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Items: 1 to 50 of 107

1.

A Cross-Sectional and Longitudinal Study of Retinal Sensitivity in RPE65-Associated Leber Congenital Amaurosis.

Kumaran N, Rubin GS, Kalitzeos A, Fujinami K, Bainbridge JWB, Weleber RG, Michaelides M.

Invest Ophthalmol Vis Sci. 2018 Jul 2;59(8):3330-3339. doi: 10.1167/iovs.18-23873.

2.

Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in Macular Degeneration.

Mehat MS, Sundaram V, Ripamonti C, Robson AG, Smith AJ, Borooah S, Robinson M, Rosenthal AN, Innes W, Weleber RG, Lee RWJ, Crossland M, Rubin GS, Dhillon B, Steel DHW, Anglade E, Lanza RP, Ali RR, Michaelides M, Bainbridge JWB.

Ophthalmology. 2018 Jun 5. pii: S0161-6420(18)30024-1. doi: 10.1016/j.ophtha.2018.04.037. [Epub ahead of print]

3.

Late neuroprogenitors contribute to normal retinal vascular development in a Hif2a-dependent manner.

Cristante E, Liyanage SE, Sampson RD, Kalargyrou A, De Rossi G, Rizzi M, Hoke J, Ribeiro J, Maswood RN, Duran Y, Matsuki T, Aghaizu ND, Luhmann UF, Smith AJ, Ali RR, Bainbridge JWB.

Development. 2018 Apr 25;145(8). pii: dev157511. doi: 10.1242/dev.157511.

PMID:
29615467
4.

Retinal gene therapy.

Kumaran N, Michaelides M, Smith AJ, Ali RR, Bainbridge JWB.

Br Med Bull. 2018 Jun 1;126(1):13-25. doi: 10.1093/bmb/ldy005.

PMID:
29506236
5.

Severe Loss of Tritan Color Discrimination in RPE65 Associated Leber Congenital Amaurosis.

Kumaran N, Ripamonti C, Kalitzeos A, Rubin GS, Bainbridge JWB, Michaelides M.

Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):85-93. doi: 10.1167/iovs.17-22905.

6.

Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell-Derived Retinal Organoids and Fetal Retinae.

Lakowski J, Welby E, Budinger D, Di Marco F, Di Foggia V, Bainbridge JWB, Wallace K, Gamm DM, Ali RR, Sowden JC.

Stem Cells. 2018 May;36(5):709-722. doi: 10.1002/stem.2775. Epub 2018 Feb 1.

7.

Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner.

Waldron PV, Di Marco F, Kruczek K, Ribeiro J, Graca AB, Hippert C, Aghaizu ND, Kalargyrou AA, Barber AC, Grimaldi G, Duran Y, Blackford SJI, Kloc M, Goh D, Zabala Aldunate E, Sampson RD, Bainbridge JWB, Smith AJ, Gonzalez-Cordero A, Sowden JC, Ali RR, Pearson RA.

Stem Cell Reports. 2018 Feb 13;10(2):406-421. doi: 10.1016/j.stemcr.2017.12.008. Epub 2018 Jan 4.

8.

In situ regeneration of retinal pigment epithelium by gene transfer of E2F2: a potential strategy for treatment of macular degenerations.

Kampik D, Basche M, Luhmann UFO, Nishiguchi KM, Williams JAE, Greenwood J, Moss SE, Han H, Azam S, Duran Y, Robbie SJ, Bainbridge JWB, Larkin DF, Smith AJ, Ali RR.

Gene Ther. 2017 Dec;24(12):810-818. doi: 10.1038/gt.2017.89. Epub 2017 Nov 30.

PMID:
29188796
9.

Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors.

Gonzalez-Cordero A, Kruczek K, Naeem A, Fernando M, Kloc M, Ribeiro J, Goh D, Duran Y, Blackford SJI, Abelleira-Hervas L, Sampson RD, Shum IO, Branch MJ, Gardner PJ, Sowden JC, Bainbridge JWB, Smith AJ, West EL, Pearson RA, Ali RR.

Stem Cell Reports. 2017 Sep 12;9(3):820-837. doi: 10.1016/j.stemcr.2017.07.022. Epub 2017 Aug 24.

10.

Retinal Oximetry Differences Between Optic Disc Collateral Vessels and New Vessels.

