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Items: 1 to 50 of 75

1.

Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury.

Bravo-Caparrós I, Ruiz-Cantero MC, Perazzoli G, Cronin SJF, Vela JM, Hamed MF, Penninger JM, Baeyens JM, Cobos EJ, Nieto FR.

FASEB J. 2020 Apr;34(4):5951-5966. doi: 10.1096/fj.201901921R. Epub 2020 Mar 10.

PMID:
32157739
2.

Urinary bladder sigma-1 receptors: A new target for cystitis treatment.

González-Cano R, Artacho-Cordón A, Romero L, Tejada MA, Nieto FR, Merlos M, Cañizares FJ, Cendán CM, Fernández-Segura E, Baeyens JM.

Pharmacol Res. 2020 Feb 24;155:104724. doi: 10.1016/j.phrs.2020.104724. [Epub ahead of print]

3.

Sigma-1 Receptor Inhibition Reduces Neuropathic Pain Induced by Partial Sciatic Nerve Transection in Mice by Opioid-Dependent and -Independent Mechanisms.

Bravo-Caparrós I, Perazzoli G, Yeste S, Cikes D, Baeyens JM, Cobos EJ, Nieto FR.

Front Pharmacol. 2019 Jun 12;10:613. doi: 10.3389/fphar.2019.00613. eCollection 2019.

4.

A novel nanoformulation of PLGA with high non-ionic surfactant content improves in vitro and in vivo PTX activity against lung cancer.

Jiménez-López J, El-Hammadi MM, Ortiz R, Cayero-Otero MD, Cabeza L, Perazzoli G, Martin-Banderas L, Baeyens JM, Prados J, Melguizo C.

Pharmacol Res. 2019 Mar;141:451-465. doi: 10.1016/j.phrs.2019.01.013. Epub 2019 Jan 8.

PMID:
30634051
5.

Modality-specific peripheral antinociceptive effects of μ-opioid agonists on heat and mechanical stimuli: Contribution of sigma-1 receptors.

Montilla-García Á, Perazzoli G, Tejada MÁ, González-Cano R, Sánchez-Fernández C, Cobos EJ, Baeyens JM.

Neuropharmacology. 2018 Jun;135:328-342. doi: 10.1016/j.neuropharm.2018.03.025. Epub 2018 Mar 24.

6.

Tripalmitin nanoparticle formulations significantly enhance paclitaxel antitumor activity against breast and lung cancer cells in vitro.

Leiva MC, Ortiz R, Contreras-Cáceres R, Perazzoli G, Mayevych I, López-Romero JM, Sarabia F, Baeyens JM, Melguizo C, Prados J.

Sci Rep. 2017 Oct 18;7(1):13506. doi: 10.1038/s41598-017-13816-z.

7.

Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice.

Tejada MA, Montilla-García A, Cronin SJ, Cikes D, Sánchez-Fernández C, González-Cano R, Ruiz-Cantero MC, Penninger JM, Vela JM, Baeyens JM, Cobos EJ.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8396-8401. doi: 10.1073/pnas.1620068114. Epub 2017 Jul 17.

8.

Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics.

Sánchez-Fernández C, Entrena JM, Baeyens JM, Cobos EJ.

Adv Exp Med Biol. 2017;964:109-132. doi: 10.1007/978-3-319-50174-1_9. Review.

PMID:
28315268
9.

Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States.

Pitcher MH, Gonzalez-Cano R, Vincent K, Lehmann M, Cobos EJ, Coderre TJ, Baeyens JM, Cervero F.

J Pain. 2017 Jun;18(6):716-725. doi: 10.1016/j.jpain.2017.02.422. Epub 2017 Feb 20.

10.

Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways.

Hockley JR, González-Cano R, McMurray S, Tejada-Giraldez MA, McGuire C, Torres A, Wilbrey AL, Cibert-Goton V, Nieto FR, Pitcher T, Knowles CH, Baeyens JM, Wood JN, Winchester WJ, Bulmer DC, Cendán CM, McMurray G.

J Physiol. 2017 Apr 15;595(8):2661-2679. doi: 10.1113/JP272837. Epub 2017 Mar 1.

