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Items: 38

1.

Discovery of an L-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100.

Kim SH, Tangallapally R, Kim IC, Trovato R, Parker D, Patton JS, Reeves L, Bradford C, Wettstein D, Baichwal V, Papac D, Bajji A, Carlson R, Yager KM.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5254-7. doi: 10.1016/j.bmcl.2015.09.053. Epub 2015 Sep 28.

PMID:
26483201
2.

Discovery of a new HIV-1 inhibitor scaffold and synthesis of potential prodrugs of indazoles.

Kim SH, Markovitz B, Trovato R, Murphy BR, Austin H, Willardsen AJ, Baichwal V, Morham S, Bajji A.

Bioorg Med Chem Lett. 2013 May 15;23(10):2888-92. doi: 10.1016/j.bmcl.2013.03.075. Epub 2013 Mar 29.

PMID:
23566519
3.

Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor.

Kim SH, Bajji A, Tangallapally R, Markovitz B, Trovato R, Shenderovich M, Baichwal V, Bartel P, Cimbora D, McKinnon R, Robinson R, Papac D, Wettstein D, Carlson R, Yager KM.

J Med Chem. 2012 Sep 13;55(17):7480-501. doi: 10.1021/jm3004619. Epub 2012 Aug 31.

PMID:
22913511
4.

Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1.

Tardif KD, Rogers A, Cassiano J, Roth BL, Cimbora DM, McKinnon R, Peterson A, Douce TB, Robinson R, Dorweiler I, Davis T, Hess MA, Ostanin K, Papac DI, Baichwal V, McAlexander I, Willardsen JA, Saunders M, Christophe H, Kumar DV, Wettstein DA, Carlson RO, Williams BL.

Mol Cancer Ther. 2011 Dec;10(12):2267-75. doi: 10.1158/1535-7163.MCT-11-0453. Epub 2011 Oct 6.

5.

A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit.

Cushing TD, Baichwal V, Berry K, Billedeau R, Bordunov V, Broka C, Cardozo M, Cheng P, Clark D, Dalrymple S, DeGraffenreid M, Gill A, Hao X, Hawley RC, He X, Jaen JC, Labadie SS, Labelle M, Lehel C, Lu PP, McIntosh J, Miao S, Parast C, Shin Y, Sjogren EB, Smith ML, Talamas FX, Tonn G, Walker KM, Walker NP, Wesche H, Whitehead C, Wright M, Browner MF.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):417-22. doi: 10.1016/j.bmcl.2010.10.126. Epub 2010 Oct 29.

PMID:
21074993
6.

A novel series of IKKβ inhibitors part II: description of a potent and pharmacologically active series of analogs.

Cushing TD, Baichwal V, Berry K, Billedeau R, Bordunov V, Broka C, Browner MF, Cardozo M, Cheng P, Clark D, Dalrymple S, DeGraffenreid M, Gill A, Hao X, Hawley RC, He X, Labadie SS, Labelle M, Lehel C, Lu PP, McIntosh J, Miao S, Parast C, Shin Y, Sjogren EB, Smith ML, Talamas FX, Tonn G, Walker KM, Walker NP, Wesche H, Whitehead C, Wright M, Jaen JC.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):423-6. doi: 10.1016/j.bmcl.2010.10.125. Epub 2010 Oct 29.

PMID:
21074992
7.

Inhibition of eEF2-K by thieno[2,3-b]pyridine analogues.

Lockman JW, Reeder MD, Suzuki K, Ostanin K, Hoff R, Bhoite L, Austin H, Baichwal V, Adam Willardsen J.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2283-6. doi: 10.1016/j.bmcl.2010.02.005. Epub 2010 Feb 6.

PMID:
20189382
8.

Triterpene based compounds with potent anti-maturation activity against HIV-1.

Gerrish D, Kim IC, Kumar DV, Austin H, Garrus JE, Baichwal V, Saunders M, McKinnon RS, Anderson MB, Carlson R, Arranz-Plaza E, Yager KM.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6377-80. doi: 10.1016/j.bmcl.2008.10.098. Epub 2008 Oct 25.

PMID:
18996008
9.

Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity.