Nicholson L, Sivapathasuntharam C, Zola M, Hykin P, Bainbridge JW, Sivaprasad S.

JAMA Ophthalmol. 2017 Sep 1;135(9):1003-1004. doi: 10.1001/jamaophthalmol.2017.2624. No abstract available.

PMID:
28772311
11.

Retinal Nonperfusion in the Posterior Pole Is Associated With Increased Risk of Neovascularization in Central Retinal Vein Occlusion.

Nicholson L, Vazquez-Alfageme C, Patrao NV, Triantafyllopolou I, Bainbridge JW, Hykin PG, Sivaprasad S.

Am J Ophthalmol. 2017 Oct;182:118-125. doi: 10.1016/j.ajo.2017.07.015. Epub 2017 Jul 22.

PMID:
28739419
12.

Early-Onset Progressive Degeneration of the Area Centralis in RPE65-Deficient Dogs.

Mowat FM, Gervais KJ, Occelli LM, Annear MJ, Querubin J, Bainbridge JW, Smith AJ, Ali RR, Petersen-Jones SM.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3268-3277. doi: 10.1167/iovs.17-21930.

PMID:
28662231
13.

Accelerated oxygen-induced retinopathy is a reliable model of ischemia-induced retinal neovascularization.

Villacampa P, Menger KE, Abelleira L, Ribeiro J, Duran Y, Smith AJ, Ali RR, Luhmann UF, Bainbridge JWB.

PLoS One. 2017 Jun 26;12(6):e0179759. doi: 10.1371/journal.pone.0179759. eCollection 2017.

14.

Ranibizumab pretreatment in diabetic vitrectomy: a pilot randomised controlled trial (the RaDiVit study).

Comyn O, Wickham L, Charteris DG, Sullivan PM, Ezra E, Gregor Z, Aylward GW, da Cruz L, Fabinyi D, Peto T, Restori M, Xing W, Bunce C, Hykin PG, Bainbridge JW.

Eye (Lond). 2017 Sep;31(9):1253-1258. doi: 10.1038/eye.2017.75. Epub 2017 May 12.

PMID:
28498374
15.

Vascular endothelial growth factor-A165b ameliorates outer-retinal barrier and vascular dysfunction in the diabetic retina.

Ved N, Hulse RP, Bestall SM, Donaldson LF, Bainbridge JW, Bates DO.

Clin Sci (Lond). 2017 Jun 1;131(12):1225-1243. doi: 10.1042/CS20170102. Epub 2017 Mar 24.

16.

VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation.

Fantin A, Lampropoulou A, Senatore V, Brash JT, Prahst C, Lange CA, Liyanage SE, Raimondi C, Bainbridge JW, Augustin HG, Ruhrberg C.

J Exp Med. 2017 Apr 3;214(4):1049-1064. doi: 10.1084/jem.20160311. Epub 2017 Mar 13.

17.

Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye.

Gardner PJ, Liyanage SE, Cristante E, Sampson RD, Dick AD, Ali RR, Bainbridge JW.

Sci Rep. 2017 Jan 23;7:40830. doi: 10.1038/srep40830.

18.

Development of an optimized AAV2/5 gene therapy vector for Leber congenital amaurosis owing to defects in RPE65.

Georgiadis A, Duran Y, Ribeiro J, Abelleira-Hervas L, Robbie SJ, Sünkel-Laing B, Fourali S, Gonzalez-Cordero A, Cristante E, Michaelides M, Bainbridge JW, Smith AJ, Ali RR.

Gene Ther. 2016 Dec;23(12):857-862. doi: 10.1038/gt.2016.66. Epub 2016 Sep 22.

19.

Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models.

Liyanage SE, Gardner PJ, Ribeiro J, Cristante E, Sampson RD, Luhmann UF, Ali RR, Bainbridge JW.

Exp Eye Res. 2016 Oct;151:160-70. doi: 10.1016/j.exer.2016.08.007. Epub 2016 Aug 18.

20.

Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging.

Robbie SJ, Georgiadis A, Barker SE, Duran Y, Smith AJ, Ali RR, Luhmann UFO, Bainbridge JW.

Neurobiol Aging. 2016 Apr;40:110-119. doi: 10.1016/j.neurobiolaging.2015.12.019. Epub 2016 Jan 4.

