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Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy.

Klepsch V, Pommermayr M, Humer D, Brigo N, Hermann-Kleiter N, Baier G.

Cell Commun Signal. 2020 Jan 14;18(1):8. doi: 10.1186/s12964-019-0454-z.


Loss-of-function phenotype of a PKCθT219A knockin mouse strain.

Thuille N, Siegmund K, Klepsch V, Schörgenhuber J, Danklmaier S, Leitges M, Baier G.

Cell Commun Signal. 2019 Nov 6;17(1):141. doi: 10.1186/s12964-019-0466-8.


Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21.

Olson WJ, Jakic B, Labi V, Schoeler K, Kind M, Klepsch V, Baier G, Hermann-Kleiter N.

Cell Rep. 2019 Sep 10;28(11):2878-2891.e5. doi: 10.1016/j.celrep.2019.08.024.


Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD.

Klepsch V, Moschen AR, Tilg H, Baier G, Hermann-Kleiter N.

Front Immunol. 2019 May 14;10:1070. doi: 10.3389/fimmu.2019.01070. eCollection 2019. Review.


Novel mutant mouse line emphasizes the importance of protein kinase C theta for CD4+ T lymphocyte activation.

Siegmund K, Thuille N, Posch N, Fresser F, Leitges M, Baier G.

Cell Commun Signal. 2019 May 28;17(1):56. doi: 10.1186/s12964-019-0364-0.


Development of a fast and sensitive method to study transcription factor activation under endogenous conditions in primary mouse T cells applying Alpha technology.

Thuille N, Baier G.

J Immunol Methods. 2019 Aug;471:57-60. doi: 10.1016/j.jim.2019.05.002. Epub 2019 May 23. No abstract available.


DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer.

Weigel C, Chaisaingmongkol J, Assenov Y, Kuhmann C, Winkler V, Santi I, Bogatyrova O, Kaucher S, Bermejo JL, Leung SY, Chan TL, Lasitschka F, Bohrer MH, Marx A, Haußen RH, Herold-Mende C, Dyckhoff G, Boukamp P, Delank KW, Hörmann K, Lippert BM, Baier G, Dietz A, Oakes CC, Plass C, Becher H, Schmezer P, Ramroth H, Popanda O.

Clin Epigenetics. 2019 May 3;11(1):67. doi: 10.1186/s13148-019-0666-5.


Fcμ receptor as a Costimulatory Molecule for T Cells.

Meryk A, Pangrazzi L, Hagen M, Hatzmann F, Jenewein B, Jakic B, Hermann-Kleiter N, Baier G, Jylhävä J, Hurme M, Trieb K, Grubeck-Loebenstein B.

Cell Rep. 2019 Mar 5;26(10):2681-2691.e5. doi: 10.1016/j.celrep.2019.02.024.


Effects of brain-derived neurotrophic factor and noise on transitions in temporal lobe epilepsy in a hippocampal network.

Zhang L, Fan D, Wang Q, Baier G.

Chaos. 2018 Oct;28(10):106322. doi: 10.1063/1.5036690.


Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b.

Peer S, Cappellano G, Hermann-Kleiter N, Albrecht-Schgoer K, Hinterleitner R, Baier G, Gruber T.

Front Immunol. 2018 Oct 8;9:2311. doi: 10.3389/fimmu.2018.02311. eCollection 2018.


Network dynamics in the healthy and epileptic developing brain.

Rosch R, Baldeweg T, Moeller F, Baier G.

Netw Neurosci. 2018 Mar 1;2(1):41-59. doi: 10.1162/NETN_a_00026. eCollection 2018 Spring.


Enzyme-Polymer Conjugates to Enhance Enzyme Shelf Life in a Liquid Detergent Formulation.

Kübelbeck S, Mikhael J, Keller H, Konradi R, Andrieu-Brunsen A, Baier G.

Macromol Biosci. 2018 Jul;18(7):e1800095. doi: 10.1002/mabi.201800095. Epub 2018 Jun 5.


Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.

Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Buscarlet M, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR, Busque L, Godley LA, Verdú EF, Barreiro LB, Jabri B.

Nature. 2018 May;557(7706):580-584. doi: 10.1038/s41586-018-0125-z. Epub 2018 May 16.


Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.

