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Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity.

Jensen IJ, Sjaastad FV, Griffith TS, Badovinac VP.

J Immunol. 2018 Mar 1;200(5):1543-1553. doi: 10.4049/jimmunol.1701618. Review.


Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B/6 versus Outbred Swiss Mice.

Martin MD, Danahy DB, Hartwig SM, Harty JT, Badovinac VP.

Front Immunol. 2017 Nov 22;8:1527. doi: 10.3389/fimmu.2017.01527. eCollection 2017.


Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.

Danahy DB, Anthony SM, Jensen IJ, Hartwig SM, Shan Q, Xue HH, Harty JT, Griffith TS, Badovinac VP.

PLoS Pathog. 2017 Sep 14;13(9):e1006569. doi: 10.1371/journal.ppat.1006569. eCollection 2017 Sep.


Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection.

Gullicksrud JA, Li F, Xing S, Zeng Z, Peng W, Badovinac VP, Harty JT, Xue HH.

J Immunol. 2017 Aug 1;199(3):911-919. doi: 10.4049/jimmunol.1700595. Epub 2017 Jun 26.


Time and Antigen-Stimulation History Influence Memory CD8 T Cell Bystander Responses.

Martin MD, Shan Q, Xue HH, Badovinac VP.

Front Immunol. 2017 Jun 8;8:634. doi: 10.3389/fimmu.2017.00634. eCollection 2017.


The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.

Shan Q, Zeng Z, Xing S, Li F, Hartwig SM, Gullicksrud JA, Kurup SP, Van Braeckel-Budimir N, Su Y, Martin MD, Varga SM, Taniuchi I, Harty JT, Peng W, Badovinac VP, Xue HH.

Nat Immunol. 2017 Aug;18(8):931-939. doi: 10.1038/ni.3773. Epub 2017 Jun 12.


Antigen Exposure History Defines CD8 T Cell Dynamics and Protection during Localized Pulmonary Infections.

Van Braeckel-Budimir N, Martin MD, Hartwig SM, Legge KL, Badovinac VP, Harty JT.

Front Immunol. 2017 Jan 27;8:40. doi: 10.3389/fimmu.2017.00040. eCollection 2017.


Sifting through CD8+ T Cell Memory.

Martin MD, Badovinac VP.

Immunity. 2016 Dec 20;45(6):1184-1186. doi: 10.1016/j.immuni.2016.12.005.


CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections.

He B, Xing S, Chen C, Gao P, Teng L, Shan Q, Gullicksrud JA, Martin MD, Yu S, Harty JT, Badovinac VP, Tan K, Xue HH.

Immunity. 2016 Dec 20;45(6):1341-1354. doi: 10.1016/j.immuni.2016.11.009. Epub 2016 Dec 13.


Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo.

Strother RK, Danahy DB, Kotov DI, Kucaba TA, Zacharias ZR, Griffith TS, Legge KL, Badovinac VP.

J Immunol. 2016 Dec 1;197(11):4301-4311. Epub 2016 Oct 26.


Enteric immunity, the gut microbiome, and sepsis: Rethinking the germ theory of disease.

Cabrera-Perez J, Badovinac VP, Griffith TS.

Exp Biol Med (Maywood). 2017 Jan;242(2):127-139. doi: 10.1177/1535370216669610. Epub 2016 Oct 4. Review.


NLRC4 suppresses melanoma tumor progression independently of inflammasome activation.

Janowski AM, Colegio OR, Hornick EE, McNiff JM, Martin MD, Badovinac VP, Norian LA, Zhang W, Cassel SL, Sutterwala FS.

J Clin Invest. 2016 Oct 3;126(10):3917-3928. doi: 10.1172/JCI86953. Epub 2016 Sep 12.


Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity.

Danahy DB, Strother RK, Badovinac VP, Griffith TS.

Crit Rev Immunol. 2016;36(1):57-74. doi: 10.1615/CritRevImmunol.2016017098. Review.


Gut Microbial Membership Modulates CD4 T Cell Reconstitution and Function after Sepsis.

Cabrera-Perez J, Babcock JC, Dileepan T, Murphy KA, Kucaba TA, Badovinac VP, Griffith TS.

J Immunol. 2016 Sep 1;197(5):1692-8. doi: 10.4049/jimmunol.1600940. Epub 2016 Jul 22.


Phenotypic and Functional Alterations in Circulating Memory CD8 T Cells with Time after Primary Infection.

Martin MD, Kim MT, Shan Q, Sompallae R, Xue HH, Harty JT, Badovinac VP.

PLoS Pathog. 2015 Oct 20;11(10):e1005219. doi: 10.1371/journal.ppat.1005219. eCollection 2015 Oct.


