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Items: 1 to 50 of 267

1.

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.

Omar F, Findlay JE, Carfray G, Allcock RW, Jiang Z, Moore C, Muir AL, Lannoy M, Fertig BA, Mai D, Day JP, Bolger G, Baillie GS, Schwiebert E, Klussmann E, Pyne NJ, Ong ACM, Bowers K, Adam JM, Adams DR, Houslay MD, Henderson DJP.

Proc Natl Acad Sci U S A. 2019 Jun 17. pii: 201822113. doi: 10.1073/pnas.1822113116. [Epub ahead of print]

2.

A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling.

Vagena E, Ryu JK, Baeza-Raja B, Walsh NM, Syme C, Day JP, Houslay MD, Baillie GS.

Transl Psychiatry. 2019 May 10;9(1):141. doi: 10.1038/s41398-019-0470-1.

3.

The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators.

Tseng CC, Baillie G, Donvito G, Mustafa MA, Juola SE, Zanato C, Massarenti C, Dall'Angelo S, Harrison WTA, Lichtman AH, Ross RA, Zanda M, Greig IR.

J Med Chem. 2019 May 23;62(10):5049-5062. doi: 10.1021/acs.jmedchem.9b00252. Epub 2019 May 14.

PMID:
31050898
4.

The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage.

Baek S, Oh TG, Secker G, Sutton DL, Okuda KS, Paterson S, Bower NI, Toubia J, Koltowska K, Capon SJ, Baillie GJ, Simons C, Muscat GEO, Lagendijk AK, Smith KA, Harvey NL, Hogan BM.

Dev Cell. 2019 Apr 22;49(2):279-292.e5. doi: 10.1016/j.devcel.2019.03.017.

PMID:
31014480
5.

AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA.

Clister T, Greenwald EC, Baillie GS, Zhang J.

Cell Chem Biol. 2019 Mar 21. pii: S2451-9456(19)30080-7. doi: 10.1016/j.chembiol.2019.03.003. [Epub ahead of print]

PMID:
30982750
6.

Investigation of the estuarine stonefish (Synanceia horrida) venom composition.

Ziegman R, Undheim EAB, Baillie G, Jones A, Alewood PF.

J Proteomics. 2019 Jun 15;201:12-26. doi: 10.1016/j.jprot.2019.04.002. Epub 2019 Apr 4.

PMID:
30953730
7.

PDE10A mutations help to unwrap the neurobiology of hyperkinetic disorders.

Whiteley EL, Tejeda GS, Baillie GS, Brandon NJ.

Cell Signal. 2019 Aug;60:31-38. doi: 10.1016/j.cellsig.2019.04.001. Epub 2019 Apr 2. Review.

PMID:
30951862
8.

Methods to Investigate Arrestins in Complex with Phosphodiesterases.

Tibbo AJ, Busiau T, Baillie GS.

Methods Mol Biol. 2019;1957:121-137. doi: 10.1007/978-1-4939-9158-7_8.

PMID:
30919351
9.

Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A - C-Raf.

Blair CM, Walsh NM, Littman BH, Marcoux FW, Baillie GS.

BMC Cancer. 2019 Mar 25;19(1):266. doi: 10.1186/s12885-019-5489-4.

10.

Phosphorylation of PDE4A5 by MAPKAPK2 attenuates fibrin degradation via p75 signalling.

Houslay KF, Fertig BA, Christian F, Tibbo AJ, Ling J, Findlay JE, Houslay MD, Baillie GS.

J Biochem. 2019 Mar 11. pii: mvz016. doi: 10.1093/jb/mvz016. [Epub ahead of print]

PMID:
30859186
11.

Myosin Vb is required for correct trafficking of N-cadherin and cardiac chamber ballooning.

Grassini DR, da Silva J, Hall TE, Baillie GJ, Simons C, Parton RG, Hogan BM, Smith KA.

Dev Dyn. 2019 Apr;248(4):284-295. doi: 10.1002/dvdy.19. Epub 2019 Mar 19.

PMID:
30801852
12.

ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses.

Azimi I, Milevskiy MJG, Chalmers SB, Yapa KTDS, Robitaille M, Henry C, Baillie GJ, Thompson EW, Roberts-Thomson SJ, Monteith GR.

Cancers (Basel). 2019 Feb 11;11(2). pii: E208. doi: 10.3390/cancers11020208.

13.

Effect of tacrolimus on skin microbiome in atopic dermatitis.

Wongpiyabovorn J, Soonthornchai W, Wilantho A, Palasuk M, Payungporn S, Sodsai P, Poomipak W, Weschawalit S, Ruchusatsawat K, Baillie GS, Hirankarn N, Somboonna N.

