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Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B), contributes to the adverse cardiac remodeling induced by pressure overload.

Polidovitch N, Yang S, Sun H, Lakin R, Ahmad F, Gao X, Turnbull PC, Chiarello C, Perry CGR, Manganiello V, Yang P, Backx PH.

J Mol Cell Cardiol. 2019 Jul;132:60-70. doi: 10.1016/j.yjmcc.2019.04.028. Epub 2019 Apr 30.


Engineering microenvironment for human cardiac tissue assembly in heart-on-a-chip platform.

Zhao Y, Rafatian N, Wang EY, Feric NT, Lai BFL, Knee-Walden EJ, Backx PH, Radisic M.

Matrix Biol. 2019 Apr 11. pii: S0945-053X(18)30483-9. doi: 10.1016/j.matbio.2019.04.001. [Epub ahead of print]


Inhibition of soluble TNFα prevents adverse atrial remodeling and atrial arrhythmia susceptibility induced in mice by endurance exercise.

Lakin R, Polidovitch N, Yang S, Guzman C, Gao X, Wauchop M, Burns J, Izaddoustdar F, Backx PH.

J Mol Cell Cardiol. 2019 Apr;129:165-173. doi: 10.1016/j.yjmcc.2019.01.012. Epub 2019 Feb 21.


A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling.

Zhao Y, Rafatian N, Feric NT, Cox BJ, Aschar-Sobbi R, Wang EY, Aggarwal P, Zhang B, Conant G, Ronaldson-Bouchard K, Pahnke A, Protze S, Lee JH, Davenport Huyer L, Jekic D, Wickeler A, Naguib HE, Keller GM, Vunjak-Novakovic G, Broeckel U, Backx PH, Radisic M.

Cell. 2019 Feb 7;176(4):913-927.e18. doi: 10.1016/j.cell.2018.11.042. Epub 2019 Jan 24.


Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy.

Hughes MC, Ramos SV, Turnbull PC, Edgett BA, Huber JS, Polidovitch N, Schlattner U, Backx PH, Simpson JA, Perry CGR.

J Physiol. 2019 Jan 23. doi: 10.1113/JP277306. [Epub ahead of print]


Changes in Heart Rate and Its Regulation by the Autonomic Nervous System Do Not Differ Between Forced and Voluntary Exercise in Mice.

Lakin R, Guzman C, Izaddoustdar F, Polidovitch N, Goodman JM, Backx PH.

Front Physiol. 2018 Jul 16;9:841. doi: 10.3389/fphys.2018.00841. eCollection 2018.


Excessive exercise in endurance athletes: Is atrial fibrillation a possible consequence?

Goodman JM, Banks L, Connelly KA, Yan AT, Backx PH, Dorian P.

Appl Physiol Nutr Metab. 2018 Sep;43(9):973-976. doi: 10.1139/apnm-2017-0764. Epub 2018 May 29.


Complex interactions in a novel SCN5A compound mutation associated with long QT and Brugada syndrome: Implications for Na+ channel blocking pharmacotherapy for de novo conduction disease.

Liu J, Bayer JD, Aschar-Sobbi R, Wauchop M, Spears D, Gollob M, Vigmond EJ, Tsushima R, Backx PH, Chauhan VS.

PLoS One. 2018 May 23;13(5):e0197273. doi: 10.1371/journal.pone.0197273. eCollection 2018.


A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair.

Zeng Y, Du WW, Wu Y, Yang Z, Awan FM, Li X, Yang W, Zhang C, Yang Q, Yee A, Chen Y, Yang F, Sun H, Huang R, Yee AJ, Li RK, Wu Z, Backx PH, Yang BB.

Theranostics. 2017 Aug 29;7(16):3842-3855. doi: 10.7150/thno.19764. eCollection 2017.


Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations.

Lee JH, Protze SI, Laksman Z, Backx PH, Keller GM.

Cell Stem Cell. 2017 Aug 3;21(2):179-194.e4. doi: 10.1016/j.stem.2017.07.003.


p53 and Mdm2 act synergistically to maintain cardiac homeostasis and mediate cardiomyocyte cell cycle arrest through a network of microRNAs.