The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses.

Khan SH, Martin MD, Starbeck-Miller GR, Xue HH, Harty JT, Badovinac VP.

PLoS Pathog. 2015 Oct 2;11(10):e1005199. doi: 10.1371/journal.ppat.1005199. eCollection 2015 Oct.


Enhancing Dendritic Cell-based Immunotherapy with IL-2/Monoclonal Antibody Complexes for Control of Established Tumors.

Kim MT, Richer MJ, Gross BP, Norian LA, Badovinac VP, Harty JT.

J Immunol. 2015 Nov 1;195(9):4537-44. doi: 10.4049/jimmunol.1501071. Epub 2015 Sep 25.


Polymicrobial Sepsis Increases Susceptibility to Chronic Viral Infection and Exacerbates CD8+ T Cell Exhaustion.

Condotta SA, Khan SH, Rai D, Griffith TS, Badovinac VP.

J Immunol. 2015 Jul 1;195(1):116-25. doi: 10.4049/jimmunol.1402473. Epub 2015 May 15.


Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses.

Khan SH, Badovinac VP.

Semin Immunopathol. 2015 May;37(3):301-10. doi: 10.1007/s00281-015-0477-5. Epub 2015 Apr 10. Review.


Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge.

Cabrera-Perez J, Condotta SA, James BR, Kashem SW, Brincks EL, Rai D, Kucaba TA, Badovinac VP, Griffith TS.

J Immunol. 2015 Feb 15;194(4):1609-20. doi: 10.4049/jimmunol.1401711. Epub 2015 Jan 16.


Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function.

Markwart R, Condotta SA, Requardt RP, Borken F, Schubert K, Weigel C, Bauer M, Griffith TS, Förster M, Brunkhorst FM, Badovinac VP, Rubio I.

PLoS One. 2014 Dec 26;9(12):e115094. doi: 10.1371/journal.pone.0115094. eCollection 2014.


Diet-induced obesity does not impact the generation and maintenance of primary memory CD8 T cells.

Khan SH, Hemann EA, Legge KL, Norian LA, Badovinac VP.

J Immunol. 2014 Dec 15;193(12):5873-82. doi: 10.4049/jimmunol.1401685. Epub 2014 Nov 5.


The longevity of memory CD8 T cell responses after repetitive antigen stimulations.

Rai D, Martin MD, Badovinac VP.

J Immunol. 2014 Jun 15;192(12):5652-9. doi: 10.4049/jimmunol.1301063. Epub 2014 May 14.


Influence of time and number of antigen encounters on memory CD8 T cell development.

Martin MD, Badovinac VP.

Immunol Res. 2014 Aug;59(1-3):35-44. doi: 10.1007/s12026-014-8522-3. Review.


Impact of sepsis on CD4 T cell immunity.

Cabrera-Perez J, Condotta SA, Badovinac VP, Griffith TS.

J Leukoc Biol. 2014 Nov;96(5):767-77. doi: 10.1189/jlb.5MR0114-067R. Epub 2014 May 2. Review.


Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.

Duong S, Condotta SA, Rai D, Martin MD, Griffith TS, Badovinac VP.

J Immunol. 2014 Apr 15;192(8):3618-25. doi: 10.4049/jimmunol.1303460. Epub 2014 Mar 19.


Cutting edge: Expression of FcγRIIB tempers memory CD8 T cell function in vivo.

Starbeck-Miller GR, Badovinac VP, Barber DL, Harty JT.

J Immunol. 2014 Jan 1;192(1):35-9. doi: 10.4049/jimmunol.1302232. Epub 2013 Nov 27.


T-cell-mediated immunity and the role of TRAIL in sepsis-induced immunosuppression.

Condotta SA, Cabrera-Perez J, Badovinac VP, Griffith TS.

Crit Rev Immunol. 2013;33(1):23-40. Review.


Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection.

Condotta SA, Rai D, James BR, Griffith TS, Badovinac VP.

J Immunol. 2013 Mar 1;190(5):1991-2000. doi: 10.4049/jimmunol.1202379. Epub 2013 Jan 25.


Epitope specificity of memory CD8+ T cells dictates vaccination-induced mortality in LCMV-infected perforin-deficient mice.

Pham NL, Badovinac VP, Harty JT.

Eur J Immunol. 2012 Jun;42(6):1488-99. doi: 10.1002/eji.201142263.


Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells.

Nolz JC, Rai D, Badovinac VP, Harty JT.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6199-204. doi: 10.1073/pnas.1118868109. Epub 2012 Apr 2.


Probing CD8 T cell responses with Listeria monocytogenes infection.

