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Items: 1 to 50 of 163

1.

Insult-induced aberrant hippocampal neurogenesis: functional consequences and possible therapeutic strategies.

Bielefeld P, Durá I, Danielewicz J, Lucassen PJ, Baekelandt V, Abrous DN, Encinas JM, Fitzsimons CP.

Behav Brain Res. 2019 Jun 11:112032. doi: 10.1016/j.bbr.2019.112032. [Epub ahead of print] Review.

PMID:
31199935
2.

Probing the Mechanisms of Repetition Suppression in Inferior Temporal Cortex with Optogenetics.

Fabbrini F, Van den Haute C, De Vitis M, Baekelandt V, Vanduffel W, Vogels R.

Curr Biol. 2019 Jun 17;29(12):1988-1998.e4. doi: 10.1016/j.cub.2019.05.014. Epub 2019 Jun 6.

PMID:
31178318
3.

Temporal changes in neuroinflammation and brain glucose metabolism in a rat model of viral vector-induced α-synucleinopathy.

Crabbé M, Van der Perren A, Kounelis S, Lavreys T, Bormans G, Baekelandt V, Casteels C, Van Laere K.

Exp Neurol. 2019 May 25;320:112964. doi: 10.1016/j.expneurol.2019.112964. [Epub ahead of print]

PMID:
31136763
4.

Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration.

Peralta Ramos JM, Iribarren P, Bousset L, Melki R, Baekelandt V, Van der Perren A.

Front Immunol. 2019 Jan 29;10:80. doi: 10.3389/fimmu.2019.00080. eCollection 2019.

5.

Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine.

Li Z, Hao MM, Van den Haute C, Baekelandt V, Boesmans W, Vanden Berghe P.

Elife. 2019 Feb 12;8. pii: e42914. doi: 10.7554/eLife.42914.

6.

Retinal α-synuclein deposits in Parkinson's disease patients and animal models.

Veys L, Vandenabeele M, Ortuño-Lizarán I, Baekelandt V, Cuenca N, Moons L, De Groef L.

Acta Neuropathol. 2019 Mar;137(3):379-395. doi: 10.1007/s00401-018-01956-z. Epub 2019 Feb 5. Review.

PMID:
30721408
7.

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.

De Schepper S, Verheijden S, Aguilera-Lizarraga J, Viola MF, Boesmans W, Stakenborg N, Voytyuk I, Schmidt I, Boeckx B, Dierckx de Casterlé I, Baekelandt V, Gonzalez Dominguez E, Mack M, Depoortere I, De Strooper B, Sprangers B, Himmelreich U, Soenen S, Guilliams M, Vanden Berghe P, Jones E, Lambrechts D, Boeckxstaens G.

Cell. 2019 Jan 24;176(3):676. doi: 10.1016/j.cell.2019.01.010. No abstract available.

PMID:
30682373
8.

Optogenetic Stimulation of the Superior Colliculus Confers Retinal Neuroprotection in a Mouse Glaucoma Model.

Geeraerts E, Claes M, Dekeyster E, Salinas-Navarro M, De Groef L, Van den Haute C, Scheyltjens I, Baekelandt V, Arckens L, Moons L.

J Neurosci. 2019 Mar 20;39(12):2313-2325. doi: 10.1523/JNEUROSCI.0872-18.2018. Epub 2019 Jan 17.

PMID:
30655352
9.

Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking.

Waschbüsch D, Hübel N, Ossendorf E, Lobbestael E, Baekelandt V, Lindsay AJ, McCaffrey MW, Khan AR, Barnekow A.

PLoS One. 2019 Jan 14;14(1):e0208889. doi: 10.1371/journal.pone.0208889. eCollection 2019.

10.

Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization.

De Wit T, Baekelandt V, Lobbestael E.

Mol Neurobiol. 2018 Dec 27. doi: 10.1007/s12035-018-1449-2. [Epub ahead of print]

PMID:
30592011
11.

RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A.

Madero-Pérez J, Fernández B, Lara Ordóñez AJ, Fdez E, Lobbestael E, Baekelandt V, Hilfiker S.

Front Mol Neurosci. 2018 Nov 13;11:417. doi: 10.3389/fnmol.2018.00417. eCollection 2018.

12.

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.

De Schepper S, Verheijden S, Aguilera-Lizarraga J, Viola MF, Boesmans W, Stakenborg N, Voytyuk I, Schmidt I, Boeckx B, Dierckx de Casterlé I, Baekelandt V, Gonzalez Dominguez E, Mack M, Depoortere I, De Strooper B, Sprangers B, Himmelreich U, Soenen S, Guilliams M, Vanden Berghe P, Jones E, Lambrechts D, Boeckxstaens G.

