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Bioengineering strategies for inducing tolerance in autoimmune diabetes.

Baekkeskov S, Hubbell JA, Phelps EA.

Adv Drug Deliv Rev. 2017 May 15;114:256-265. doi: 10.1016/j.addr.2017.06.007. Epub 2017 Jun 15. Review.


Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation.

Phelps EA, Cianciaruso C, Santo-Domingo J, Pasquier M, Galliverti G, Piemonti L, Berishvili E, Burri O, Wiederkehr A, Hubbell JA, Baekkeskov S.

Sci Rep. 2017 May 9;7:46801. doi: 10.1038/srep46801. No abstract available.


Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation.

Phelps EA, Cianciaruso C, Santo-Domingo J, Pasquier M, Galliverti G, Piemonti L, Berishvili E, Burri O, Wiederkehr A, Hubbell JA, Baekkeskov S.

Sci Rep. 2017 Apr 12;7:45961. doi: 10.1038/srep45961. Erratum in: Sci Rep. 2017 May 09;7:46801.


Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity.

Cianciaruso C, Phelps EA, Pasquier M, Hamelin R, Demurtas D, Alibashe Ahmed M, Piemonti L, Hirosue S, Swartz MA, De Palma M, Hubbell JA, Baekkeskov S.

Diabetes. 2017 Feb;66(2):460-473. doi: 10.2337/db16-0671. Epub 2016 Nov 21.


Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity.

Phelps EA, Cianciaruso C, Michael IP, Pasquier M, Kanaani J, Nano R, Lavallard V, Billestrup N, Hubbell JA, Baekkeskov S.

Diabetes. 2016 Sep;65(9):2686-99. doi: 10.2337/db16-0180. Epub 2016 Jun 9.


Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons.

Kanaani J, Cianciaruso C, Phelps EA, Pasquier M, Brioudes E, Billestrup N, Baekkeskov S.

PLoS One. 2015 Feb 3;10(2):e0117130. doi: 10.1371/journal.pone.0117130. eCollection 2015.


Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters.

Kanaani J, Kolibachuk J, Martinez H, Baekkeskov S.

J Cell Biol. 2010 Sep 6;190(5):911-25. doi: 10.1083/jcb.200912101. Epub 2010 Aug 30.


Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.

Elagin RB, Balijepalli S, Diacovo MJ, Baekkeskov S, Jaume JC.

J Autoimmun. 2009 Aug;33(1):50-7. doi: 10.1016/j.jaut.2009.02.004. Epub 2009 Mar 16.


Palmitoylation cycles and regulation of protein function (Review).

Baekkeskov S, Kanaani J.

Mol Membr Biol. 2009 Jan;26(1):42-54. doi: 10.1080/09687680802680108. Epub 2009 Jan 30. Review.


A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes.

Kanaani J, Patterson G, Schaufele F, Lippincott-Schwartz J, Baekkeskov S.

J Cell Sci. 2008 Feb 15;121(Pt 4):437-49. doi: 10.1242/jcs.011916. Epub 2008 Jan 29.


Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro.

Kanaani J, Prusiner SB, Diacovo J, Baekkeskov S, Legname G.

J Neurochem. 2005 Dec;95(5):1373-86.


Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters.

Kanaani J, Diacovo MJ, El-Husseini Ael-D, Bredt DS, Baekkeskov S.

J Cell Sci. 2004 Apr 15;117(Pt 10):2001-13. Epub 2004 Mar 23.


Isolation and characterization of human monoclonal autoantibodies to glutamic acid decarboxylase.

Hayakawa N, Premawardhana LD, Powell M, Masuda M, Arnold C, Sanders J, Evans M, Chen S, Jaume JC, Baekkeskov S, Smith BR, Furmaniak J.

Autoimmunity. 2002 Aug;35(5):343-55.


A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65.

Kanaani J, el-Husseini Ael-D, Aguilera-Moreno A, Diacovo JM, Bredt DS, Baekkeskov S.

J Cell Biol. 2002 Sep 30;158(7):1229-38.


Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety.

Wolfe T, Bot A, Hughes A, Möhrle U, Rodrigo E, Jaume JC, Baekkeskov S, von Herrath M.

Eur J Immunol. 2002 Jan;32(1):113-21.


Does GAD have a unique role in triggering IDDM?

Baekkeskov S, Kanaani J, Jaume JC, Kash S.

J Autoimmun. 2000 Nov;15(3):279-86. Review. No abstract available.


Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion.

Shi Y, Kanaani J, Menard-Rose V, Ma YH, Chang PY, Hanahan D, Tobin A, Grodsky G, Baekkeskov S.

Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E684-94.


Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients.

Roll U, Turck CW, Gitelman SE, Rosenthal SM, Nolte MS, Masharani U, Ziegler AG, Baekkeskov S.

Diabetologia. 2000 May;43(5):598-608.


A non-cleavable mutant of Fas ligand does not prevent neutrophilic destruction of islet transplants.

Kang SM, Braat D, Schneider DB, O'Rourke RW, Lin Z, Ascher NL, Dichek DA, Baekkeskov S, Stock PG.

Transplantation. 2000 May 15;69(9):1813-7.


A dendritic cell line genetically modified to express CTLA4-IG as a means to prolong islet allograft survival.

O'Rourke RW, Kang SM, Lower JA, Feng S, Ascher NL, Baekkeskov S, Stock PG.

Transplantation. 2000 Apr 15;69(7):1440-6.