Klepsch V, Hermann-Kleiter N, Do-Dinh P, Jakic B, Offermann A, Efremova M, Sopper S, Rieder D, Krogsdam A, Gamerith G, Perner S, Tzankov A, Trajanoski Z, Wolf D, Baier G.

Nat Commun. 2018 Apr 18;9(1):1538. doi: 10.1038/s41467-018-04004-2.


Protein kinase N1 critically regulates cerebellar development and long-term function.

zur Nedden S, Eith R, Schwarzer C, Zanetti L, Seitter H, Fresser F, Koschak A, Cameron AJ, Parker PJ, Baier G, Baier-Bitterlich G.

J Clin Invest. 2018 May 1;128(5):2076-2088. doi: 10.1172/JCI96165. Epub 2018 Apr 16.


Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution.

Efremova M, Rieder D, Klepsch V, Charoentong P, Finotello F, Hackl H, Hermann-Kleiter N, Löwer M, Baier G, Krogsdam A, Trajanoski Z.

Nat Commun. 2018 Jan 2;9(1):32. doi: 10.1038/s41467-017-02424-0.


NAD metabolism fuels human and mouse intestinal inflammation.

Gerner RR, Klepsch V, Macheiner S, Arnhard K, Adolph TE, Grander C, Wieser V, Pfister A, Moser P, Hermann-Kleiter N, Baier G, Oberacher H, Tilg H, Moschen AR.

Gut. 2018 Oct;67(10):1813-1823. doi: 10.1136/gutjnl-2017-314241. Epub 2017 Sep 6.


Nuclear orphan receptor NR2F6 as a safeguard against experimental murine colitis.

Klepsch V, Gerner RR, Klepsch S, Olson WJ, Tilg H, Moschen AR, Baier G, Hermann-Kleiter N.

Gut. 2018 Aug;67(8):1434-1444. doi: 10.1136/gutjnl-2016-313466. Epub 2017 Aug 4.


Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.

Peer S, Baier G, Gruber T.

Oncotarget. 2017 Jun 27;8(26):41841-41853. doi: 10.18632/oncotarget.18360.


Protein kinase C theta is dispensable for suppression mediated by CD25+CD4+ regulatory T cells.

Siegmund K, Thuille N, Wachowicz K, Hermann-Kleiter N, Baier G.

PLoS One. 2017 May 22;12(5):e0175463. doi: 10.1371/journal.pone.0175463. eCollection 2017.


Understanding Epileptiform After-Discharges as Rhythmic Oscillatory Transients.

Baier G, Taylor PN, Wang Y.

Front Comput Neurosci. 2017 Apr 18;11:25. doi: 10.3389/fncom.2017.00025. eCollection 2017.


Interleukin-2 Functionalized Nanocapsules for T Cell-Based Immunotherapy.

Frick SU, Domogalla MP, Baier G, Wurm FR, Mailänder V, Landfester K, Steinbrink K.

ACS Nano. 2016 Oct 25;10(10):9216-9226. doi: 10.1021/acsnano.5b07973. Epub 2016 Oct 12.


Novel Insights into the PKCβ-dependent Regulation of the Oxidoreductase p66Shc.

Haller M, Khalid S, Kremser L, Fresser F, Furlan T, Hermann M, Guenther J, Drasche A, Leitges M, Giorgio M, Baier G, Lindner H, Troppmair J.

J Biol Chem. 2016 Nov 4;291(45):23557-23568. Epub 2016 Sep 13.


Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.

Siegmund K, Klepsch V, Hermann-Kleiter N, Baier G.

J Biol Chem. 2016 Oct 14;291(42):22086-22092. Epub 2016 Aug 26.


Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice.

Pfeifhofer-Obermair C, Albrecht-Schgoer K, Peer S, Nairz M, Siegmund K, Klepsch V, Haschka D, Thuille N, Hermann-Kleiter N, Gruber T, Weiss G, Baier G.

Cell Commun Signal. 2016 Jul 28;14(1):14. doi: 10.1186/s12964-016-0137-y.


Inhibition of CBLB protects from lethal Candida albicans sepsis.

Wirnsberger G, Zwolanek F, Asaoka T, Kozieradzki I, Tortola L, Wimmer RA, Kavirayani A, Fresser F, Baier G, Langdon WY, Ikeda F, Kuchler K, Penninger JM.

