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Items: 1 to 50 of 52

1.

Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells.

Zwergel C, Czepukojc B, Evain-Bana E, Xu Z, Stazi G, Mori M, Patsilinakos A, Mai A, Botta B, Ragno R, Bagrel D, Kirsch G, Meiser P, Jacob C, Montenarh M, Valente S.

Eur J Med Chem. 2017 Jul 7;134:316-333. doi: 10.1016/j.ejmech.2017.04.012. Epub 2017 Apr 10.

PMID:
28431339
2.

Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases.

Evain-Bana E, Schiavo L, Bour C, Lanfranchi DA, Berardozzi S, Ghirga F, Bagrel D, Botta B, Hanquet G, Mori M.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):113-118. doi: 10.1080/14756366.2016.1238364. Epub 2016 Oct 23.

3.

Screening of indeno[1,2-b]indoloquinones by MALDI-MS: a new set of potential CDC25 phosphatase inhibitors brought to light.

Alchab F, Sibille E, Ettouati L, Bana E, Bouaziz Z, Mularoni A, Monniot E, Bagrel D, Jose J, Le Borgne M, Chaimbault P.

J Enzyme Inhib Med Chem. 2016;31(sup3):25-32. Epub 2016 Jun 30.

PMID:
27362889
4.

The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites.

Ehrhardt K, Deregnaucourt C, Goetz AA, Tzanova T, Gallo V, Arese P, Pradines B, Adjalley SH, Bagrel D, Blandin S, Lanzer M, Davioud-Charvet E.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5146-58. doi: 10.1128/AAC.02975-15. Print 2016 Sep.

5.

2-(Thienothiazolylimino)-1,3-thiazolidin-4-ones inhibit cell division cycle 25 A phosphatase.

Huber-Villaume S, Revelant G, Sibille E, Philippot S, Morabito A, Dunand S, Chaimbault P, Bagrel D, Kirsch G, Hesse S, Schohn H.

Bioorg Med Chem. 2016 Jul 1;24(13):2920-2928. doi: 10.1016/j.bmc.2016.04.063. Epub 2016 May 2.

PMID:
27178385
6.

Plumbagin modulates leukemia cell redox status.

Gaascht F, Teiten MH, Cerella C, Dicato M, Bagrel D, Diederich M.

Molecules. 2014 Jul 10;19(7):10011-32. doi: 10.3390/molecules190710011.

7.

A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death.

Bana E, Sibille E, Valente S, Cerella C, Chaimbault P, Kirsch G, Dicato M, Diederich M, Bagrel D.

Mol Carcinog. 2015 Mar;54(3):229-41. doi: 10.1002/mc.22094. Epub 2013 Oct 24.

PMID:
24155226
8.

Development of a matrix-assisted laser desorption/ionization-mass spectrometry screening test to evidence reversible and irreversible inhibitors of CDC25 phosphatases.

Sibille E, Bana E, Chaouni W, Diederich M, Bagrel D, Chaimbault P.

Anal Biochem. 2012 Nov 1;430(1):83-91. doi: 10.1016/j.ab.2012.08.006. Epub 2012 Aug 16.

PMID:
22902804
9.

Genotoxic stress modulates CDC25C phosphatase alternative splicing in human breast cancer cell lines.

Albert H, Battaglia E, Monteiro C, Bagrel D.

Mol Oncol. 2012 Oct;6(5):542-52. doi: 10.1016/j.molonc.2012.06.003. Epub 2012 Jul 27.

10.

Aurones: interesting natural and synthetic compounds with emerging biological potential.

Zwergel C, Gaascht F, Valente S, Diederich M, Bagrel D, Kirsch G.

Nat Prod Commun. 2012 Mar;7(3):389-94. Review.

PMID:
22545415
11.

Protection of CDC25 phosphatases against oxidative stress in breast cancer cells: evaluation of the implication of the thioredoxin system.

Beillerot A, Battaglia E, Bennasroune A, Bagrel D.

