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Proteasome Inhibition in Multiple Myeloma: Head-to-Head Comparison of Currently Available Proteasome Inhibitors.

Besse A, Besse L, Kraus M, Mendez-Lopez M, Bader J, Xin BT, de Bruin G, Maurits E, Overkleeft HS, Driessen C.

Cell Chem Biol. 2018 Nov 26. pii: S2451-9456(18)30429-X. doi: 10.1016/j.chembiol.2018.11.007. [Epub ahead of print]


Time for Precision: A World Without Susceptibility Breakpoints.

Bader JC, Lakota EA, Andes DR, Rubino CM, Ambrose PG, Bhavnani SM.

Open Forum Infect Dis. 2018 Oct 31;5(12):ofy282. doi: 10.1093/ofid/ofy282. eCollection 2018 Dec.


Clodronate-Liposome treatment results in neutrophilia, anemia, and is not effective in limiting obesity-linked metabolic impairments.

Bader JE, Enos RT, Velazquez KT, Carson MS, Sougiannis A, McGuinness OP, Robinson CM, Murphy EA.

Am J Physiol Endocrinol Metab. 2018 Dec 21. doi: 10.1152/ajpendo.00438.2018. [Epub ahead of print]


Pharmacokinetic/Pharmacodynamic Evaluation of a Novel Aminomethylcycline Antibiotic, KBP-7072, in the Neutropenic Murine Pneumonia Model against S. aureus and S. pneumoniae.

Lepak AJ, Zhao M, Liu Q, Wang P, Wang Y, Bader JC, Ambrose PG, Andes DR.

Antimicrob Agents Chemother. 2018 Dec 17. pii: AAC.02404-18. doi: 10.1128/AAC.02404-18. [Epub ahead of print]


Genome analysis of Mycobacterium avium subspecies hominissuis strain 109.

Matern WM, Bader JS, Karakousis PC.

Sci Data. 2018 Dec 4;5:180277. doi: 10.1038/sdata.2018.277.


Traumatic Divergent Elbow Dislocation with Associated Forearm Amputation in an Adult: A Case Report.

Greene RM, Bader JE, Mauter L, Sears BW, Tirre CJ, Hatzidakis AM.

JBJS Case Connect. 2018 Oct-Dec;8(4):e92-5. doi: 10.2106/JBJS.CC.17.00252.


Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity.

Hartmann H, Hornburg D, Czuppa M, Bader J, Michaelsen M, Farny D, Arzberger T, Mann M, Meissner F, Edbauer D.

Life Sci Alliance. 2018 May 16;1(2):e201800070. doi: 10.26508/lsa.201800070. eCollection 2018 May.


Effects of high fat diet-induced obesity on mammary tumorigenesis in the PyMT/MMTV murine model.

Cranford TL, Velázquez KT, Enos RT, Sougiannis AT, Bader JE, Carson MS, Bellone RR, Chatzistamou I, Nagarkatti M, Murphy EA.

Cancer Biol Ther. 2018 Nov 2:1-10. doi: 10.1080/15384047.2018.1537574. [Epub ahead of print]


Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD+ Synthesis.

Palzer L, Bader JJ, Angel F, Witzel M, Blaser S, McNeil A, Wandersee MK, Leu NA, Lengner CJ, Cho CE, Welch KD, Kirkland JB, Meyer RG, Meyer-Ficca ML.

Cell Rep. 2018 Oct 30;25(5):1359-1370.e4. doi: 10.1016/j.celrep.2018.09.091.


Femoral Hernias: Analysis of Preoperative Risk Factors and 30-Day Outcomes of Initial Groin Hernias Using ACS-NSQIP.

Halgas B, Viera J, Dilday J, Bader J, Holt D.

Am Surg. 2018 Sep 1;84(9):1455-1461.


Guidance, Training and Exercises for Responding to an Improvised Nuclear Device: First Receivers, Public Health.

Case C Jr, Coleman CN, Bader JL, Hick J, Hanfling D.

Health Phys. 2018 Feb;114(2):165-172. doi: 10.1097/HP.0000000000000759.


Predictors of Acute Complications Following Traumatic Upper Extremity Amputation.