Allergy. 2019 Feb 11. doi: 10.1111/all.13743. [Epub ahead of print] No abstract available.

PMID:
30742708
14.

A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase.

Strembitska A, Mancini SJ, Gamwell JM, Palmer TM, Baillie GS, Salt IP.

Int J Mol Sci. 2018 Dec 5;19(12). pii: E3886. doi: 10.3390/ijms19123886.

15.

Platypus Induced Pluripotent Stem Cells: The Unique Pluripotency Signature of a Monotreme.

Whitworth DJ, Limnios IJ, Gauthier ME, Weeratunga P, Ovchinnikov DA, Baillie G, Grimmond SM, Graves JAM, Wolvetang EJ.

Stem Cells Dev. 2019 Feb 1;28(3):151-164. doi: 10.1089/scd.2018.0179. Epub 2019 Jan 9.

PMID:
30417748
16.

Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation.

Friedman CE, Nguyen Q, Lukowski SW, Helfer A, Chiu HS, Miklas J, Levy S, Suo S, Han JJ, Osteil P, Peng G, Jing N, Baillie GJ, Senabouth A, Christ AN, Bruxner TJ, Murry CE, Wong ES, Ding J, Wang Y, Hudson J, Ruohola-Baker H, Bar-Joseph Z, Tam PPL, Powell JE, Palpant NJ.

Cell Stem Cell. 2018 Oct 4;23(4):586-598.e8. doi: 10.1016/j.stem.2018.09.009.

PMID:
30290179
17.

A role for APP in Wnt signalling links synapse loss with β-amyloid production.

Elliott C, Rojo AI, Ribe E, Broadstock M, Xia W, Morin P, Semenov M, Baillie G, Cuadrado A, Al-Shawi R, Ballard CG, Simons P, Killick R.

Transl Psychiatry. 2018 Sep 20;8(1):179. doi: 10.1038/s41398-018-0231-6.

18.

A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins.

Maziarz M, Broselid S, DiGiacomo V, Park JC, Luebbers A, Garcia-Navarrete L, Blanco-Canosa JB, Baillie GS, Garcia-Marcos M.

J Biol Chem. 2018 Nov 2;293(44):16964-16983. doi: 10.1074/jbc.RA118.003580. Epub 2018 Sep 7.

19.

The Prognostic PDE4D7 Score in a Diagnostic Biopsy Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.

van Strijp D, de Witz C, Vos PC, den Biezen-Timmermans E, van Brussel A, Wrobel J, Baillie GS, Tennstedt P, Schlomm T, Heitkötter B, Huss S, Bögemann M, Houslay MD, Bangma C, Semjonow A, Hoffmann R.

Prostate Cancer. 2018 Jul 26;2018:5821616. doi: 10.1155/2018/5821616. eCollection 2018.

20.

RAB40C regulates RACK1 stability via the ubiquitin-proteasome system.

Day JP, Whiteley E, Freeley M, Long A, Malacrida B, Kiely P, Baillie GS.

Future Sci OA. 2018 Jul 2;4(7):FSO317. doi: 10.4155/fsoa-2018-0022. eCollection 2018 Jul.

21.

The F238L Point Mutation in the Cannabinoid Type 1 Receptor Enhances Basal Endocytosis via Lipid Rafts.

Wickert M, Hildick KL, Baillie GL, Jelinek R, Aparisi Rey A, Monory K, Schneider M, Ross RA, Henley JM, Lutz B.

Front Mol Neurosci. 2018 Jul 5;11:230. doi: 10.3389/fnmol.2018.00230. eCollection 2018.

22.

PDE4-Mediated cAMP Signalling.

Fertig BA, Baillie GS.

J Cardiovasc Dev Dis. 2018 Jan 31;5(1). pii: E8. doi: 10.3390/jcdd5010008. Review.

23.

Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability.

Williams JJL, Alotaiq N, Mullen W, Burchmore R, Liu L, Baillie GS, Schaper F, Pilch PF, Palmer TM.

Nat Commun. 2018 Jan 12;9(1):168. doi: 10.1038/s41467-017-02585-y.

24.

Identification of miR-29b targets using 3-cyanovinylcarbazole containing mimics.

Choudhary A, Vanichkina DP, Ender C, Crawford J, Baillie GJ, Calcino AD, Ru K, Taft RJ.

RNA. 2018 Apr;24(4):597-608. doi: 10.1261/rna.064923.117. Epub 2017 Dec 15.

25.

Increase in Ca2+ current by sustained cAMP levels enhances proliferation rate in GH3 cells.

