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Items: 12


The in vivo transformation and pharmacokinetic properties of a liquid crystalline drug delivery system.

Otte A, Báez-Santos YM, Mun EA, Soh BK, Lee YN, Park K.

Int J Pharm. 2017 Oct 30;532(1):345-351. doi: 10.1016/j.ijpharm.2017.08.098. Epub 2017 Aug 24.


X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design.

Clasman JR, Báez-Santos YM, Mettelman RC, O'Brien A, Baker SC, Mesecar AD.

Sci Rep. 2017 Jan 12;7:40292. doi: 10.1038/srep40292.


Formulation and characterization of a liquid crystalline hexagonal mesophase region of phosphatidylcholine, sorbitan monooleate, and tocopherol acetate for sustained delivery of leuprolide acetate.

Báez-Santos YM, Otte A, Mun EA, Soh BK, Song CG, Lee YN, Park K.

Int J Pharm. 2016 Nov 30;514(1):314-321. doi: 10.1016/j.ijpharm.2016.06.138.


A Fast and Sensitive Method for the Detection of Leuprolide Acetate: A High-Throughput Approach for the In Vitro Evaluation of Liquid Crystal Formulations.

Báez-Santos YM, Otte A, Park K.

Anal Chem. 2016 May 3;88(9):4613-8. doi: 10.1021/acs.analchem.6b00190. Epub 2016 Apr 22.


The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.

Báez-Santos YM, St John SE, Mesecar AD.

Antiviral Res. 2015 Mar;115:21-38. doi: 10.1016/j.antiviral.2014.12.015. Epub 2014 Dec 29. Review.


Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.

Báez-Santos YM, Mielech AM, Deng X, Baker S, Mesecar AD.

J Virol. 2014 Nov;88(21):12511-27. doi: 10.1128/JVI.01294-14. Epub 2014 Aug 20.


Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease.

Ratia K, Kilianski A, Baez-Santos YM, Baker SC, Mesecar A.

PLoS Pathog. 2014 May 22;10(5):e1004113. doi: 10.1371/journal.ppat.1004113. eCollection 2014 May.


X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases.

Báez-Santos YM, Barraza SJ, Wilson MW, Agius MP, Mielech AM, Davis NM, Baker SC, Larsen SD, Mesecar AD.

J Med Chem. 2014 Mar 27;57(6):2393-412. doi: 10.1021/jm401712t. Epub 2014 Mar 14.


MERS-CoV papain-like protease has deISGylating and deubiquitinating activities.

Mielech AM, Kilianski A, Baez-Santos YM, Mesecar AD, Baker SC.

Virology. 2014 Feb;450-451:64-70. doi: 10.1016/j.virol.2013.11.040. Epub 2013 Dec 22.


Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding.

Turlington M, Chun A, Tomar S, Eggler A, Grum-Tokars V, Jacobs J, Daniels JS, Dawson E, Saldanha A, Chase P, Baez-Santos YM, Lindsley CW, Hodder P, Mesecar AD, Stauffer SR.

Bioorg Med Chem Lett. 2013 Nov 15;23(22):6172-7. doi: 10.1016/j.bmcl.2013.08.112. Epub 2013 Sep 7.


Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease.

Jacobs J, Grum-Tokars V, Zhou Y, Turlington M, Saldanha SA, Chase P, Eggler A, Dawson ES, Baez-Santos YM, Tomar S, Mielech AM, Baker SC, Lindsley CW, Hodder P, Mesecar A, Stauffer SR.

J Med Chem. 2013 Jan 24;56(2):534-46. doi: 10.1021/jm301580n. Epub 2013 Jan 3.


Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.

Clementz MA, Chen Z, Banach BS, Wang Y, Sun L, Ratia K, Baez-Santos YM, Wang J, Takayama J, Ghosh AK, Li K, Mesecar AD, Baker SC.

J Virol. 2010 May;84(9):4619-29. doi: 10.1128/JVI.02406-09. Epub 2010 Feb 24.

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