Cell. 2018 Oct 4;175(2):400-415.e13. doi: 10.1016/j.cell.2018.07.048. Epub 2018 Aug 30. Erratum in: Cell. 2019 Jan 24;176(3):676.

PMID:
30173915
13.

Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease.

Gelders G, Baekelandt V, Van der Perren A.

J Immunol Res. 2018 Apr 16;2018:4784268. doi: 10.1155/2018/4784268. eCollection 2018. Review.

14.

ɑ-Synuclein strains and seeding in Parkinson's disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences.

Peelaerts W, Bousset L, Baekelandt V, Melki R.

Cell Tissue Res. 2018 Jul;373(1):195-212. doi: 10.1007/s00441-018-2839-5. Epub 2018 Apr 27. Review.

PMID:
29704213
15.

Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation.

Janssen B, Vugts DJ, Wilkinson SM, Ory D, Chalon S, Hoozemans JJM, Schuit RC, Beaino W, Kooijman EJM, van den Hoek J, Chishty M, Doméné A, Van der Perren A, Villa A, Maggi A, Molenaar GT, Funke U, Shevchenko RV, Baekelandt V, Bormans G, Lammertsma AA, Kassiou M, Windhorst AD.

Sci Rep. 2018 Apr 26;8(1):6580. doi: 10.1038/s41598-018-24814-0.

16.

Proximal and distal modulation of neural activity by spatially confined optogenetic activation with an integrated high-density optoelectrode.

Libbrecht S, Hoffman L, Welkenhuysen M, Van den Haute C, Baekelandt V, Braeken D, Haesler S.

J Neurophysiol. 2018 Jul 1;120(1):149-161. doi: 10.1152/jn.00888.2017. Epub 2018 Mar 28.

PMID:
29589813
17.

LRRK2 Phosphorylation: Behind the Scenes.

De Wit T, Baekelandt V, Lobbestael E.

Neuroscientist. 2018 Oct;24(5):486-500. doi: 10.1177/1073858418756309. Epub 2018 Jan 31. Review.

PMID:
29385885
18.

Transient and localized optogenetic activation of somatostatin-interneurons in mouse visual cortex abolishes long-term cortical plasticity due to vision loss.

Scheyltjens I, Vreysen S, Van den Haute C, Sabanov V, Balschun D, Baekelandt V, Arckens L.

Brain Struct Funct. 2018 Jun;223(5):2073-2095. doi: 10.1007/s00429-018-1611-7. Epub 2018 Jan 25.

19.

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.

Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, Taymans JM, Chartier-Harlin MC, Beilina A, Gonnelli A, Cookson MR, Greggio E, Hilfiker S.

Mol Neurodegener. 2018 Jan 23;13(1):3. doi: 10.1186/s13024-018-0235-y.

20.

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.

Civiero L, Cogo S, Kiekens A, Morganti C, Tessari I, Lobbestael E, Baekelandt V, Taymans JM, Chartier-Harlin MC, Franchin C, Arrigoni G, Lewis PA, Piccoli G, Bubacco L, Cookson MR, Pinton P, Greggio E.

Front Mol Neurosci. 2017 Dec 14;10:417. doi: 10.3389/fnmol.2017.00417. eCollection 2017.

21.

Altered mGluR5 binding potential and glutamine concentration in the 6-OHDA rat model of acute Parkinson's disease and levodopa-induced dyskinesia.

Crabbé M, Van der Perren A, Weerasekera A, Himmelreich U, Baekelandt V, Van Laere K, Casteels C.

Neurobiol Aging. 2018 Jan;61:82-92. doi: 10.1016/j.neurobiolaging.2017.09.006. Epub 2017 Sep 21.

PMID:
29055799
22.

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes.

Sejwal K, Chami M, Rémigy H, Vancraenenbroeck R, Sibran W, Sütterlin R, Baumgartner P, McLeod R, Chartier-Harlin MC, Baekelandt V, Stahlberg H, Taymans JM.

Sci Rep. 2017 Aug 17;7(1):8667. doi: 10.1038/s41598-017-09126-z.

23.

ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function.

Demirsoy S, Martin S, Motamedi S, van Veen S, Holemans T, Van den Haute C, Jordanova A, Baekelandt V, Vangheluwe P, Agostinis P.

Hum Mol Genet. 2017 May 1;26(9):1656-1669. doi: 10.1093/hmg/ddx070.

PMID:
28334751
24.

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation.

Lobbestael E, Civiero L, De Wit T, Taymans JM, Greggio E, Baekelandt V.

Sci Rep. 2016 Sep 23;6:33897. doi: 10.1038/srep33897.

25.

Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate.

Vazquez-Martin A, Van den Haute C, Cufí S, Corominas-Faja B, Cuyàs E, Lopez-Bonet E, Rodriguez-Gallego E, Fernández-Arroyo S, Joven J, Baekelandt V, Menendez JA.

