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Items: 1 to 50 of 101

1.

The effects of a CCR3 inhibitor, AXP1275, on allergen-induced airway responses in adults with mild-to-moderate atopic asthma.

Gauvreau GM, FitzGerald JM, Boulet LP, Watson RM, Hui L, Villineuve H, Scime TX, Schlatman AR, Obminski C, Kum J, Boehme S, Ly TW, Bacon KB, O'Byrne PM.

Clin Exp Allergy. 2018 Apr;48(4):445-451. doi: 10.1111/cea.13114. Epub 2018 Mar 13.

PMID:
29423947
2.

MAP3K19 Is Overexpressed in COPD and Is a Central Mediator of Cigarette Smoke-Induced Pulmonary Inflammation and Lower Airway Destruction.

Boehme SA, Franz-Bacon K, Ludka J, DiTirro DN, Ly TW, Bacon KB.

PLoS One. 2016 Dec 9;11(12):e0167169. doi: 10.1371/journal.pone.0167169. eCollection 2016.

3.

Image Restoration and Analysis of Influenza Virions Binding to Membrane Receptors Reveal Adhesion-Strengthening Kinetics.

Lee DW, Hsu HL, Bacon KB, Daniel S.

PLoS One. 2016 Oct 3;11(10):e0163437. doi: 10.1371/journal.pone.0163437. eCollection 2016.

4.

MAP3K19 Is a Novel Regulator of TGF-β Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis.

Boehme SA, Franz-Bacon K, DiTirro DN, Ly TW, Bacon KB.

PLoS One. 2016 May 4;11(5):e0154874. doi: 10.1371/journal.pone.0154874. eCollection 2016.

5.

Single-Particle Tracking Shows that a Point Mutation in the Carnivore Parvovirus Capsid Switches Binding between Host-Specific Transferrin Receptors.

Lee DW, Allison AB, Bacon KB, Parrish CR, Daniel S.

J Virol. 2016 Apr 14;90(9):4849-53. doi: 10.1128/JVI.03204-15. Print 2016 May.

6.

A role for mitogen kinase kinase 3 in pulmonary inflammation validated from a proteomic approach.

Holand T, Riffo-Vasquez Y, Spina D, O'Connor B, Woisin F, Sand C, Marber M, Bacon KB, Rohlff C, Page CP.

Pulm Pharmacol Ther. 2014 Apr;27(2):156-63. doi: 10.1016/j.pupt.2014.01.006. Epub 2014 Jan 27.

PMID:
24480516
7.

Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4.

Golfier S, Kondo S, Schulze T, Takeuchi T, Vassileva G, Achtman AH, Gräler MH, Abbondanzo SJ, Wiekowski M, Kremmer E, Endo Y, Lira SA, Bacon KB, Lipp M.

FASEB J. 2010 Dec;24(12):4701-10. doi: 10.1096/fj.09-141473. Epub 2010 Aug 4.

PMID:
20686109
8.

Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2).

Boehme SA, Franz-Bacon K, Chen EP, Ly TW, Kawakami Y, Bacon KB.

Int Immunol. 2009 Jun;21(6):621-32. doi: 10.1093/intimm/dxp031. Epub 2009 Apr 3.

PMID:
19346259
9.

Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms.

Boehme SA, Chen EP, Franz-Bacon K, Sásik R, Sprague LJ, Ly TW, Hardiman G, Bacon KB.

Int Immunol. 2009 Jan;21(1):1-17. doi: 10.1093/intimm/dxn118. Epub 2008 Dec 9.

10.

A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation.

Boehme SA, Franz-Bacon K, Chen EP, Sásik R, Sprague LJ, Ly TW, Hardiman G, Bacon KB.

Int Immunol. 2009 Jan;21(1):81-93. doi: 10.1093/intimm/dxn127. Epub 2008 Dec 9.

11.

CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation.

Lukacs NW, Berlin AA, Franz-Bacon K, Sásik R, Sprague LJ, Ly TW, Hardiman G, Boehme SA, Bacon KB.

Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L767-79. doi: 10.1152/ajplung.90351.2008. Epub 2008 Aug 29.

12.

Cinnabaramides A-G: analogues of lactacystin and salinosporamide from a terrestrial streptomycete.

Stadler M, Bitzer J, Mayer-Bartschmid A, Müller H, Benet-Buchholz J, Gantner F, Tichy HV, Reinemer P, Bacon KB.

J Nat Prod. 2007 Feb;70(2):246-52. Epub 2007 Jan 24.

PMID:
17249727
13.

Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4.

Okigami H, Takeshita K, Tajimi M, Komura H, Albers M, Lehmann TE, Rölle T, Bacon KB.

Eur J Pharmacol. 2007 Mar 22;559(2-3):202-9. Epub 2006 Dec 12.

PMID:
17234179
14.

PAR-2 deficient CD4+ T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice.

Shichijo M, Kondo S, Ishimori M, Watanabe S, Helin H, Yamasaki T, Stevens ME, Gantner F, Bacon KB.

Allergol Int. 2006 Sep;55(3):271-8.

15.

CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses.

Sugimoto H, Shichijo M, Okano M, Bacon KB.

Eur J Pharmacol. 2005 Nov 7;524(1-3):30-7. Epub 2005 Oct 27.

PMID:
16256979
16.

Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview.

Ly TW, Bacon KB.

Expert Opin Investig Drugs. 2005 Jul;14(7):769-73. Review.

PMID:
16022566
17.

Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor.

Sanda T, Iida S, Ogura H, Asamitsu K, Murata T, Bacon KB, Ueda R, Okamoto T.

Clin Cancer Res. 2005 Mar 1;11(5):1974-82.

18.

A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity.

Ziegelbauer K, Gantner F, Lukacs NW, Berlin A, Fuchikami K, Niki T, Sakai K, Inbe H, Takeshita K, Ishimori M, Komura H, Murata T, Lowinger T, Bacon KB.

Br J Pharmacol. 2005 May;145(2):178-92.

19.

Cockroach allergen extract stimulates protease-activated receptor-2 (PAR-2) expressed in mouse lung fibroblast.

Kondo S, Helin H, Shichijo M, Bacon KB.

Inflamm Res. 2004 Sep;53(9):489-96.

PMID:
15551003
20.

Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2.

Yoshimura-Uchiyama C, Iikura M, Yamaguchi M, Nagase H, Ishii A, Matsushima K, Yamamoto K, Shichijo M, Bacon KB, Hirai K.

Clin Exp Allergy. 2004 Aug;34(8):1283-90.

PMID:
15298571
21.

Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents.

Murata T, Shimada M, Sakakibara S, Yoshino T, Masuda T, Shintani T, Sato H, Koriyama Y, Fukushima K, Nunami N, Yamauchi M, Fuchikami K, Komura H, Watanabe A, Ziegelbauer KB, Bacon KB, Lowinger TB.

Bioorg Med Chem Lett. 2004 Aug 2;14(15):4019-22.

PMID:
15225718
22.

Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 2: Improvement of in vitro activity.

Murata T, Shimada M, Kadono H, Sakakibara S, Yoshino T, Masuda T, Shimazaki M, Shintani T, Fuchikami K, Bacon KB, Ziegelbauer KB, Lowinger TB.

Bioorg Med Chem Lett. 2004 Aug 2;14(15):4013-7.

PMID:
15225717
23.

CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation.

Takeshita K, Yamasaki T, Nagao K, Sugimoto H, Shichijo M, Gantner F, Bacon KB.

Int Immunol. 2004 Jul;16(7):947-59. Epub 2004 Jun 1.

PMID:
15173122
24.

Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse.

Takeshita K, Yamasaki T, Akira S, Gantner F, Bacon KB.

Int Immunol. 2004 May;16(5):685-95. Epub 2004 Mar 29.

PMID:
15096484
25.

Critical role of L-selectin and histamine H4 receptor in zymosan-induced neutrophil recruitment from the bone marrow: comparison with carrageenan.

Takeshita K, Bacon KB, Gantner F.

J Pharmacol Exp Ther. 2004 Jul;310(1):272-80. Epub 2004 Mar 2.

PMID:
14996947
26.

A versatile high-throughput screen for inhibitors of lipid kinase activity: development of an immobilized phospholipid plate assay for phosphoinositide 3-kinase gamma.

Fuchikami K, Togame H, Sagara A, Satoh T, Gantner F, Bacon KB, Reinemer P.

J Biomol Screen. 2002 Oct;7(5):441-50.

PMID:
14599360
27.

Critical role of histamine H4 receptor in leukotriene B4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo.

Takeshita K, Sakai K, Bacon KB, Gantner F.

J Pharmacol Exp Ther. 2003 Dec;307(3):1072-8. Epub 2003 Oct 9.

PMID:
14551291
28.

Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats.

Shichijo M, Sugimoto H, Nagao K, Inbe H, Encinas JA, Takeshita K, Bacon KB, Gantner F.

J Pharmacol Exp Ther. 2003 Nov;307(2):518-25. Epub 2003 Sep 15.

PMID:
12975488
29.

CD40-dependent and -independent activation of human tonsil B cells by CpG oligodeoxynucleotides.

Gantner F, Hermann P, Nakashima K, Matsukawa S, Sakai K, Bacon KB.

Eur J Immunol. 2003 Jun;33(6):1576-85.

30.

CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells.

Liu N, Ohnishi N, Ni L, Akira S, Bacon KB.

Nat Immunol. 2003 Jul;4(7):687-93. Epub 2003 May 25.

PMID:
12766768
31.

The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents.

Yamamoto N, Takeshita K, Shichijo M, Kokubo T, Sato M, Nakashima K, Ishimori M, Nagai H, Li YF, Yura T, Bacon KB.

J Pharmacol Exp Ther. 2003 Sep;306(3):1174-81. Epub 2003 May 23.

PMID:
12766258
32.

Chemokine receptor binding and signal transduction in native cells of the central nervous system.

Davis CN, Chen S, Boehme SA, Bacon KB, Harrison JK.

