Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 32

1.

Long-term exposure to PFE-360 in the AAV-α-synuclein rat model: findings and implications.

Andersen MA, Sotty F, Jensen PH, Badolo L, Jeggo R, Smith GP, Christensen KV.

eNeuro. 2019 Nov 4. pii: ENEURO.0453-18.2019. doi: 10.1523/ENEURO.0453-18.2019. [Epub ahead of print]

2.

Flexible 3D Cell-Based Platforms for the Discovery and Profiling of Novel Drugs Targeting Plasmodium Hepatic Infection.

Arez F, Rebelo SP, Fontinha D, Simão D, Martins TR, Machado M, Fischli C, Oeuvray C, Badolo L, Carrondo MJT, Rottmann M, Spangenberg T, Brito C, Greco B, Prudêncio M, Alves PM.

ACS Infect Dis. 2019 Nov 8;5(11):1831-1842. doi: 10.1021/acsinfecdis.9b00144. Epub 2019 Sep 13.

PMID:
31479238
3.

Improved Prediction of in Vivo Supersaturation and Precipitation of Poorly Soluble Weakly Basic Drugs Using a Biorelevant Bicarbonate Buffer in a Gastrointestinal Transfer Model.

Jede C, Wagner C, Kubas H, Weigandt M, Weber C, Lecomte M, Badolo L, Koziolek M, Weitschies W.

Mol Pharm. 2019 Sep 3;16(9):3938-3947. doi: 10.1021/acs.molpharmaceut.9b00534. Epub 2019 Aug 7.

PMID:
31335153
4.

Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery.

Petersson C, Papasouliotis O, Lecomte M, Badolo L, Dolgos H.

Xenobiotica. 2019 Jun 19:1-10. doi: 10.1080/00498254.2019.1625084. [Epub ahead of print]

PMID:
31215316
5.

Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation.

Andersen MA, Christensen KV, Badolo L, Smith GP, Jeggo R, Jensen PH, Andersen KJ, Sotty F.

Neurobiol Dis. 2018 Aug;116:13-27. doi: 10.1016/j.nbd.2018.04.011. Epub 2018 Apr 20.

PMID:
29680709
6.

PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats.

Andersen MA, Wegener KM, Larsen S, Badolo L, Smith GP, Jeggo R, Jensen PH, Sotty F, Christensen KV, Thougaard A.

Toxicology. 2018 Feb 15;395:15-22. doi: 10.1016/j.tox.2018.01.003. Epub 2018 Jan 4.

7.

The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors.

Smith GP, Badolo L, Chell V, Chen IJ, Christensen KV, David L, Daechsel JA, Hentzer M, Herzig MC, Mikkelsen GK, Watson SP, Williamson DS.

Bioorg Med Chem Lett. 2017 Sep 15;27(18):4500-4505. doi: 10.1016/j.bmcl.2017.07.072. Epub 2017 Aug 1.

PMID:
28802631
8.

A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo.

Frederiksen K, Lu D, Yang J, Jensen HS, Bastlund JF, Larsen PH, Liu H, Crestey F, Dekermendjian K, Badolo L, Laursen M, Hougaard C, Yang C, Svenstrup N, Grunnet M.

Eur J Neurosci. 2017 Aug;46(3):1887-1896. doi: 10.1111/ejn.13626. Epub 2017 Jul 20.

PMID:
28635024
9.

Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain.

Thirstrup K, Sotty F, Montezinho LC, Badolo L, Thougaard A, Kristjánsson M, Jensen T, Watson S, Nielsen SM.

Pharmacol Res. 2016 Feb;104:197-205. doi: 10.1016/j.phrs.2015.12.028. Epub 2015 Dec 29.

PMID:
26731018
10.

An invertebrate model for CNS drug discovery: Transcriptomic and functional analysis of a mammalian P-glycoprotein ortholog.

Al-Qadi S, Schiøtt M, Hansen SH, Nielsen PA, Badolo L.

