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An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability.

Slezak T, Bailey LJ, Jaskolowski M, Nahotko DA, Filippova EV, Davydova EK, Kossiakoff AA.

Protein Sci. 2019 Oct 17. doi: 10.1002/pro.3751. [Epub ahead of print]


Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin.

Farcasanu M, Wang AG, Uchański T, Bailey LJ, Yue J, Chen Z, Wu X, Kossiakoff A, Tang WJ.

Biochemistry. 2019 Jul 9;58(27):2996-3004. doi: 10.1021/acs.biochem.9b00184. Epub 2019 Jun 19.


Obstetric neuraxial anesthesia at low platelet counts in the context of immune thrombocytopenia: a systematic review and meta-analysis.

Bailey LJ, Shehata N, De France B, Carvalho JCA, Malinowski AK.

Can J Anaesth. 2019 Nov;66(11):1396-1414. doi: 10.1007/s12630-019-01420-w. Epub 2019 Jun 19.


PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells.

Bailey LJ, Bianchi J, Doherty AJ.

Nucleic Acids Res. 2019 May 7;47(8):4026-4038. doi: 10.1093/nar/gkz056.


The Involvement of Aβ42 and Tau in Nucleolar and Protein Synthesis Machinery Dysfunction.

Maina MB, Bailey LJ, Doherty AJ, Serpell LC.

Front Cell Neurosci. 2018 Aug 3;12:220. doi: 10.3389/fncel.2018.00220. eCollection 2018.


The involvement of tau in nucleolar transcription and the stress response.

Maina MB, Bailey LJ, Wagih S, Biasetti L, Pollack SJ, Quinn JP, Thorpe JR, Doherty AJ, Serpell LC.

Acta Neuropathol Commun. 2018 Jul 31;6(1):70. doi: 10.1186/s40478-018-0565-6.


Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.

Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ.

Elife. 2018 Mar 29;7. pii: e33572. doi: 10.7554/eLife.33572.


Protein kinase D1 conditional null mice show minimal bone loss following ovariectomy.

Bollag WB, Ding KH, Choudhary V, Xu J, Zhong Q, Elsayed R, Bailey LJ, Elsalanty M, Yu K, Johnson MH, McGee-Lawrence ME, Isales CM.

Mol Cell Endocrinol. 2018 Oct 15;474:176-183. doi: 10.1016/j.mce.2018.03.006. Epub 2018 Mar 9.


EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation.

Silva J, Aivio S, Knobel PA, Bailey LJ, Casali A, Vinaixa M, Garcia-Cao I, Coyaud É, Jourdain AA, Pérez-Ferreros P, Rojas AM, Antolin-Fontes A, Samino-Gené S, Raught B, González-Reyes A, Ribas de Pouplana L, Doherty AJ, Yanes O, Stracker TH.

Nat Cell Biol. 2018 Feb;20(2):162-174. doi: 10.1038/s41556-017-0016-9. Epub 2018 Jan 15.


Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography.

Koirala D, Shelke SA, Dupont M, Ruiz S, DasGupta S, Bailey LJ, Benner SA, Piccirilli JA.

Nucleic Acids Res. 2018 Mar 16;46(5):2624-2635. doi: 10.1093/nar/gkx1292.


Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.

Bailey LJ, Sheehy KM, Dominik PK, Liang WG, Rui H, Clark M, Jaskolowski M, Kim Y, Deneka D, Tang WJ, Kossiakoff AA.

J Mol Biol. 2018 Feb 2;430(3):337-347. doi: 10.1016/j.jmb.2017.12.012. Epub 2017 Dec 19.


Deletion of protein kinase D1 in osteoprogenitor cells results in decreased osteogenesis in vitro and reduced bone mineral density in vivo.

Bollag WB, Choudhary V, Zhong Q, Ding KH, Xu J, Elsayed R, Yu K, Su Y, Bailey LJ, Shi XM, Elsalanty M, Johnson MH, McGee-Lawrence ME, Isales CM.

Mol Cell Endocrinol. 2018 Feb 5;461:22-31. doi: 10.1016/j.mce.2017.08.005. Epub 2017 Aug 12.


