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Items: 10

1.

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells.

Foulkes DM, Byrne DP, Yeung W, Shrestha S, Bailey FP, Ferries S, Eyers CE, Keeshan K, Wells C, Drewry DH, Zuercher WJ, Kannan N, Eyers PA.

Sci Signal. 2018 Sep 25;11(549). pii: eaat7951. doi: 10.1126/scisignal.aat7951.

PMID:
30254057
2.

Kinome-wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics.

Bailey FP, Clarke K, Kalirai H, Kenyani J, Shahidipour H, Falciani F, Coulson JM, Sacco JJ, Coupland SE, Eyers PA.

Pigment Cell Melanoma Res. 2018 Mar;31(2):253-266. doi: 10.1111/pcmr.12650. Epub 2017 Oct 15.

PMID:
28972303
3.

The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.

Bago R, Sommer E, Castel P, Crafter C, Bailey FP, Shpiro N, Baselga J, Cross D, Eyers PA, Alessi DR.

EMBO J. 2016 Oct 17;35(20):2263. No abstract available.

4.

The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.

Bago R, Sommer E, Castel P, Crafter C, Bailey FP, Shpiro N, Baselga J, Cross D, Eyers PA, Alessi DR.

EMBO J. 2016 Sep 1;35(17):1902-22. doi: 10.15252/embj.201693929. Epub 2016 Aug 1. Erratum in: EMBO J. 2016 Oct 17;35(20):2263.

5.

Tribbles pseudokinases: novel targets for chemical biology and drug discovery?

Foulkes DM, Byrne DP, Bailey FP, Eyers PA.

Biochem Soc Trans. 2015 Oct;43(5):1095-103. doi: 10.1042/BST20150109. Review.

PMID:
26517930
6.

2) Going for broke: targeting the human cancer pseudokinome.

Bailey FP, Byrne DP, McSkimming D, Kannan N, Eyers PA.

Biochem J. 2015 Feb 15;466(1):201. No abstract available.

PMID:
25656056
7.

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner.

Bailey FP, Byrne DP, Oruganty K, Eyers CE, Novotny CJ, Shokat KM, Kannan N, Eyers PA.

Biochem J. 2015 Apr 1;467(1):47-62. doi: 10.1042/BJ20141441.

8.

Going for broke: targeting the human cancer pseudokinome.

Bailey FP, Byrne DP, McSkimming D, Kannan N, Eyers PA.

Biochem J. 2015 Jan 15;465(2):195-211. doi: 10.1042/BJ20141060. Review. Erratum in: Biochem J. 2015 Feb 15;466(1):201.

PMID:
25559089
9.

The resistance tetrad: amino acid hotspots for kinome-wide exploitation of drug-resistant protein kinase alleles.

Bailey FP, Andreev VI, Eyers PA.

Methods Enzymol. 2014;548:117-46. doi: 10.1016/B978-0-12-397918-6.00005-7. Review.

PMID:
25399644
10.

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.

Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D, Hammaren H, Silvennoinen O, Varghese LN, Chen K, Tripaydonis A, Jura N, Fukuda K, Qin J, Nimchuk Z, Mudgett MB, Elowe S, Gee CL, Liu L, Daly RJ, Manning G, Babon JJ, Lucet IS.

Biochem J. 2014 Jan 15;457(2):323-34. doi: 10.1042/BJ20131174.

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