and metabolism.

Kalsi KK, Baker EH, Fraser O, Chung YL, Mace OJ, Tarelli E, Philips BJ, Baines DL.

Pflugers Arch. 2009 Mar;457(5):1061-70. doi: 10.1007/s00424-008-0576-4. Epub 2008 Sep 10.


AICAR decreases the activity of two distinct amiloride-sensitive Na+-permeable channels in H441 human lung epithelial cell monolayers.

Albert AP, Woollhead AM, Mace OJ, Baines DL.

Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L837-48. doi: 10.1152/ajplung.90353.2008. Epub 2008 Aug 22.


AICAR activates AMPK and alters PIP2 association with the epithelial sodium channel ENaC to inhibit Na+ transport in H441 lung epithelial cells.

Mace OJ, Woollhead AM, Baines DL.

J Physiol. 2008 Sep 15;586(18):4541-57. doi: 10.1113/jphysiol.2008.158253. Epub 2008 Jul 31.


KCNQ-encoded channels regulate Na+ transport across H441 lung epithelial cells.

Greenwood IA, Yeung SY, Hettiarachi S, Andersson M, Baines DL.

Pflugers Arch. 2009 Feb;457(4):785-94. doi: 10.1007/s00424-008-0557-7. Epub 2008 Jul 29.


TGF-beta activates ERK5 in human renal epithelial cells.

Browne JA, Pearson AL, Zahr RA, Niculescu-Duvaz I, Baines DL, Dockrell ME.

Biochem Biophys Res Commun. 2008 Aug 29;373(3):440-4. doi: 10.1016/j.bbrc.2008.06.058. Epub 2008 Jun 25.


Apical and basolateral localisation of GLUT2 transporters in human lung epithelial cells.

Kalsi KK, Baker EH, Medina RA, Rice S, Wood DM, Ratoff JC, Philips BJ, Baines DL.

Pflugers Arch. 2008 Aug;456(5):991-1003. doi: 10.1007/s00424-008-0459-8. Epub 2008 Feb 1.


Role played by disabled-2 in albumin induced MAP Kinase signalling.

Diwakar R, Pearson AL, Colville-Nash P, Baines DL, Dockrell ME.

Biochem Biophys Res Commun. 2008 Feb 15;366(3):675-80. Epub 2007 Dec 10.


Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells.

Woollhead AM, Sivagnanasundaram J, Kalsi KK, Pucovsky V, Pellatt LJ, Scott JW, Mustard KJ, Hardie DG, Baines DL.

Br J Pharmacol. 2007 Aug;151(8):1204-15. Epub 2007 Jul 2.


Hyperglycemia and cystic fibrosis alter respiratory fluid glucose concentrations estimated by breath condensate analysis.

Baker EH, Clark N, Brennan AL, Fisher DA, Gyi KM, Hodson ME, Philips BJ, Baines DL, Wood DM.

J Appl Physiol (1985). 2007 May;102(5):1969-75. Epub 2007 Feb 15.


Hyperglycaemia and pulmonary infection.

Baker EH, Wood DM, Brennan AL, Clark N, Baines DL, Philips BJ.

Proc Nutr Soc. 2006 Aug;65(3):227-35. Review.


Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosis.

Brennan AL, Gyi KM, Wood DM, Johnson J, Holliman R, Baines DL, Philips BJ, Geddes DM, Hodson ME, Baker EH.

J Cyst Fibros. 2007 Apr;6(2):101-9. Epub 2006 Jul 17.


Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease.

Baker EH, Janaway CH, Philips BJ, Brennan AL, Baines DL, Wood DM, Jones PW.

Thorax. 2006 Apr;61(4):284-9. Epub 2006 Jan 31.


The hormonal control of uterine luminal fluid secretion and absorption.

Salleh N, Baines DL, Naftalin RJ, Milligan SR.

J Membr Biol. 2005 Jul;206(1):17-28.


New insights into the glucose oxidase stick test for cerebrospinal fluid rhinorrhoea.

Baker EH, Wood DM, Brennan AL, Baines DL, Philips BJ.

Emerg Med J. 2005 Aug;22(8):556-7.


Estrogen and progesterone regulate alpha, beta, and gammaENaC subunit mRNA levels in female rat kidney.

Gambling L, Dunford S, Wilson CA, McArdle HJ, Baines DL.

Kidney Int. 2004 May;65(5):1774-81.


Primary care physicians' attitudes to health care reform in England.

Whynes DK, Baines DL.

Health Policy. 2002 May;60(2):111-32.


Fatty acid modulation and sequence identity of fetal guinea pig alveolar type II cell amiloride-sensitive Na+ channel.

Baines DL, MacGregor GG, Kemp PJ.

Biochem Biophys Res Commun. 2001 Nov 2;288(3):727-35.


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