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Items: 1 to 50 of 151

1.

Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease.

Gelders G, Baekelandt V, Van der Perren A.

J Immunol Res. 2018 Apr 16;2018:4784268. doi: 10.1155/2018/4784268. eCollection 2018. Review.

2.

ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences.

Peelaerts W, Bousset L, Baekelandt V, Melki R.

Cell Tissue Res. 2018 Jul;373(1):195-212. doi: 10.1007/s00441-018-2839-5. Epub 2018 Apr 27. Review.

PMID:
29704213
3.

Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation.

Janssen B, Vugts DJ, Wilkinson SM, Ory D, Chalon S, Hoozemans JJM, Schuit RC, Beaino W, Kooijman EJM, van den Hoek J, Chishty M, Doméné A, Van der Perren A, Villa A, Maggi A, Molenaar GT, Funke U, Shevchenko RV, Baekelandt V, Bormans G, Lammertsma AA, Kassiou M, Windhorst AD.

Sci Rep. 2018 Apr 26;8(1):6580. doi: 10.1038/s41598-018-24814-0.

4.

Proximal and distal modulation of neural activity by spatially confined optogenetic activation with an integrated high-density optoelectrode.

Libbrecht S, Hoffman L, Welkenhuysen M, Van den Haute C, Baekelandt V, Braeken D, Haesler S.

J Neurophysiol. 2018 Jul 1;120(1):149-161. doi: 10.1152/jn.00888.2017. Epub 2018 Mar 28.

PMID:
29589813
5.

LRRK2 Phosphorylation: Behind the Scenes.

De Wit T, Baekelandt V, Lobbestael E.

Neuroscientist. 2018 Jan 1:1073858418756309. doi: 10.1177/1073858418756309. [Epub ahead of print]

PMID:
29385885
6.

Transient and localized optogenetic activation of somatostatin-interneurons in mouse visual cortex abolishes long-term cortical plasticity due to vision loss.

Scheyltjens I, Vreysen S, Van den Haute C, Sabanov V, Balschun D, Baekelandt V, Arckens L.

Brain Struct Funct. 2018 Jun;223(5):2073-2095. doi: 10.1007/s00429-018-1611-7. Epub 2018 Jan 25.

7.

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.

Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, Taymans JM, Chartier-Harlin MC, Beilina A, Gonnelli A, Cookson MR, Greggio E, Hilfiker S.

Mol Neurodegener. 2018 Jan 23;13(1):3. doi: 10.1186/s13024-018-0235-y.

8.

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.

Civiero L, Cogo S, Kiekens A, Morganti C, Tessari I, Lobbestael E, Baekelandt V, Taymans JM, Chartier-Harlin MC, Franchin C, Arrigoni G, Lewis PA, Piccoli G, Bubacco L, Cookson MR, Pinton P, Greggio E.

Front Mol Neurosci. 2017 Dec 14;10:417. doi: 10.3389/fnmol.2017.00417. eCollection 2017.

9.

Altered mGluR5 binding potential and glutamine concentration in the 6-OHDA rat model of acute Parkinson's disease and levodopa-induced dyskinesia.

Crabbé M, Van der Perren A, Weerasekera A, Himmelreich U, Baekelandt V, Van Laere K, Casteels C.

Neurobiol Aging. 2018 Jan;61:82-92. doi: 10.1016/j.neurobiolaging.2017.09.006. Epub 2017 Sep 21.

PMID:
29055799
10.

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes.

Sejwal K, Chami M, Rémigy H, Vancraenenbroeck R, Sibran W, Sütterlin R, Baumgartner P, McLeod R, Chartier-Harlin MC, Baekelandt V, Stahlberg H, Taymans JM.

Sci Rep. 2017 Aug 17;7(1):8667. doi: 10.1038/s41598-017-09126-z.

11.

ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function.

Demirsoy S, Martin S, Motamedi S, van Veen S, Holemans T, Van den Haute C, Jordanova A, Baekelandt V, Vangheluwe P, Agostinis P.

Hum Mol Genet. 2017 May 1;26(9):1656-1669. doi: 10.1093/hmg/ddx070.

PMID:
28334751
12.

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation.

Lobbestael E, Civiero L, De Wit T, Taymans JM, Greggio E, Baekelandt V.

Sci Rep. 2016 Sep 23;6:33897. doi: 10.1038/srep33897.

13.

Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate.

Vazquez-Martin A, Van den Haute C, Cufí S, Corominas-Faja B, Cuyàs E, Lopez-Bonet E, Rodriguez-Gallego E, Fernández-Arroyo S, Joven J, Baekelandt V, Menendez JA.

