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Items: 1 to 50 of 331

1.

Pharmmaker: Pharmacophore modeling and hit identification based on druggability simulations.

Lee JY, Krieger JM, Li H, Bahar I.

Protein Sci. 2019 Oct 1. doi: 10.1002/pro.3732. [Epub ahead of print]

PMID:
31576621
2.

Regulation of CFTR Bicarbonate Channel Activity by WNK1: Implications for Pancreatitis and CFTR-Related Disorders.

Kim Y, Jun I, Shin DH, Yoon JG, Piao H, Jung J, Park HW, Cheng MH, Bahar I, Whitcomb DC, Lee MG.

Cell Mol Gastroenterol Hepatol. 2019 Sep 24. pii: S2352-345X(19)30121-3. doi: 10.1016/j.jcmgh.2019.09.003. [Epub ahead of print]

3.

Dupilumab-induced ocular surface disease (DIOSD) in patients with atopic dermatitis: clinical presentation, risk factors for development and outcomes of treatment with tacrolimus ointment.

Nahum Y, Mimouni M, Livny E, Bahar I, Hodak E, Leshem YA.

Br J Ophthalmol. 2019 Sep 25. pii: bjophthalmol-2019-315010. doi: 10.1136/bjophthalmol-2019-315010. [Epub ahead of print]

PMID:
31554632
4.

Severe burnout among critical care workers in Turkey.

Elay G, Bahar I, Demirkiran H, Oksüz H.

Saudi Med J. 2019 Sep;40(9):943-948. doi: 10.15537/smj.2019.9.24520.

5.

Radioresistance of Serpinb3a-/- Mice and Derived Hematopoietic and Marrow Stromal Cell Lines.

Thermozier S, Zhang X, Hou W, Fisher R, Epperly MW, Liu B, Bahar I, Wang H, Greenberger JS.

Radiat Res. 2019 Sep;192(3):267-281. doi: 10.1667/RR15379.1. Epub 2019 Jul 11.

PMID:
31295086
6.

Monoamine transporters: structure, intrinsic dynamics and allosteric regulation.

Cheng MH, Bahar I.

Nat Struct Mol Biol. 2019 Jul;26(7):545-556. doi: 10.1038/s41594-019-0253-7. Epub 2019 Jul 3. Review.

7.

Trimerization of dopamine transporter triggered by AIM-100 binding: Molecular mechanism and effect of mutations.

Cheng MH, Ponzoni L, Sorkina T, Lee JY, Zhang S, Sorkin A, Bahar I.

Neuropharmacology. 2019 Jun 20:107676. doi: 10.1016/j.neuropharm.2019.107676. [Epub ahead of print]

PMID:
31228486
8.

Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology.

Taylor DL, Gough A, Schurdak ME, Vernetti L, Chennubhotla CS, Lefever D, Pei F, Faeder JR, Lezon TR, Stern AM, Bahar I.

Handb Exp Pharmacol. 2019 Jun 15. doi: 10.1007/164_2019_239. [Epub ahead of print]

PMID:
31201557
9.

Comparative analysis of biomechanical parameters of the corneas following Descemet membrane endothelial keratoplasty and contralateral healthy corneas.

Shilova NF, Nahum Y, Adler A, Bahar I, Malyugin BE, Anisimova NS, Livny E.

Graefes Arch Clin Exp Ophthalmol. 2019 Sep;257(9):1925-1929. doi: 10.1007/s00417-019-04387-y. Epub 2019 Jun 11.

PMID:
31187244
10.

Comparison of Subconjunctival Aflibercept and Betamethasone for the Treatment of Formed Corneal Neovascularization in a Rabbit Model.

Eiger-Moscovich M, Livny E, Sella R, Gal-Or O, Nisgav Y, Livnat T, Bahar I.

Ophthalmic Res. 2019;62(2):116-122. doi: 10.1159/000499165. Epub 2019 May 21.

11.
12.

A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy.

Zhou Z, Feng Z, Hu D, Yang P, Gur M, Bahar I, Cristofanilli M, Gradishar WJ, Xie XQ, Wan Y.

EBioMedicine. 2019 Jun;44:98-111. doi: 10.1016/j.ebiom.2019.05.011. Epub 2019 May 14.

13.

Shared Signature Dynamics Tempered by Local Fluctuations Enables Fold Adaptability and Specificity.

Zhang S, Li H, Krieger JM, Bahar I.

Mol Biol Evol. 2019 Sep 1;36(9):2053-2068. doi: 10.1093/molbev/msz102.

14.

Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1.

Pei F, Li H, Liu B, Bahar I.

