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Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine.

Rahim MN, Wee EG, He S, Audet J, Tierney K, Moyo N, Hannoun Z, Crook A, Baines A, Korber B, Qiu X, Hanke T.

PLoS Pathog. 2019 Feb 28;15(2):e1007564. doi: 10.1371/journal.ppat.1007564. eCollection 2019 Feb.


Impact of Naja nigricollis Venom on the Production of Methaemoglobin.

Williams HF, Hayter P, Ravishankar D, Baines A, Layfield HJ, Croucher L, Wark C, Bicknell AB, Trim S, Vaiyapuri S.

Toxins (Basel). 2018 Dec 15;10(12). pii: E539. doi: 10.3390/toxins10120539.


Anti-inflammatory duration of action of fluticasone furoate/vilanterol trifenatate in asthma: a cross-over randomised controlled trial.

Bardsley G, Daley-Yates P, Baines A, Kempsford R, Williams M, Mallon T, Braithwaite I, Riddell K, Joshi S, Bareille P, Beasley R, Fingleton J; study team.

Respir Res. 2018 Jul 13;19(1):133. doi: 10.1186/s12931-018-0836-6.


Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth.

Krulikas LJ, McDonald IM, Lee B, Okumu DO, East MP, Gilbert TSK, Herring LE, Golitz BT, Wells CI, Axtman AD, Zuercher WJ, Willson TM, Kireev D, Yeh JJ, Johnson GL, Baines AT, Graves LM.

SLAS Discov. 2018 Sep;23(8):850-861. doi: 10.1177/2472555218773045. Epub 2018 May 9.


Effectiveness of ivacaftor in cystic fibrosis patients with non-G551D gating mutations.

Guimbellot J, Solomon GM, Baines A, Heltshe SL, VanDalfsen J, Joseloff E, Sagel SD, Rowe SM; GOALe(2) Investigators.

J Cyst Fibros. 2019 Jan;18(1):102-109. doi: 10.1016/j.jcf.2018.04.004. Epub 2018 Apr 21.


Germline mutations in the alternative pathway of complement predispose to HELLP syndrome.

Vaught AJ, Braunstein EM, Jasem J, Yuan X, Makhlin I, Eloundou S, Baines AC, Merrill SA, Chaturvedi S, Blakemore K, Sperati CJ, Brodsky RA.

JCI Insight. 2018 Mar 22;3(6). pii: 99128. doi: 10.1172/jci.insight.99128.


Ivacaftor-treated Patients with Cystic Fibrosis Derive Long-Term Benefit Despite No Short-Term Clinical Improvement.

Heltshe SL, Rowe SM, Skalland M, Baines A, Jain M; GOAL Investigators of the Cystic Fibrosis Foundation Therapeutics Development Network.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1483-1486. doi: 10.1164/rccm.201710-2046LE. No abstract available.


Longitudinal development of initial, chronic and mucoid Pseudomonas aeruginosa infection in young children with cystic fibrosis.

Heltshe SL, Khan U, Beckett V, Baines A, Emerson J, Sanders DB, Gibson RL, Morgan W, Rosenfeld M.

J Cyst Fibros. 2018 May;17(3):341-347. doi: 10.1016/j.jcf.2017.10.008. Epub 2017 Oct 28.


A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model.

Yuan X, Li Z, Baines AC, Gavriilaki E, Ye Z, Wen Z, Braunstein EM, Biesecker LG, Cheng L, Dong X, Brodsky RA.

PLoS One. 2017 Apr 25;12(4):e0174074. doi: 10.1371/journal.pone.0174074. eCollection 2017.



Baines AC, Brodsky RA.

Blood Rev. 2017 Jul;31(4):213-223. doi: 10.1016/j.blre.2017.02.003. Epub 2017 Feb 6. Review.


Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS.

Saintas E, Abrahams L, Ahmad GT, Ajakaiye AM, AlHumaidi AS, Ashmore-Harris C, Clark I, Dura UK, Fixmer CN, Ike-Morris C, Mato Prado M, Mccullough D, Mishra S, Schöler KM, Timur H, Williamson MD, Alatsatianos M, Bahsoun B, Blackburn E, Hogwood CE, Lithgow PE, Rowe M, Yiangou L, Rothweiler F, Cinatl J Jr, Zehner R, Baines AJ, Garrett MD, Gourlay CW, Griffin DK, Gullick WJ, Hargreaves E, Howard MJ, Lloyd DR, Rossman JS, Smales CM, Tsaousis AD, von der Haar T, Wass MN, Michaelis M.