Aging (Albany NY). 2016 Jul;8(7):1330-52. doi: 10.18632/aging.100976.

14.

Evaluation of WGA-Cre-dependent topological transgene expression in the rodent brain.

Libbrecht S, Van den Haute C, Malinouskaya L, Gijsbers R, Baekelandt V.

Brain Struct Funct. 2017 Mar;222(2):717-733. doi: 10.1007/s00429-016-1241-x. Epub 2016 Jun 3.

PMID:
27259586
15.

α-synuclein folds: the cards are on the table.

Peelaerts W, Baekelandt V.

Nat Struct Mol Biol. 2016 May 4;23(5):359-60. doi: 10.1038/nsmb.3209. No abstract available.

PMID:
27142318
16.

Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks.

Pulizzi R, Musumeci G, Van den Haute C, Van De Vijver S, Baekelandt V, Giugliano M.

Sci Rep. 2016 Apr 21;6:24701. doi: 10.1038/srep24701.

17.

Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2.

Martin S, van Veen S, Holemans T, Demirsoy S, van den Haute C, Baekelandt V, Agostinis P, Eggermont J, Vangheluwe P.

Parkinsons Dis. 2016;2016:9531917. doi: 10.1155/2016/9531917. Epub 2016 Mar 17.

18.

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector.

Van der Perren A, Casteels C, Van Laere K, Gijsbers R, Van den Haute C, Baekelandt V.

J Vis Exp. 2016 Feb 28;(108):53670. doi: 10.3791/53670.

19.

ɑ-Synuclein strains and the variable pathologies of synucleinopathies.

Peelaerts W, Baekelandt V.

J Neurochem. 2016 Oct;139 Suppl 1:256-274. doi: 10.1111/jnc.13595. Epub 2016 Mar 30. Review.

20.

Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex.

Gerits A, Vancraeyenest P, Vreysen S, Laramée ME, Michiels A, Gijsbers R, Van den Haute C, Moons L, Debyser Z, Baekelandt V, Arckens L, Vanduffel W.

Neurophotonics. 2015 Jul;2(3):031209. doi: 10.1117/1.NPh.2.3.031209. Epub 2015 Oct 1.

21.

An integrated multi-electrode-optrode array for in vitro optogenetics.

Welkenhuysen M, Hoffman L, Luo Z, De Proft A, Van den Haute C, Baekelandt V, Debyser Z, Gielen G, Puers R, Braeken D.

Sci Rep. 2016 Feb 2;6:20353. doi: 10.1038/srep20353.

22.

High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease.

Macchi F, Deleersnijder A, Van den Haute C, Munck S, Pottel H, Michiels A, Debyser Z, Gerard M, Baekelandt V.

J Neurosci Methods. 2016 Mar 1;261:117-27. doi: 10.1016/j.jneumeth.2015.11.009. Epub 2015 Nov 24.

PMID:
26620202
23.

Long-Term Fate Mapping Using Conditional Lentiviral Vectors Reveals a Continuous Contribution of Radial Glia-Like Cells to Adult Hippocampal Neurogenesis in Mice.

Aelvoet SA, Pascual-Brazo J, Libbrecht S, Reumers V, Gijsbers R, Van den Haute C, Baekelandt V.

PLoS One. 2015 Nov 23;10(11):e0143772. doi: 10.1371/journal.pone.0143772. eCollection 2015.

24.

Noninvasive Imaging Reveals Stable Transgene Expression in Mouse Airways After Delivery of a Nonintegrating Recombinant Adeno-Associated Viral Vector.

Vidović D, Gijsbers R, Quiles-Jimenez A, Dooley J, Van den Haute C, Van der Perren A, Liston A, Baekelandt V, Debyser Z, Carlon MS.

Hum Gene Ther. 2016 Jan;27(1):60-71. doi: 10.1089/hum.2015.109. Epub 2015 Dec 21. Erratum in: Hum Gene Ther. 2016 Nov;27(11):946.

PMID:
26567984
25.

Tackling Glaucoma from within the Brain: An Unfortunate Interplay of BDNF and TrkB.

Dekeyster E, Geeraerts E, Buyens T, Van den Haute C, Baekelandt V, De Groef L, Salinas-Navarro M, Moons L.

PLoS One. 2015 Nov 11;10(11):e0142067. doi: 10.1371/journal.pone.0142067. eCollection 2015.

26.

rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice.

