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Items: 30


Preconditioning in the Rhesus Macaque Induces a Proteomic Signature Following Cerebral Ischemia that Is Associated with Neuroprotection.

Stevens SL, Liu T, Bahjat FR, Petyuk VA, Schepmoes AA, Sontag RL, Gritsenko MA, Wu C, Wang S, Shukla AK, Jacobs JM, Smith RD, Rodland KD, Alexander West G, Kohama SG, Glynn C, Stenzel-Poore MP.

Transl Stroke Res. 2019 Aug;10(4):440-448. doi: 10.1007/s12975-018-0670-7. Epub 2018 Oct 19.


Preclinical Development of a Prophylactic Neuroprotective Therapy for the Preventive Treatment of Anticipated Ischemia-Reperfusion Injury.

Bahjat FR, Alexander West G, Kohama SG, Glynn C, Urbanski HF, Hobbs TR, Earl E, Stevens SL, Stenzel-Poore MP.

Transl Stroke Res. 2017 Aug;8(4):322-333. doi: 10.1007/s12975-017-0532-8. Epub 2017 Apr 5.


Serum Immunoregulatory Proteins as Predictors of Overall Survival of Metastatic Melanoma Patients Treated with Ipilimumab.

Koguchi Y, Hoen HM, Bambina SA, Rynning MD, Fuerstenberg RK, Curti BD, Urba WJ, Milburn C, Bahjat FR, Korman AJ, Bahjat KS.

Cancer Res. 2015 Dec 1;75(23):5084-92. doi: 10.1158/0008-5472.CAN-15-2303.


Cytosolic Receptor Melanoma Differentiation-Associated Protein 5 Mediates Preconditioning-Induced Neuroprotection Against Cerebral Ischemic Injury.

Gesuete R, Christensen SN, Bahjat FR, Packard AE, Stevens SL, Liu M, Salazar AM, Stenzel-Poore MP.

Stroke. 2016 Jan;47(1):262-6. doi: 10.1161/STROKEAHA.115.010329. Epub 2015 Nov 12.


GDF10 is a signal for axonal sprouting and functional recovery after stroke.

Li S, Nie EH, Yin Y, Benowitz LI, Tung S, Vinters HV, Bahjat FR, Stenzel-Poore MP, Kawaguchi R, Coppola G, Carmichael ST.

Nat Neurosci. 2015 Dec;18(12):1737-45. doi: 10.1038/nn.4146. Epub 2015 Oct 26.


Changes in spontaneous activity assessed by accelerometry correlate with extent of cerebral ischemia-reperfusion injury in the nonhuman primate.

Urbanski HF, Kohama SG, West GA, Glynn C, Williams-Karnesky RL, Earl E, Neuringer MN, Renner L, Weiss A, Stenzel-Poore M, Bahjat FR.

Transl Stroke Res. 2012 Dec;3(4):442-51. doi: 10.1007/s12975-012-0191-8.


Steps to translate preconditioning from basic research to the clinic.

Bahjat FR, Gesuete R, Stenzel-Poore MP.

Transl Stroke Res. 2013 Feb;4(1):89-103. doi: 10.1007/s12975-012-0223-4. Epub 2012 Nov 2. Review.


Poly-ICLC preconditioning protects the blood-brain barrier against ischemic injury in vitro through type I interferon signaling.

Gesuete R, Packard AE, Vartanian KB, Conrad VK, Stevens SL, Bahjat FR, Yang T, Stenzel-Poore MP.

J Neurochem. 2012 Nov;123 Suppl 2:75-85. doi: 10.1111/j.1471-4159.2012.07946.x.


TLR9 bone marrow chimeric mice define a role for cerebral TNF in neuroprotection induced by CpG preconditioning.

Packard AE, Leung PY, Vartanian KB, Stevens SL, Bahjat FR, Stenzel-Poore MP.

J Cereb Blood Flow Metab. 2012 Dec;32(12):2193-200. doi: 10.1038/jcbfm.2012.140. Epub 2012 Sep 26.


Poly-IC preconditioning protects against cerebral and renal ischemia-reperfusion injury.

Packard AE, Hedges JC, Bahjat FR, Stevens SL, Conlin MJ, Salazar AM, Stenzel-Poore MP.

J Cereb Blood Flow Metab. 2012 Feb;32(2):242-7. doi: 10.1038/jcbfm.2011.160. Epub 2011 Nov 16.


Proof of concept: pharmacological preconditioning with a Toll-like receptor agonist protects against cerebrovascular injury in a primate model of stroke.

Bahjat FR, Williams-Karnesky RL, Kohama SG, West GA, Doyle KP, Spector MD, Hobbs TR, Stenzel-Poore MP.

J Cereb Blood Flow Metab. 2011 May;31(5):1229-42. doi: 10.1038/jcbfm.2011.6. Epub 2011 Feb 2.


Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice.

Deng GM, Liu L, Bahjat FR, Pine PR, Tsokos GC.

Arthritis Rheum. 2010 Jul;62(7):2086-92. doi: 10.1002/art.27452.


An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus.

Bahjat FR, Pine PR, Reitsma A, Cassafer G, Baluom M, Grillo S, Chang B, Zhao FF, Payan DG, Grossbard EB, Daikh DI.