Free Radic Res. 2012 May;46(5):674-89. doi: 10.3109/10715762.2012.669039. Epub 2012 Mar 20.

PMID:
22360685
12.

Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells.

Saidu NE, Valente S, Bana E, Kirsch G, Bagrel D, Montenarh M.

Bioorg Med Chem. 2012 Feb 15;20(4):1584-93. doi: 10.1016/j.bmc.2011.12.032. Epub 2011 Dec 30.

PMID:
22264758
13.

Control of oxidative posttranslational cysteine modifications: from intricate chemistry to widespread biological and medical applications.

Jacob C, Battaglia E, Burkholz T, Peng D, Bagrel D, Montenarh M.

Chem Res Toxicol. 2012 Mar 19;25(3):588-604. doi: 10.1021/tx200342b. Epub 2011 Dec 12. Review.

PMID:
22106817
14.

Differential expression of CDC25 phosphatases splice variants in human breast cancer cells.

Albert H, Santos S, Battaglia E, Brito M, Monteiro C, Bagrel D.

Clin Chem Lab Med. 2011 Oct;49(10):1707-14. doi: 10.1515/CCLM.2011.635. Epub 2011 Jun 16.

PMID:
21675940
15.

Functional genomics towards personalized healthcare and systems medicine.

Siest G, Nezhad MA, Bagrel D, El Shamieh S, Lambert D, Ndiaye NC, Shahabi P, Visvikis-Siest S.

Per Med. 2011 May;8(3):227-242. doi: 10.2217/pme.10.89.

16.

Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases.

Viry E, Anwar A, Kirsch G, Jacob C, Diederich M, Bagrel D.

Int J Oncol. 2011 Apr;38(4):1103-11. doi: 10.3892/ijo.2011.913. Epub 2011 Jan 20.

PMID:
21253673
17.

Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases.

Valente S, Bana E, Viry E, Bagrel D, Kirsch G.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5827-30. doi: 10.1016/j.bmcl.2010.07.130. Epub 2010 Aug 3.

PMID:
20800482
18.

eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development.

Malta-Vacas J, Chauvin C, Gonçalves L, Nazaré A, Carvalho C, Monteiro C, Bagrel D, Jean-Jean O, Brito M.

Oncol Rep. 2009 Jun;21(6):1551-8.

PMID:
19424636
19.

Synthesis and antioxidant potential of novel synthetic benzophenone analogues.

Tzanova T, Gerova M, Petrov O, Karaivanova M, Bagrel D.

Eur J Med Chem. 2009 Jun;44(6):2724-30. doi: 10.1016/j.ejmech.2008.09.010. Epub 2008 Sep 19.

PMID:
18950902
20.

A sugar-modified phosphole gold complex with antiproliferative properties acting as a thioredoxin reductase inhibitor in MCF-7 cells.

Viry E, Battaglia E, Deborde V, Müller T, Réau R, Davioud-Charvet E, Bagrel D.

ChemMedChem. 2008 Nov;3(11):1667-70. doi: 10.1002/cmdc.200800210. No abstract available.

PMID:
18759235
21.

Apoptosis/necrosis switch in two different cancer cell lines: influence of benzoquinone- and hydrogen peroxide-induced oxidative stress intensity, and glutathione.

Baigi MG, Brault L, Néguesque A, Beley M, Hilali RE, Gaüzère F, Bagrel D.

Toxicol In Vitro. 2008 Sep;22(6):1547-54. doi: 10.1016/j.tiv.2008.06.008. Epub 2008 Jun 24.

PMID:
18619529
22.

Impact of chronic treatment with red wine polyphenols (RWP) on cerebral arterioles in the spontaneous hypertensive rat.

Chan SL, Tabellion A, Bagrel D, Perrin-Sarrado C, Capdeville-Atkinson C, Atkinson J.

J Cardiovasc Pharmacol. 2008 Mar;51(3):304-10. doi: 10.1097/FJC.0b013e318163a946.

PMID:
18356696
23.

