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Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme.

Tejeda GS, Whiteley EL, Deeb TZ, Bürli RW, Moss SJ, Sheridan E, Brandon NJ, Baillie GS.

Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):677-688. doi: 10.1073/pnas.1916398117. Epub 2019 Dec 23.


Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches.

Tibbo AJ, Tejeda GS, Baillie GS.

Biochem Soc Trans. 2019 Oct 31;47(5):1557-1565. doi: 10.1042/BST20190763.


Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes.

Blair CM, Baillie GS.

Biochem Soc Trans. 2019 Oct 31;47(5):1405-1414. doi: 10.1042/BST20190252.


Therapeutic targeting of 3',5'-cyclic nucleotide phosphodiesterases: inhibition and beyond.

Baillie GS, Tejeda GS, Kelly MP.

Nat Rev Drug Discov. 2019 Oct;18(10):770-796. doi: 10.1038/s41573-019-0033-4. Epub 2019 Aug 6. Review.


The Association of the Long Prostate Cancer Expressed PDE4D Transcripts to Poor Patient Outcome Depends on the Tumour's TMPRSS2-ERG Fusion Status.

van Strijp D, de Witz C, Heitkötter B, Huss S, Bögemann M, Baillie GS, Houslay MD, Bangma C, Semjonow A, Hoffmann R.

Prostate Cancer. 2019 Jun 2;2019:8107807. doi: 10.1155/2019/8107807. eCollection 2019.


Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.

Omar F, Findlay JE, Carfray G, Allcock RW, Jiang Z, Moore C, Muir AL, Lannoy M, Fertig BA, Mai D, Day JP, Bolger G, Baillie GS, Schwiebert E, Klussmann E, Pyne NJ, Ong ACM, Bowers K, Adam JM, Adams DR, Houslay MD, Henderson DJP.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329. doi: 10.1073/pnas.1822113116. Epub 2019 Jun 17.


A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling.

Vagena E, Ryu JK, Baeza-Raja B, Walsh NM, Syme C, Day JP, Houslay MD, Baillie GS.

Transl Psychiatry. 2019 May 10;9(1):141. doi: 10.1038/s41398-019-0470-1.


AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA.

Clister T, Greenwald EC, Baillie GS, Zhang J.

Cell Chem Biol. 2019 Jun 20;26(6):885-891.e4. doi: 10.1016/j.chembiol.2019.03.003. Epub 2019 Apr 11.


PDE10A mutations help to unwrap the neurobiology of hyperkinetic disorders.

Whiteley EL, Tejeda GS, Baillie GS, Brandon NJ.

Cell Signal. 2019 Aug;60:31-38. doi: 10.1016/j.cellsig.2019.04.001. Epub 2019 Apr 2. Review.


Methods to Investigate Arrestins in Complex with Phosphodiesterases.

Tibbo AJ, Busiau T, Baillie GS.

Methods Mol Biol. 2019;1957:121-137. doi: 10.1007/978-1-4939-9158-7_8.


Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A - C-Raf.

Blair CM, Walsh NM, Littman BH, Marcoux FW, Baillie GS.

BMC Cancer. 2019 Mar 25;19(1):266. doi: 10.1186/s12885-019-5489-4.


Phosphorylation of PDE4A5 by MAPKAPK2 attenuates fibrin degradation via p75 signalling.

Houslay KF, Fertig BA, Christian F, Tibbo AJ, Ling J, Findlay JE, Houslay MD, Baillie GS.

J Biochem. 2019 Jul 1;166(1):97-106. doi: 10.1093/jb/mvz016.


Effect of tacrolimus on skin microbiome in atopic dermatitis.

Wongpiyabovorn J, Soonthornchai W, Wilantho A, Palasuk M, Payungporn S, Sodsai P, Poomipak W, Weschawalit S, Ruchusatsawat K, Baillie GS, Hirankarn N, Somboonna N.

Allergy. 2019 Jul;74(7):1400-1406. doi: 10.1111/all.13743. Epub 2019 Mar 11. No abstract available.


A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase.

Strembitska A, Mancini SJ, Gamwell JM, Palmer TM, Baillie GS, Salt IP.

Int J Mol Sci. 2018 Dec 5;19(12). pii: E3886. doi: 10.3390/ijms19123886.


A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins.

Maziarz M, Broselid S, DiGiacomo V, Park JC, Luebbers A, Garcia-Navarrete L, Blanco-Canosa JB, Baillie GS, Garcia-Marcos M.

J Biol Chem. 2018 Nov 2;293(44):16964-16983. doi: 10.1074/jbc.RA118.003580. Epub 2018 Sep 7.


The Prognostic PDE4D7 Score in a Diagnostic Biopsy Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.

van Strijp D, de Witz C, Vos PC, den Biezen-Timmermans E, van Brussel A, Wrobel J, Baillie GS, Tennstedt P, Schlomm T, Heitkötter B, Huss S, Bögemann M, Houslay MD, Bangma C, Semjonow A, Hoffmann R.

Prostate Cancer. 2018 Jul 26;2018:5821616. doi: 10.1155/2018/5821616. eCollection 2018.