11.

Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin.

Entrena JM, Sánchez-Fernández C, Nieto FR, González-Cano R, Yeste S, Cobos EJ, Baeyens JM.

Sci Rep. 2016 Nov 25;6:37835. doi: 10.1038/srep37835.

12.

Use of Very-Low-Dose Methadone and Haloperidol for Pain Control in Palliative Care Patients: Are the Sigma-1 Receptors Involved?

Cobos EJ, Baeyens JM.

J Palliat Med. 2015 Aug;18(8):660. doi: 10.1089/jpm.2015.0147. Epub 2015 Jun 18. No abstract available.

PMID:
26087240
13.

Sigma-1 receptor inhibition reverses acute inflammatory hyperalgesia in mice: role of peripheral sigma-1 receptors.

Tejada MA, Montilla-García A, Sánchez-Fernández C, Entrena JM, Perazzoli G, Baeyens JM, Cobos EJ.

Psychopharmacology (Berl). 2014 Oct;231(19):3855-69. doi: 10.1007/s00213-014-3524-3. Epub 2014 Mar 18.

PMID:
24639046
14.

Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice.

Nieto FR, Cendán CM, Cañizares FJ, Cubero MA, Vela JM, Fernández-Segura E, Baeyens JM.

Mol Pain. 2014 Feb 11;10:11. doi: 10.1186/1744-8069-10-11.

15.

Modulation of peripheral μ-opioid analgesia by σ1 receptors.

Sánchez-Fernández C, Montilla-García Á, González-Cano R, Nieto FR, Romero L, Artacho-Cordón A, Montes R, Fernández-Pastor B, Merlos M, Baeyens JM, Entrena JM, Cobos EJ.

J Pharmacol Exp Ther. 2014 Jan;348(1):32-45. doi: 10.1124/jpet.113.208272. Epub 2013 Oct 23.

PMID:
24155346
16.

Sigma-1 receptor antagonism as opioid adjuvant strategy: enhancement of opioid antinociception without increasing adverse effects.

Vidal-Torres A, de la Puente B, Rocasalbas M, Touriño C, Bura SA, Fernández-Pastor B, Romero L, Codony X, Zamanillo D, Buschmann H, Merlos M, Baeyens JM, Maldonado R, Vela JM.

Eur J Pharmacol. 2013 Jul 5;711(1-3):63-72. doi: 10.1016/j.ejphar.2013.04.018. Epub 2013 Apr 28.

PMID:
23632394
17.

Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.

Nieto FR, Cobos EJ, Entrena JM, Parra A, García-Granados A, Baeyens JM.

J Nat Prod. 2013 Apr 26;76(4):737-40. doi: 10.1021/np300783a. Epub 2013 Mar 29.

PMID:
23540838
18.

Potentiation of morphine-induced mechanical antinociception by σ₁ receptor inhibition: role of peripheral σ₁ receptors.

Sánchez-Fernández C, Nieto FR, González-Cano R, Artacho-Cordón A, Romero L, Montilla-García Á, Zamanillo D, Baeyens JM, Entrena JM, Cobos EJ.

Neuropharmacology. 2013 Jul;70:348-58. doi: 10.1016/j.neuropharm.2013.03.002. Epub 2013 Mar 21.

PMID:
23524304
19.

σ1 receptors are involved in the visceral pain induced by intracolonic administration of capsaicin in mice.

González-Cano R, Merlos M, Baeyens JM, Cendán CM.

Anesthesiology. 2013 Mar;118(3):691-700. doi: 10.1097/ALN.0b013e318280a60a.

PMID:
23299362
20.

Role of sigma-1 receptors in paclitaxel-induced neuropathic pain in mice.

Nieto FR, Cendán CM, Sánchez-Fernández C, Cobos EJ, Entrena JM, Tejada MA, Zamanillo D, Vela JM, Baeyens JM.

J Pain. 2012 Nov;13(11):1107-21. doi: 10.1016/j.jpain.2012.08.006. Epub 2012 Oct 12.

PMID:
23063344
21.