Molecular basis for PrimPol recruitment to replication forks by RPA.

Guilliam TA, Brissett NC, Ehlinger A, Keen BA, Kolesar P, Taylor EM, Bailey LJ, Lindsay HD, Chazin WJ, Doherty AJ.

Nat Commun. 2017 May 23;8:15222. doi: 10.1038/ncomms15222.


Mitochondrial DNA replication: a PrimPol perspective.

Bailey LJ, Doherty AJ.

Biochem Soc Trans. 2017 Apr 15;45(2):513-529. doi: 10.1042/BST20160162. Review.


In-crystal reaction cycle of a toluene-bound diiron hydroxylase.

Acheson JF, Bailey LJ, Brunold TC, Fox BG.

Nature. 2017 Apr 13;544(7649):191-195. doi: 10.1038/nature21681. Epub 2017 Mar 27.


Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis.

Bailey LJ, Alahari S, Tagliaferro A, Post M, Caniggia I.

Cell Death Dis. 2017 Feb 2;8(2):e2590. doi: 10.1038/cddis.2016.483.


Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia: The Hemodynamic Perspective.

Giesinger RE, Bailey LJ, Deshpande P, McNamara PJ.

J Pediatr. 2017 Jan;180:22-30.e2. doi: 10.1016/j.jpeds.2016.09.009. Epub 2016 Oct 11. No abstract available.


Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria.

Akman G, Desai R, Bailey LJ, Yasukawa T, Dalla Rosa I, Durigon R, Holmes JB, Moss CF, Mennuni M, Houlden H, Crouch RJ, Hanna MG, Pitceathly RD, Spinazzola A, Holt IJ.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4276-85. doi: 10.1073/pnas.1600537113. Epub 2016 Jul 8.


A polar ring endows improved specificity to an antibody fragment.

Schaefer ZP, Bailey LJ, Kossiakoff AA.

Protein Sci. 2016 Jul;25(7):1290-8. doi: 10.1002/pro.2888. Epub 2016 Mar 9.


Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides.

Kobayashi K, Guilliam TA, Tsuda M, Yamamoto J, Bailey LJ, Iwai S, Takeda S, Doherty AJ, Hirota K.

Cell Cycle. 2016 Aug 2;15(15):1997-2008. doi: 10.1080/15384101.2016.1191711. Epub 2016 May 26.


3' Rapid Amplification of cDNA Ends (3' RACE) Using Arabidopsis Samples.

Rodríguez-Cazorla E, Andújar A, Ripoll JJ, Bailey LJ, Martínez-Laborda A, Yanofsky MF, Vera A.

Bio Protoc. 2015 Oct 5;5(19):e1604.


PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities.

Guilliam TA, Bailey LJ, Brissett NC, Doherty AJ.

Nucleic Acids Res. 2016 Apr 20;44(7):3317-29. doi: 10.1093/nar/gkw175. Epub 2016 Mar 16.


PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage.

Bailey LJ, Bianchi J, Hégarat N, Hochegger H, Doherty AJ.

Cell Cycle. 2016;15(7):908-18. doi: 10.1080/15384101.2015.1128597. Epub 2015 Dec 22.


PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells.

Schiavone D, Jozwiakowski SK, Romanello M, Guilbaud G, Guilliam TA, Bailey LJ, Sale JE, Doherty AJ.

Mol Cell. 2016 Jan 7;61(1):161-9. doi: 10.1016/j.molcel.2015.10.038. Epub 2015 Nov 25.


Author response: PRIMPOL mutation: functional study does not always reveal the truth.

Keen BA, Bailey LJ, Jozwiakowski SK, Doherty AJ.

Invest Ophthalmol Vis Sci. 2015 Feb 13;56(2):1183. doi: 10.1167/iovs.14-16123. No abstract available.


K-homology nuclear ribonucleoproteins regulate floral organ identity and determinacy in arabidopsis.

Rodríguez-Cazorla E, Ripoll JJ, Andújar A, Bailey LJ, Martínez-Laborda A, Yanofsky MF, Vera A.

PLoS Genet. 2015 Feb 6;11(2):e1004983. doi: 10.1371/journal.pgen.1004983. eCollection 2015 Feb.


Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins.

Guilliam TA, Jozwiakowski SK, Ehlinger A, Barnes RP, Rudd SG, Bailey LJ, Skehel JM, Eckert KA, Chazin WJ, Doherty AJ.

Nucleic Acids Res. 2015 Jan;43(2):1056-68. doi: 10.1093/nar/gku1321. Epub 2014 Dec 29.


microRNA regulation of fruit growth.

José Ripoll J, Bailey LJ, Mai QA, Wu SL, Hon CT, Chapman EJ, Ditta GS, Estelle M, Yanofsky MF.

Nat Plants. 2015 Mar 30;1(4):15036. doi: 10.1038/nplants.2015.36.


Applications for an engineered Protein-G variant with a pH controllable affinity to antibody fragments.

Bailey LJ, Sheehy KM, Hoey RJ, Schaefer ZP, Ura M, Kossiakoff AA.

J Immunol Methods. 2014 Dec 15;415:24-30. doi: 10.1016/j.jim.2014.10.003. Epub 2014 Oct 22.


Human PrimPol mutation associated with high myopia has a DNA replication defect.

Keen BA, Bailey LJ, Jozwiakowski SK, Doherty AJ.

Nucleic Acids Res. 2014 Oct 29;42(19):12102-11. doi: 10.1093/nar/gku879. Epub 2014 Sep 27.


Structural basis for biomolecular recognition in overlapping binding sites in a diiron enzyme system.

Acheson JF, Bailey LJ, Elsen NL, Fox BG.

Nat Commun. 2014 Sep 24;5:5009. doi: 10.1038/ncomms6009.


Preparation of primary cultures of mouse epidermal keratinocytes and the measurement of phospholipase D activity.

Bailey LJ, Choudhary V, Merai P, Bollag WB.

Methods Mol Biol. 2014;1195:111-31. doi: 10.1007/7651_2014_80.


Mice lacking NOX2 are hyperphagic and store fat preferentially in the liver.

Costford SR, Castro-Alves J, Chan KL, Bailey LJ, Woo M, Belsham DD, Brumell JH, Klip A.

Am J Physiol Endocrinol Metab. 2014 Jun 15;306(12):E1341-53. doi: 10.1152/ajpendo.00089.2014. Epub 2014 Apr 22.


Molecular dissection of the domain architecture and catalytic activities of human PrimPol.

Keen BA, Jozwiakowski SK, Bailey LJ, Bianchi J, Doherty AJ.

Nucleic Acids Res. 2014 May;42(9):5830-45. doi: 10.1093/nar/gku214. Epub 2014 Mar 20.


PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication.

Bianchi J, Rudd SG, Jozwiakowski SK, Bailey LJ, Soura V, Taylor E, Stevanovic I, Green AJ, Stracker TH, Lindsay HD, Doherty AJ.

Mol Cell. 2013 Nov 21;52(4):566-73. doi: 10.1016/j.molcel.2013.10.035.


Amantadine for the treatment of refractory absence seizures in children.

Perry MS, Bailey LJ, Kotecha AC, Malik SI, Hernandez AW.

Pediatr Neurol. 2012 Apr;46(4):243-5. doi: 10.1016/j.pediatrneurol.2012.02.004.


Crystallographic analysis of active site contributions to regiospecificity in the diiron enzyme toluene 4-monooxygenase.

Bailey LJ, Acheson JF, McCoy JG, Elsen NL, Phillips GN Jr, Fox BG.

Biochemistry. 2012 Feb 14;51(6):1101-13. doi: 10.1021/bi2018333. Epub 2012 Feb 2.


Actin and myosin contribute to mammalian mitochondrial DNA maintenance.

Reyes A, He J, Mao CC, Bailey LJ, Di Re M, Sembongi H, Kazak L, Dzionek K, Holmes JB, Cluett TJ, Harbour ME, Fearnley IM, Crouch RJ, Conti MA, Adelstein RS, Walker JE, Holt IJ.

Nucleic Acids Res. 2011 Jul;39(12):5098-108. doi: 10.1093/nar/gkr052. Epub 2011 Mar 11.


Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid.