RAB40C regulates RACK1 stability via the ubiquitin-proteasome system.

Day JP, Whiteley E, Freeley M, Long A, Malacrida B, Kiely P, Baillie GS.

Future Sci OA. 2018 Jul 2;4(7):FSO317. doi: 10.4155/fsoa-2018-0022. eCollection 2018 Jul.


PDE4-Mediated cAMP Signalling.

Fertig BA, Baillie GS.

J Cardiovasc Dev Dis. 2018 Jan 31;5(1). pii: E8. doi: 10.3390/jcdd5010008. Review.


Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability.

Williams JJL, Alotaiq N, Mullen W, Burchmore R, Liu L, Baillie GS, Schaper F, Pilch PF, Palmer TM.

Nat Commun. 2018 Jan 12;9(1):168. doi: 10.1038/s41467-017-02585-y.


Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase.

Lemonidis K, MacLeod R, Baillie GS, Chamberlain LH.

J Biol Chem. 2017 Oct 20;292(42):17190-17202. doi: 10.1074/jbc.M117.799650. Epub 2017 Sep 7.


PDE8 controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex.

Basole CP, Nguyen RK, Lamothe K, Vang A, Clark R, Baillie GS, Epstein PM, Brocke S.

Cell Signal. 2017 Dec;40:62-72. doi: 10.1016/j.cellsig.2017.08.007. Epub 2017 Aug 26.


Validation of Cyclic Adenosine Monophosphate Phosphodiesterase-4D7 for its Independent Contribution to Risk Stratification in a Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.

Alves de Inda M, van Strijp D, den Biezen-Timmermans E, van Brussel A, Wrobel J, van Zon H, Vos P, Baillie GS, Tennstedt P, Schlomm T, Houslay MD, Bangma C, Hoffmann R.

Eur Urol Focus. 2018 Apr;4(3):376-384. doi: 10.1016/j.euf.2017.05.010. Epub 2017 Jun 13.


PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex.

Javadi A, Deevi RK, Evergren E, Blondel-Tepaz E, Baillie GS, Scott MG, Campbell FC.

Elife. 2017 Jul 27;6. pii: e24578. doi: 10.7554/eLife.24578.


FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system.

Yalla K, Elliott C, Day JP, Findlay J, Barratt S, Hughes ZA, Wilson L, Whiteley E, Popiolek M, Li Y, Dunlop J, Killick R, Adams DR, Brandon NJ, Houslay MD, Hao B, Baillie GS.

Mol Psychiatry. 2018 May;23(5):1278-1286. doi: 10.1038/mp.2017.138. Epub 2017 Jul 20.


Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS.

Nishi K, Luo H, Ishikura S, Doi K, Iwaihara Y, Wills L, Baillie GS, Sakata T, Shirasawa S, Tsunoda T.

Anticancer Res. 2017 Jul;37(7):3833-3839.


Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.

de Opakua AI, Parag-Sharma K, DiGiacomo V, Merino N, Leyme A, Marivin A, Villate M, Nguyen LT, de la Cruz-Morcillo MA, Blanco-Canosa JB, Ramachandran S, Baillie GS, Cerione RA, Blanco FJ, Garcia-Marcos M.

Nat Commun. 2017 May 18;8:15163. doi: 10.1038/ncomms15163.


Modelling and mathematical analysis of the M$_{2}$ receptor-dependent joint signalling and secondary messenger network in CHO cells.

Engelhardt B, Holze J, Elliott C, Baillie GS, Kschischo M, Fröhlich H.

Math Med Biol. 2018 Sep 11;35(3):279-297. doi: 10.1093/imammb/dqx003.


TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.

Diamantopoulou Z, White G, Fadlullah MZH, Dreger M, Pickering K, Maltas J, Ashton G, MacLeod R, Baillie GS, Kouskoff V, Lacaud G, Murray GI, Sansom OJ, Hurlstone AFL, Malliri A.

Cancer Cell. 2017 May 8;31(5):621-634.e6. doi: 10.1016/j.ccell.2017.03.007. Epub 2017 Apr 13.


Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks.

Schoenherr C, Byron A, Sandilands E, Paliashvili K, Baillie GS, Garcia-Munoz A, Valacca C, Cecconi F, Serrels B, Frame MC.

Elife. 2017 Mar 31;6. pii: e23172. doi: 10.7554/eLife.23172.


Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.

McGirr A, Lipina TV, Mun HS, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JG, Liu F, Baillie GS, Clapcote SJ, Roder JC.

Neuropsychopharmacology. 2017 Apr;42(5):1178. doi: 10.1038/npp.2016.263. No abstract available.


Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle.

Deschamps T, Bazot Q, Leske DM, MacLeod R, Mompelat D, Tafforeau L, Lotteau V, Maréchal V, Baillie GS, Gruffat H, Wilson JB, Manet E.

J Gen Virol. 2017 Feb;98(2):251-265. doi: 10.1099/jgv.0.000681.


Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42-mediated cytotoxicity.

Cameron RT, Whiteley E, Day JP, Parachikova AI, Baillie GS.