Stanley-Hasnain S, Hauck L, Grothe D, Aschar-Sobbi R, Beca S, Butany J, Backx PH, Mak TW, Billia F.

Cell Cycle. 2017;16(17):1585-1600. doi: 10.1080/15384101.2017.1346758. Epub 2017 Jul 26.


Modeling Atrial Fibrillation using Human Embryonic Stem Cell-Derived Atrial Tissue.

Laksman Z, Wauchop M, Lin E, Protze S, Lee J, Yang W, Izaddoustdar F, Shafaattalab S, Gepstein L, Tibbits GF, Keller G, Backx PH.

Sci Rep. 2017 Jul 13;7(1):5268. doi: 10.1038/s41598-017-05652-y.


Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome.

Yin JC, Platt MJ, Tian X, Wu X, Backx PH, Simpson JA, Araki T, Neel BG.

Nat Commun. 2017 May 26;8:15518. doi: 10.1038/ncomms15518.


Ultrasound biomicroscopy validation of a murine model of cardiac hypertrophic preconditioning: comparison with a hemodynamic assessment.

Huang J, Wu J, Wang S, You J, Ye Y, Ding Z, Yang F, Wang X, Guo J, Ma L, Yuan J, Shen Y, Yang X, Sun A, Jiang H, Bu L, Backx PH, Ge J, Zou Y.

Am J Physiol Heart Circ Physiol. 2017 Jul 1;313(1):H138-H148. doi: 10.1152/ajpheart.00004.2017. Epub 2017 Apr 28.


Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure.

Kroetsch JT, Levy AS, Zhang H, Aschar-Sobbi R, Lidington D, Offermanns S, Nedospasov SA, Backx PH, Heximer SP, Bolz SS.

Nat Commun. 2017 Apr 5;8:14805. doi: 10.1038/ncomms14805.


Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker.

Protze SI, Liu J, Nussinovitch U, Ohana L, Backx PH, Gepstein L, Keller GM.

Nat Biotechnol. 2017 Jan;35(1):56-68. doi: 10.1038/nbt.3745. Epub 2016 Dec 12.


Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase.

Olofsson PS, Steinberg BE, Sobbi R, Cox MA, Ahmed MN, Oswald M, Szekeres F, Hanes WM, Introini A, Liu SF, Holodick NE, Rothstein TL, Lövdahl C, Chavan SS, Yang H, Pavlov VA, Broliden K, Andersson U, Diamond B, Miller EJ, Arner A, Gregersen PK, Backx PH, Mak TW, Tracey KJ.

Nat Biotechnol. 2016 Oct;34(10):1066-1071. doi: 10.1038/nbt.3663. Epub 2016 Sep 12.


Amlodipine Therapy for Iron-Overload Cardiomyopathy: The Enduring Value of Translational Research.

Oudit GY, Backx PH.

Can J Cardiol. 2016 Aug;32(8):938-40. doi: 10.1016/j.cjca.2015.11.017. Epub 2015 Nov 26. No abstract available.


The electrophysiological development of cardiomyocytes.

Liu J, Laksman Z, Backx PH.

Adv Drug Deliv Rev. 2016 Jan 15;96:253-73. Review.


Irx3 is required for postnatal maturation of the mouse ventricular conduction system.

Kim KH, Rosen A, Hussein SM, Puviindran V, Korogyi AS, Chiarello C, Nagy A, Hui CC, Backx PH.

Sci Rep. 2016 Jan 20;6:19197. doi: 10.1038/srep19197.


Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic β-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor κB.

Panama BK, Korogyi AS, Aschar-Sobbi R, Oh Y, Gray CB, Gang H, Brown JH, Kirshenbaum LA, Backx PH.

J Biol Chem. 2016 Feb 19;291(8):4156-65. doi: 10.1074/jbc.M115.694984. Epub 2016 Jan 7.


Physiological roles of the transient outward current Ito in normal and diseased hearts.

Cordeiro JM, Calloe K, Aschar-Sobbi R, Kim KH, Korogyi A, Occhipinti D, Backx PH, Panama BK.

