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Items: 28

1.

Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer.

Aggarwal C, Cohen RB, Morrow MP, Kraynyak KA, Sylvester AJ, Knoblock DM, Bauml JM, Weinstein GS, Lin A, Boyer J, Sakata L, Tan S, Anton A, Dickerson K, Mangrolia D, Vang R, Dallas M, Oyola S, Duff S, Esser M, Kumar R, Weiner D, Csiki I, Bagarazzi ML.

Clin Cancer Res. 2019 Jan 1;25(1):110-124. doi: 10.1158/1078-0432.CCR-18-1763. Epub 2018 Sep 21.

PMID:
30242022
2.

Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy.

Morrow MP, Kraynyak KA, Sylvester AJ, Dallas M, Knoblock D, Boyer JD, Yan J, Vang R, Khan AS, Humeau L, Sardesai NY, Kim JJ, Plotkin S, Weiner DB, Trimble CL, Bagarazzi ML.

Clin Cancer Res. 2018 Jan 15;24(2):276-294. doi: 10.1158/1078-0432.CCR-17-2335. Epub 2017 Oct 30.

3.

Augmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100.

Morrow MP, Kraynyak KA, Sylvester AJ, Shen X, Amante D, Sakata L, Parker L, Yan J, Boyer J, Roh C, Humeau L, Khan AS, Broderick K, Marcozzi-Pierce K, Giffear M, Lee J, Trimble CL, Kim JJ, Sardesai NY, Weiner DB, Bagarazzi ML.

Mol Ther Oncolytics. 2016 Nov 30;3:16025. doi: 10.1038/mto.2016.25. eCollection 2016.

4.

Rethinking the Regulatory Infrastructure for Human Gene Transfer Clinical Trials.

Jenkins CL, Bagarazzi ML, Kiem HP, Levine AJ, Ando D, June CH, Reid T, Emery DW.

Mol Ther. 2016 Aug;24(7):1173-7. doi: 10.1038/mt.2016.133. No abstract available.

5.

Safety, bioavailability, and pharmacokinetics of VGX-1027-A novel oral anti-inflammatory drug in healthy human subjects.

Lee JC, Menacherry S, Diehl MC, Giffear MD, White CJ, Juba R, Bagarazzi ML, Muthumani K, Boyer J, Agarwal V, Nicoletti F, Bart S, Kim JJ, Weiner DB, Sardesai NY.

Clin Pharmacol Drug Dev. 2016 Mar;5(2):91-101. doi: 10.1002/cpdd.193. Epub 2015 Jun 8.

PMID:
27138022
6.

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial.

Trimble CL, Morrow MP, Kraynyak KA, Shen X, Dallas M, Yan J, Edwards L, Parker RL, Denny L, Giffear M, Brown AS, Marcozzi-Pierce K, Shah D, Slager AM, Sylvester AJ, Khan A, Broderick KE, Juba RJ, Herring TA, Boyer J, Lee J, Sardesai NY, Weiner DB, Bagarazzi ML.

Lancet. 2015 Nov 21;386(10008):2078-2088. doi: 10.1016/S0140-6736(15)00239-1. Epub 2015 Sep 17.

7.

Synthetic consensus HIV-1 DNA induces potent cellular immune responses and synthesis of granzyme B, perforin in HIV infected individuals.

Morrow MP, Tebas P, Yan J, Ramirez L, Slager A, Kraynyak K, Diehl M, Shah D, Khan A, Lee J, Boyer J, Kim JJ, Sardesai NY, Weiner DB, Bagarazzi ML.

Mol Ther. 2015 Mar;23(3):591-601. doi: 10.1038/mt.2014.245. Epub 2014 Dec 22.

8.

Tolerability of intramuscular and intradermal delivery by CELLECTRA(®) adaptive constant current electroporation device in healthy volunteers.

Diehl MC, Lee JC, Daniels SE, Tebas P, Khan AS, Giffear M, Sardesai NY, Bagarazzi ML.

Hum Vaccin Immunother. 2013 Oct;9(10):2246-52. doi: 10.4161/hv.24702. Epub 2013 Jun 4.

9.

Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses.

Bagarazzi ML, Yan J, Morrow MP, Shen X, Parker RL, Lee JC, Giffear M, Pankhong P, Khan AS, Broderick KE, Knott C, Lin F, Boyer JD, Draghia-Akli R, White CJ, Kim JJ, Weiner DB, Sardesai NY.

Sci Transl Med. 2012 Oct 10;4(155):155ra138. doi: 10.1126/scitranslmed.3004414.

10.

Issues for improving multiplasmid DNA vaccines for HIV-1.

Muthumani K, Kudchodkar S, Zhang D, Bagarazzi ML, Kim JJ, Boyer JD, Ayyavoo V, Pavlakis GN, Weiner DB.

Vaccine. 2002 May 6;20(15):1999-2003. Review.

PMID:
11983262
11.

Therapeutic immunization of HIV-infected chimpanzees using HIV-1 plasmid antigens and interleukin-12 expressing plasmids.

Boyer JD, Cohen AD, Ugen KE, Edgeworth RL, Bennett M, Shah A, Schumann K, Nath B, Javadian A, Bagarazzi ML, Kim J, Weiner DB.

AIDS. 2000 Jul 28;14(11):1515-22.

PMID:
10983638
12.

Vaccination of seronegative volunteers with a human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines.

Boyer JD, Cohen AD, Vogt S, Schumann K, Nath B, Ahn L, Lacy K, Bagarazzi ML, Higgins TJ, Baine Y, Ciccarelli RB, Ginsberg RS, MacGregor RR, Weiner DB.