PLoS One. 2017 Feb 13;12(2):e0172140. doi: 10.1371/journal.pone.0172140. eCollection 2017.


Current and Emerging Targeting Strategies for Treatment of Pancreatic Cancer.

Baines AT, Martin PM, Rorie CJ.

Prog Mol Biol Transl Sci. 2016;144:277-320. doi: 10.1016/bs.pmbts.2016.09.006. Epub 2016 Oct 26. Review.


Microbiological efficacy of early MRSA treatment in cystic fibrosis in a randomised controlled trial.

Muhlebach MS, Beckett V, Popowitch E, Miller MB, Baines A, Mayer-Hamblett N, Zemanick ET, Hoover WC, VanDalfsen JM, Campbell P, Goss CH; STAR-too study team.

Thorax. 2017 Apr;72(4):318-326. doi: 10.1136/thoraxjnl-2016-208949. Epub 2016 Nov 15.


Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.

Yuan X, Gavriilaki E, Thanassi JA, Yang G, Baines AC, Podos SD, Huang Y, Huang M, Brodsky RA.

Haematologica. 2017 Mar;102(3):466-475. doi: 10.3324/haematol.2016.153312. Epub 2016 Nov 3.


Randomised, double-blind, placebo-controlled, cross-over single dose study of the bronchodilator duration of action of combination fluticasone furoate/vilanterol inhaler in adult asthma.

Braithwaite I, Williams M, Power S, Pilcher J, Weatherall M, Baines A, Moynihan J, Kempsford R, Beasley R; FF/VI Study Team.

Respir Med. 2016 Oct;119:115-121. doi: 10.1016/j.rmed.2016.09.006. Epub 2016 Sep 4.


The efficacy of fluticasone furoate administered in the morning or evening is comparable in patients with persistent asthma.

Kempsford RD, Bal J, Baines A, Renaux J, Ravindranath R, Thomas PS.

Respir Med. 2016 Mar;112:18-24. doi: 10.1016/j.rmed.2015.12.011. Epub 2016 Jan 12.


Protein 4.1G Regulates Cell Adhesion, Spreading, and Migration of Mouse Embryonic Fibroblasts through the β1 Integrin Pathway.

Chen L, Wang T, Wang Y, Zhang J, Qi Y, Weng H, Kang Q, Guo X, Baines AJ, Mohandas N, An X.

J Biol Chem. 2016 Jan 29;291(5):2170-80. doi: 10.1074/jbc.M115.658591. Epub 2015 Dec 7.


Effect of Disease Severity in Asthma and Chronic Obstructive Pulmonary Disease on Inhaler-Specific Inhalation Profiles Through the ELLIPTA® Dry Powder Inhaler.

Prime D, de Backer W, Hamilton M, Cahn A, Preece A, Kelleher D, Baines A, Moore A, Brealey N, Moynihan J.

J Aerosol Med Pulm Drug Deliv. 2015 Dec;28(6):486-97. doi: 10.1089/jamp.2015.1224. Epub 2015 Sep 15.


Pseudomonas aeruginosa in cystic fibrosis patients with G551D-CFTR treated with ivacaftor.

Heltshe SL, Mayer-Hamblett N, Burns JL, Khan U, Baines A, Ramsey BW, Rowe SM; GOAL (the G551D Observation-AL) Investigators of the Cystic Fibrosis Foundation Therapeutics Development Network.

Clin Infect Dis. 2015 Mar 1;60(5):703-12. doi: 10.1093/cid/ciu944. Epub 2014 Nov 25.


Comprehensive characterization of protein 4.1 expression in epithelium of large intestine.

Zhang J, Yang S, An C, Wang J, Yan H, Huang Y, Song J, Yin C, Baines AJ, Mohandas N, An X.

Histochem Cell Biol. 2014 Nov;142(5):529-39. doi: 10.1007/s00418-014-1224-z. Epub 2014 Jun 10.


Pulmonary exacerbations and parent-reported outcomes in children <6 years with cystic fibrosis.

Brumback LC, Baines A, Ratjen F, Davis SD, Daniel SL, Quittner AL, Rosenfeld M; ISIS Study Group.

Pediatr Pulmonol. 2015 Mar;50(3):236-243. doi: 10.1002/ppul.23056. Epub 2014 Apr 29.


A 130-kDa protein 4.1B regulates cell adhesion, spreading, and migration of mouse embryo fibroblasts by influencing actin cytoskeleton organization.

Wang J, Song J, An C, Dong W, Zhang J, Yin C, Hale J, Baines AJ, Mohandas N, An X.