Fisher TF, Kusnezov NA, Bader JA, Blair JA.

J Surg Orthop Adv. Summer 2018;27(2):113-118.


PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF, Kerr KF, Krijthe BP, Lyytikäinen LP, Müller C, Müller-Nurasyid M, Nolte IM, Padmanabhan S, Ritchie MD, Robino A, Smith AV, Steri M, Tanaka T, Teumer A, Trompet S, Ulivi S, Verweij N, Yin X, Arnar DO, Asselbergs FW, Bader JS, Barnard J, Bis J, Blankenberg S, Boerwinkle E, Bradford Y, Buckley BM, Chung MK, Crawford D, den Hoed M, Denny JC, Dominiczak AF, Ehret GB, Eijgelsheim M, Ellinor PT, Felix SB, Franco OH, Franke L, Harris TB, Holm H, Ilaria G, Iorio A, Kähönen M, Kolcic I, Kors JA, Lakatta EG, Launer LJ, Lin H, Lin HJ, Loos RJF, Lubitz SA, Macfarlane PW, Magnani JW, Leach IM, Meitinger T, Mitchell BD, Munzel T, Papanicolaou GJ, Peters A, Pfeufer A, Pramstaller PP, Raitakari OT, Rotter JI, Rudan I, Samani NJ, Schlessinger D, Silva Aldana CT, Sinner MF, Smith JD, Snieder H, Soliman EZ, Spector TD, Stott DJ, Strauch K, Tarasov KV, Thorsteinsdottir U, Uitterlinden AG, Van Wagoner DR, Völker U, Völzke H, Waldenberger M, Jan Westra H, Wild PS, Zeller T, Alonso A, Avery CL, Bandinelli S, Benjamin EJ, Cucca F, Dörr M, Ferrucci L, Gasparini P, Gudnason V, Hayward C, Heckbert SR, Hicks AA, Jukema JW, Kääb S, Lehtimäki T, Liu Y, Munroe PB, Parsa A, Polasek O, Psaty BM, Roden DM, Schnabel RB, Sinagra G, Stefansson K, Stricker BH, van der Harst P, van Duijn CM, Wilson JF, Gharib SA, de Bakker PIW, Isaacs A, Arking DE, Sotoodehnia N.

Nat Commun. 2018 Jul 25;9(1):2904. doi: 10.1038/s41467-018-04766-9.


Evaluation of a tiered in vitro testing strategy for assessing the ocular and dermal irritation/corrosion potential of pharmaceutical compounds for worker safety.

Graham JC, Wilt N, Costin GE, Villano C, Bader J, Krawiec L, Sly E, Gould J.

Cutan Ocul Toxicol. 2018 Dec;37(4):380-390. doi: 10.1080/15569527.2018.1483944. Epub 2018 Jul 23.


Proposed "Exposure And Symptom Triage" (EAST) Tool to Assess Radiation Exposure After a Nuclear Detonation.

Hick JL, Bader JL, Coleman CN, Ansari AJ, Chang A, Salame-Alfie A, Hanfling D, Koerner JF.

Disaster Med Public Health Prep. 2018 Jun;12(3):386-395. doi: 10.1017/dmp.2017.86. Epub 2017 Jul 31.


Nanobody-Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses.

Woodham AW, Cheloha RW, Ling J, Rashidian M, Kolifrath SC, Mesyngier M, Duarte JN, Bader JM, Skeate JG, Da Silva DM, Kast WM, Ploegh HL.

Cancer Immunol Res. 2018 Jul;6(7):870-880. doi: 10.1158/2326-6066.CIR-17-0661. Epub 2018 May 23.


Heterozygous diploid and interspecies SCRaMbLEing.

Shen MJ, Wu Y, Yang K, Li Y, Xu H, Zhang H, Li BZ, Li X, Xiao WH, Zhou X, Mitchell LA, Bader JS, Yuan Y, Boeke JD.

Nat Commun. 2018 May 22;9(1):1934. doi: 10.1038/s41467-018-04157-0.


Determination of Proper Timing for the Placement of Intra-Abdominal Mesh after Incidental Enterotomy in a Rodent Model (Rattus norvegicus).