PMID:
26973110
21.

Investigation of Aberrant Splicing Induced by AIPL1 Variations as a Cause of Leber Congenital Amaurosis.

Bellingham J, Davidson AE, Aboshiha J, Simonelli F, Bainbridge JW, Michaelides M, van der Spuy J.

Invest Ophthalmol Vis Sci. 2015 Dec 1;56(13):7784-7793. doi: 10.1167/iovs.15-18092.

PMID:
26650897
22.

Spectral sensitivity measurements reveal partial success in restoring missing rod function with gene therapy.

Ripamonti C, Henning GB, Robbie SJ, Sundaram V, van den Born LI, Casteels I, de Ravel TJ, Moore AT, Smith AJ, Bainbridge JW, Ali RR, Stockman A.

J Vis. 2015;15(15):20. doi: 10.1167/15.15.20.

PMID:
26605849
23.

Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization--Brief Report.

Liyanage SE, Fantin A, Villacampa P, Lange CA, Denti L, Cristante E, Smith AJ, Ali RR, Luhmann UF, Bainbridge JW, Ruhrberg C.

Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):19-24. doi: 10.1161/ATVBAHA.115.306681. Epub 2015 Nov 24.

24.

A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocyanine green dye.

Sim DA, Chu CJ, Selvam S, Powner MB, Liyanage S, Copland DA, Keane PA, Tufail A, Egan CA, Bainbridge JW, Lee RW, Dick AD, Fruttiger M.

Dis Model Mech. 2015 Nov;8(11):1479-87. doi: 10.1242/dmm.019018. Epub 2015 Aug 20.

25.

Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age.

Herrmann P, Cowing JA, Cristante E, Liyanage SE, Ribeiro J, Duran Y, Abelleira Hervas L, Carvalho LS, Bainbridge JW, Luhmann UF, Ali RR.

Neurobiol Aging. 2015 Sep;36(9):2637-48. doi: 10.1016/j.neurobiolaging.2015.05.019. Epub 2015 Jun 9.

26.

Novel CCR3 Antagonists Are Effective Mono- and Combination Inhibitors of Choroidal Neovascular Growth and Vascular Permeability.

Nagai N, Ju M, Izumi-Nagai K, Robbie SJ, Bainbridge JW, Gale DC, Pierre E, Krauss AH, Adamson P, Shima DT, Ng YS.

Am J Pathol. 2015 Sep;185(9):2534-49. doi: 10.1016/j.ajpath.2015.04.029. Epub 2015 Jul 16.

27.

IL-4 regulates specific Arg-1(+) macrophage sFlt-1-mediated inhibition of angiogenesis.

Wu WK, Georgiadis A, Copland DA, Liyanage S, Luhmann UF, Robbie SJ, Liu J, Wu J, Bainbridge JW, Bates DO, Ali RR, Nicholson LB, Dick AD.

Am J Pathol. 2015 Aug;185(8):2324-35. doi: 10.1016/j.ajpath.2015.04.013. Epub 2015 Jun 13.

PMID:
26079814
28.

Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel From Embryonic Stem Cell-Derived Self-Forming Retina.

Lakowski J, Gonzalez-Cordero A, West EL, Han YT, Welby E, Naeem A, Blackford SJ, Bainbridge JW, Pearson RA, Ali RR, Sowden JC.

Stem Cells. 2015 Aug;33(8):2469-82. doi: 10.1002/stem.2051. Epub 2015 May 27.

29.

Long-term effect of gene therapy on Leber's congenital amaurosis.

Bainbridge JW, Mehat MS, Sundaram V, Robbie SJ, Barker SE, Ripamonti C, Georgiadis A, Mowat FM, Beattie SG, Gardner PJ, Feathers KL, Luong VA, Yzer S, Balaggan K, Viswanathan A, de Ravel TJ, Casteels I, Holder GE, Tyler N, Fitzke FW, Weleber RG, Nardini M, Moore AT, Thompson DA, Petersen-Jones SM, Michaelides M, van den Born LI, Stockman A, Smith AJ, Rubin G, Ali RR.

N Engl J Med. 2015 May 14;372(20):1887-97. doi: 10.1056/NEJMoa1414221. Epub 2015 May 4.

30.

Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179.