Activity of novel Cdc25 inhibitors and preliminary evaluation of their potentiation of chemotherapeutic drugs in human breast cancer cells.

Brault L, Bagrel D.

Life Sci. 2008 Jan 30;82(5-6):315-23. doi: 10.1016/j.lfs.2007.12.001. Epub 2007 Dec 14.

PMID:
18191419
24.

Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin.

Beillerot A, Domínguez JC, Kirsch G, Bagrel D.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1102-5. doi: 10.1016/j.bmcl.2007.12.004. Epub 2007 Dec 7.

PMID:
18164200
25.

Interaction of the electrophilic ketoprofenyl-glucuronide and ketoprofenyl-coenzyme A conjugates with cytosolic glutathione S-transferases.

Osbild S, Bour J, Maunit B, Guillaume C, Asensio C, Muller JF, Netter P, Kirsch G, Bagrel D, Lapicque F, Battaglia E.

Drug Metab Dispos. 2008 Feb;36(2):260-7. Epub 2007 Oct 25.

PMID:
17962374
26.

Melatonin counteracts the loss of agonist-evoked contraction of aortic rings induced by incubation.

Lartaud I, Faure S, Tabellion A, Resende AC, Nadaud S, Bagrel D, Capdeville-Atkinson C, Atkinson J.

Fundam Clin Pharmacol. 2007 Jun;21(3):273-9.

PMID:
17521296
27.

Mangiferin protects against 1-methyl-4-phenylpyridinium toxicity mediated by oxidative stress in N2A cells.

Amazzal L, Lapôtre A, Quignon F, Bagrel D.

Neurosci Lett. 2007 May 17;418(2):159-64. Epub 2007 Mar 14.

PMID:
17433543
28.

Resistance to cisplatin and adriamycin is associated with the inhibition of glutathione efflux in MCF-7-derived cells.

Osbild S, Brault L, Battaglia E, Bagrel D.

Anticancer Res. 2006 Sep-Oct;26(5A):3595-600.

29.

Synthesis and biological evaluation of dialkylsubstituted maleic anhydrides as novel inhibitors of Cdc25 dual specificity phosphatases.

Brault L, Denancé M, Banaszak E, El Maadidi S, Battaglia E, Bagrel D, Samadi M.

Eur J Med Chem. 2007 Feb;42(2):243-7. Epub 2006 Nov 2.

PMID:
17084000
30.

New thiophene analogues of kenpaullone: synthesis and biological evaluation in breast cancer cells.

Brault L, Migianu E, Néguesque A, Battaglia E, Bagrel D, Kirsch G.

Eur J Med Chem. 2005 Aug;40(8):757-63. Epub 2005 Apr 12.

PMID:
16122578
31.

Modulation of sensitivity to doxorubicin by the histone deacetylase inhibitor sodium butyrate in breast cancer cells.

Louis M, Rosato RR, Battaglia E, Néguesque A, Lapotre A, Grant S, Bagrel D.

Int J Oncol. 2005 Jun;26(6):1569-74.

PMID:
15870871
32.

Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells.

Gonçalves J, Malta-Vacas J, Louis M, Brault L, Bagrel D, Monteiro C, Brito M.

Clin Chem Lab Med. 2005;43(2):151-6.

PMID:
15843208
33.

The histone deacetylase inhibitor sodium butyrate induces breast cancer cell apoptosis through diverse cytotoxic actions including glutathione depletion and oxidative stress.

Louis M, Rosato RR, Brault L, Osbild S, Battaglia E, Yang XH, Grant S, Bagrel D.

Int J Oncol. 2004 Dec;25(6):1701-11.

PMID:
15547708
34.

Incubation of rat aortic rings produces a specific reduction in agonist-evoked contraction: effect of age of donor.

Resende AC, Tabellion A, Nadaud S, Lartaud I, Bagrel D, Faure S, Atkinson J, Capdeville-Atkinson C.

Life Sci. 2004 Nov 19;76(1):9-20.

PMID:
15501476
35.
36.