J Infect Dis. 2000 Feb;181(2):476-83.

PMID:
10669329
13.

HIV-1 DNA vaccines and chemokines.

Boyer JD, Kim J, Ugen K, Cohen AD, Ahn L, Schumann K, Lacy K, Bagarazzi ML, Javadian A, Ciccarelli RB, Ginsberg RS, MacGregor RR, Weiner DB.

Vaccine. 1999 Oct 1;17 Suppl 2:S53-64.

PMID:
10506409
14.

Systemic and mucosal immunity is elicited after both intramuscular and intravaginal delivery of human immunodeficiency virus type 1 DNA plasmid vaccines to pregnant chimpanzees.

Bagarazzi ML, Boyer JD, Javadian MA, Chattergoon MA, Shah AR, Cohen AD, Bennett MK, Ciccarelli RB, Ugen KE, Weiner DB.

J Infect Dis. 1999 Oct;180(4):1351-5.

PMID:
10479171
15.

Enhancement of cellular immune response in HIV-1 seropositive individuals: A DNA-based trial.

Boyer JD, Chattergoon MA, Ugen KE, Shah A, Bennett M, Cohen A, Nyland S, Lacy KE, Bagarazzi ML, Higgins TJ, Baine Y, Ciccarelli RB, Ginsberg RS, MacGregor RR, Weiner DB.

Clin Immunol. 1999 Jan;90(1):100-7.

PMID:
9884357
16.

Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees.

Bagarazzi ML, Boyer JD, Ugen KE, Javadian MA, Chattergoon M, Shah A, Bennett M, Ciccarelli R, Carrano R, Coney L, Weiner DB.

Vaccine. 1998 Nov;16(19):1836-41.

PMID:
9795389
17.

Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes.

Kim JJ, Nottingham LK, Wilson DM, Bagarazzi ML, Tsai A, Morrison LD, Javadian A, Chalian AA, Agadjanyan MG, Weiner DB.

Vaccine. 1998 Nov;16(19):1828-35.

PMID:
9795388
18.

DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans.

Ugen KE, Nyland SB, Boyer JD, Vidal C, Lera L, Rasheid S, Chattergoon M, Bagarazzi ML, Ciccarelli R, Higgins T, Baine Y, Ginsberg R, Macgregor RR, Weiner DB.

Vaccine. 1998 Nov;16(19):1818-21.

PMID:
9795386
19.

First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response.

MacGregor RR, Boyer JD, Ugen KE, Lacy KE, Gluckman SJ, Bagarazzi ML, Chattergoon MA, Baine Y, Higgins TJ, Ciccarelli RB, Coney LR, Ginsberg RS, Weiner DB.

J Infect Dis. 1998 Jul;178(1):92-100.

PMID:
9652427
20.

Nucleic acid-based vaccines as an approach to immunization against human immunodeficiency virus type-1.

Bagarazzi ML, Boyer JD, Ayyavoo V, Weiner DB.

Curr Top Microbiol Immunol. 1998;226:107-43. Review. No abstract available.

PMID:
9479839
21.

DNA vaccination as anti-human immunodeficiency virus immunotherapy in infected chimpanzees.

Boyer JD, Ugen KE, Chattergoon M, Wang B, Shah A, Agadjanyan M, Bagarazzi ML, Javadian A, Carrano R, Coney L, Williams WV, Weiner DB.

J Infect Dis. 1997 Dec;176(6):1501-9.

PMID:
9395361
22.

Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes.

Kim JJ, Bagarazzi ML, Trivedi N, Hu Y, Kazahaya K, Wilson DM, Ciccarelli R, Chattergoon MA, Dang K, Mahalingam S, Chalian AA, Agadjanyan MG, Boyer JD, Wang B, Weiner DB.

Nat Biotechnol. 1997 Jul;15(7):641-6.

PMID:
9219266
23.

Development of a multicomponent candidate vaccine for HIV-1.

Kim JJ, Ayyavoo V, Bagarazzi ML, Chattergoon M, Boyer JD, Wang B, Weiner DB.

Vaccine. 1997 Jun;15(8):879-83.

PMID:
9234538
24.

Picture of the month. Filariasis.

Bagarazzi ML, McCarthy J, Kim IK, Reynolds J, Nutman T, Watson B.

Arch Pediatr Adolesc Med. 1997 May;151(5):521-2. No abstract available.

PMID:
9158448
25.

Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination.

Boyer JD, Ugen KE, Wang B, Agadjanyan M, Gilbert L, Bagarazzi ML, Chattergoon M, Frost P, Javadian A, Williams WV, Refaeli Y, Ciccarelli RB, McCallus D, Coney L, Weiner DB.

Nat Med. 1997 May;3(5):526-32.

PMID:
9142121
26.

Safety and immunogenicity of intramuscular and intravaginal delivery of HIV-1 DNA constructs to infant chimpanzees.

Bagarazzi ML, Boyer JD, Javadian MA, Chattergoon M, Dang K, Kim G, Shah J, Wang B, Weiner DB.

J Med Primatol. 1997 Feb-Apr;26(1-2):27-33.

PMID:
9271186
27.

In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen.

Kim JJ, Ayyavoo V, Bagarazzi ML, Chattergoon MA, Dang K, Wang B, Boyer JD, Weiner DB.

J Immunol. 1997 Jan 15;158(2):816-26.

PMID:
8992999
28.

Pulmonary Mycobacterium gordonae infection in a two-year-old child: case report.

Bagarazzi ML, Watson B, Kim IK, Hogarty M, McGowan KL.

Clin Infect Dis. 1996 Jun;22(6):1124-5. No abstract available.

PMID:
8783736

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