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Items: 19


Molecular strategy for blocking isopeptide bond formation in nascent pilin proteins.

Rivas-Pardo JA, Badilla CL, Tapia-Rojo R, Alonso-Caballero Á, Fernández JM.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9222-9227. doi: 10.1073/pnas.1807689115. Epub 2018 Aug 27.


Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity.

Giganti D, Yan K, Badilla CL, Fernandez JM, Alegre-Cebollada J.

Nat Commun. 2018 Jan 12;9(1):185. doi: 10.1038/s41467-017-02528-7.


A HaloTag Anchored Ruler for Week-Long Studies of Protein Dynamics.

Popa I, Rivas-Pardo JA, Eckels EC, Echelman DJ, Badilla CL, Valle-Orero J, Fernández JM.

J Am Chem Soc. 2016 Aug 24;138(33):10546-53. doi: 10.1021/jacs.6b05429. Epub 2016 Aug 9.


CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks.

Echelman DJ, Alegre-Cebollada J, Badilla CL, Chang C, Ton-That H, Fernández JM.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2490-5. doi: 10.1073/pnas.1522946113. Epub 2016 Feb 16.


Single-molecule Force Spectroscopy Predicts a Misfolded, Domain-swapped Conformation in human γD-Crystallin Protein.

Garcia-Manyes S, Giganti D, Badilla CL, Lezamiz A, Perales-Calvo J, Beedle AE, Fernández JM.

J Biol Chem. 2016 Feb 19;291(8):4226-35. doi: 10.1074/jbc.M115.673871. Epub 2015 Dec 24.


Probing the effect of force on HIV-1 receptor CD4.

Perez-Jimenez R, Alonso-Caballero A, Berkovich R, Franco D, Chen MW, Richard P, Badilla CL, Fernandez JM.

ACS Nano. 2014 Oct 28;8(10):10313-20. doi: 10.1021/nn503557w. Epub 2014 Oct 14.


Altered thiol chemistry in human amyotrophic lateral sclerosis-linked mutants of superoxide dismutase 1.

Solsona C, Kahn TB, Badilla CL, Álvarez-Zaldiernas C, Blasi J, Fernandez JM, Alegre-Cebollada J.

J Biol Chem. 2014 Sep 26;289(39):26722-32. doi: 10.1074/jbc.M114.565333. Epub 2014 Aug 4.


Nanomechanics of HaloTag tethers.

Popa I, Berkovich R, Alegre-Cebollada J, Badilla CL, Rivas-Pardo JA, Taniguchi Y, Kawakami M, Fernandez JM.

J Am Chem Soc. 2013 Aug 28;135(34):12762-71. doi: 10.1021/ja4056382. Epub 2013 Aug 19.


Protein folding drives disulfide formation.

Kosuri P, Alegre-Cebollada J, Feng J, Kaplan A, Inglés-Prieto A, Badilla CL, Stockwell BR, Sanchez-Ruiz JM, Holmgren A, Fernández JM.

Cell. 2012 Nov 9;151(4):794-806. doi: 10.1016/j.cell.2012.09.036.


Spontaneous dimerization of titin protein Z1Z2 domains induces strong nanomechanical anchoring.

Garcia-Manyes S, Badilla CL, Alegre-Cebollada J, Javadi Y, Fernández JM.

J Biol Chem. 2012 Jun 8;287(24):20240-7. doi: 10.1074/jbc.M112.355883. Epub 2012 Apr 21.


Isopeptide bonds block the mechanical extension of pili in pathogenic Streptococcus pyogenes.

Alegre-Cebollada J, Badilla CL, Fernández JM.

J Biol Chem. 2010 Apr 9;285(15):11235-42. doi: 10.1074/jbc.M110.102962. Epub 2010 Feb 5.


Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence.

Grützner A, Garcia-Manyes S, Kötter S, Badilla CL, Fernandez JM, Linke WA.

Biophys J. 2009 Aug 5;97(3):825-34. doi: 10.1016/j.bpj.2009.05.037.


Single homopolypeptide chains collapse into mechanically rigid conformations.

Dougan L, Li J, Badilla CL, Berne BJ, Fernandez JM.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12605-10. doi: 10.1073/pnas.0900678106. Epub 2009 Jun 19.


Direct observation of an ensemble of stable collapsed states in the mechanical folding of ubiquitin.

Garcia-Manyes S, Dougan L, Badilla CL, Brujic J, Fernández JM.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10534-9. doi: 10.1073/pnas.0901213106. Epub 2009 Jun 16.


Mechanical characterization of protein L in the low-force regime by electromagnetic tweezers/evanescent nanometry.

Liu R, Garcia-Manyes S, Sarkar A, Badilla CL, Fernández JM.

Biophys J. 2009 May 6;96(9):3810-21. doi: 10.1016/j.bpj.2009.01.043.


Force-clamp spectroscopy of single-protein monomers reveals the individual unfolding and folding pathways of I27 and ubiquitin.

Garcia-Manyes S, Brujić J, Badilla CL, Fernández JM.

Biophys J. 2007 Oct 1;93(7):2436-46. Epub 2007 Jun 1.


Signatures of hydrophobic collapse in extended proteins captured with force spectroscopy.

Walther KA, Gräter F, Dougan L, Badilla CL, Berne BJ, Fernandez JM.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7916-21. Epub 2007 Apr 30.


Ligand binding modulates the mechanical stability of dihydrofolate reductase.

Ainavarapu SR, Li L, Badilla CL, Fernandez JM.

Biophys J. 2005 Nov;89(5):3337-44. Epub 2005 Aug 12.


Mechanical unfolding intermediates observed by single-molecule force spectroscopy in a fibronectin type III module.

Li L, Huang HH, Badilla CL, Fernandez JM.

J Mol Biol. 2005 Jan 28;345(4):817-26.


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