Biochim Biophys Acta. 2015 Dec;1850(12):2439-51. doi: 10.1016/j.bbagen.2015.09.002. Epub 2015 Sep 10.

PMID:
26363463
11.

Characterization of midazolam metabolism in locusts: the role of a CYP3A4-like enzyme in the formation of 1'-OH and 4-OH midazolam.

Olsen LR, Gabel-Jensen C, Wubshet SG, Kongstad KT, Janfelt C, Badolo L, Hansen SH.

Xenobiotica. 2016;46(2):99-107. doi: 10.3109/00498254.2015.1051604. Epub 2015 Jul 24.

PMID:
26207435
12.

Evaluation of 309 molecules as inducers of CYP3A4, CYP2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture.

Badolo L, Jensen B, Säll C, Norinder U, Kallunki P, Montanari D.

Xenobiotica. 2015 Feb;45(2):177-87. doi: 10.3109/00498254.2014.955831. Epub 2014 Sep 3.

PMID:
25183402
13.

An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1.

Helms HC, Hersom M, Kuhlmann LB, Badolo L, Nielsen CU, Brodin B.

AAPS J. 2014 Sep;16(5):1046-55. doi: 10.1208/s12248-014-9628-1. Epub 2014 Jun 17.

14.

Identification of a functional homolog of the mammalian CYP3A4 in locusts.

Olsen LR, Gabel-Jensen C, Nielsen PA, Hansen SH, Badolo L.

Drug Metab Dispos. 2014 Jul;42(7):1153-62. doi: 10.1124/dmd.114.057430. Epub 2014 Apr 28.

PMID:
24778367
15.

The grasshopper: a novel model for assessing vertebrate brain uptake.

Andersson O, Hansen SH, Hellman K, Olsen LR, Andersson G, Badolo L, Svenstrup N, Nielsen PA.

J Pharmacol Exp Ther. 2013 Aug;346(2):211-8. doi: 10.1124/jpet.113.205476. Epub 2013 May 13.

PMID:
23671124
16.

The role of hepatic transport and metabolism in the interactions between pravastatin or repaglinide and two rOatp inhibitors in rats.

Badolo L, Bundgaard C, Garmer M, Jensen B.

Eur J Pharm Sci. 2013 Jul 16;49(4):767-72. doi: 10.1016/j.ejps.2013.04.030. Epub 2013 May 3.

PMID:
23648783
17.

RO4938581, a GABAAα5 modulator, displays strong CYP1A2 autoinduction properties in rats.

Bundgaard C, Badolo L, Redrobe JP.

Biochem Pharmacol. 2013 May 1;85(9):1363-9. doi: 10.1016/j.bcp.2013.02.004. Epub 2013 Feb 13.

PMID:
23415905
18.

Radiolabelling and PET brain imaging of the α₁-adrenoceptor antagonist Lu AE43936.

Risgaard R, Ettrup A, Balle T, Dyssegaard A, Hansen HD, Lehel S, Madsen J, Pedersen H, Püschl A, Badolo L, Bang-Andersen B, Knudsen GM, Kristensen JL.

Nucl Med Biol. 2013 Jan;40(1):135-40. doi: 10.1016/j.nucmedbio.2012.09.010. Epub 2012 Nov 17.

PMID:
23165140
19.

Does brain slices from pentylenetetrazole-kindled mice provide a more predictive screening model for antiepileptic drugs?

Hansen SL, Sterjev Z, Werngreen M, Simonsen BJ, Knudsen KE, Nielsen AH, Pedersen ME, Badolo L, Kristiansen U, Vestergaard HT.

Eur J Pharmacol. 2012 May 5;682(1-3):43-9. doi: 10.1016/j.ejphar.2012.01.044. Epub 2012 Feb 15.

PMID:
22366211
20.

Time-course activities of Oct1, Mrp3, and cytochrome P450s in cultures of cryopreserved rat hepatocytes.