Rodrigues AL, Brescia M, Koschinski A, Moreira TH, Cameron RT, Baillie G, Beirão PSL, Zaccolo M, Cruz JS.

Life Sci. 2018 Jan 1;192:144-150. doi: 10.1016/j.lfs.2017.11.040. Epub 2017 Nov 26.

PMID:
29183797
26.

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil.

Sellers KJ, Elliott C, Jackson J, Ghosh A, Ribe E, Rojo AI, Jarosz-Griffiths HH, Watson IA, Xia W, Semenov M, Morin P, Hooper NM, Porter R, Preston J, Al-Shawi R, Baillie G, Lovestone S, Cuadrado A, Harte M, Simons P, Srivastava DP, Killick R.

Alzheimers Dement. 2018 Mar;14(3):306-317. doi: 10.1016/j.jalz.2017.09.008. Epub 2017 Oct 19.

27.

Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase.

Lemonidis K, MacLeod R, Baillie GS, Chamberlain LH.

J Biol Chem. 2017 Oct 20;292(42):17190-17202. doi: 10.1074/jbc.M117.799650. Epub 2017 Sep 7.

28.

PDE8 controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex.

Basole CP, Nguyen RK, Lamothe K, Vang A, Clark R, Baillie GS, Epstein PM, Brocke S.

Cell Signal. 2017 Dec;40:62-72. doi: 10.1016/j.cellsig.2017.08.007. Epub 2017 Aug 26.

PMID:
28851628
29.

Validation of Cyclic Adenosine Monophosphate Phosphodiesterase-4D7 for its Independent Contribution to Risk Stratification in a Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.

Alves de Inda M, van Strijp D, den Biezen-Timmermans E, van Brussel A, Wrobel J, van Zon H, Vos P, Baillie GS, Tennstedt P, Schlomm T, Houslay MD, Bangma C, Hoffmann R.

Eur Urol Focus. 2018 Apr;4(3):376-384. doi: 10.1016/j.euf.2017.05.010. Epub 2017 Jun 13.

30.

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex.

Javadi A, Deevi RK, Evergren E, Blondel-Tepaz E, Baillie GS, Scott MG, Campbell FC.

Elife. 2017 Jul 27;6. pii: e24578. doi: 10.7554/eLife.24578.

31.

FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system.

Yalla K, Elliott C, Day JP, Findlay J, Barratt S, Hughes ZA, Wilson L, Whiteley E, Popiolek M, Li Y, Dunlop J, Killick R, Adams DR, Brandon NJ, Houslay MD, Hao B, Baillie GS.

Mol Psychiatry. 2018 May;23(5):1278-1286. doi: 10.1038/mp.2017.138. Epub 2017 Jul 20.

32.

Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS.

Nishi K, Luo H, Ishikura S, Doi K, Iwaihara Y, Wills L, Baillie GS, Sakata T, Shirasawa S, Tsunoda T.

Anticancer Res. 2017 Jul;37(7):3833-3839.

PMID:
28668883
33.

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.

de Opakua AI, Parag-Sharma K, DiGiacomo V, Merino N, Leyme A, Marivin A, Villate M, Nguyen LT, de la Cruz-Morcillo MA, Blanco-Canosa JB, Ramachandran S, Baillie GS, Cerione RA, Blanco FJ, Garcia-Marcos M.

Nat Commun. 2017 May 18;8:15163. doi: 10.1038/ncomms15163.

34.

Modelling and mathematical analysis of the M$_{2}$ receptor-dependent joint signalling and secondary messenger network in CHO cells.

Engelhardt B, Holze J, Elliott C, Baillie GS, Kschischo M, Fröhlich H.

Math Med Biol. 2018 Sep 11;35(3):279-297. doi: 10.1093/imammb/dqx003.

PMID:
28505258
35.

PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling.

Monterisi S, Lobo MJ, Livie C, Castle JC, Weinberger M, Baillie G, Surdo NC, Musheshe N, Stangherlin A, Gottlieb E, Maizels R, Bortolozzi M, Micaroni M, Zaccolo M.

Elife. 2017 May 2;6. pii: e21374. doi: 10.7554/eLife.21374.

36.

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.

Diamantopoulou Z, White G, Fadlullah MZH, Dreger M, Pickering K, Maltas J, Ashton G, MacLeod R, Baillie GS, Kouskoff V, Lacaud G, Murray GI, Sansom OJ, Hurlstone AFL, Malliri A.

Cancer Cell. 2017 May 8;31(5):621-634.e6. doi: 10.1016/j.ccell.2017.03.007. Epub 2017 Apr 13.