Front Pharmacol. 2019 Mar 8;10:191. doi: 10.3389/fphar.2019.00191. eCollection 2019.

15.

PINK1 Interacts with VCP/p97 and Activates PKA to Promote NSFL1C/p47 Phosphorylation and Dendritic Arborization in Neurons.

Wang KZQ, Steer E, Otero PA, Bateman NW, Cheng MH, Scott AL, Wu C, Bahar I, Shih YT, Hsueh YP, Chu CT.

eNeuro. 2018 Jan 10;5(6). pii: ENEURO.0466-18.2018. doi: 10.1523/ENEURO.0466-18.2018. eCollection 2018 Nov-Dec.

16.

[PREVALENCE OF DEMODEX PARASITES IN PATIENTS WITH CHRONIC BLEPHARITIS AND HEALTHY CONTROLS IN ISRAEL].

Livny E, Rosenblatt A, Abu Ghosh Z, Yassur I, Bahar I.

Harefuah. 2019 Feb;158(2):87-90. Hebrew.

PMID:
30779483
17.

Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members.

Mikulska-Ruminska K, Shrivastava I, Krieger J, Zhang S, Li H, Bayır H, Wenzel SE, VanDemark AP, Kagan VE, Bahar I.

J Chem Inf Model. 2019 May 28;59(5):2496-2508. doi: 10.1021/acs.jcim.9b00006. Epub 2019 Feb 28.

18.

Allostery in Its Many Disguises: From Theory to Applications.

Wodak SJ, Paci E, Dokholyan NV, Berezovsky IN, Horovitz A, Li J, Hilser VJ, Bahar I, Karanicolas J, Stock G, Hamm P, Stote RH, Eberhardt J, Chebaro Y, Dejaegere A, Cecchini M, Changeux JP, Bolhuis PG, Vreede J, Faccioli P, Orioli S, Ravasio R, Yan L, Brito C, Wyart M, Gkeka P, Rivalta I, Palermo G, McCammon JA, Panecka-Hofman J, Wade RC, Di Pizio A, Niv MY, Nussinov R, Tsai CJ, Jang H, Padhorny D, Kozakov D, McLeish T.

Structure. 2019 Apr 2;27(4):566-578. doi: 10.1016/j.str.2019.01.003. Epub 2019 Feb 7. Review.

19.

An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z.

Wang Y, Cobanoglu MC, Li J, Hidvegi T, Hale P, Ewing M, Chu AS, Gong Z, Muzumdar R, Pak SC, Silverman GA, Bahar I, Perlmutter DH.

PLoS One. 2019 Jan 23;14(1):e0209748. doi: 10.1371/journal.pone.0209748. eCollection 2019.

20.

Survey of the analysis of continuous conformational variability of biological macromolecules by electron microscopy.

Sorzano COS, Jiménez A, Mota J, Vilas JL, Maluenda D, Martínez M, Ramírez-Aportela E, Majtner T, Segura J, Sánchez-García R, Rancel Y, Del Caño L, Conesa P, Melero R, Jonic S, Vargas J, Cazals F, Freyberg Z, Krieger J, Bahar I, Marabini R, Carazo JM.

Acta Crystallogr F Struct Biol Commun. 2019 Jan 1;75(Pt 1):19-32. doi: 10.1107/S2053230X18015108. Epub 2019 Jan 1. Review.

PMID:
30605122
21.

Druggability Simulations and X-Ray Crystallography Reveal a Ligand-Binding Site in the GluA3 AMPA Receptor N-Terminal Domain.

Lee JY, Krieger J, Herguedas B, García-Nafría J, Dutta A, Shaikh SA, Greger IH, Bahar I.

Structure. 2019 Feb 5;27(2):241-252.e3. doi: 10.1016/j.str.2018.10.017. Epub 2018 Dec 6.

PMID:
30528594
22.

Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE.

Anthonymuthu TS, Kenny EM, Shrivastava I, Tyurina YY, Hier ZE, Ting HC, Dar HH, Tyurin VA, Nesterova A, Amoscato AA, Mikulska-Ruminska K, Rosenbaum JC, Mao G, Zhao J, Conrad M, Kellum JA, Wenzel SE, VanDemark AP, Bahar I, Kagan VE, Bayır H.

J Am Chem Soc. 2018 Dec 26;140(51):17835-17839. doi: 10.1021/jacs.8b09913. Epub 2018 Dec 17.

PMID:
30525572
23.

"PI-less DMEK": results of Descemet's membrane endothelial keratoplasty (DMEK) without a peripheral iridotomy.

Livny E, Bahar I, Levy I, Mimouni M, Nahum Y.