J Biol Chem. 2014 Feb 28;289(9):5925-37. doi: 10.1074/jbc.M113.516617. Epub 2013 Dec 31.


Calcium-dependent regulation of Rab activation and vesicle fusion by an intracellular P2X ion channel.

Parkinson K, Baines AE, Keller T, Gruenheit N, Bragg L, North RA, Thompson CR.

Nat Cell Biol. 2014 Jan;16(1):87-98. doi: 10.1038/ncb2887. Epub 2013 Dec 15.


Sympatric inhibition and niche differentiation suggest alternative coevolutionary trajectories among Streptomycetes.

Kinkel LL, Schlatter DC, Xiao K, Baines AD.

ISME J. 2014 Feb;8(2):249-56. doi: 10.1038/ismej.2013.175. Epub 2013 Oct 24. Erratum in: ISME J. 2014 Feb;8(2):492.


A conserved sequence in calmodulin regulated spectrin-associated protein 1 links its interaction with spectrin and calmodulin to neurite outgrowth.

King MD, Phillips GW, Bignone PA, Hayes NV, Pinder JC, Baines AJ.

J Neurochem. 2014 Feb;128(3):391-402. doi: 10.1111/jnc.12462. Epub 2013 Oct 24.


Link up and fold up--templating the formation of spectrin tetramers.

Baines AJ.

J Mol Biol. 2014 Jan 9;426(1):7-10. doi: 10.1016/j.jmb.2013.10.005. Epub 2013 Oct 7. No abstract available.


Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine.

Xu D, Cobb MG, Gavilano L, Witherspoon SM, Williams D, White CD, Taverna P, Bednarski BK, Kim HJ, Baldwin AS, Baines AT.

Cancer Biol Ther. 2013 Jun;14(6):492-501. doi: 10.4161/cbt.24343.


The Protein 4.1 family: hub proteins in animals for organizing membrane proteins.

Baines AJ, Lu HC, Bennett PM.

Biochim Biophys Acta. 2014 Feb;1838(2):605-19. doi: 10.1016/j.bbamem.2013.05.030. Epub 2013 Jun 4. Review.


Functional properties of five Dictyostelium discoideum P2X receptors.

Baines A, Parkinson K, Sim JA, Bragg L, Thompson CR, North RA.

J Biol Chem. 2013 Jul 19;288(29):20992-1000. doi: 10.1074/jbc.M112.445346. Epub 2013 Jun 5.


Disruption of the Sec24d gene results in early embryonic lethality in the mouse.

Baines AC, Adams EJ, Zhang B, Ginsburg D.

PLoS One. 2013 Apr 15;8(4):e61114. doi: 10.1371/journal.pone.0061114. Print 2013.


SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.

Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX, Ma D, Bai Y, Liu HH, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG, Schekman R, Ginsburg D.

Elife. 2013 Apr 9;2:e00444. doi: 10.7554/eLife.00444.


Analgesic efficacy and safety of the novel p38 MAP kinase inhibitor, losmapimod, in patients with neuropathic pain following peripheral nerve injury: a double-blind, placebo-controlled study.

Ostenfeld T, Krishen A, Lai RY, Bullman J, Baines AJ, Green J, Anand P, Kelly M.

Eur J Pain. 2013 Jul;17(6):844-57. doi: 10.1002/j.1532-2149.2012.00256.x. Epub 2012 Dec 14.


Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca2+ homeostasis system.

Pinder JC, Taylor-Harris PM, Bennett PM, Carter E, Hayes NV, King MD, Holt MR, Maggs AM, Gascard P, Baines AJ.

Exp Cell Res. 2012 Aug 1;318(13):1467-79. doi: 10.1016/j.yexcr.2012.03.003. Epub 2012 Mar 10.


Expression of the blood-group-related glycosyltransferase B4galnt2 influences the intestinal microbiota in mice.

Staubach F, Künzel S, Baines AC, Yee A, McGee BM, Bäckhed F, Baines JF, Johnsen JM.

ISME J. 2012 Jul;6(7):1345-55. doi: 10.1038/ismej.2011.204. Epub 2012 Jan 26.


Inhibition of Ras for cancer treatment: the search continues.

Baines AT, Xu D, Der CJ.

Future Med Chem. 2011 Oct;3(14):1787-808. doi: 10.4155/fmc.11.121. Review.


Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.

Zhang B, Zheng C, Zhu M, Tao J, Vasievich MP, Baines A, Kim J, Schekman R, Kaufman RJ, Ginsburg D.