Sirisoma N, Kasibhatla S, Pervin A, Zhang H, Jiang S, Willardsen JA, Anderson MB, Baichwal V, Mather GG, Jessing K, Hussain R, Hoang K, Pleiman CM, Tseng B, Drewe J, Cai SX.

J Med Chem. 2008 Aug 14;51(15):4771-9. doi: 10.1021/jm8003653. Epub 2008 Jul 24.

PMID:
18651728
10.

MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps.

Kasibhatla S, Baichwal V, Cai SX, Roth B, Skvortsova I, Skvortsov S, Lukas P, English NM, Sirisoma N, Drewe J, Pervin A, Tseng B, Carlson RO, Pleiman CM.

Cancer Res. 2007 Jun 15;67(12):5865-71.

11.

Hydrophilic, pro-drug analogues of T138067 are efficacious in controlling tumor growth in vivo and show a decreased ability to cross the blood brain barrier.

Rubenstein SM, Baichwal V, Beckmann H, Clark DL, Frankmoelle W, Roche D, Santha E, Schwender S, Thoolen M, Ye Q, Jaen JC.

J Med Chem. 2001 Oct 25;44(22):3599-605.

PMID:
11606124
12.

Novel antineoplastic agents with efficacy against multidrug resistant tumor cells.

Medina JC, Shan B, Beckmann H, Farrell RP, Clark DL, Learned RM, Roche D, Li A, Baichwal V, Case C, Baeuerle PA, Rosen T, Jaen JC.

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2653-6.

PMID:
9873597
13.

Identification of ERF-1 as a member of the AP2 transcription factor family.

McPherson LA, Baichwal VR, Weigel RJ.

Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4342-7.

14.

Activate NF-kappa B or die?

Baichwal VR, Baeuerle PA.

Curr Biol. 1997 Feb 1;7(2):R94-6. Review.

15.

NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.

Baeuerle PA, Baichwal VR.

Adv Immunol. 1997;65:111-37. Review. No abstract available.

PMID:
9238509
16.
17.

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.

Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV.

Immunity. 1996 Apr;4(4):387-96.

18.

Sp1 is a component of the cytokine-inducible enhancer in the promoter of vascular cell adhesion molecule-1.

Neish AS, Khachigian LM, Park A, Baichwal VR, Collins T.

J Biol Chem. 1995 Dec 1;270(48):28903-9.

23.

Intramolecular charge heterogeneity in purified major histocompatibility class II alpha and beta polypeptide chains.

Nag B, Arimilli S, Koukis B, Rhodes E, Baichwal V, Sharma SD.

J Biol Chem. 1994 Apr 1;269(13):10061-70.

24.
25.

Transcription factor based therapeutics: drugs of the future?

Peterson MG, Baichwal VR.

Trends Biotechnol. 1993 Jan;11(1):11-8. Review.

PMID:
7763378
26.

Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.

Chou SY, Baichwal V, Ferrell JE Jr.

Mol Biol Cell. 1992 Oct;3(10):1117-30.

27.
28.

Structure-function analysis of the histidine permease and comparison with cystic fibrosis mutations.

Shyamala V, Baichwal V, Beall E, Ames GF.

J Biol Chem. 1991 Oct 5;266(28):18714-9.

29.

v-Src and EJ Ras alleviate repression of c-Jun by a cell-specific inhibitor.

Baichwal VR, Park A, Tjian R.

Nature. 1991 Jul 11;352(6331):165-8.

PMID:
1906140
30.

Rapid polymerase chain reaction amplification using intact bacterial cells.

Joshi AK, Baichwal V, Ames GF.

Biotechniques. 1991 Jan;10(1):42, 44-5.

PMID:
2003920
33.

Characterization of the BNLF-1 oncogene of Epstein-Barr virus.

Baichwal VR, Hammerschmidt W, Sugden B.

Curr Top Microbiol Immunol. 1989;144:233-9. No abstract available.

PMID:
2551585
35.

Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus.

Baichwal VR, Sugden B.

Oncogene. 1988 May;2(5):461-7.

PMID:
2836780
36.

Latency comes of age for herpesviruses.

Baichwal VR, Sugden B.

Cell. 1988 Mar 25;52(6):787-9. Review. No abstract available.

PMID:
2832064

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