Eye (Lond). 2019 Apr;33(4):653-658. doi: 10.1038/s41433-018-0294-x. Epub 2018 Dec 5.

PMID:
30518974
24.

The evolution of toxic anterior segment syndrome.

Shouchane-Blum K, Dotan A, Bahar I.

Curr Opin Ophthalmol. 2019 Jan;30(1):50-55. doi: 10.1097/ICU.0000000000000540. Review.

PMID:
30489360
25.

"Ghost DMEK" Technique: Circular Peripheral Staining of Descemet's Membrane Endothelial Keratoplasty Grafts.

Livny E, Bahar I, Nahum Y.

Cornea. 2019 Feb;38(2):252-255. doi: 10.1097/ICO.0000000000001816.

PMID:
30422864
26.

Antibacterial and physical properties of a novel sonochemical-assisted Zn-CuO contact lens nanocoating.

Nahum Y, Israeli R, Mircus G, Perelshtein I, Ehrenberg M, Gutfreund S, Gedanken A, Bahar I.

Graefes Arch Clin Exp Ophthalmol. 2019 Jan;257(1):95-100. doi: 10.1007/s00417-018-4172-9. Epub 2018 Oct 27.

PMID:
30367291
27.

Current Statement of Intensive Care Units in Turkey: Data obtained from 67 Centers.

Ediboğlu Ö, Moçin ÖY, Özyılmaz E, Saltürk C, Önalan T, Seydaoğlu G, Çelikel T, Arıkan H, Ataman S, Kıraklı C, Özçelik Z, Kultufan S, Kara İ, Kara A, Dağlı E, Bülbül SD, Kahveci K, Dinçer M, Şenoğlu N, Özkarakaş H, Bahar İ, Cengiz M, Ramazanoğlu A, Çelik B, Gaygısız Ü, Kır G, Bindal A, Akan B, Turan IÖ, Yıldırım F, Başarık B, Ulukan ZA, Efe S, Sungur M, Temel Ş, İzdeş S, Hoşgün D, Karadeniz N, Tuncay E, Gökşenoğlu NÇ, Irmak İ, Datlı U, Zerman A, Akdağ D, Özdemir L, Elay G, Karaçayır Y, Topeli A, Hancı P, Kaya EK, Güven P, Sazak H, Aydemir S, Aygencel G, Aydemir Y, Doğanay Z, Kömürcü Ö, Hancı V, Karakoç E, Sözütek D, Coşkun G, Ateş G, Tiryaki C, Soytürk AN, Girgin NK, Çalışkan G, Bıyıklı O, Gökmen N, Koca U, Çiledağ A, Süner KÖ, Cinel İ, Arslantaş MK, Gül F, Ergün R, Yılmaz N, Altıntaş D, Talan L, Yalçınsoy M, Güllü MN, Özcan PE, Orhun G, Savran Y, Tokur ME, Akpınar S, Şen P, Gürsel G, Şerifoğlu İ, Gedik E, Balbay ÖA, Akbaş T, Cesur S, Yolacan H, Sağmen SB, Ekren PK, Bacakoğlu F, Ergan B, Günay E, Sarıaydın M, Sağlam DA, Karakurt S, Eryüksel E, Öztuna F, Mürtezaoğlu ESA, Cinemre H, Nalbant A, Yağmurkaya Ö, Mandal T, İkidağ B.

Turk Thorac J. 2018 Sep 13. doi: 10.5152/TurkThoracJ.2018.170104. [Epub ahead of print]

28.

Key residues controlling bidirectional ion movements in Na+/Ca2+ exchanger.

van Dijk L, Giladi M, Refaeli B, Hiller R, Cheng MH, Bahar I, Khananshvili D.

Cell Calcium. 2018 Dec;76:10-22. doi: 10.1016/j.ceca.2018.09.004. Epub 2018 Sep 15.

29.

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

Stoyanovsky DA, Tyurina YY, Shrivastava I, Bahar I, Tyurin VA, Protchenko O, Jadhav S, Bolevich SB, Kozlov AV, Vladimirov YA, Shvedova AA, Philpott CC, Bayir H, Kagan VE.

Free Radic Biol Med. 2019 Mar;133:153-161. doi: 10.1016/j.freeradbiomed.2018.09.008. Epub 2018 Sep 12. Review.

PMID:
30217775
30.

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium.