Nat Med. 2016 Aug;22(8):915-23. doi: 10.1038/nm.4134. Epub 2016 Jul 18.


Beyond CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy.

Klepsch V, Hermann-Kleiter N, Baier G.

Immunol Lett. 2016 Oct;178:31-6. doi: 10.1016/j.imlet.2016.03.007. Epub 2016 Mar 15. Review.


cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation.

Khalid S, Drasche A, Thurner M, Hermann M, Ashraf MI, Fresser F, Baier G, Kremser L, Lindner H, Troppmair J.

Sci Rep. 2016 Feb 12;6:20930. doi: 10.1038/srep20930.


Glutathione Responsive Hyaluronic Acid Nanocapsules Obtained by Bioorthogonal Interfacial "Click" Reaction.

Baier G, Fichter M, Kreyes A, Klein K, Mailänder V, Gehring S, Landfester K.

Biomacromolecules. 2016 Jan 11;17(1):148-53. doi: 10.1021/acs.biomac.5b01279. Epub 2015 Dec 16.


The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.

Hermann-Kleiter N, Klepsch V, Wallner S, Siegmund K, Klepsch S, Tuzlak S, Villunger A, Kaminski S, Pfeifhofer-Obermair C, Gruber T, Wolf D, Baier G.

Cell Rep. 2015 Sep 29;12(12):2072-85. doi: 10.1016/j.celrep.2015.08.035. Epub 2015 Sep 17.


Critical Materials Recovery from Solutions and Wastes: Retrospective and Outlook.

Diallo MS, Baier G, Moyer BA, Hamelers B.

Environ Sci Technol. 2015 Aug 18;49(16):9387-9. doi: 10.1021/acs.est.5b03694. No abstract available.


Enzyme-responsive nanocomposites for wound infection prophylaxis in burn management: in vitro evaluation of their compatibility with healing processes.

Grützner V, Unger RE, Baier G, Choritz L, Freese C, Böse T, Landfester K, Kirkpatrick CJ.

Int J Nanomedicine. 2015 Jun 24;10:4111-24. doi: 10.2147/IJN.S81263. eCollection 2015.


Attachment of Poly(l-lactide) Nanoparticles to Plasma-Treated Non-Woven Polymer Fabrics Using Inkjet Printing.

Ivanova TV, Baier G, Landfester K, Musin E, Al-Bataineh SA, Cameron DC, Homola T, Whittle JD, Sillanpää M.

Macromol Biosci. 2015 Sep;15(9):1274-82. doi: 10.1002/mabi.201500067. Epub 2015 May 27.


Novel protein kinase C θ: coronin 1A complex in T lymphocytes.

Siegmund K, Thuille N, Posch N, Fresser F, Baier G.

Cell Commun Signal. 2015 Mar 31;13:22. doi: 10.1186/s12964-015-0100-3.


Protein corona of nanoparticles: distinct proteins regulate the cellular uptake.

Ritz S, Schöttler S, Kotman N, Baier G, Musyanovych A, Kuharev J, Landfester K, Schild H, Jahn O, Tenzer S, Mailänder V.

Biomacromolecules. 2015 Apr 13;16(4):1311-21. doi: 10.1021/acs.biomac.5b00108. Epub 2015 Apr 3.


Heparin-based nanocapsules as potential drug delivery systems.

Baier G, Winzen S, Messerschmidt C, Frank D, Fichter M, Gehring S, Mailänder V, Landfester K.

Macromol Biosci. 2015 Jun;15(6):765-76. doi: 10.1002/mabi.201500035. Epub 2015 Mar 12.


Complementary analysis of the hard and soft protein corona: sample preparation critically effects corona composition.

Winzen S, Schoettler S, Baier G, Rosenauer C, Mailaender V, Landfester K, Mohr K.

Nanoscale. 2015 Feb 21;7(7):2992-3001. doi: 10.1039/c4nr05982d.


Monophosphoryl lipid A coating of hydroxyethyl starch nanocapsules drastically increases uptake and maturation by dendritic cells while minimizing the adjuvant dosage.

Fichter M, Dedters M, Pietrzak-Nguyen A, Pretsch L, Meyer CU, Strand S, Zepp F, Baier G, Landfester K, Gehring S.

