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Items: 16


Mutation-specific dual potentiators maximize rescue of CFTR gating mutants.

Veit G, Da Fonte DF, Avramescu RG, Premchandar A, Bagdany M, Xu H, Bensinger D, Stubba D, Schmidt B, Matouk E, Lukacs GL.

J Cyst Fibros. 2019 Oct 30. pii: S1569-1993(19)30924-5. doi: 10.1016/j.jcf.2019.10.011. [Epub ahead of print]


Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia.

Schnúr A, Premchandar A, Bagdany M, Lukacs GL.

Sci Rep. 2019 Sep 3;9(1):12706. doi: 10.1038/s41598-019-48971-y.


Structure-guided combination therapy to potently improve the function of mutant CFTRs.

Veit G, Xu H, Dreano E, Avramescu RG, Bagdany M, Beitel LK, Roldan A, Hancock MA, Lay C, Li W, Morin K, Gao S, Mak PA, Ainscow E, Orth AP, McNamara P, Edelman A, Frenkiel S, Matouk E, Sermet-Gaudelus I, Barnes WG, Lukacs GL.

Nat Med. 2018 Nov;24(11):1732-1742. doi: 10.1038/s41591-018-0200-x. Epub 2018 Oct 8.


Dual-Laser Tetra-Polarization FRET (4polFRET) for Site-Selective Control of Homo-FRET in Hetero-FRET Systems on the Cell Surface: The Homo-FRET Gate.

Bene L, Bagdány M, Ungvári T, Damjanovich L.

Anal Chem. 2018 Sep 4;90(17):10159-10170. doi: 10.1021/acs.analchem.7b05441. Epub 2018 Aug 22.


Checkpoint for helicity conservation in fluorescence at the nanoscale: Energy and helicity transfer (hFRET) from a rotating donor dipole.

Bene L, Bagdány M, Damjanovich L.

Biophys Chem. 2018 Aug;239:38-53. doi: 10.1016/j.bpc.2018.05.002. Epub 2018 May 22.


Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.

Bagdany M, Veit G, Fukuda R, Avramescu RG, Okiyoneda T, Baaklini I, Singh J, Sovak G, Xu H, Apaja PM, Sattin S, Beitel LK, Roldan A, Colombo G, Balch W, Young JC, Lukacs GL.

Nat Commun. 2017 Aug 30;8(1):398. doi: 10.1038/s41467-017-00444-4.


Perrin and Förster unified: Dual-laser triple-polarization FRET (3polFRET) for interactions at the Förster-distance and beyond.

Ungvári T, Gogolák P, Bagdány M, Damjanovich L, Bene L.

Biochim Biophys Acta. 2016 Apr;1863(4):703-16. doi: 10.1016/j.bbamcr.2016.02.002. Epub 2016 Feb 6.


Depolarized FRET (depolFRET) on the cell surface: FRET control by photoselection.

Bene L, Gogolák P, Ungvári T, Bagdány M, Nagy I, Damjanovich L.

Biochim Biophys Acta. 2016 Feb;1863(2):322-34. doi: 10.1016/j.bbamcr.2015.12.003. Epub 2015 Dec 3.


Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL.

Sci Transl Med. 2014 Jul 23;6(246):246ra97. doi: 10.1126/scitranslmed.3008889.


Mechanism-based corrector combination restores ΔF508-CFTR folding and function.

Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL.

Nat Chem Biol. 2013 Jul;9(7):444-54. doi: 10.1038/nchembio.1253. Epub 2013 May 12.


Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function.

Rabeh WM, Bossard F, Xu H, Okiyoneda T, Bagdany M, Mulvihill CM, Du K, di Bernardo S, Liu Y, Konermann L, Roldan A, Lukacs GL.

Cell. 2012 Jan 20;148(1-2):150-63. doi: 10.1016/j.cell.2011.11.024.


Peripheral protein quality control removes unfolded CFTR from the plasma membrane.

Okiyoneda T, Barrière H, Bagdány M, Rabeh WM, Du K, Höhfeld J, Young JC, Lukacs GL.

Science. 2010 Aug 13;329(5993):805-10. doi: 10.1126/science.1191542. Epub 2010 Jul 1.


Revisiting the role of cystic fibrosis transmembrane conductance regulator and counterion permeability in the pH regulation of endocytic organelles.

Barriere H, Bagdany M, Bossard F, Okiyoneda T, Wojewodka G, Gruenert D, Radzioch D, Lukacs GL.

Mol Biol Cell. 2009 Jul;20(13):3125-41. doi: 10.1091/mbc.E09-01-0061. Epub 2009 May 6.


Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes.

Bagdány M, Batista CV, Valdez-Cruz NA, Somodi S, Rodriguez de la Vega RC, Licea AF, Varga Z, Gáspár R, Possani LD, Panyi G.

Mol Pharmacol. 2005 Apr;67(4):1034-44. Epub 2004 Dec 22.


Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells.

Panyi G, Vámosi G, Bacsó Z, Bagdány M, Bodnár A, Varga Z, Gáspár R, Mátyus L, Damjanovich S.

Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1285-90. Epub 2004 Jan 26.


Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes.

Panyi G, Bagdány M, Bodnár A, Vámosi G, Szentesi G, Jenei A, Mátyus L, Varga S, Waldmann TA, Gáspar R, Damjanovich S.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2592-7. Epub 2003 Feb 25.

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