The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid release.

Tian N, Petersen C, Kash S, Baekkeskov S, Copenhagen D, Nicoll R.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12911-6.


Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice.

Kash SF, Condie BG, Baekkeskov S.

Horm Metab Res. 1999 May;31(5):340-4.


High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase.

Schwartz HL, Chandonia JM, Kash SF, Kanaani J, Tunnell E, Domingo A, Cohen FE, Banga JP, Madec AM, Richter W, Baekkeskov S.

J Mol Biol. 1999 Apr 16;287(5):983-99.


Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.

Kash SF, Tecott LH, Hodge C, Baekkeskov S.

Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1698-703.


Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells.

Bridgett M, Cetkovic-Cvrlje M, O'Rourke R, Shi Y, Narayanswami S, Lambert J, Ramiya V, Baekkeskov S, Leiter EH.

Diabetes. 1998 Dec;47(12):1848-56.


Local GABA circuit control of experience-dependent plasticity in developing visual cortex.

Hensch TK, Fagiolini M, Mataga N, Stryker MP, Baekkeskov S, Kash SF.

Science. 1998 Nov 20;282(5393):1504-8.


Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.

Kash SF, Johnson RS, Tecott LH, Noebels JL, Mayfield RD, Hanahan D, Baekkeskov S.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14060-5.


Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction.

Kang SM, Schneider DB, Lin Z, Hanahan D, Dichek DA, Stock PG, Baekkeskov S.

Nat Med. 1997 Jul;3(7):738-43.


Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha.

Namchuk M, Lindsay L, Turck CW, Kanaani J, Baekkeskov S.

J Biol Chem. 1997 Jan 17;272(3):1548-57. Erratum in: J Biol Chem 1997 Jul 4;272(27):17246.


Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase.

Syren K, Lindsay L, Stoehrer B, Jury K, Lühder F, Baekkeskov S, Richter W.

J Immunol. 1996 Dec 1;157(11):5208-14.


Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes.

Aanstoot HJ, Kang SM, Kim J, Lindsay LA, Roll U, Knip M, Atkinson M, Mose-Larsen P, Fey S, Ludvigsson J, Landin L, Bruining J, Maclaren N, Akerblom HK, Baekkeskov S.

J Clin Invest. 1996 Jun 15;97(12):2772-83.


Value of antibodies to GAD65 combined with islet cell cytoplasmic antibodies for predicting IDDM in a childhood population.

Aanstoot HJ, Sigurdsson E, Jaffe M, Shi Y, Christgau S, Grobbee D, Bruining GJ, Molenaar JL, Hofman A, Baekkeskov S.

Diabetologia. 1994 Sep;37(9):917-24.


Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.

Kim J, Namchuk M, Bugawan T, Fu Q, Jaffe M, Shi Y, Aanstoot HJ, Turck CW, Erlich H, Lennon V, Baekkeskov S.

J Exp Med. 1994 Aug 1;180(2):595-606.


Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.

Kim J, Richter W, Aanstoot HJ, Shi Y, Fu Q, Rajotte R, Warnock G, Baekkeskov S.

Diabetes. 1993 Dec;42(12):1799-808.


Transfer of type 1 (insulin-dependent) diabetes mellitus associated autoimmunity to mice with severe combined immunodeficiency (SCID).

Petersen JS, Marshall MO, Baekkeskov S, Hejnaes KR, Høier-Madsen M, Dyrberg T.

Diabetologia. 1993 Jun;36(6):510-5.


The glutamate decarboxylase and 38KD autoantigens in type 1 diabetes: aspects of structure and epitope recognition.

Baekkeskov S, Aanstoot HJ, Fu Q, Jaffe M, Kim J, Quan J, Richter W, Shi Y.

Autoimmunity. 1993;15 Suppl:24-6. Review. No abstract available.


Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas.

Møller CJ, Christgau S, Williamson MR, Madsen OD, Niu ZP, Bock E, Baekkeskov S.

Mol Endocrinol. 1992 Aug;6(8):1332-42.


Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain.

Christgau S, Aanstoot HJ, Schierbeck H, Begley K, Tullin S, Hejnaes K, Baekkeskov S.

J Cell Biol. 1992 Jul;118(2):309-20.


Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble.

Christgau S, Schierbeck H, Aanstoot HJ, Aagaard L, Begley K, Kofod H, Hejnaes K, Baekkeskov S.

J Biol Chem. 1991 Dec 5;266(34):23516. No abstract available.


Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.

Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, De Camilli P.

Nature. 1990 Sep 13;347(6289):151-6. Erratum in: Nature 1990 Oct 25;347(6295):782. Camilli, PD [corrected to De Camilli, P].


Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes.

Christie MR, Pipeleers DG, Lernmark A, Baekkeskov S.

J Biol Chem. 1990 Jan 5;265(1):376-81.


The 64-kDa beta cell membrane autoantigen and other target molecules of humoral autoimmunity in insulin-dependent diabetes mellitus.

Sigurdsson E, Baekkeskov S.

Curr Top Microbiol Immunol. 1990;164:143-68. Review. No abstract available.


Preclinical and manifest diabetes mellitus in young patients with Friedreich's ataxia: no evidence of immune process behind the islet cell destruction.

Schoenle EJ, Boltshauser EJ, Baekkeskov S, Landin Olsson M, Torresani T, von Felten A.

Diabetologia. 1989 Jun;32(6):378-81.


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