Changes in morphine-induced activation of cerebral Na(+),K(+)-ATPase during morphine tolerance: biochemical and behavioral consequences.

Gonzalez LG, Masocha W, Sánchez-Fernández C, Agil A, Ocaña M, Del Pozo E, Baeyens JM.

Biochem Pharmacol. 2012 Jun 1;83(11):1572-81. doi: 10.1016/j.bcp.2012.02.023. Epub 2012 Mar 3.

PMID:
22410004
22.

Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization.

Romero L, Zamanillo D, Nadal X, Sánchez-Arroyos R, Rivera-Arconada I, Dordal A, Montero A, Muro A, Bura A, Segalés C, Laloya M, Hernández E, Portillo-Salido E, Escriche M, Codony X, Encina G, Burgueño J, Merlos M, Baeyens JM, Giraldo J, López-García JA, Maldonado R, Plata-Salamán CR, Vela JM.

Br J Pharmacol. 2012 Aug;166(8):2289-306. doi: 10.1111/j.1476-5381.2012.01942.x.

23.

Sigma-1 receptors do not regulate calcium influx through voltage-dependent calcium channels in mouse brain synaptosomes.

González LG, Sánchez-Fernández C, Cobos EJ, Baeyens JM, del Pozo E.

Eur J Pharmacol. 2012 Feb 29;677(1-3):102-6. doi: 10.1016/j.ejphar.2011.12.029. Epub 2011 Dec 29.

PMID:
22227337
24.

Selective sigma-1 (sigma1) receptor antagonists: emerging target for the treatment of neuropathic pain.

Díaz JL, Zamanillo D, Corbera J, Baeyens JM, Maldonado R, Pericàs MA, Vela JM, Torrens A.

Cent Nerv Syst Agents Med Chem. 2009 Sep;9(3):172-83. Review.

PMID:
20021351
25.

Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury.

de la Puente B, Nadal X, Portillo-Salido E, Sánchez-Arroyos R, Ovalle S, Palacios G, Muro A, Romero L, Entrena JM, Baeyens JM, López-García JA, Maldonado R, Zamanillo D, Vela JM.

Pain. 2009 Oct;145(3):294-303. doi: 10.1016/j.pain.2009.05.013. Epub 2009 Jun 7.

PMID:
19505761
26.

Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: studies with selective sigma-1 ligands and sigma-1 knockout mice.

Entrena JM, Cobos EJ, Nieto FR, Cendán CM, Gris G, Del Pozo E, Zamanillo D, Baeyens JM.

Pain. 2009 Jun;143(3):252-61. doi: 10.1016/j.pain.2009.03.011. Epub 2009 Apr 17.

PMID:
19375855
27.

Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.

Entrena JM, Cobos EJ, Nieto FR, Cendán CM, Baeyens JM, Del Pozo E.

Psychopharmacology (Berl). 2009 Jul;205(1):21-33. doi: 10.1007/s00213-009-1513-8. Epub 2009 Mar 27.

28.

5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice.

Brenchat A, Romero L, García M, Pujol M, Burgueño J, Torrens A, Hamon M, Baeyens JM, Buschmann H, Zamanillo D, Vela JM.

Pain. 2009 Feb;141(3):239-47. doi: 10.1016/j.pain.2008.11.009. Epub 2008 Dec 31.

PMID:
19118950
29.

Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice.

Nieto FR, Entrena JM, Cendán CM, Pozo ED, Vela JM, Baeyens JM.

Pain. 2008 Jul 31;137(3):520-31. Epub 2007 Nov 26.

PMID:
18037242
30.
31.

The antinociceptive effect of morphine is reversed by okadaic acid in morphine-naive but not in morphine-tolerant mice.

Ocaña M, Entrena JM, Baeyens JM, Del Pozo E.

Pharmacol Biochem Behav. 2007 Jan;86(1):21-6. Epub 2006 Dec 15.

PMID:
17234262
32.
33.

Antinociceptive effects of haloperidol and its metabolites in the formalin test in mice.

Cendán CM, Pujalte JM, Portillo-Salido E, Baeyens JM.

