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Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism.

Rosina E, Battan B, Siracusano M, Di Criscio L, Hollis F, Pacini L, Curatolo P, Bagni C.

Transl Psychiatry. 2019 Jan 31;9(1):50. doi: 10.1038/s41398-018-0335-z.


FXS-Like Phenotype in Two Unrelated Patients Carrying a Methylated Premutation of the FMR1 Gene.

Fernández E, Gennaro E, Pirozzi F, Baldo C, Forzano F, Turolla L, Faravelli F, Gastaldo D, Coviello D, Grasso M, Bagni C.

Front Genet. 2018 Nov 2;9:442. doi: 10.3389/fgene.2018.00442. eCollection 2018.


Alpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs.

Comhair J, Devoght J, Morelli G, Harvey RJ, Briz V, Borrie SC, Bagni C, Rigo JM, Schiffmann SN, Gall D, Brône B, Molchanova SM.

Front Mol Neurosci. 2018 Oct 15;11:380. doi: 10.3389/fnmol.2018.00380. eCollection 2018.


Maintenance mechanisms of circuit-integrated axons.

Mariano V, Domínguez-Iturza N, Neukomm LJ, Bagni C.

Curr Opin Neurobiol. 2018 Dec;53:162-173. doi: 10.1016/j.conb.2018.08.007. Epub 2018 Sep 18. Review.


Protein synthesis levels are increased in a subset of individuals with fragile X syndrome.

Jacquemont S, Pacini L, Jønch AE, Cencelli G, Rozenberg I, He Y, D'Andrea L, Pedini G, Eldeeb M, Willemsen R, Gasparini F, Tassone F, Hagerman R, Gomez-Mancilla B, Bagni C.

Hum Mol Genet. 2018 Nov 1;27(21):3825. doi: 10.1093/hmg/ddy291. No abstract available.


Protein synthesis levels are increased in a subset of individuals with fragile X syndrome.

Jacquemont S, Pacini L, Jønch AE, Cencelli G, Rozenberg I, He Y, D'Andrea L, Pedini G, Eldeeb M, Willemsen R, Gasparini F, Tassone F, Hagerman R, Gomez-Mancilla B, Bagni C.

Hum Mol Genet. 2018 Jun 15;27(12):2039-2051. doi: 10.1093/hmg/ddy099. Erratum in: Hum Mol Genet. 2018 Nov 1;27(21):3825.


Editorial overview: Neurobiology of disease (2018).

Bagni C, Kreitzer AC.

Curr Opin Neurobiol. 2018 Feb;48:iv-vi. doi: 10.1016/j.conb.2018.01.005. Epub 2018 Jan 30. No abstract available.


Gender Equality from a European Perspective: Myth and Reality.

Salinas PC, Bagni C.

Neuron. 2017 Nov 15;96(4):721-729. doi: 10.1016/j.neuron.2017.10.002.


The fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells.

Zalfa F, Panasiti V, Carotti S, Zingariello M, Perrone G, Sancillo L, Pacini L, Luciani F, Roberti V, D'Amico S, Coppola R, Abate SO, Rana RA, De Luca A, Fiers M, Melocchi V, Bianchi F, Farace MG, Achsel T, Marine JC, Morini S, Bagni C.

Cell Death Dis. 2017 Nov 16;8(11):e3169. doi: 10.1038/cddis.2017.521.


Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice.

Santini E, Huynh TN, Longo F, Koo SY, Mojica E, D'Andrea L, Bagni C, Klann E.

Sci Signal. 2017 Nov 7;10(504). pii: eaan0665. doi: 10.1126/scisignal.aan0665.


Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence.

Fernández E, Collins MO, Frank RAW, Zhu F, Kopanitsa MV, Nithianantharajah J, Lemprière SA, Fricker D, Elsegood KA, McLaughlin CL, Croning MDR, Mclean C, Armstrong JD, Hill WD, Deary IJ, Cencelli G, Bagni C, Fromer M, Purcell SM, Pocklington AJ, Choudhary JS, Komiyama NH, Grant SGN.

Cell Rep. 2017 Oct 17;21(3):679-691. doi: 10.1016/j.celrep.2017.09.045.


New insights into the metastatic behavior after breast cancer surgery, according to well-established clinicopathological variables and molecular subtypes.

Buonomo OC, Caredda E, Portarena I, Vanni G, Orlandi A, Bagni C, Petrella G, Palombi L, Orsaria P.