Methods. 2003 Apr;29(4):326-34.

PMID:
12725799
33.

Mononuclear cell-infiltrate inhibition by blocking macrophage-derived chemokine results in attenuation of developing crescentic glomerulonephritis.

Garcia GE, Xia Y, Harrison J, Wilson CB, Johnson RJ, Bacon KB, Feng L.

Am J Pathol. 2003 Apr;162(4):1061-73.

34.

An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro.

Sugimoto H, Shichijo M, Iino T, Manabe Y, Watanabe A, Shimazaki M, Gantner F, Bacon KB.

J Pharmacol Exp Ther. 2003 Apr;305(1):347-52.

PMID:
12649388
35.

Discovery of novel and selective IKK-beta serine-threonine protein kinase inhibitors. Part 1.

Murata T, Shimada M, Sakakibara S, Yoshino T, Kadono H, Masuda T, Shimazaki M, Shintani T, Fuchikami K, Sakai K, Inbe H, Takeshita K, Niki T, Umeda M, Bacon KB, Ziegelbauer KB, Lowinger TB.

Bioorg Med Chem Lett. 2003 Mar 10;13(5):913-8. Erratum in: Bioorg Med Chem Lett. 2003 Oct 20;13(20):3627.

PMID:
12617920
36.

Molecular cloning and functional characterization of Cynomolgus monkey (Macaca fascicularis) CC chemokine receptor, CCR3.

Iino T, Sugimoto H, Watanabe A, Encinas JA, Liu N, Floeckner J, Bacon KB.

Cytokine. 2002 Sep 21;19(6):276-86.

PMID:
12421570
37.

Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells.

Gantner F, Sakai K, Tusche MW, Cruikshank WW, Center DM, Bacon KB.

J Pharmacol Exp Ther. 2002 Oct;303(1):300-7.

PMID:
12235264
38.

FTY720, a novel transplantation drug, modulates lymphocyte migratory responses to chemokines.

Chen S, Bacon KB, Garcia G, Liao R, Pan ZK, Sullivan SK, Nakano H, Matsuzawa A, Brinkmann V, Feng L.

Transplant Proc. 2001 Nov-Dec;33(7-8):3057-63. No abstract available.

PMID:
11750317
39.

Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine.

Mizoue LS, Sullivan SK, King DS, Kledal TN, Schwartz TW, Bacon KB, Handel TM.

J Biol Chem. 2001 Sep 7;276(36):33906-14. Epub 2001 Jun 29.

40.

The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors.

Wu JY, Feng L, Park HT, Havlioglu N, Wen L, Tang H, Bacon KB, Jiang Zh, Zhang Xc, Rao Y.

Nature. 2001 Apr 19;410(6831):948-52.

41.

Chemokine receptor antagonism as a new therapy for multiple sclerosis.

Ransohoff RM, Bacon KB.

Expert Opin Investig Drugs. 2000 May;9(5):1079-97. Review.

PMID:
11060729
42.

The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia.

Boehme SA, Lio FM, Maciejewski-Lenoir D, Bacon KB, Conlon PJ.

J Immunol. 2000 Jul 1;165(1):397-403.

43.

NF-kappaB-dependent fractalkine induction in rat aortic endothelial cells stimulated by IL-1beta, TNF-alpha, and LPS.

Garcia GE, Xia Y, Chen S, Wang Y, Ye RD, Harrison JK, Bacon KB, Zerwes HG, Feng L.

J Leukoc Biol. 2000 Apr;67(4):577-84.

PMID:
10770292
44.

Chemokines and their receptors in neurobiology: perspectives in physiology and homeostasis.

Bacon KB, Harrison JK.

J Neuroimmunol. 2000 Apr 3;104(1):92-7. Review.

PMID:
10683519
45.

MIP-3alpha induces human eosinophil migration and activation of the mitogen-activated protein kinases (p42/p44 MAPK).

Sullivan SK, McGrath DA, Liao F, Boehme SA, Farber JM, Bacon KB.

J Leukoc Biol. 1999 Oct;66(4):674-82.

PMID:
10534125
47.

Prevention of crescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 rapid communication.

Feng L, Chen S, Garcia GE, Xia Y, Siani MA, Botti P, Wilson CB, Harrison JK, Bacon KB.

Kidney Int. 1999 Aug;56(2):612-20.

48.

Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia.

Maciejewski-Lenoir D, Chen S, Feng L, Maki R, Bacon KB.

J Immunol. 1999 Aug 1;163(3):1628-35.

49.

Activation of mitogen-activated protein kinase regulates eotaxin-induced eosinophil migration.

Boehme SA, Sullivan SK, Crowe PD, Santos M, Conlon PJ, Sriramarao P, Bacon KB.

J Immunol. 1999 Aug 1;163(3):1611-8.

50.

Human thymocytes express CCR-3 and are activated by eotaxin.

Franz-Bacon K, Dairaghi DJ, Boehme SA, Sullivan SK, Schall TJ, Conlon PJ, Taylor N, Bacon KB.

Blood. 1999 May 15;93(10):3233-40.

PMID:
10233874

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