Pohjoismäki JL, Holmes JB, Wood SR, Yang MY, Yasukawa T, Reyes A, Bailey LJ, Cluett TJ, Goffart S, Willcox S, Rigby RE, Jackson AP, Spelbrink JN, Griffith JD, Crouch RJ, Jacobs HT, Holt IJ.

J Mol Biol. 2010 Apr 16;397(5):1144-55. doi: 10.1016/j.jmb.2010.02.029. Epub 2010 Feb 23.


Quality of life research: types of publication output over time for cancer patients, a systematic review.

Bailey LJ, Sanson-Fisher R, Aranda S, D'Este C, Sharkey K, Schofield P.

Eur J Cancer Care (Engl). 2010 Sep;19(5):581-8. doi: 10.1111/j.1365-2354.2009.01109.x. Epub 2009 Oct 14. Review.


Quality of life research: is there a difference in output between the major cancer types?

Sanson-Fisher R, Bailey LJ, Aranda S, D'Este C, Stojanovski E, Sharkey K, Schofield P.

Eur J Cancer Care (Engl). 2010 Nov;19(6):714-20. doi: 10.1111/j.1365-2354.2009.01158.x. Review.


Crystallographic and catalytic studies of the peroxide-shunt reaction in a diiron hydroxylase.

Bailey LJ, Fox BG.

Biochemistry. 2009 Sep 29;48(38):8932-9. doi: 10.1021/bi901150a.


The accessory subunit of mitochondrial DNA polymerase gamma determines the DNA content of mitochondrial nucleoids in human cultured cells.

Di Re M, Sembongi H, He J, Reyes A, Yasukawa T, Martinsson P, Bailey LJ, Goffart S, Boyd-Kirkup JD, Wong TS, Fersht AR, Spelbrink JN, Holt IJ.

Nucleic Acids Res. 2009 Sep;37(17):5701-13. doi: 10.1093/nar/gkp614. Epub 2009 Jul 22.


Structural and functional studies of truncated hemolysin A from Proteus mirabilis.

Weaver TM, Smith JA, Hocking JM, Bailey LJ, Wawrzyn GT, Howard DR, Sikkink LA, Ramirez-Alvarado M, Thompson JR.

J Biol Chem. 2009 Aug 14;284(33):22297-309. doi: 10.1074/jbc.M109.014431. Epub 2009 Jun 3. Erratum in: J Biol Chem. 2013 Apr 5;288(14):10092. Smith, Joshua A [added].


The state of residential care for people with mental illness; insights from an audit of the screening tool for entry to licensed residential facilities.

Bailey LJ, Sheehy RJ.

Aust N Z J Public Health. 2009 Apr;33(2):140-3. doi: 10.1111/j.1753-6405.2009.00360.x.


Role for threonine 201 in the catalytic cycle of the soluble diiron hydroxylase toluene 4-monooxygenase.

Elsen NL, Bailey LJ, Hauser AD, Fox BG.

Biochemistry. 2009 May 12;48(18):3838-46. doi: 10.1021/bi900144a.


Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA.

Bailey LJ, Cluett TJ, Reyes A, Prolla TA, Poulton J, Leeuwenburgh C, Holt IJ.

Nucleic Acids Res. 2009 Apr;37(7):2327-35. doi: 10.1093/nar/gkp091. Epub 2009 Feb 25.


Structural consequences of effector protein complex formation in a diiron hydroxylase.

Bailey LJ, McCoy JG, Phillips GN Jr, Fox BG.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19194-8. doi: 10.1073/pnas.0807948105. Epub 2008 Nov 25.


We are what we do: research outputs of public health.

Sanson-Fisher RW, Campbell EM, Htun AT, Bailey LJ, Millar CJ.

Am J Prev Med. 2008 Oct;35(4):380-5. doi: 10.1016/j.amepre.2008.06.039. Epub 2008 Aug 6.


Discovery of sarcosine dimethylglycine methyltransferase from Galdieria sulphuraria.

McCoy JG, Bailey LJ, Ng YH, Bingman CA, Wrobel R, Weber AP, Fox BG, Phillips GN Jr.

Proteins. 2009 Feb 1;74(2):368-77. doi: 10.1002/prot.22147.

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