PLoS One. 2017 Sep 18;12(9):e0184680. doi: 10.1371/journal.pone.0184680. eCollection 2017.


Cognitive Dysfunctions in Intellectual Disabilities: The Contributions of the Ras-MAPK and PI3K-AKT-mTOR Pathways.

Borrie SC, Brems H, Legius E, Bagni C.

Annu Rev Genomics Hum Genet. 2017 Aug 31;18:115-142. doi: 10.1146/annurev-genom-091416-035332. Review.


The non-coding RNA BC1 regulates experience-dependent structural plasticity and learning.

Briz V, Restivo L, Pasciuto E, Juczewski K, Mercaldo V, Lo AC, Baatsen P, Gounko NV, Borreca A, Girardi T, Luca R, Nys J, Poorthuis RB, Mansvelder HD, Fisone G, Ammassari-Teule M, Arckens L, Krieger P, Meredith R, Bagni C.

Nat Commun. 2017 Aug 17;8(1):293. doi: 10.1038/s41467-017-00311-2.


Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse.

Filippini A, Bonini D, Lacoux C, Pacini L, Zingariello M, Sancillo L, Bosisio D, Salvi V, Mingardi J, La Via L, Zalfa F, Bagni C, Barbon A.

RNA Biol. 2017 Nov 2;14(11):1580-1591. doi: 10.1080/15476286.2017.1338232. Epub 2017 Sep 5.


Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives.

Hollis F, Kanellopoulos AK, Bagni C.

Curr Opin Neurobiol. 2017 Aug;45:178-187. doi: 10.1016/j.conb.2017.05.018. Epub 2017 Jun 16. Review.


Clinical and Molecular Assessment in a Female with Fragile X Syndrome and Tuberous Sclerosis.

Yrigollen CM, Pacini L, Nobile V, Lozano R, Hagerman RJ, Bagni C, Tassone F.

J Genet Disord Genet Rep. 2016;5(3). pii: 139. doi: 10.4172/2327-5790.1000139. Epub 2016 Jul 15.


Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease.

Geuens T, De Winter V, Rajan N, Achsel T, Mateiu L, Almeida-Souza L, Asselbergh B, Bouhy D, Auer-Grumbach M, Bagni C, Timmerman V.

Acta Neuropathol Commun. 2017 Jan 11;5(1):5. doi: 10.1186/s40478-016-0407-3.


Impaired GABAergic inhibition in the hippocampus of Fmr1 knockout mice.

Sabanov V, Braat S, D'Andrea L, Willemsen R, Zeidler S, Rooms L, Bagni C, Kooy RF, Balschun D.

Neuropharmacology. 2017 Apr;116:71-81. doi: 10.1016/j.neuropharm.2016.12.010. Epub 2016 Dec 21.


Neurons acetylate their way to migration.

Borrie SC, Bagni C.

EMBO Rep. 2016 Dec;17(12):1674-1676. Epub 2016 Oct 21. No abstract available.


Somatosensory map expansion and altered processing of tactile inputs in a mouse model of fragile X syndrome.

Juczewski K, von Richthofen H, Bagni C, Celikel T, Fisone G, Krieger P.

Neurobiol Dis. 2016 Dec;96:201-215. doi: 10.1016/j.nbd.2016.09.007. Epub 2016 Sep 8.


Cooperativity in RNA-protein interactions: the complex is more than the sum of its partners.

Achsel T, Bagni C.

Curr Opin Neurobiol. 2016 Aug;39:146-51. doi: 10.1016/j.conb.2016.06.007. Epub 2016 Jun 25. Review.


Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.

Stepniak B, Kästner A, Poggi G, Mitjans M, Begemann M, Hartmann A, Van der Auwera S, Sananbenesi F, Krueger-Burg D, Matuszko G, Brosi C, Homuth G, Völzke H, Benseler F, Bagni C, Fischer U, Dityatev A, Grabe HJ, Rujescu D, Fischer A, Ehrenreich H.

EMBO Mol Med. 2015 Dec;7(12):1565-79. doi: 10.15252/emmm.201505696.


MD and Docking Studies Reveal That the Functional Switch of CYFIP1 is Mediated by a Butterfly-like Motion.

Di Marino D, Chillemi G, De Rubeis S, Tramontano A, Achsel T, Bagni C.

J Chem Theory Comput. 2015 Jul 14;11(7):3401-10. doi: 10.1021/ct500431h.


Altered neuronal network and rescue in a human MECP2 duplication model.