Dar HH, Tyurina YY, Mikulska-Ruminska K, Shrivastava I, Ting HC, Tyurin VA, Krieger J, St Croix CM, Watkins S, Bayir E, Mao G, Armbruster CR, Kapralov A, Wang H, Parsek MR, Anthonymuthu TS, Ogunsola AF, Flitter BA, Freedman CJ, Gaston JR, Holman TR, Pilewski JM, Greenberger JS, Mallampalli RK, Doi Y, Lee JS, Bahar I, Bomberger JM, Bayır H, Kagan VE.

J Clin Invest. 2018 Oct 1;128(10):4639-4653. doi: 10.1172/JCI99490. Epub 2018 Sep 10.

31.

Shared dynamics of LeuT superfamily members and allosteric differentiation by structural irregularities and multimerization.

Ponzoni L, Zhang S, Cheng MH, Bahar I.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 19;373(1749). pii: 20170177. doi: 10.1098/rstb.2017.0177.

32.

Structural dynamics is a determinant of the functional significance of missense variants.

Ponzoni L, Bahar I.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4164-4169. doi: 10.1073/pnas.1715896115. Epub 2018 Apr 2.

33.

Z-LASIK and Trans-PRK for correction of high-grade myopia: safety, efficacy, predictability and clinical outcomes.

Gershoni A, Mimouni M, Livny E, Bahar I.

Int Ophthalmol. 2019 Apr;39(4):753-763. doi: 10.1007/s10792-018-0868-4. Epub 2018 Mar 12.

PMID:
29532217
34.

Author Correction: Nanomechanics of multidomain neuronal cell adhesion protein contactin revealed by single molecule AFM and SMD.

Mikulska-Ruminska K, Kulik AJ, Benadiba C, Bahar I, Dietler G, Nowak W.

Sci Rep. 2018 Mar 6;8(1):4291. doi: 10.1038/s41598-018-21746-7.

35.

Activation and desensitization of ionotropic glutamate receptors by selectively triggering pre-existing motions.

Krieger J, Lee JY, Greger IH, Bahar I.

Neurosci Lett. 2019 May 1;700:22-29. doi: 10.1016/j.neulet.2018.02.050. Epub 2018 Feb 23. Review.

36.

Heterogeneities in Axonal Structure and Transporter Distribution Lower Dopamine Reuptake Efficiency.

Kaya C, Cheng MH, Block ER, Bartol TM, Sejnowski TJ, Sorkin A, Faeder JR, Bahar I.

eNeuro. 2018 Feb 5;5(1). pii: ENEURO.0298-17.2017. doi: 10.1523/ENEURO.0298-17.2017. eCollection 2018 Jan-Feb.

37.

Allosteric Modulation of Intact γ-Secretase Structural Dynamics.

Lee JY, Feng Z, Xie XQ, Bahar I.

Biophys J. 2017 Dec 19;113(12):2634-2649. doi: 10.1016/j.bpj.2017.10.012.

38.

Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.

Pei F, Li H, Henderson MJ, Titus SA, Jadhav A, Simeonov A, Cobanoglu MC, Mousavi SH, Shun T, McDermott L, Iyer P, Fioravanti M, Carlisle D, Friedlander RM, Bahar I, Taylor DL, Lezon TR, Stern AM, Schurdak ME.

Sci Rep. 2017 Dec 19;7(1):17803. doi: 10.1038/s41598-017-17378-y.

39.

Quantitative assessment of cell fate decision between autophagy and apoptosis.

Liu B, Oltvai ZN, Bayır H, Silverman GA, Pak SC, Perlmutter DH, Bahar I.

Sci Rep. 2017 Dec 14;7(1):17605. doi: 10.1038/s41598-017-18001-w.

40.

Quantitative Assessment of the Energetics of Dopamine Translocation by Human Dopamine Transporter.

Cheng MH, Kaya C, Bahar I.

J Phys Chem B. 2018 May 31;122(21):5336-5346. doi: 10.1021/acs.jpcb.7b10340. Epub 2017 Dec 26.

41.

Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways.

Steinman J, Epperly M, Hou W, Willis J, Wang H, Fisher R, Liu B, Bahar I, McCaw T, Kagan V, Bayir H, Yu J, Wipf P, Li S, Huq MS, Greenberger JS.

Radiat Res. 2018 Jan;189(1):68-83. doi: 10.1667/RR14787.1. Epub 2017 Nov 15.

42.

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.

Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H, Kagan VE.

Cell. 2017 Oct 19;171(3):628-641.e26. doi: 10.1016/j.cell.2017.09.044.

43.

Increased DNA damage and increased apoptosis and necrosis in patients with severe sepsis and septic shock.

Bahar I, Elay G, Başkol G, Sungur M, Donmez-Altuntas H.