Vidović D, Carlon MS, da Cunha MF, Dekkers JF, Hollenhorst MI, Bijvelds MJ, Ramalho AS, Van den Haute C, Ferrante M, Baekelandt V, Janssens HM, De Boeck K, Sermet-Gaudelus I, de Jonge HR, Gijsbers R, Beekman JM, Edelman A, Debyser Z.

Am J Respir Crit Care Med. 2016 Feb 1;193(3):288-98. doi: 10.1164/rccm.201505-0914OC.

PMID:
26509335
27.

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.

Civiero L, Cirnaru MD, Beilina A, Rodella U, Russo I, Belluzzi E, Lobbestael E, Reyniers L, Hondhamuni G, Lewis PA, Van den Haute C, Baekelandt V, Bandopadhyay R, Bubacco L, Piccoli G, Cookson MR, Taymans JM, Greggio E.

J Neurochem. 2015 Dec;135(6):1242-56. doi: 10.1111/jnc.13369. Epub 2015 Oct 19.

28.

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.

Bourdenx M, Dovero S, Engeln M, Bido S, Bastide MF, Dutheil N, Vollenweider I, Baud L, Piron C, Grouthier V, Boraud T, Porras G, Li Q, Baekelandt V, Scheller D, Michel A, Fernagut PO, Georges F, Courtine G, Bezard E, Dehay B.

Acta Neuropathol Commun. 2015 Jul 25;3:46. doi: 10.1186/s40478-015-0222-2.

29.

A lipid switch unlocks Parkinson's disease-associated ATP13A2.

Holemans T, Sørensen DM, van Veen S, Martin S, Hermans D, Kemmer GC, Van den Haute C, Baekelandt V, Günther Pomorski T, Agostinis P, Wuytack F, Palmgren M, Eggermont J, Vangheluwe P.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9040-5. doi: 10.1073/pnas.1508220112. Epub 2015 Jul 1.

30.

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.

Van Rompuy AS, Oliveras-Salvá M, Van der Perren A, Corti O, Van den Haute C, Baekelandt V.

Mol Neurodegener. 2015 Jun 23;10:23. doi: 10.1186/s13024-015-0017-8.

31.

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.

Peelaerts W, Bousset L, Van der Perren A, Moskalyuk A, Pulizzi R, Giugliano M, Van den Haute C, Melki R, Baekelandt V.

Nature. 2015 Jun 18;522(7556):340-4. doi: 10.1038/nature14547. Epub 2015 Jun 10.

PMID:
26061766
32.

Evaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex.

Scheyltjens I, Laramée ME, Van den Haute C, Gijsbers R, Debyser Z, Baekelandt V, Vreysen S, Arckens L.

J Comp Neurol. 2015 Oct 1;523(14):2019-42. doi: 10.1002/cne.23819. Epub 2015 Jun 19.

PMID:
26012540
33.

Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis.

Sierra A, Martín-Suárez S, Valcárcel-Martín R, Pascual-Brazo J, Aelvoet SA, Abiega O, Deudero JJ, Brewster AL, Bernales I, Anderson AE, Baekelandt V, Maletić-Savatić M, Encinas JM.

Cell Stem Cell. 2015 May 7;16(5):488-503. doi: 10.1016/j.stem.2015.04.003.

34.

Oncostatin M protects against demyelination by inducing a protective microglial phenotype.

Janssens K, Maheshwari A, Van den Haute C, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N.

Glia. 2015 Oct;63(10):1729-37. doi: 10.1002/glia.22840. Epub 2015 Apr 29.

PMID:
25921393
35.

Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein.

Bentea E, Van der Perren A, Van Liefferinge J, El Arfani A, Albertini G, Demuyser T, Merckx E, Michotte Y, Smolders I, Baekelandt V, Massie A.

Front Behav Neurosci. 2015 Mar 31;9:68. doi: 10.3389/fnbeh.2015.00068. eCollection 2015.

36.

Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.

Krumova P, Reyniers L, Meyer M, Lobbestael E, Stauffer D, Gerrits B, Muller L, Hoving S, Kaupmann K, Voshol J, Fabbro D, Bauer A, Rovelli G, Taymans JM, Bouwmeester T, Baekelandt V.

FASEB J. 2015 Jul;29(7):2980-92. doi: 10.1096/fj.14-262329. Epub 2015 Apr 8.

PMID:
25854701
37.

IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity.

Pereira L, Font-Nieves M, Van den Haute C, Baekelandt V, Planas AM, Pozas E.

Front Cell Neurosci. 2015 Feb 25;9:57. doi: 10.3389/fncel.2015.00057. eCollection 2015.

38.

FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease.