Muir KB, Smoot CP, Viera JL, Sirkin MR, Yoon B, Bader J, Smiley R, Holt D, Hofmann LJ.

Am Surg. 2018 Apr 1;84(4):593-598.


Gene Enrichment Analysis Reveals Major Regulators of Mycobacterium tuberculosis Gene Expression in Two Models of Antibiotic Tolerance.

Matern WM, Rifat D, Bader JS, Karakousis PC.

Front Microbiol. 2018 Apr 4;9:610. doi: 10.3389/fmicb.2018.00610. eCollection 2018.


A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors.

Venkataraman A, Yang K, Irizarry J, Mackiewicz M, Mita P, Kuang Z, Xue L, Ghosh D, Liu S, Ramos P, Hu S, Bayron Kain D, Keegan S, Saul R, Colantonio S, Zhang H, Behn FP, Song G, Albino E, Asencio L, Ramos L, Lugo L, Morell G, Rivera J, Ruiz K, Almodovar R, Nazario L, Murphy K, Vargas I, Rivera-Pacheco ZA, Rosa C, Vargas M, McDade J, Clark BS, Yoo S, Khambadkone SG, de Melo J, Stevanovic M, Jiang L, Li Y, Yap WY, Jones B, Tandon A, Campbell E, Montelione GT, Anderson S, Myers RM, Boeke JD, Fenyö D, Whiteley G, Bader JS, Pino I, Eichinger DJ, Zhu H, Blackshaw S.

Nat Methods. 2018 May;15(5):330-338. doi: 10.1038/nmeth.4632. Epub 2018 Mar 19.



Bader J, Havens SJ.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-.
2018 Dec 13.


Overcoming the Resistance Hurdle: Pharmacokinetic-Pharmacodynamic Target Attainment Analyses for Rezafungin (CD101) against Candida albicans and Candida glabrata.

Bader JC, Lakota EA, Flanagan S, Ong V, Sandison T, Rubino CM, Bhavnani SM, Ambrose PG.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02614-17. doi: 10.1128/AAC.02614-17. Print 2018 Jun.


Exploration of spatial patterns of congenital anomalies in Los Angeles County using the vital statistics birth master file.

Rible R, Aguilar E, Chen A, Bader JL, Goodyear-Moya L, Singh KT, Paulson SE, Friedman J, Izadpanah N, Pregler J.

Environ Monit Assess. 2018 Mar 2;190(4):184. doi: 10.1007/s10661-018-6539-0.


Activation of Acetonitrile with (C2 F5 )3 PF2 and Amines.

Bader J, Neumann B, Stammler HG, Ignat'ev N, Hoge B.

Chemistry. 2018 May 11;24(27):6975-6982. doi: 10.1002/chem.201800682. Epub 2018 Mar 22.


Influence of 2 caries-detecting devices on clinical decision making and lesion depth for suspicious occlusal lesions: A randomized trial from The National Dental Practice-Based Research Network.

Makhija SK, Bader JD, Shugars DA, Litaker MS, Nagarkar S, Gordan VV, Rindal DB, Pihlstrom DJ, Mungia R, Meyerowitz C, Gilbert GH; National Dental Practice-Based Research Network (PBRN) Collaborative Group.

J Am Dent Assoc. 2018 Apr;149(4):299-307.e1. doi: 10.1016/j.adaj.2017.11.001. Epub 2018 Feb 21.


Correction to: PK-PD Compass: bringing infectious diseases pharmacometrics to the patient's bedside.

Bulik CC, Bader JC, Zhang L, Van Wart SA, Rubino CM, Bhavnani SM, Sweeney KL, Ambrose PG.

J Pharmacokinet Pharmacodyn. 2018 Apr;45(2):351. doi: 10.1007/s10928-018-9572-2.


Phenotypic co-receptor tropism and Maraviroc sensitivity in HIV-1 subtype C from East Africa.

Siddik AB, Haas A, Rahman MS, Aralaguppe SG, Amogne W, Bader J, Klimkait T, Neogi U.

Sci Rep. 2018 Feb 5;8(1):2363. doi: 10.1038/s41598-018-20814-2.


Norepinephrine in Combination with Antibiotic Therapy Increases both the Bacterial Replication Rate and Bactericidal Activity.