Nishiguchi KM, Carvalho LS, Rizzi M, Powell K, Holthaus SM, Azam SA, Duran Y, Ribeiro J, Luhmann UF, Bainbridge JW, Smith AJ, Ali RR.

Nat Commun. 2015 Jan 23;6:6006. doi: 10.1038/ncomms7006.

31.

Preserved outer retina in AIPL1 Leber's congenital amaurosis: implications for gene therapy.

Aboshiha J, Dubis AM, van der Spuy J, Nishiguchi KM, Cheeseman EW, Ayuso C, Ehrenberg M, Simonelli F, Bainbridge JW, Michaelides M.

Ophthalmology. 2015 Apr;122(4):862-4. doi: 10.1016/j.ophtha.2014.11.019. Epub 2015 Jan 14. No abstract available.

PMID:
25596619
32.

Nature of the visual loss in observers with Leber's congenital amaurosis caused by specific mutations in RPE65.

Ripamonti C, Henning GB, Ali RR, Bainbridge JW, Robbie SJ, Sundaram V, Luong VA, van den Born LI, Casteels I, de Ravel TJ, Moore AT, Stockman A.

Invest Ophthalmol Vis Sci. 2014 Sep 25;55(10):6817-28. doi: 10.1167/iovs.14-14923.

PMID:
25257057
33.

Dark-adaptation functions in molecularly confirmed achromatopsia and the implications for assessment in retinal therapy trials.

Aboshiha J, Luong V, Cowing J, Dubis AM, Bainbridge JW, Ali RR, Webster AR, Moore AT, Fitzke FW, Michaelides M.

Invest Ophthalmol Vis Sci. 2014 Aug 28;55(10):6340-9. doi: 10.1167/iovs.14-14910.

34.

The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors.

Luhmann UF, Carvalho LS, Holthaus SM, Cowing JA, Greenaway S, Chu CJ, Herrmann P, Smith AJ, Munro PM, Potter P, Bainbridge JW, Ali RR.

Hum Mol Genet. 2015 Jan 1;24(1):128-41. doi: 10.1093/hmg/ddu424. Epub 2014 Aug 21.

35.

A prospective longitudinal study of retinal structure and function in achromatopsia.

Aboshiha J, Dubis AM, Cowing J, Fahy RT, Sundaram V, Bainbridge JW, Ali RR, Dubra A, Nardini M, Webster AR, Moore AT, Rubin G, Carroll J, Michaelides M.

Invest Ophthalmol Vis Sci. 2014 Aug 7;55(9):5733-43. doi: 10.1167/iovs.14-14937.

36.

The relevance of chemokine signalling in modulating inherited and age-related retinal degenerations.

Luhmann UF, Robbie SJ, Bainbridge JW, Ali RR.

Adv Exp Med Biol. 2014;801:427-33. doi: 10.1007/978-1-4614-3209-8_54. Review.

PMID:
24664727
37.

A randomized trial to assess functional and structural effects of ranibizumab versus laser in diabetic macular edema (the LUCIDATE study).

Comyn O, Sivaprasad S, Peto T, Neveu MM, Holder GE, Xing W, Bunce CV, Patel PJ, Egan CA, Bainbridge JW, Hykin PG.

Am J Ophthalmol. 2014 May;157(5):960-70. doi: 10.1016/j.ajo.2014.02.019. Epub 2014 Feb 14.

PMID:
24531025
38.

Hsp90 inhibition protects against inherited retinal degeneration.

Aguilà M, Bevilacqua D, McCulley C, Schwarz N, Athanasiou D, Kanuga N, Novoselov SS, Lange CA, Ali RR, Bainbridge JW, Gias C, Coffey PJ, Garriga P, Cheetham ME.

Hum Mol Genet. 2014 Apr 15;23(8):2164-75. doi: 10.1093/hmg/ddt613. Epub 2013 Dec 2.

39.

CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization.

Horie S, Robbie SJ, Liu J, Wu WK, Ali RR, Bainbridge JW, Nicholson LB, Mochizuki M, Dick AD, Copland DA.

Sci Rep. 2013 Oct 30;3:3072. doi: 10.1038/srep03072.

40.

Retinal structure and function in achromatopsia: implications for gene therapy.