Psychopharmacology (Berl). 2005 Nov;182(4):485-93. Epub 2005 Oct 19.

PMID:
16075285
34.

Formalin-induced pain is reduced in sigma(1) receptor knockout mice.

Cendán CM, Pujalte JM, Portillo-Salido E, Montoliu L, Baeyens JM.

Eur J Pharmacol. 2005 Mar 21;511(1):73-4.

PMID:
15777781
36.
37.

Potassium channels and pain: present realities and future opportunities.

Ocaña M, Cendán CM, Cobos EJ, Entrena JM, Baeyens JM.

Eur J Pharmacol. 2004 Oct 1;500(1-3):203-19. Review.

PMID:
15464034
38.

Role of Na(+), K(+)-ATPase in morphine-induced antinociception.

Masocha W, Horvath G, Agil A, Ocana M, Del Pozo E, Szikszay M, Baeyens JM.

J Pharmacol Exp Ther. 2003 Sep;306(3):1122-8. Epub 2003 May 19.

PMID:
12756273
39.

Effects of serine/threonine protein phosphatase inhibitors on morphine-induced antinociception in the tail flick test in mice.

Moncada A, Cendán CM, Baeyens JM, Del Pozo E.

Eur J Pharmacol. 2003 Mar 28;465(1-2):53-60.

PMID:
12650833
40.

Evaluation of endomorphin-1 on the activity of Na(+),K(+)-ATPase using in vitro and in vivo studies.

Horvath G, Agil A, Joo G, Dobos I, Benedek G, Baeyens JM.

Eur J Pharmacol. 2003 Jan 5;458(3):291-7.

PMID:
12504785
41.

Mechanisms involved in morphine-induced activation of synaptosomal Na+,K+-ATPase.

Masocha W, González LG, Baeyens JM, Agil A.

Brain Res. 2002 Dec 13;957(2):311-9.

PMID:
12445973
42.

Changes in [(3)H]glibenclamide binding to mouse forebrain membranes during morphine tolerance.

González LG, Portillo E, Del Pozo E, Baeyens JM.

Eur J Pharmacol. 2001 Apr 20;418(1-2):29-37.

PMID:
11334862
43.

The NMDA receptor antagonist dizocilpine (MK-801) stereoselectively inhibits morphine-induced place preference conditioning in mice.

Del Pozo E, Barrios M, Baeyens JM.

Psychopharmacology (Berl). 1996 Jun;125(3):209-13.

PMID:
8815955
44.
45.

Effects of K+ channel blockers and openers on antinociception induced by agonists of 5-HT1A receptors.

Robles LI, Barrios M, Del Pozo E, Dordal A, Baeyens JM.

Eur J Pharmacol. 1996 Jan 11;295(2-3):181-8.

PMID:
8720582
46.

Subgroups among mu-opioid receptor agonists distinguished by ATP-sensitive K+ channel-acting drugs.

Ocaña M, Del Pozo E, Barrios M, Baeyens JM.

Br J Pharmacol. 1995 Mar;114(6):1296-302.

47.

Role of ATP-sensitive K+ channels in antinociception induced by R-PIA, an adenosine A1 receptor agonist.

Ocaña M, Baeyens JM.

Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;350(1):57-62.

PMID:
7935855
48.

Electron probe microanalysis of gentamicin-induced changes on ionic composition of the vestibular gelatinous membrane.

López-Escámez JA, Cañizares FJ, Crespo PV, Baeyens JM, Campos A.

Hear Res. 1994 Jun 1;76(1-2):60-6.

PMID:
7928715
49.

ATP-sensitive K+ channel openers inhibit morphine withdrawal.

Robles LI, Barrios M, Baeyens JM.

Eur J Pharmacol. 1994 Jan 4;251(1):113-5.

PMID:
8137867
50.

Gentamicin ototoxicity in otoconia: quantitative electron probe X-ray microanalysis.

Campos A, López-Escámez JA, Crespo PV, Cañizares FJ, Baeyens JM.

Acta Otolaryngol. 1994 Jan;114(1):18-23.

PMID:
8128848

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