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Items: 25


Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition.

Mahadevan V, Khademullah CS, Dargaei Z, Chevrier J, Uvarov P, Kwan J, Bagshaw RD, Pawson T, Emili A, De Koninck Y, Anggono V, Airaksinen M, Woodin MA.

Elife. 2017 Oct 13;6. pii: e28270. doi: 10.7554/eLife.28270.


Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.

Schlam D, Bagshaw RD, Freeman SA, Collins RF, Pawson T, Fairn GD, Grinstein S.

Nat Commun. 2015 Oct 14;6:8623. doi: 10.1038/ncomms9623.


A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.

Abraham S, Scarcia M, Bagshaw RD, McMahon K, Grant G, Harvey T, Yeo M, Esteves FOG, Thygesen HH, Jones PF, Speirs V, Hanby AM, Selby PJ, Lorger M, Dear TN, Pawson T, Marshall CJ, Mavria G.

Nat Commun. 2015 Jul 1;6:7286. doi: 10.1038/ncomms8286.


Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor.

Tian R, Wang H, Gish GD, Petsalaki E, Pasculescu A, Shi Y, Mollenauer M, Bagshaw RD, Yosef N, Hunter T, Gingras AC, Weiss A, Pawson T.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1594-603. doi: 10.1073/pnas.1503286112. Epub 2015 Mar 17.


Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP.

Gray EJ, Petsalaki E, James DA, Bagshaw RD, Stacey MM, Rocks O, Gingras AC, Pawson T.

J Biol Chem. 2014 Dec 19;289(51):35397-408. doi: 10.1074/jbc.M114.615112. Epub 2014 Oct 20.


Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

Couzens AL, Knight JD, Kean MJ, Teo G, Weiss A, Dunham WH, Lin ZY, Bagshaw RD, Sicheri F, Pawson T, Wrana JL, Choi H, Gingras AC.

Sci Signal. 2013 Nov 19;6(302):rs15. doi: 10.1126/scisignal.2004712.


The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.

Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin ZY, Badillo BG, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga G, Colinge J, Heck AJ, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras AC, Nesvizhskii AI.

Nat Methods. 2013 Aug;10(8):730-6. doi: 10.1038/nmeth.2557. Epub 2013 Jul 7.


Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.

Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T.

Cell. 2013 Feb 28;152(5):1008-20. doi: 10.1016/j.cell.2013.01.056.


Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.

Kaniuk NA, Canadien V, Bagshaw RD, Bakowski M, Braun V, Landekic M, Mitra S, Huang J, Heo WD, Meyer T, Pelletier L, Andrews-Polymenis H, McClelland M, Pawson T, Grinstein S, Brumell JH.

Cell Microbiol. 2011 Nov;13(11):1812-23. doi: 10.1111/j.1462-5822.2011.01663.x. Epub 2011 Sep 14.


The integral membrane of lysosomes: its proteins and their roles in disease.

Callahan JW, Bagshaw RD, Mahuran DJ.

J Proteomics. 2009 Feb 15;72(1):23-33. doi: 10.1016/j.jprot.2008.11.007. Epub 2008 Nov 18. Review.


Cryptic splice site in the complementary DNA of glucocerebrosidase causes inefficient expression.

Bukovac SW, Bagshaw RD, Rigat BA, Callahan JW, Clarke JT, Mahuran DJ.

Anal Biochem. 2008 Oct 15;381(2):276-8. doi: 10.1016/j.ab.2008.06.029. Epub 2008 Jun 21.


Lysosomal membranes from beige mice contain higher than normal levels of endoplasmic reticulum proteins.

Zhang H, Fan X, Bagshaw RD, Zhang L, Mahuran DJ, Callahan JW.

J Proteome Res. 2007 Jan;6(1):240-9.


Identification of the gene encoding the enzyme deficient in mucopolysaccharidosis IIIC (Sanfilippo disease type C).

Fan X, Zhang H, Zhang S, Bagshaw RD, Tropak MB, Callahan JW, Mahuran DJ.

Am J Hum Genet. 2006 Oct;79(4):738-44. Epub 2006 Aug 23.


The Arf-family protein, Arl8b, is involved in the spatial distribution of lysosomes.

Bagshaw RD, Callahan JW, Mahuran DJ.

Biochem Biophys Res Commun. 2006 Jun 16;344(4):1186-91. Epub 2006 Apr 19.


A comparative study of cytoplasmic granules imaged by the real-time microscope, Nile Red and Filipin in fibroblasts from patients with lipid storage diseases.

Pham NA, Gal MR, Bagshaw RD, Mohr AJ, Chue B, Richardson T, Callahan JW.

J Inherit Metab Dis. 2005;28(6):991-1004.


Lysosomal membrane proteomics and biogenesis of lysosomes.

Bagshaw RD, Mahuran DJ, Callahan JW.

Mol Neurobiol. 2005 Aug;32(1):27-41. Review.


Identification of the hydrophobic glycoproteins of Caenorhabditis elegans.

Fan X, She YM, Bagshaw RD, Callahan JW, Schachter H, Mahuran DJ.

Glycobiology. 2005 Oct;15(10):952-64. Epub 2005 May 11.


A proteomic analysis of lysosomal integral membrane proteins reveals the diverse composition of the organelle.

Bagshaw RD, Mahuran DJ, Callahan JW.

Mol Cell Proteomics. 2005 Feb;4(2):133-43. Epub 2004 Dec 2.


A method for proteomic identification of membrane-bound proteins containing Asn-linked oligosaccharides.

Fan X, She YM, Bagshaw RD, Callahan JW, Schachter H, Mahuran DJ.

Anal Biochem. 2004 Sep 1;332(1):178-86.


Membrane-associated estrogen receptor and caveolin-1 are present in central nervous system myelin and oligodendrocyte plasma membranes.

Arvanitis DN, Wang H, Bagshaw RD, Callahan JW, Boggs JM.

J Neurosci Res. 2004 Mar 1;75(5):603-13.


Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane.

Pasternak SH, Bagshaw RD, Guiral M, Zhang S, Ackerley CA, Pak BJ, Callahan JW, Mahuran DJ.

J Biol Chem. 2003 Jul 18;278(29):26687-94. Epub 2003 May 7.


Functional post-translational proteomics approach to study the role of N-glycans in the development of Caenorhabditis elegans.

Schachter H, Chen S, Zhang W, Spence AM, Zhu S, Callahan JW, Mahuran DJ, Fan X, Bagshaw RD, She YM, Rosa JC, Reinhold VN.

Biochem Soc Symp. 2002;(69):1-21. Review.


Nicastrin is a resident lysosomal membrane protein.

Bagshaw RD, Pasternak SH, Mahuran DJ, Callahan JW.

Biochem Biophys Res Commun. 2003 Jan 17;300(3):615-8.


Novel mutations (Asn 484 Lys, Thr 500 Ala, Gly 438 Glu) in Morquio B disease.

Bagshaw RD, Zhang S, Hinek A, Skomorowski MA, Whelan D, Clarke JT, Callahan JW.

Biochim Biophys Acta. 2002 Dec 12;1588(3):247-53.


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