Ambrose PG, VanScoy BD, Adams J, Fikes S, Bader JC, Bhavnani SM, Rubino CM.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02257-17. doi: 10.1128/AAC.02257-17. Print 2018 Apr.


In Vivo Pharmacokinetics and Pharmacodynamics of APX001 against Candida spp. in a Neutropenic Disseminated Candidiasis Mouse Model.

Zhao M, Lepak AJ, VanScoy B, Bader JC, Marchillo K, Vanhecker J, Ambrose PG, Andes DR.

Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02542-17. doi: 10.1128/AAC.02542-17. Print 2018 Apr.


Comparing clinician use of three ankle fracture classifications.

Cordova CB, Dunn JC, Kusnezov N, Bader JM, Waterman BR, Orr JD.

JAAPA. 2018 Feb;31(2):36-39. doi: 10.1097/01.JAA.0000529773.90897.9f.


We can do better: a fresh look at echinocandin dosing.

Bader JC, Bhavnani SM, Andes DR, Ambrose PG.

J Antimicrob Chemother. 2018 Jan 11. doi: 10.1093/jac/dky013. [Epub ahead of print] No abstract available.


Muscle activity during maximal isometric forearm rotation using a power grip.

Bader J, Boland MR, Greybe D, Nitz A, Uhl T, Pienkowski D.

J Biomech. 2018 Feb 8;68:24-32. doi: 10.1016/j.jbiomech.2017.12.011. Epub 2017 Dec 15.


We can do better: a fresh look at echinocandin dosing.

Bader JC, Bhavnani SM, Andes DR, Ambrose PG.

J Antimicrob Chemother. 2018 Jan 1;73(suppl_1):i44-i50. doi: 10.1093/jac/dkx448.


Predictors of Persistent Pain After Fixation of Distal Clavicle Fractures in an Active Military Population.

Lanier PJ, Speirs J, Koehler L, Bader J, Abdelgawad A, Waterman BR.

Orthopedics. 2018 Jan 1;41(1):e117-e126. doi: 10.3928/01477447-20171127-02. Epub 2017 Dec 1.


Occupational outcomes following combat-related gunshot injury: Cohort study.

Laughlin MD, Belmont PJ Jr, Lanier PJ, Bader JO, Waterman BR, Schoenfeld AJ.

Int J Surg. 2017 Dec;48:286-290. doi: 10.1016/j.ijsu.2017.11.037. Epub 2017 Nov 27.


Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus (HIV)-protease inhibitors lopinavir or nelfinavir.

Abt D, Besse A, Sedlarikova L, Kraus M, Bader J, Silzle T, Vodinska M, Slaby O, Schmid HP, Engeler DS, Driessen C, Besse L.

BJU Int. 2018 Apr;121(4):600-609. doi: 10.1111/bju.14083. Epub 2017 Dec 10.


A systematic surveillance programme for infectious salmon anaemia virus supports its absence in the Pacific Northwest of the United States.

Gustafson LL, Creekmore LH, Snekvik KR, Ferguson JA, Warg JV, Blair M, Meyers TR, Stewart B, Warheit KI, Kerwin J, Goodwin AE, Rhodes LD, Whaley JE, Purcell MK, Bentz C, Shasa D, Bader J, Winton JR.

J Fish Dis. 2018 Feb;41(2):337-346. doi: 10.1111/jfd.12733. Epub 2017 Nov 21.


Ensuring quality pharmacokinetic analyses in antimicrobial drug development programs.

Lakota EA, Bader JC, Rubino CM.

Curr Opin Pharmacol. 2017 Oct;36:139-145. doi: 10.1016/j.coph.2017.10.014. Epub 2017 Nov 20. Review.


Relatively enriched housing conditions delay binge onset but do not attenuate binge size.

Preston KE, Corwin RL, Bader JO, Crimmins SL.

Physiol Behav. 2018 Feb 1;184:196-204. doi: 10.1016/j.physbeh.2017.11.018. Epub 2017 Nov 15.


Dentists' decision strategies for suspicious occlusal caries lesions in a National Dental PBRN study.