Vaccine. 2015 Feb 11;33(7):838-46. doi: 10.1016/j.vaccine.2014.12.072. Epub 2015 Jan 6.


A computational study of stimulus driven epileptic seizure abatement.

Taylor PN, Wang Y, Goodfellow M, Dauwels J, Moeller F, Stephani U, Baier G.

PLoS One. 2014 Dec 22;9(12):e114316. doi: 10.1371/journal.pone.0114316. eCollection 2014.


Pharmacokinetics on a microscale: visualizing Cy5-labeled oligonucleotide release from poly(n-butylcyanoacrylate) nanocapsules in cells.

Tomcin S, Baier G, Landfester K, Mailänder V.

Int J Nanomedicine. 2014 Nov 26;9:5471-89. doi: 10.2147/IJN.S70908. eCollection 2014.


Protein kinase Cθ: the pleiotropic T-cell signalling intermediate.

Wachowicz K, Baier G.

Biochem Soc Trans. 2014 Dec;42(6):1512-8. doi: 10.1042/BST20140179.


Dynamic mechanisms of neocortical focal seizure onset.

Wang Y, Goodfellow M, Taylor PN, Baier G.

PLoS Comput Biol. 2014 Aug 14;10(8):e1003787. doi: 10.1371/journal.pcbi.1003787. eCollection 2014 Aug.


Synthesis and surface immobilization of antibacterial hybrid silver-poly(l-lactide) nanoparticles.

Taheri S, Baier G, Majewski P, Barton M, Förch R, Landfester K, Vasilev K.

Nanotechnology. 2014 Aug 1;25(30):305102. doi: 10.1088/0957-4484/25/30/305102. Epub 2014 Jul 10.


Corrigendum to "PKC∝ and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription" [Immunol. Lett. 151 (1-2) (2013) 31-38)].

Lutz-Nicoladoni C, Thuille N, Wachowicz K, Gruber T, Leitges M, Baier G.

Immunol Lett. 2014 Jul;160(1):104. doi: 10.1016/j.imlet.2013.11.020. Epub 2013 Dec 7. No abstract available.


Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions.

Hermann-Kleiter N, Baier G.

Cell Commun Signal. 2014 Jun 12;12:38. doi: 10.1186/1478-811X-12-38. Review.


Enhanced in vivo targeting of murine nonparenchymal liver cells with monophosphoryl lipid A functionalized microcapsules.

Pietrzak-Nguyen A, Fichter M, Dedters M, Pretsch L, Gregory SH, Meyer C, Doganci A, Diken M, Landfester K, Baier G, Gehring S.

Biomacromolecules. 2014 Jul 14;15(7):2378-88. doi: 10.1021/bm5006728. Epub 2014 Jun 26.


Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration.

Ong ST, Freeley M, Skubis-Zegadło J, Fazil MH, Kelleher D, Fresser F, Baier G, Verma NK, Long A.

J Biol Chem. 2014 Jul 11;289(28):19420-34. doi: 10.1074/jbc.M113.545863. Epub 2014 May 28.


Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells.

Wachowicz K, Hermann-Kleiter N, Meisel M, Siegmund K, Thuille N, Baier G.

PLoS One. 2014 May 2;9(5):e96401. doi: 10.1371/journal.pone.0096401. eCollection 2014.


LAMTOR2-mediated modulation of NGF/MAPK activation kinetics during differentiation of PC12 cells.

Thauerer B, Voegele P, Hermann-Kleiter N, Thuille N, de Araujo ME, Offterdinger M, Baier G, Huber LA, Baier-Bitterlich G.

PLoS One. 2014 Apr 21;9(4):e95863. doi: 10.1371/journal.pone.0095863. eCollection 2014.


The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.

Paolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, Jamieson AM, Langdon WY, Ikeda F, Fededa JP, Cronin SJ, Nitsch R, Schultz-Fademrecht C, Eickhoff J, Menninger S, Unger A, Torka R, Gruber T, Hinterleitner R, Baier G, Wolf D, Ullrich A, Klebl BM, Penninger JM.

Nature. 2014 Mar 27;507(7493):508-12. doi: 10.1038/nature12998. Epub 2014 Feb 19.

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