Arthritis Rheum. 2008 May;58(5):1433-44. doi: 10.1002/art.23428.


Differential maturation of murine bone-marrow derived dendritic cells with lipopolysaccharide and tumor necrosis factor-alpha.

Efron PA, Tsujimoto H, Bahjat FR, Ungaro R, Debernardis J, Tannahill C, Baker HV, Edwards CK, Moldawer LL.

J Endotoxin Res. 2005;11(3):145-60.


Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis.

Oberholzer A, Oberholzer C, Efron PA, Scumpia PO, Uchida T, Bahjat K, Ungaro R, Tannahill CL, Murday M, Bahjat FR, Tsai V, Hutchins B, Moldawer LL, Laface D, Clare-Salzler MJ.

Shock. 2005 Jun;23(6):507-15.


Influence of recombinant adenovirus on liver injury in endotoxicosis and its modulation by IL-10 expression.

Oberholzer C, Oberholzer A, Tschoeke SK, Minter RM, Bahjat FR, LaFace D, Hutchins B, Moldawer LL.

J Endotoxin Res. 2004;10(6):393-401.


A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation.

Chao TH, Lam T, Vong BG, Través PG, Hortelano S, Chowdhury C, Bahjat FR, Lloyd GK, Moldawer LL, Boscá L, Palladino MA, Theodorakis EA.

Chembiochem. 2005 Jan;6(1):133-44.


Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis.

Efron PA, Martins A, Minnich D, Tinsley K, Ungaro R, Bahjat FR, Hotchkiss R, Clare-Salzler M, Moldawer LL.

J Immunol. 2004 Sep 1;173(5):3035-43.


Aberrant signaling in the TNFalpha/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse.

Blenman KR, Bahjat FR, Moldawer LL, Morel L.

Clin Immunol. 2004 Feb;110(2):124-33.


Anti-TNF-alpha therapies: the next generation.

Palladino MA, Bahjat FR, Theodorakis EA, Moldawer LL.

Nat Rev Drug Discov. 2003 Sep;2(9):736-46. Review.


Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents.

Lam T, Ling T, Chowdhury C, Chao TH, Bahjat FR, Lloyd GK, Moldawer LL, Palladino MA, Theodorakis EA.

Bioorg Med Chem Lett. 2003 Oct 6;13(19):3217-21.


Fas stimulation results in selective islet infiltrate apoptosis in situ and reversal of diabetes.

Dharnidharka VR, Van Patten Y, Bahjat FR, Clare-Salzler M.

Ann N Y Acad Sci. 2002 Apr;958:160-2.


Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells.

Oberholzer A, Oberholzer C, Bahjat KS, Ungaro R, Tannahill CL, Murday M, Bahjat FR, Abouhamze Z, Tsai V, LaFace D, Hutchins B, Moldawer LL, Clare-Salzler MJ.

J Immunol. 2002 Apr 1;168(7):3412-8.


Genetic determinants of lipopolysaccharide and D-galactosamine-mediated hepatocellular apoptosis and lethality.

Oberholzer A, Oberholzer C, Bahjat FR, Edwards CK 3rd, Moldawer LL.

J Endotoxin Res. 2001;7(5):375-80.


Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis.

Oberholzer C, Oberholzer A, Bahjat FR, Minter RM, Tannahill CL, Abouhamze A, LaFace D, Hutchins B, Clare-Salzler MJ, Moldawer LL.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11503-8. Epub 2001 Sep 11.


Adenoviral delivery of human and viral IL-10 in murine sepsis.

Minter RM, Ferry MA, Murday ME, Tannahill CL, Bahjat FR, Oberholzer C, Oberholzer A, LaFace D, Hutchins B, Wen S, Shinoda J, Copeland EM 3rd, Moldawer LL.

J Immunol. 2001 Jul 15;167(2):1053-9.


Extended lung expression and increased tissue localization of viral IL-10 with adenoviral gene therapy.

Minter RM, Ferry MA, Rectenwald JE, Bahjat FR, Oberholzer A, Oberholzer C, La Face D, Tsai V, Ahmed CM, Hutchins B, Copeland EM 3rd, Ginsberg HS, Moldawer LL.

Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):277-82.


Reduced susceptibility of nonobese diabetic mice to TNF-alpha and D-galactosamine-mediated hepatocellular apoptosis and lethality.

Bahjat FR, Dharnidharka VR, Fukuzuka K, Morel L, Crawford JM, Clare-Salzler MJ, Moldawer LL.

J Immunol. 2000 Dec 1;165(11):6559-67.


LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor.

Nowak M, Gaines GC, Rosenberg J, Minter R, Bahjat FR, Rectenwald J, MacKay SL, Edwards CK 3rd, Moldawer LL.

Am J Physiol Regul Integr Comp Physiol. 2000 May;278(5):R1202-9.


Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand.

Josephs MD, Bahjat FR, Fukuzuka K, Ksontini R, Solorzano CC, Edwards CK 3rd, Tannahill CL, MacKay SL, Copeland EM 3rd, Moldawer LL.

Am J Physiol Regul Integr Comp Physiol. 2000 May;278(5):R1196-201.

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