Aging (Albany NY). 2016 Jul;8(7):1330-52. doi: 10.18632/aging.100976.

26.

Evaluation of WGA-Cre-dependent topological transgene expression in the rodent brain.

Libbrecht S, Van den Haute C, Malinouskaya L, Gijsbers R, Baekelandt V.

Brain Struct Funct. 2017 Mar;222(2):717-733. doi: 10.1007/s00429-016-1241-x. Epub 2016 Jun 3.

PMID:
27259586
27.

α-synuclein folds: the cards are on the table.

Peelaerts W, Baekelandt V.

Nat Struct Mol Biol. 2016 May 4;23(5):359-60. doi: 10.1038/nsmb.3209. No abstract available.

PMID:
27142318
28.

Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks.

Pulizzi R, Musumeci G, Van den Haute C, Van De Vijver S, Baekelandt V, Giugliano M.

Sci Rep. 2016 Apr 21;6:24701. doi: 10.1038/srep24701.

29.

Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2.

Martin S, van Veen S, Holemans T, Demirsoy S, van den Haute C, Baekelandt V, Agostinis P, Eggermont J, Vangheluwe P.

Parkinsons Dis. 2016;2016:9531917. doi: 10.1155/2016/9531917. Epub 2016 Mar 17.

30.

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector.

Van der Perren A, Casteels C, Van Laere K, Gijsbers R, Van den Haute C, Baekelandt V.

J Vis Exp. 2016 Feb 28;(108):53670. doi: 10.3791/53670.

31.

ɑ-Synuclein strains and the variable pathologies of synucleinopathies.

Peelaerts W, Baekelandt V.

J Neurochem. 2016 Oct;139 Suppl 1:256-274. doi: 10.1111/jnc.13595. Epub 2016 Mar 30. Review.

32.

Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex.

Gerits A, Vancraeyenest P, Vreysen S, Laramée ME, Michiels A, Gijsbers R, Van den Haute C, Moons L, Debyser Z, Baekelandt V, Arckens L, Vanduffel W.

Neurophotonics. 2015 Jul;2(3):031209. doi: 10.1117/1.NPh.2.3.031209. Epub 2015 Oct 1.

33.

An integrated multi-electrode-optrode array for in vitro optogenetics.

Welkenhuysen M, Hoffman L, Luo Z, De Proft A, Van den Haute C, Baekelandt V, Debyser Z, Gielen G, Puers R, Braeken D.

Sci Rep. 2016 Feb 2;6:20353. doi: 10.1038/srep20353.

34.

High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease.

Macchi F, Deleersnijder A, Van den Haute C, Munck S, Pottel H, Michiels A, Debyser Z, Gerard M, Baekelandt V.

J Neurosci Methods. 2016 Mar 1;261:117-27. doi: 10.1016/j.jneumeth.2015.11.009. Epub 2015 Nov 24.

PMID:
26620202
35.

Long-Term Fate Mapping Using Conditional Lentiviral Vectors Reveals a Continuous Contribution of Radial Glia-Like Cells to Adult Hippocampal Neurogenesis in Mice.

Aelvoet SA, Pascual-Brazo J, Libbrecht S, Reumers V, Gijsbers R, Van den Haute C, Baekelandt V.

PLoS One. 2015 Nov 23;10(11):e0143772. doi: 10.1371/journal.pone.0143772. eCollection 2015.

36.

Noninvasive Imaging Reveals Stable Transgene Expression in Mouse Airways After Delivery of a Nonintegrating Recombinant Adeno-Associated Viral Vector.

Vidović D, Gijsbers R, Quiles-Jimenez A, Dooley J, Van den Haute C, Van der Perren A, Liston A, Baekelandt V, Debyser Z, Carlon MS.

Hum Gene Ther. 2016 Jan;27(1):60-71. doi: 10.1089/hum.2015.109. Epub 2015 Dec 21. Erratum in: Hum Gene Ther. 2016 Nov;27(11):946.

PMID:
26567984
37.

Tackling Glaucoma from within the Brain: An Unfortunate Interplay of BDNF and TrkB.

Dekeyster E, Geeraerts E, Buyens T, Van den Haute C, Baekelandt V, De Groef L, Salinas-Navarro M, Moons L.

PLoS One. 2015 Nov 11;10(11):e0142067. doi: 10.1371/journal.pone.0142067. eCollection 2015.

38.

rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice.

Vidović D, Carlon MS, da Cunha MF, Dekkers JF, Hollenhorst MI, Bijvelds MJ, Ramalho AS, Van den Haute C, Ferrante M, Baekelandt V, Janssens HM, De Boeck K, Sermet-Gaudelus I, de Jonge HR, Gijsbers R, Beekman JM, Edelman A, Debyser Z.