Blood. 2011 Sep 22;118(12):3384-91. doi: 10.1182/blood-2011-05-352815. Epub 2011 Jul 27.


Protein 4.1R regulates cell adhesion, spreading, migration and motility of mouse keratinocytes by modulating surface expression of beta1 integrin.

Chen L, Hughes RA, Baines AJ, Conboy J, Mohandas N, An X.

J Cell Sci. 2011 Jul 15;124(Pt 14):2478-87. doi: 10.1242/jcs.078170. Epub 2011 Jun 21.


Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury.

Anand P, Shenoy R, Palmer JE, Baines AJ, Lai RY, Robertson J, Bird N, Ostenfeld T, Chizh BA.

Eur J Pain. 2011 Nov;15(10):1040-8. doi: 10.1016/j.ejpain.2011.04.005. Epub 2011 May 14.


Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility.

Yang S, Weng H, Chen L, Guo X, Parra M, Conboy J, Debnath G, Lambert AJ, Peters LL, Baines AJ, Mohandas N, An X.

Mol Cell Biol. 2011 Jun;31(11):2276-86. doi: 10.1128/MCB.01105-10. Epub 2011 Apr 11.


Differential trafficking of adenosine receptors in hippocampal neurons monitored using GFP- and super-ecliptic pHluorin-tagged receptors.

Baines AE, Corrêa SA, Irving AJ, Frenguelli BG.

Neuropharmacology. 2011 Jul-Aug;61(1-2):1-11. doi: 10.1016/j.neuropharm.2011.02.005. Epub 2011 Feb 17.


The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells.

Xu D, Allsop SA, Witherspoon SM, Snider JL, Yeh JJ, Fiordalisi JJ, White CD, Williams D, Cox AD, Baines AT.

Carcinogenesis. 2011 Apr;32(4):488-95. doi: 10.1093/carcin/bgr007. Epub 2011 Jan 24.


Inter-subunit interactions in erythroid and non-erythroid spectrins.

An X, Guo X, Yang Y, Gratzer WB, Baines AJ, Mohandas N.

Biochim Biophys Acta. 2011 Mar;1814(3):420-7. doi: 10.1016/j.bbapap.2010.12.010. Epub 2011 Jan 5.


Comprehensive characterization of expression patterns of protein 4.1 family members in mouse adrenal gland: implications for functions.

Wang H, Liu C, Debnath G, Baines AJ, Conboy JG, Mohandas N, An X.

Histochem Cell Biol. 2010 Oct;134(4):411-20. doi: 10.1007/s00418-010-0749-z. Epub 2010 Oct 2.


Evolution of the spectrin-based membrane skeleton.

Baines AJ.

Transfus Clin Biol. 2010 Sep;17(3):95-103. doi: 10.1016/j.tracli.2010.06.008. Epub 2010 Aug 4.


The spectrin-ankyrin-4.1-adducin membrane skeleton: adapting eukaryotic cells to the demands of animal life.

Baines AJ.

Protoplasma. 2010 Aug;244(1-4):99-131. doi: 10.1007/s00709-010-0181-1. Epub 2010 Jul 29. Review.


Evolution of spectrin function in cytoskeletal and membrane networks.

Baines AJ.

Biochem Soc Trans. 2009 Aug;37(Pt 4):796-803. doi: 10.1042/BST0370796. Review.


The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins.

Baines AJ, Bignone PA, King MD, Maggs AM, Bennett PM, Pinder JC, Phillips GW.

Mol Biol Evol. 2009 Sep;26(9):2005-14. doi: 10.1093/molbev/msp115. Epub 2009 Jun 9.


Protein 4.1 and the control of ion channels.

Baines AJ, Bennett PM, Carter EW, Terracciano C.

Blood Cells Mol Dis. 2009 May-Jun;42(3):211-5. doi: 10.1016/j.bcmd.2009.01.016. Epub 2009 Mar 9. Review.


Fungal phyllosphere communities are altered by indirect interactions among trophic levels.

Perez JL, French JV, Summy KR, Baines AD, Little CR.

Microb Ecol. 2009 May;57(4):766-74. doi: 10.1007/s00248-008-9477-5. Epub 2009 Jan 6.


Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart.

Stagg MA, Carter E, Sohrabi N, Siedlecka U, Soppa GK, Mead F, Mohandas N, Taylor-Harris P, Baines A, Bennett P, Yacoub MH, Pinder JC, Terracciano CM.

Circ Res. 2008 Oct 10;103(8):855-63. doi: 10.1161/CIRCRESAHA.108.176461. Epub 2008 Sep 11.


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