Van der Perren A, Macchi F, Toelen J, Carlon MS, Maris M, de Loor H, Kuypers DR, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V.

Neurobiol Aging. 2015 Mar;36(3):1559-68. doi: 10.1016/j.neurobiolaging.2015.01.014. Epub 2015 Jan 21.

PMID:
25660193
39.

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.

Van der Perren A, Toelen J, Casteels C, Macchi F, Van Rompuy AS, Sarre S, Casadei N, Nuber S, Himmelreich U, Osorio Garcia MI, Michotte Y, D'Hooge R, Bormans G, Van Laere K, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V.

Neurobiol Aging. 2015 Mar;36(3):1543-58. doi: 10.1016/j.neurobiolaging.2014.11.015. Epub 2014 Dec 17.

PMID:
25599874
40.

Leukemia inhibitory factor tips the immune balance towards regulatory T cells in multiple sclerosis.

Janssens K, Van den Haute C, Baekelandt V, Lucas S, van Horssen J, Somers V, Van Wijmeersch B, Stinissen P, Hendriks JJ, Slaets H, Hellings N.

Brain Behav Immun. 2015 Mar;45:180-8. doi: 10.1016/j.bbi.2014.11.010. Epub 2014 Dec 13.

PMID:
25514345
41.

Noninvasive bioluminescence imaging of α-synuclein oligomerization in mouse brain using split firefly luciferase reporters.

Aelvoet SA, Ibrahimi A, Macchi F, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V.

J Neurosci. 2014 Dec 3;34(49):16518-32. doi: 10.1523/JNEUROSCI.4933-13.2014.

42.

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism.

Taymans JM, Baekelandt V.

Front Genet. 2014 Nov 7;5:382. doi: 10.3389/fgene.2014.00382. eCollection 2014. Review.

43.

Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond.

Göring S, Taymans JM, Baekelandt V, Schmidt B.

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4630-4637. doi: 10.1016/j.bmcl.2014.08.049. Epub 2014 Aug 29.

PMID:
25219901
44.

Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases.

Taymans JM, Baekelandt V, Harvey K.

Front Mol Neurosci. 2014 Jul 29;7:71. doi: 10.3389/fnmol.2014.00071. eCollection 2014. No abstract available.

45.

Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.

Oliveras-Salvá M, Macchi F, Coessens V, Deleersnijder A, Gérard M, Van der Perren A, Van den Haute C, Baekelandt V.

Neurobiol Aging. 2014 Nov;35(11):2625-2636. doi: 10.1016/j.neurobiolaging.2014.04.032. Epub 2014 Jun 14.

PMID:
25037286
46.

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.

Reyniers L, Del Giudice MG, Civiero L, Belluzzi E, Lobbestael E, Beilina A, Arrigoni G, Derua R, Waelkens E, Li Y, Crosio C, Iaccarino C, Cookson MR, Baekelandt V, Greggio E, Taymans JM.

J Neurochem. 2014 Oct;131(2):239-50. doi: 10.1111/jnc.12798. Epub 2014 Jul 14.

47.

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.

Vancraenenbroeck R, De Raeymaecker J, Lobbestael E, Gao F, De Maeyer M, Voet A, Baekelandt V, Taymans JM.

Front Mol Neurosci. 2014 Jun 3;7:51. doi: 10.3389/fnmol.2014.00051. eCollection 2014.

48.

Bioluminescence imaging of stroke-induced endogenous neural stem cell response.

Vandeputte C, Reumers V, Aelvoet SA, Thiry I, De Swaef S, Van den Haute C, Pascual-Brazo J, Farr TD, Vande Velde G, Hoehn M, Himmelreich U, Van Laere K, Debyser Z, Gijsbers R, Baekelandt V.

Neurobiol Dis. 2014 Sep;69:144-55. doi: 10.1016/j.nbd.2014.05.014. Epub 2014 May 27.

PMID:
24878507
49.

Viral vector-based models of Parkinson's disease.

Van der Perren A, Van den Haute C, Baekelandt V.

Curr Top Behav Neurosci. 2015;22:271-301. doi: 10.1007/7854_2014_310. Review.

PMID:
24839101
50.

Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways.

Carlon MS, Vidović D, Dooley J, da Cunha MM, Maris M, Lampi Y, Toelen J, Van den Haute C, Baekelandt V, Deprest J, Verbeken E, Liston A, Gijsbers R, Debyser Z.

Hum Gene Ther. 2014 Jun;25(6):517-28. doi: 10.1089/hum.2013.196. Epub 2014 Mar 26.

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