The glutathione-related detoxification system is increased in human breast cancer in correlation with clinical and histopathological features.

Perquin M, Oster T, Maul A, Froment N, Untereiner M, Bagrel D.

J Cancer Res Clin Oncol. 2001;127(6):368-74.

PMID:
11414197
37.

The glutathione-related detoxification pathway in the human breast: a highly coordinated system disrupted in the tumour tissues.

Perquin M, Oster T, Maul A, Froment N, Untereiner M, Bagrel D.

Cancer Lett. 2000 Sep 29;158(1):7-16.

PMID:
10940503
38.

Glycosylation of gamma-glutamyltransferase is modified by ethanol in H5-6 hepatoma cell line.

Odoul M, Bagrel D, Peyrieras N, Bodaud H, Siest G.

Clin Chim Acta. 1994 Feb;225(1):1-15.

PMID:
7913424
39.

Expression and regulation of drug metabolizing enzymes in an immortalized rat hepatocyte cell line.

Bayad J, Bagrel D, Sabolovic N, Magdalou J, Siest G.

Biochem Pharmacol. 1991 Sep 12;42(7):1345-51.

PMID:
1681808
40.

Influence of the isolation method on the stability of differentiated phenotype in cultured rat hepatocytes.

Bayad J, Sabolovic N, Bagrel D, Magdalou J, Siest G.

J Pharmacol Methods. 1991 Mar;25(1):85-94.

PMID:
1851520
41.
42.

Gamma-glutamyltransferase from human hepatoma cell lines: purification and cell culture of HepG2 on microcarriers.

Visvikis A, Goergen JL, Oster T, Bagrel D, Wellman M, Marc A, Engasser JM, Siest G.

Clin Chim Acta. 1990 Nov 5;191(3):221-32.

PMID:
1979762
43.

Production, cross reactivity, and epitope analysis of monoclonal antibodies against rat kidney gamma glutamyltransferase.

Bayad J, Sabolovic N, Bagrel D, Visvikis A, Wellman M, Siest G.

Cell Biol Toxicol. 1990 Apr;6(2):157-70.

PMID:
1694466
44.

[Changes of plasma and tissue gamma-glutamyltransferase under the influence of drugs].

Siest G, Strazielle N, L'Hôte H, Wellman M, Bagrel D, Batt AM, Schiele F, Galteau MM.

Therapie. 1989 Jan-Feb;44(1):19-28. Review. French.

PMID:
2567537
45.

Study of the in vitro bioactivation of albendazole in human liver microsomes and hepatoma cell lines.

Rolin S, Souhaili-el Amri H, Batt AM, Levy M, Bagrel D, Siest G.

Cell Biol Toxicol. 1989 Jan;5(1):1-14.

PMID:
2563953
46.

Cellular and molecular aspects of UDP-glucuronosyltransferases.

Siest G, Fournel-Gigleux S, Magdalou J, Bagrel D.

Drug Metab Rev. 1989;20(2-4):721-31. Review. No abstract available.

PMID:
2509185
47.

Measurement of plasma gamma-glutamyltransferase in clinical chemistry: kinetic basis and standardisation propositions.

Schiele F, Artur Y, Bagrel D, Petitclerc C, Siest G.

Clin Chim Acta. 1981 May 5;112(2):187-95.

PMID:
6113067
48.

Some kinetic properties of gamma-glutamyltransferase from rabbit liver.

Bagrel D, Petitclerc C, Schiele F, Siest G.

Biochim Biophys Acta. 1981 Apr 14;658(2):220-31.

PMID:
6113845
49.

Kinetic properties of gamma-glutamyltransferase from human liver.

PetitClerc C, Shiele F, Bagrel D, Mahassen A, Siest G.

Clin Chem. 1980 Nov;26(12):1688-93.

PMID:
6107181
50.

Evolution with ageing of four plasma androgens in postmenopausal women.

Roger M, Nahoul K, Scholler R, Bagrel D.

Maturitas. 1980 Oct;2(3):171-7. No abstract available.

PMID:
7442551

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