Jacobsen JK, Jensen B, Skonberg C, Hansen SH, Badolo L.

Eur J Pharm Sci. 2011 Oct 9;44(3):427-36. doi: 10.1016/j.ejps.2011.09.001. Epub 2011 Sep 8.

PMID:
21925601
21.

Cognitive enhancing effects of an AMPA receptor positive modulator on place learning in mice.

Malá H, Chen Y, Worm VH, Kure J, Kaae BH, Madsen U, Badolo L, Pickering DS, Mogensen J.

Behav Brain Res. 2012 Jan 1;226(1):18-25. doi: 10.1016/j.bbr.2011.08.036. Epub 2011 Sep 1.

PMID:
21906629
22.

Effect of cryopreservation on the activity of OATP1B1/3 and OCT1 in isolated human hepatocytes.

Badolo L, Trancart MM, Gustavsson L, Chesné C.

Chem Biol Interact. 2011 Apr 25;190(2-3):165-70. doi: 10.1016/j.cbi.2011.02.025. Epub 2011 Feb 26.

PMID:
21356203
23.

Screening of OATP1B1/3 and OCT1 inhibitors in cryopreserved hepatocytes in suspension.

Badolo L, Rasmussen LM, Hansen HR, Sveigaard C.

Eur J Pharm Sci. 2010 Jul 11;40(4):282-8. doi: 10.1016/j.ejps.2010.03.023. Epub 2010 Apr 8.

PMID:
20381614
24.

Simple and rapid enzymatic assay of ornithine decarboxylase activity.

Badolo L, Berlaimont V, Helson-Cambier M, Hanocq M, Dubois J.

Talanta. 1999 Jan;48(1):127-34.

PMID:
18967451
25.

Development of an in vitro assay for the investigation of metabolism-induced drug hepatotoxicity.

Otto M, Hansen SH, Dalgaard L, Dubois J, Badolo L.

Cell Biol Toxicol. 2008 Jan;24(1):87-99. Epub 2007 Jun 5.

PMID:
17549590
26.

Evidence of Oatp and Mdr1 in cryopreserved rat hepatocytes.

Jørgensen L, Van Beek J, Lund S, Schousboe A, Badolo L.

Eur J Pharm Sci. 2007 Feb;30(2):181-9. Epub 2006 Nov 15.

PMID:
17174077
27.

New alpha(1)-adrenoceptor antagonists derived from the antipsychotic sertindole - carbon-11 labelling and pet examination of brain uptake in the cynomolgus monkey.

Balle T, Halldin C, Andersen L, Hjorth Alifrangis L, Badolo L, Gjervig Jensen K, Chou YW, Andersen K, Perregaard J, Farde L.

Nucl Med Biol. 2004 Apr;31(3):327-36.

PMID:
15028245
28.

Effect of the polyamine oxidase inactivator MDL 72527 on N(1)-(n-octanesulfonyl)spermine toxicity.

Seiler N, Badolo L, Duranton B, Vincent F, Schneider Y, Gossé F, Raul F.

Int J Biochem Cell Biol. 2000 Oct;32(10):1055-68.

PMID:
11091138
29.

Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells.

Schneider Y, Vincent F, Duranton B, Badolo L, Gossé F, Bergmann C, Seiler N, Raul F.

Cancer Lett. 2000 Sep 29;158(1):85-91.

PMID:
10940513
30.
31.

Inhibition of ornithine decarboxylase by ifenprodil.

Badolo L, Dubois J, Helson-Cambier M, Hanocq M.

Eur J Pharmacol. 1998 Jan 26;342(2-3):R1-R2.

PMID:
9548411
32.

Synthesis and cytotoxicity studies of new analogues of polyamines.

Badolo L, Gelbcke M, Dubois J, Hanocq M.

Pharmazie. 1998 Jan;53(1):15-9.

PMID:
9476255

Supplemental Content

Loading ...
Support Center