Condotta SA, Richer MJ, Badovinac VP, Harty JT.

Adv Immunol. 2012;113:51-80. doi: 10.1016/B978-0-12-394590-7.00005-1. Review.


Population dynamics of naive and memory CD8 T cell responses after antigen stimulations in vivo.

Martin MD, Condotta SA, Harty JT, Badovinac VP.

J Immunol. 2012 Feb 1;188(3):1255-65. doi: 10.4049/jimmunol.1101579. Epub 2011 Dec 28.


The impact of pre-existing memory on differentiation of newly recruited naive CD8 T cells.

Martin MD, Wirth TC, Lauer P, Harty JT, Badovinac VP.

J Immunol. 2011 Sep 15;187(6):2923-31. doi: 10.4049/jimmunol.1100698. Epub 2011 Aug 10.


Immune unresponsiveness to secondary heterologous bacterial infection after sepsis induction is TRAIL dependent.

Gurung P, Rai D, Condotta SA, Babcock JC, Badovinac VP, Griffith TS.

J Immunol. 2011 Sep 1;187(5):2148-54. doi: 10.4049/jimmunol.1101180. Epub 2011 Jul 25.


Secondary CD8+ T-cell responses are controlled by systemic inflammation.

Wirth TC, Martin MD, Starbeck-Miller G, Harty JT, Badovinac VP.

Eur J Immunol. 2011 May;41(5):1321-33. doi: 10.1002/eji.201040730. Epub 2011 Mar 21.


Differential role of "Signal 3" inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo.

Pham NL, Badovinac VP, Harty JT.

Front Immunol. 2011 Feb 11;2:4. doi: 10.3389/fimmu.2011.00004. eCollection 2011.


Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1.

Zhou X, Yu S, Zhao DM, Harty JT, Badovinac VP, Xue HH.

Immunity. 2010 Aug 27;33(2):229-40. doi: 10.1016/j.immuni.2010.08.002.


Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.

Schmidt NW, Butler NS, Badovinac VP, Harty JT.

PLoS Pathog. 2010 Jul 15;6(7):e1000998. doi: 10.1371/journal.ppat.1000998.


Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation.

Wirth TC, Xue HH, Rai D, Sabel JT, Bair T, Harty JT, Badovinac VP.

Immunity. 2010 Jul 23;33(1):128-40. doi: 10.1016/j.immuni.2010.06.014. Epub 2010 Jul 8.


Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly.

Pham NL, Pewe LL, Fleenor CJ, Langlois RA, Legge KL, Badovinac VP, Harty JT.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12198-203. doi: 10.1073/pnas.1004661107. Epub 2010 Jun 21.


Modulating numbers and phenotype of CD8+ T cells in secondary immune responses.

Wirth TC, Harty JT, Badovinac VP.

Eur J Immunol. 2010 Jul;40(7):1916-26. doi: 10.1002/eji.201040310.


Constitutive activation of Wnt signaling favors generation of memory CD8 T cells.

Zhao DM, Yu S, Zhou X, Haring JS, Held W, Badovinac VP, Harty JT, Xue HH.

J Immunol. 2010 Feb 1;184(3):1191-9. doi: 10.4049/jimmunol.0901199. Epub 2009 Dec 21.


Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts.

Rai D, Pham NL, Harty JT, Badovinac VP.

J Immunol. 2009 Dec 15;183(12):7672-81. doi: 10.4049/jimmunol.0902874.


Predicting CD62L expression during the CD8+ T-cell response in vivo.

Schlub TE, Badovinac VP, Sabel JT, Harty JT, Davenport MP.

Immunol Cell Biol. 2010 Feb;88(2):157-64. doi: 10.1038/icb.2009.80. Epub 2009 Oct 27.


Differentiation of central memory CD8 T cells is independent of CD62L-mediated trafficking to lymph nodes.

Wirth TC, Badovinac VP, Zhao L, Dailey MO, Harty JT.

J Immunol. 2009 May 15;182(10):6195-206. doi: 10.4049/jimmunol.0803315.


High initial frequency of TCR-transgenic CD8 T cells alters inflammation and pathogen clearance without affecting memory T cell function.

Wirth TC, Pham NL, Harty JT, Badovinac VP.

Mol Immunol. 2009 Nov;47(1):71-8. doi: 10.1016/j.molimm.2008.12.018. Epub 2009 Feb 5.


Adaptable TCR avidity thresholds for negative selection.

Stojakovic M, Salazar-Fontana LI, Tatari-Calderone Z, Badovinac VP, Santori FR, Kovalovsky D, Sant'Angelo D, Harty JT, Vukmanovic S.

J Immunol. 2008 Nov 15;181(10):6770-8.

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