Am J Respir Crit Care Med. 2016 Feb 1;193(3):288-98. doi: 10.1164/rccm.201505-0914OC.

PMID:
26509335
39.

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.

Civiero L, Cirnaru MD, Beilina A, Rodella U, Russo I, Belluzzi E, Lobbestael E, Reyniers L, Hondhamuni G, Lewis PA, Van den Haute C, Baekelandt V, Bandopadhyay R, Bubacco L, Piccoli G, Cookson MR, Taymans JM, Greggio E.

J Neurochem. 2015 Dec;135(6):1242-56. doi: 10.1111/jnc.13369. Epub 2015 Oct 19.

40.

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.

Bourdenx M, Dovero S, Engeln M, Bido S, Bastide MF, Dutheil N, Vollenweider I, Baud L, Piron C, Grouthier V, Boraud T, Porras G, Li Q, Baekelandt V, Scheller D, Michel A, Fernagut PO, Georges F, Courtine G, Bezard E, Dehay B.

Acta Neuropathol Commun. 2015 Jul 25;3:46. doi: 10.1186/s40478-015-0222-2.

41.

A lipid switch unlocks Parkinson's disease-associated ATP13A2.

Holemans T, Sørensen DM, van Veen S, Martin S, Hermans D, Kemmer GC, Van den Haute C, Baekelandt V, Günther Pomorski T, Agostinis P, Wuytack F, Palmgren M, Eggermont J, Vangheluwe P.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9040-5. doi: 10.1073/pnas.1508220112. Epub 2015 Jul 1.

42.

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.

Van Rompuy AS, Oliveras-Salvá M, Van der Perren A, Corti O, Van den Haute C, Baekelandt V.

Mol Neurodegener. 2015 Jun 23;10:23. doi: 10.1186/s13024-015-0017-8.

43.

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.

Peelaerts W, Bousset L, Van der Perren A, Moskalyuk A, Pulizzi R, Giugliano M, Van den Haute C, Melki R, Baekelandt V.

Nature. 2015 Jun 18;522(7556):340-4. doi: 10.1038/nature14547. Epub 2015 Jun 10.

PMID:
26061766
44.

Evaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex.

Scheyltjens I, Laramée ME, Van den Haute C, Gijsbers R, Debyser Z, Baekelandt V, Vreysen S, Arckens L.

J Comp Neurol. 2015 Oct 1;523(14):2019-42. doi: 10.1002/cne.23819. Epub 2015 Jun 19.

PMID:
26012540
45.

Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis.

Sierra A, Martín-Suárez S, Valcárcel-Martín R, Pascual-Brazo J, Aelvoet SA, Abiega O, Deudero JJ, Brewster AL, Bernales I, Anderson AE, Baekelandt V, Maletić-Savatić M, Encinas JM.

Cell Stem Cell. 2015 May 7;16(5):488-503. doi: 10.1016/j.stem.2015.04.003.

46.

Oncostatin M protects against demyelination by inducing a protective microglial phenotype.

Janssens K, Maheshwari A, Van den Haute C, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N.

Glia. 2015 Oct;63(10):1729-37. doi: 10.1002/glia.22840. Epub 2015 Apr 29.

PMID:
25921393
47.

Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein.

Bentea E, Van der Perren A, Van Liefferinge J, El Arfani A, Albertini G, Demuyser T, Merckx E, Michotte Y, Smolders I, Baekelandt V, Massie A.

Front Behav Neurosci. 2015 Mar 31;9:68. doi: 10.3389/fnbeh.2015.00068. eCollection 2015.

48.

Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.

Krumova P, Reyniers L, Meyer M, Lobbestael E, Stauffer D, Gerrits B, Muller L, Hoving S, Kaupmann K, Voshol J, Fabbro D, Bauer A, Rovelli G, Taymans JM, Bouwmeester T, Baekelandt V.

FASEB J. 2015 Jul;29(7):2980-92. doi: 10.1096/fj.14-262329. Epub 2015 Apr 8.

PMID:
25854701
49.

IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity.

Pereira L, Font-Nieves M, Van den Haute C, Baekelandt V, Planas AM, Pozas E.

Front Cell Neurosci. 2015 Feb 25;9:57. doi: 10.3389/fncel.2015.00057. eCollection 2015.

50.

FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease.

Van der Perren A, Macchi F, Toelen J, Carlon MS, Maris M, de Loor H, Kuypers DR, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V.

Neurobiol Aging. 2015 Mar;36(3):1559-68. doi: 10.1016/j.neurobiolaging.2015.01.014. Epub 2015 Jan 21.

PMID:
25660193

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