Nageshappa S, Carromeu C, Trujillo CA, Mesci P, Espuny-Camacho I, Pasciuto E, Vanderhaeghen P, Verfaillie CM, Raitano S, Kumar A, Carvalho CM, Bagni C, Ramocki MB, Araujo BH, Torres LB, Lupski JR, Van Esch H, Muotri AR.

Mol Psychiatry. 2016 Feb;21(2):178-88. doi: 10.1038/mp.2015.128. Epub 2015 Sep 8.


Synaptopathy--From Biology to Therapy.

Grant SG, Bagni C, O'Dell TJ.

Neuropharmacology. 2016 Jan;100:1. doi: 10.1016/j.neuropharm.2015.08.022. Epub 2015 Aug 17. No abstract available.


Autism Spectrum Disorders: Translating human deficits into mouse behavior.

Pasciuto E, Borrie SC, Kanellopoulos AK, Santos AR, Cappuyns E, D'Andrea L, Pacini L, Bagni C.

Neurobiol Learn Mem. 2015 Oct;124:71-87. doi: 10.1016/j.nlm.2015.07.013. Epub 2015 Jul 26. Review.


Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.

Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Müller UC, Di Luca M, De Strooper B, Bagni C.

Neuron. 2015 Jul 15;87(2):382-98. doi: 10.1016/j.neuron.2015.06.032. Erratum in: Neuron. 2015 Aug 19;87(4):908.


FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression.

Fernández E, Li KW, Rajan N, De Rubeis S, Fiers M, Smit AB, Achsel T, Bagni C.

J Neurosci. 2015 Jun 24;35(25):9402-8. doi: 10.1523/JNEUROSCI.4800-14.2015.


A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors.

Di Marino D, D'Annessa I, Tancredi H, Bagni C, Gallicchio E.

Protein Sci. 2015 Sep;24(9):1370-82. doi: 10.1002/pro.2708.


The GABAA receptor is an FMRP target with therapeutic potential in fragile X syndrome.

Braat S, D'Hulst C, Heulens I, De Rubeis S, Mientjes E, Nelson DL, Willemsen R, Bagni C, Van Dam D, De Deyn PP, Kooy RF.

Cell Cycle. 2015;14(18):2985-95. doi: 10.4161/15384101.2014.989114.


Nuclear accumulation of mRNAs underlies G4C2-repeat-induced translational repression in a cellular model of C9orf72 ALS.

Rossi S, Serrano A, Gerbino V, Giorgi A, Di Francesco L, Nencini M, Bozzo F, Schininà ME, Bagni C, Cestra G, Carrì MT, Achsel T, Cozzolino M.

J Cell Sci. 2015 May 1;128(9):1787-99. doi: 10.1242/jcs.165332. Epub 2015 Mar 18.


Sm-like proteins in the pathogenesis of Spinal Muscular Atrophy.

Achsel T, Doms R, Bagni C, Renzi F.

Springerplus. 2015 Jun 12;4(Suppl 1):L53. doi: 10.1186/2193-1801-4-S1-L53. eCollection 2015. No abstract available.


Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK.

Panja D, Kenney JW, D'Andrea L, Zalfa F, Vedeler A, Wibrand K, Fukunaga R, Bagni C, Proud CG, Bramham CR.

Cell Rep. 2014 Nov 20;9(4):1430-45. doi: 10.1016/j.celrep.2014.10.016. Epub 2014 Nov 6.


FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry.

La Fata G, Gärtner A, Domínguez-Iturza N, Dresselaers T, Dawitz J, Poorthuis RB, Averna M, Himmelreich U, Meredith RM, Achsel T, Dotti CG, Bagni C.

Nat Neurosci. 2014 Dec;17(12):1693-700. doi: 10.1038/nn.3870. Epub 2014 Nov 17.


SnapShot: FMRP interacting proteins.

Pasciuto E, Bagni C.

Cell. 2014 Sep 25;159(1):218-218.e1. doi: 10.1016/j.cell.2014.08.036.


Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us.

Santos AR, Kanellopoulos AK, Bagni C.

Learn Mem. 2014 Sep 16;21(10):543-55. doi: 10.1101/lm.035956.114. Print 2014 Oct. Review.


SnapShot: FMRP mRNA targets and diseases.

Pasciuto E, Bagni C.

Cell. 2014 Sep 11;158(6):1446-1446.e1. doi: 10.1016/j.cell.2014.08.035.


Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

Hsia HE, Kumar R, Luca R, Takeda M, Courchet J, Nakashima J, Wu S, Goebbels S, An W, Eickholt BJ, Polleux F, Rotin D, Wu H, Rossner MJ, Bagni C, Rhee JS, Brose N, Kawabe H.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13205-10. doi: 10.1073/pnas.1400737111. Epub 2014 Aug 25.


Changes in gene expression profile in two multidrug resistant cell lines derived from a same drug sensitive cell line.

Moreira MA, Bagni C, de Pinho MB, Mac-Cormick TM, dos Santos Mota M, Pinto-Silva FE, Daflon-Yunes N, Rumjanek VM.

Leuk Res. 2014 Aug;38(8):983-7. doi: 10.1016/j.leukres.2014.06.001. Epub 2014 Jun 12.


The Fragile X mental retardation protein regulates matrix metalloproteinase 9 mRNA at synapses.

Janusz A, Milek J, Perycz M, Pacini L, Bagni C, Kaczmarek L, Dziembowska M.

J Neurosci. 2013 Nov 13;33(46):18234-41. doi: 10.1523/JNEUROSCI.2207-13.2013.


The FMRP regulon: from targets to disease convergence.

Fernández E, Rajan N, Bagni C.

Front Neurosci. 2013 Oct 24;7:191. doi: 10.3389/fnins.2013.00191. Review.


Fragile X syndrome: From protein function to therapy.

Bagni C, Oostra BA.

Am J Med Genet A. 2013 Nov;161A(11):2809-21. doi: 10.1002/ajmg.a.36241. Epub 2013 Sep 24. Review.


The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation.

Lucá R, Averna M, Zalfa F, Vecchi M, Bianchi F, La Fata G, Del Nonno F, Nardacci R, Bianchi M, Nuciforo P, Munck S, Parrella P, Moura R, Signori E, Alston R, Kuchnio A, Farace MG, Fazio VM, Piacentini M, De Strooper B, Achsel T, Neri G, Neven P, Evans DG, Carmeliet P, Mazzone M, Bagni C.

EMBO Mol Med. 2013 Oct;5(10):1523-36. doi: 10.1002/emmm.201302847. Epub 2013 Sep 16. Erratum in: EMBO Mol Med. 2014 Apr;6(4):567.


CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation.

De Rubeis S, Pasciuto E, Li KW, Fernández E, Di Marino D, Buzzi A, Ostroff LE, Klann E, Zwartkruis FJ, Komiyama NH, Grant SG, Poujol C, Choquet D, Achsel T, Posthuma D, Smit AB, Bagni C.

Neuron. 2013 Sep 18;79(6):1169-82. doi: 10.1016/j.neuron.2013.06.039.


Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B.

Iannilli F, Zalfa F, Gartner A, Bagni C, Dotti CG.

PLoS One. 2013 Jun 18;8(6):e66602. doi: 10.1371/journal.pone.0066602. Print 2013.


Molecular dynamics simulations show how the FMRP Ile304Asn mutation destabilizes the KH2 domain structure and affects its function.

Di Marino D, Achsel T, Lacoux C, Falconi M, Bagni C.

J Biomol Struct Dyn. 2014;32(3):337-50. doi: 10.1080/07391102.2013.768552. Epub 2013 Mar 25.


Low hippocampal PI(4,5)P₂ contributes to reduced cognition in old mice as a result of loss of MARCKS.

Trovò L, Ahmed T, Callaerts-Vegh Z, Buzzi A, Bagni C, Chuah M, Vandendriessche T, D'Hooge R, Balschun D, Dotti CG.

Nat Neurosci. 2013 Apr;16(4):449-55. doi: 10.1038/nn.3342. Epub 2013 Feb 24.


Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia.

De Keersmaecker K, Atak ZK, Li N, Vicente C, Patchett S, Girardi T, Gianfelici V, Geerdens E, Clappier E, Porcu M, Lahortiga I, Lucà R, Yan J, Hulselmans G, Vranckx H, Vandepoel R, Sweron B, Jacobs K, Mentens N, Wlodarska I, Cauwelier B, Cloos J, Soulier J, Uyttebroeck A, Bagni C, Hassan BA, Vandenberghe P, Johnson AW, Aerts S, Cools J.

Nat Genet. 2013 Feb;45(2):186-90. doi: 10.1038/ng.2508. Epub 2012 Dec 23.


Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics.

Bagni C, Tassone F, Neri G, Hagerman R.

J Clin Invest. 2012 Dec;122(12):4314-22. doi: 10.1172/JCI63141. Epub 2012 Dec 3.

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