Sundaram V, Wilde C, Aboshiha J, Cowing J, Han C, Langlo CS, Chana R, Davidson AE, Sergouniotis PI, Bainbridge JW, Ali RR, Dubra A, Rubin G, Webster AR, Moore AT, Nardini M, Carroll J, Michaelides M.

Ophthalmology. 2014 Jan;121(1):234-245. doi: 10.1016/j.ophtha.2013.08.017. Epub 2013 Oct 20.

41.

Successful gene therapy in older Rpe65-deficient dogs following subretinal injection of an adeno-associated vector expressing RPE65.

Annear MJ, Mowat FM, Bartoe JT, Querubin J, Azam SA, Basche M, Curran PG, Smith AJ, Bainbridge JW, Ali RR, Petersen-Jones SM.

Hum Gene Ther. 2013 Oct;24(10):883-93. doi: 10.1089/hum.2013.146.

PMID:
24028205
42.

Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina.

Gonzalez-Cordero A, West EL, Pearson RA, Duran Y, Carvalho LS, Chu CJ, Naeem A, Blackford SJI, Georgiadis A, Lakowski J, Hubank M, Smith AJ, Bainbridge JWB, Sowden JC, Ali RR.

Nat Biotechnol. 2013 Aug;31(8):741-7. doi: 10.1038/nbt.2643. Epub 2013 Jul 21.

43.

Assessment and in vivo scoring of murine experimental autoimmune uveoretinitis using optical coherence tomography.

Chu CJ, Herrmann P, Carvalho LS, Liyanage SE, Bainbridge JW, Ali RR, Dick AD, Luhmann UF.

PLoS One. 2013 May 14;8(5):e63002. doi: 10.1371/journal.pone.0063002. Print 2013.

44.

Reply to comment on "Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration" by Luhmann et al. (Exp. Eye Res. 107, February 2013, 80-87).

Luhmann UF, Carvalho LS, Robbie SJ, Bainbridge JW, Ali RR.

Exp Eye Res. 2013 Jun;111:136. doi: 10.1016/j.exer.2013.02.001. Epub 2013 Feb 9. No abstract available.

45.

Assessing a novel depot delivery strategy for noninvasive administration of VEGF/PDGF RTK inhibitors for ocular neovascular disease.

Robbie SJ, Lundh von Leithner P, Ju M, Lange CA, King AG, Adamson P, Lee D, Sychterz C, Coffey P, Ng YS, Bainbridge JW, Shima DT.

Invest Ophthalmol Vis Sci. 2013 Feb 27;54(2):1490-500. doi: 10.1167/iovs.12-10169.

PMID:
23385800
46.

Repair of the degenerate retina by photoreceptor transplantation.

Barber AC, Hippert C, Duran Y, West EL, Bainbridge JW, Warre-Cornish K, Luhmann UF, Lakowski J, Sowden JC, Ali RR, Pearson RA.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):354-9. doi: 10.1073/pnas.1212677110. Epub 2012 Dec 17.

47.

Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration.

Luhmann UF, Carvalho LS, Robbie SJ, Cowing JA, Duran Y, Munro PM, Bainbridge JW, Ali RR.

Exp Eye Res. 2013 Feb;107:80-7. doi: 10.1016/j.exer.2012.11.015. Epub 2012 Dec 8.

48.

Repeatability of Spectralis OCT measurements of macular thickness and volume in diabetic macular edema.

Comyn O, Heng LZ, Ikeji F, Bibi K, Hykin PG, Bainbridge JW, Patel PJ.

Invest Ophthalmol Vis Sci. 2012 Nov 21;53(12):7754-9. doi: 10.1167/iovs.12-10895.

PMID:
23111610
49.

RPE65 gene therapy slows cone loss in Rpe65-deficient dogs.

Mowat FM, Breuwer AR, Bartoe JT, Annear MJ, Zhang Z, Smith AJ, Bainbridge JW, Petersen-Jones SM, Ali RR.

Gene Ther. 2013 May;20(5):545-55. doi: 10.1038/gt.2012.63. Epub 2012 Sep 6.

PMID:
22951453
50.

Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development.

Lange CA, Luhmann UF, Mowat FM, Georgiadis A, West EL, Abrahams S, Sayed H, Powner MB, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JW.

Development. 2012 Jul;139(13):2340-50. doi: 10.1242/dev.070813. Epub 2012 May 23.

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