J Crit Care. 2018 Feb;43:271-275. doi: 10.1016/j.jcrc.2017.09.035. Epub 2017 Sep 22.

PMID:
28954254
44.

"Only a Life Lived for Others Is Worth Living": Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions.

Tyurina YY, Shrivastava I, Tyurin VA, Mao G, Dar HH, Watkins S, Epperly M, Bahar I, Shvedova AA, Pitt B, Wenzel SE, Mallampalli RK, Sadovsky Y, Gabrilovich D, Greenberger JS, Bayır H, Kagan VE.

Antioxid Redox Signal. 2018 Nov 1;29(13):1333-1358. doi: 10.1089/ars.2017.7124. Epub 2017 Oct 16. Review.

PMID:
28835115
45.

Nanomechanics of multidomain neuronal cell adhesion protein contactin revealed by single molecule AFM and SMD.

Mikulska-Ruminska K, Kulik AJ, Benadiba C, Bahar I, Dietler G, Nowak W.

Sci Rep. 2017 Aug 18;7(1):8852. doi: 10.1038/s41598-017-09482-w. Erratum in: Sci Rep. 2018 Mar 6;8(1):4291.

46.

Human Gut Microbiota: Toward an Ecology of Disease.

Selber-Hnatiw S, Rukundo B, Ahmadi M, Akoubi H, Al-Bizri H, Aliu AF, Ambeaghen TU, Avetisyan L, Bahar I, Baird A, Begum F, Ben Soussan H, Blondeau-Éthier V, Bordaries R, Bramwell H, Briggs A, Bui R, Carnevale M, Chancharoen M, Chevassus T, Choi JH, Coulombe K, Couvrette F, D'Abreau S, Davies M, Desbiens MP, Di Maulo T, Di Paolo SA, Do Ponte S, Dos Santos Ribeiro P, Dubuc-Kanary LA, Duncan PK, Dupuis F, El-Nounou S, Eyangos CN, Ferguson NK, Flores-Chinchilla NR, Fotakis T, Gado Oumarou H D M, Georgiev M, Ghiassy S, Glibetic N, Grégoire Bouchard J, Hassan T, Huseen I, Ibuna Quilatan MF, Iozzo T, Islam S, Jaunky DB, Jeyasegaram A, Johnston MA, Kahler MR, Kaler K, Kamani C, Karimian Rad H, Konidis E, Konieczny F, Kurianowicz S, Lamothe P, Legros K, Leroux S, Li J, Lozano Rodriguez ME, Luponio-Yoffe S, Maalouf Y, Mantha J, McCormick M, Mondragon P, Narayana T, Neretin E, Nguyen TTT, Niu I, Nkemazem RB, O'Donovan M, Oueis M, Paquette S, Patel N, Pecsi E, Peters J, Pettorelli A, Poirier C, Pompa VR, Rajen H, Ralph RO, Rosales-Vasquez J, Rubinshtein D, Sakr S, Sebai MS, Serravalle L, Sidibe F, Sinnathurai A, Soho D, Sundarakrishnan A, Svistkova V, Ugbeye TE, Vasconcelos MS, Vincelli M, Voitovich O, Vrabel P, Wang L, Wasfi M, Zha CY, Gamberi C.

Front Microbiol. 2017 Jul 17;8:1265. doi: 10.3389/fmicb.2017.01265. eCollection 2017. Review.

47.

Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter.

Ma S, Cheng MH, Guthrie DA, Newman AH, Bahar I, Sorkin A.

Sci Rep. 2017 Jul 14;7(1):5399. doi: 10.1038/s41598-017-05637-x.

48.

'Blue bubble' technique: an ab interno approach for Descemet separation in deep anterior lamellar keratoplasty using trypan blue stained viscoelastic device.

Livny E, Bahar I, Hammel N, Nahum Y.

Clin Exp Ophthalmol. 2018 Apr;46(3):275-279. doi: 10.1111/ceo.13017. Epub 2017 Aug 17.

PMID:
28672072
49.

Dynamic Modulation of Binding Affinity as a Mechanism for Regulating Interferon Signaling.

Li H, Sharma N, General IJ, Schreiber G, Bahar I.

J Mol Biol. 2017 Aug 4;429(16):2571-2589. doi: 10.1016/j.jmb.2017.06.011. Epub 2017 Jun 23.

50.

Allosteric modulation of human dopamine transporter activity under conditions promoting its dimerization.

Cheng MH, Garcia-Olivares J, Wasserman S, DiPietro J, Bahar I.

J Biol Chem. 2017 Jul 28;292(30):12471-12482. doi: 10.1074/jbc.M116.763565. Epub 2017 Jun 5.

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