Makhija SK, Robinson ME, Bader JD, Shugars DA, Litaker MS, Im HR, Rindal DB, Pihlstrom DJ, Meyerowitz C, Gordan VV, Buchberg MK, Gilbert GH; National Dental PBRNCollaborative Group.

J Dent. 2018 Feb;69:83-87. doi: 10.1016/j.jdent.2017.11.004. Epub 2017 Nov 11.


Surface characteristics and lesion depth and activity of suspicious occlusal carious lesions: Findings from The National Dental Practice-Based Research Network.

Makhija SK, Shugars DA, Gilbert GH, Litaker MS, Bader JD, Schaffer R, Gordan VV, Rindal DB, Pihlstrom DJ, Mungia R, Meyerowitz C; National Dental Practice-Based Research Network Collaborative Group.

J Am Dent Assoc. 2017 Dec;148(12):922-929. doi: 10.1016/j.adaj.2017.08.009. Epub 2017 Oct 18.


Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer.

Bader JE, Enos RT, Velázquez KT, Carson MS, Nagarkatti M, Nagarkatti PS, Chatzistamou I, Davis JM, Carson JA, Robinson CM, Murphy EA.

Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G22-G31. doi: 10.1152/ajpgi.00229.2017. Epub 2017 Oct 12.


Cannabinoid Receptor-2 Ameliorates Inflammation in Murine Model of Crohn's Disease.

Leinwand KL, Jones AA, Huang RH, Jedlicka P, Kao DJ, de Zoeten EF, Ghosh S, Moaddel R, Wehkamp J, Ostaff MJ, Bader J, Aherne CM, Collins CB.

J Crohns Colitis. 2017 Oct 27;11(11):1369-1380. doi: 10.1093/ecco-jcc/jjx096.


miR155 deficiency aggravates high-fat diet-induced adipose tissue fibrosis in male mice.

Velázquez KT, Enos RT, Carson MS, Cranford TL, Bader JE, Sougiannis AT, Pritchett C, Fan D, Carson JA, Murphy EA.

Physiol Rep. 2017 Sep;5(18). pii: e13412. doi: 10.14814/phy2.13412.


Epidemiology of Posterior Glenohumeral Instability in a Young Athletic Population.

Lanzi JT Jr, Chandler PJ, Cameron KL, Bader JM, Owens BD.

Am J Sports Med. 2017 Dec;45(14):3315-3321. doi: 10.1177/0363546517725067. Epub 2017 Sep 25.


Pharmacological Basis of CD101 Efficacy: Exposure Shape Matters.

Lakota EA, Bader JC, Ong V, Bartizal K, Miesel L, Andes DR, Bhavnani SM, Rubino CM, Ambrose PG, Lepak AJ.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e00758-17. doi: 10.1128/AAC.00758-17. Print 2017 Nov.


The first-in-class alkylating HDAC inhibitor EDO-S101 is highly synergistic with proteasome inhibition against multiple myeloma through activation of multiple pathways.

Besse L, Kraus M, Besse A, Bader J, Silzle T, Mehrling T, Driessen C.

Blood Cancer J. 2017 Jul 28;7(7):e589. doi: 10.1038/bcj.2017.69. No abstract available.


Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma.

Besse A, Stolze SC, Rasche L, Weinhold N, Morgan GJ, Kraus M, Bader J, Overkleeft HS, Besse L, Driessen C.

Leukemia. 2018 Feb;32(2):391-401. doi: 10.1038/leu.2017.212. Epub 2017 Jul 5.


Anteromedializing Tibial Tubercle Osteotomy for Patellofemoral Instability: Occupational and Functional Outcomes in U.S. Military Service Members.

Belmont PJ Jr, Fisher TF, Bader JM, Lanzi JT, Owens BD, Waterman BR.

J Knee Surg. 2018 Apr;31(4):306-313. doi: 10.1055/s-0037-1603639. Epub 2017 Jun 15.


Short-Term Perioperative Complications and Mortality After Total Ankle Arthroplasty in the United States.

Heida KA, Waterman B, Tatro E, Bader J, McCoy AC, Rensing N, Orr J.

Foot Ankle Spec. 2018 Apr;11(2):123-132. doi: 10.1177/1938640017709912. Epub 2017 Jun 5.


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