FEBS Open Bio. 2016 Dec 5;7(1):64-73. doi: 10.1002/2211-5463.12156. eCollection 2017 Jan.


George Baillie on peptide array, a technique that transformed research on phosphodiesterases.

Baillie GS.

Future Sci OA. 2015 Nov 1;1(3):FSO27. doi: 10.4155/fso.15.25. eCollection 2015 Nov.


The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease.

MacLeod R, Hillert EK, Cameron RT, Baillie GS.

Future Sci OA. 2015 Nov 1;1(3):FSO11. doi: 10.4155/fso.15.9. eCollection 2015 Nov. Review.


Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners.

Houslay KF, Christian F, MacLeod R, Adams DR, Houslay MD, Baillie GS.

Biochem J. 2017 Feb 15;474(4):597-609. doi: 10.1042/BCJ20160849. Epub 2016 Dec 19.


Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.

Rutherford C, Speirs C, Williams JJ, Ewart MA, Mancini SJ, Hawley SA, Delles C, Viollet B, Costa-Pereira AP, Baillie GS, Salt IP, Palmer TM.

Sci Signal. 2016 Nov 8;9(453):ra109.


Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases.

Böttcher R, Dulla K, van Strijp D, Dits N, Verhoef EI, Baillie GS, van Leenders GJ, Houslay MD, Jenster G, Hoffmann R.

Oncotarget. 2016 Oct 25;7(43):70669-70684. doi: 10.18632/oncotarget.12204.


RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells.

Kiely M, Adams DR, Hayes SL, O'Connor R, Baillie GS, Kiely PA.

Cell Signal. 2017 Jul;35:290-300. doi: 10.1016/j.cellsig.2016.09.001. Epub 2016 Sep 4.


Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.

Havekes R, Park AJ, Tolentino RE, Bruinenberg VM, Tudor JC, Lee Y, Hansen RT, Guercio LA, Linton E, Neves-Zaph SR, Meerlo P, Baillie GS, Houslay MD, Abel T.

J Neurosci. 2016 Aug 24;36(34):8936-46. doi: 10.1523/JNEUROSCI.0248-16.2016.


Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1.

Havekes R, Park AJ, Tudor JC, Luczak VG, Hansen RT, Ferri SL, Bruinenberg VM, Poplawski SG, Day JP, Aton SJ, Radwańska K, Meerlo P, Houslay MD, Baillie GS, Abel T.

Elife. 2016 Aug 23;5. pii: e13424. doi: 10.7554/eLife.13424.


Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling.

Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U, Taylor SS, Stefan E.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7786-91. doi: 10.1073/pnas.1608061113. Epub 2016 Jun 28.


Non-genetic therapeutic approaches to Canavan disease.

Roscoe RB, Elliott C, Zarros A, Baillie GS.

J Neurol Sci. 2016 Jul 15;366:116-124. doi: 10.1016/j.jns.2016.05.012. Epub 2016 May 10. Review.


Editorial: Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels.

Baillie GS, Christian F, Zarros A.

Front Pharmacol. 2016 Jan 29;7:4. doi: 10.3389/fphar.2016.00004. eCollection 2016. No abstract available.



Baillie GS.

Cell Signal. 2016 Jul;28(7):699-700. doi: 10.1016/j.cellsig.2016.02.001. Epub 2016 Feb 3. No abstract available.


Location, location, location: PDE4D5 function is directed by its unique N-terminal region.

Wills L, Ehsan M, Whiteley EL, Baillie GS.

Cell Signal. 2016 Jul;28(7):701-5. doi: 10.1016/j.cellsig.2016.01.008. Epub 2016 Jan 22. Review. No abstract available.


p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.

Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K.

Cell Rep. 2016 Jan 12;14(2):255-68. doi: 10.1016/j.celrep.2015.12.028. Epub 2015 Dec 31.


Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice.

Dachtler J, Elliott C, Rodgers RJ, Baillie GS, Clapcote SJ.

Sci Rep. 2016 Jan 5;6:18748. doi: 10.1038/srep18748.


Acetylcholinesterase activity as a neurotoxicity marker within the context of experimentally-simulated hyperprolinaemia: An in vitro approach.

Kalafatakis K, Gkanti V, Mackenzie-Gray Scott CA, Zarros A, Baillie GS, Tsakiris S.

J Nat Sci Biol Med. 2015 Aug;6(Suppl 1):S98-S101. doi: 10.4103/0976-9668.166099.


Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression.

Böttcher R, Henderson DJ, Dulla K, van Strijp D, Waanders LF, Tevz G, Lehman ML, Merkle D, van Leenders GJ, Baillie GS, Jenster G, Houslay MD, Hoffmann R.

Br J Cancer. 2015 Nov 17;113(10):1502-11. doi: 10.1038/bjc.2015.335.


Heat shock protein 20 (HSP20) is a novel substrate for protein kinase D1 (PKD1).

Sin YY, Baillie GS.

Cell Biochem Funct. 2015 Oct;33(7):421-6. doi: 10.1002/cbf.3147. Epub 2015 Oct 6.

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