37.

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks.

Schoenherr C, Byron A, Sandilands E, Paliashvili K, Baillie GS, Garcia-Munoz A, Valacca C, Cecconi F, Serrels B, Frame MC.

Elife. 2017 Mar 31;6. pii: e23172. doi: 10.7554/eLife.23172.

38.

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1.

Parnell E, McElroy SP, Wiejak J, Baillie GL, Porter A, Adams DR, Rehmann H, Smith BO, Yarwood SJ.

Sci Rep. 2017 Mar 22;7(1):294. doi: 10.1038/s41598-017-00455-7.

39.

In Vitro Assay Development and HTS of Small-Molecule Human ABAD/17β-HSD10 Inhibitors as Therapeutics in Alzheimer's Disease.

Aitken L, Baillie G, Pannifer A, Morrison A, Jones PS, Smith TK, McElroy SP, Gunn-Moore FJ.

SLAS Discov. 2017 Jul;22(6):676-685. doi: 10.1177/2472555217697964. Epub 2017 Mar 17.

PMID:
28314118
40.

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.

McGirr A, Lipina TV, Mun HS, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JG, Liu F, Baillie GS, Clapcote SJ, Roder JC.

Neuropsychopharmacology. 2017 Apr;42(5):1178. doi: 10.1038/npp.2016.263. No abstract available.

41.

Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle.

Deschamps T, Bazot Q, Leske DM, MacLeod R, Mompelat D, Tafforeau L, Lotteau V, Maréchal V, Baillie GS, Gruffat H, Wilson JB, Manet E.

J Gen Virol. 2017 Feb;98(2):251-265. doi: 10.1099/jgv.0.000681.

PMID:
28284242
42.

Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42-mediated cytotoxicity.

Cameron RT, Whiteley E, Day JP, Parachikova AI, Baillie GS.

FEBS Open Bio. 2016 Dec 5;7(1):64-73. doi: 10.1002/2211-5463.12156. eCollection 2017 Jan.

43.

Prediction of the Total Liver Weight using anthropological clinical parameters: does complexity result in better accuracy?

Allard MA, Baillié G, Castro-Benitez C, Faron M, Blandin F, Cherqui D, Castaing D, Cunha AS, Adam R, Vibert É.

HPB (Oxford). 2017 Apr;19(4):338-344. doi: 10.1016/j.hpb.2016.11.012. Epub 2016 Dec 30.

44.

George Baillie on peptide array, a technique that transformed research on phosphodiesterases.

Baillie GS.

Future Sci OA. 2015 Nov 1;1(3):FSO27. doi: 10.4155/fso.15.25. eCollection 2015 Nov.

45.

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease.

MacLeod R, Hillert EK, Cameron RT, Baillie GS.

Future Sci OA. 2015 Nov 1;1(3):FSO11. doi: 10.4155/fso.15.9. eCollection 2015 Nov. Review.

46.

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners.

Houslay KF, Christian F, MacLeod R, Adams DR, Houslay MD, Baillie GS.

Biochem J. 2017 Feb 15;474(4):597-609. doi: 10.1042/BCJ20160849. Epub 2016 Dec 19.

47.

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.

Rutherford C, Speirs C, Williams JJ, Ewart MA, Mancini SJ, Hawley SA, Delles C, Viollet B, Costa-Pereira AP, Baillie GS, Salt IP, Palmer TM.

Sci Signal. 2016 Nov 8;9(453):ra109.

48.

Utilising polymorphisms to achieve allele-specific genome editing in zebrafish.

Capon SJ, Baillie GJ, Bower NI, da Silva JA, Paterson S, Hogan BM, Simons C, Smith KA.

Biol Open. 2017 Jan 15;6(1):125-131. doi: 10.1242/bio.020974.

49.

The Snake with the Scorpion's Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus).

Yang DC, Deuis JR, Dashevsky D, Dobson J, Jackson TN, Brust A, Xie B, Koludarov I, Debono J, Hendrikx I, Hodgson WC, Josh P, Nouwens A, Baillie GJ, Bruxner TJ, Alewood PF, Lim KK, Frank N, Vetter I, Fry BG.

Toxins (Basel). 2016 Oct 18;8(10). pii: E303.

50.

CRIg-expressing peritoneal macrophages are associated with disease severity in patients with cirrhosis and ascites.

Irvine KM, Banh X, Gadd VL, Wojcik KK, Ariffin JK, Jose S, Lukowski S, Baillie GJ, Sweet MJ, Powell EE.

JCI Insight. 2016 Jun 2;1(8):e86914. doi: 10.1172/jci.insight.86914.

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