Front Biosci (Schol Ed). 2016 Jan 1;8:143-59. Review.


Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.

Liu J, Kim KH, Morales MJ, Heximer SP, Hui CC, Backx PH.

PLoS One. 2015 Jul 21;10(7):e0133274. doi: 10.1371/journal.pone.0133274. eCollection 2015.


Adiponectin is required for cardiac MEF2 activation during pressure overload induced hypertrophy.

Dadson K, Turdi S, Hashemi S, Zhao J, Polidovitch N, Beca S, Backx PH, McDermott JC, Sweeney G.

J Mol Cell Cardiol. 2015 Sep;86:102-9. doi: 10.1016/j.yjmcc.2015.06.020. Epub 2015 Jul 19.


Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury.

Chung YW, Lagranha C, Chen Y, Sun J, Tong G, Hockman SC, Ahmad F, Esfahani SG, Bae DH, Polidovitch N, Wu J, Rhee DK, Lee BS, Gucek M, Daniels MP, Brantner CA, Backx PH, Murphy E, Manganiello VC.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2253-62. doi: 10.1073/pnas.1416230112. Epub 2015 Apr 15.


Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα.

Aschar-Sobbi R, Izaddoustdar F, Korogyi AS, Wang Q, Farman GP, Yang F, Yang W, Dorian D, Simpson JA, Tuomi JM, Jones DL, Nanthakumar K, Cox B, Wehrens XH, Dorian P, Backx PH.

Nat Commun. 2015 Jan 19;6:6018. doi: 10.1038/ncomms7018.


Atrial fibrillation and the athletic heart.

Redpath CJ, Backx PH.

Curr Opin Cardiol. 2015 Jan;30(1):17-23. doi: 10.1097/HCO.0000000000000130. Review.


Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.

Wang DY, Abbasi C, El-Rass S, Li JY, Dawood F, Naito K, Sharma P, Bousette N, Singh S, Backx PH, Cox B, Wen XY, Liu PP, Gramolini AO.

J Am Heart Assoc. 2014 Oct 20;3(5):e001018. doi: 10.1161/JAHA.114.001018.


Evaluation of genes encoding for the transient outward current (Ito) identifies the KCND2 gene as a cause of J-wave syndrome associated with sudden cardiac death.

Perrin MJ, Adler A, Green S, Al-Zoughool F, Doroshenko P, Orr N, Uppal S, Healey JS, Birnie D, Sanatani S, Gardner M, Champagne J, Simpson C, Ahmad K, van den Berg MP, Chauhan V, Backx PH, van Tintelen JP, Krahn AD, Gollob MH.

Circ Cardiovasc Genet. 2014 Dec;7(6):782-9. doi: 10.1161/CIRCGENETICS.114.000623. Epub 2014 Sep 11.


Patch-clamp technique in ESC-derived cardiomyocytes.

Liu J, Backx PH.

Methods Mol Biol. 2014;1181:203-14. doi: 10.1007/978-1-4939-1047-2_18.


Complexity, confusion and controversy continue complicating the contribution of RyR2 channel phosphorylation to heart function.

Backx PH.

J Physiol. 2014 May 1;592(9):1911-2. doi: 10.1113/jphysiol.2014.272575. No abstract available.


Enhanced cell volume regulation: a key mechanism in local and remote ischemic preconditioning.

Diaz RJ, Harvey K, Boloorchi A, Hossain T, Hinek A, Backx PH, Wilson GJ.

Am J Physiol Cell Physiol. 2014 Jun 15;306(12):C1191-9. doi: 10.1152/ajpcell.00259.2013. Epub 2014 Apr 23.


Coagulation factor XIIa-kinin-mediated contribution to hypertension of chronic kidney disease.

Papageorgiou PC, Chan CT, Yeo EL, Backx PH, Floras JS.

J Hypertens. 2014 Jul;32(7):1523-33; discussion 1533. doi: 10.1097/HJH.0000000000000192.


Heart failure in congenital heart disease: the role of genes and hemodynamics.

Vanderlaan RD, Caldarone CA, Backx PH.

Pflugers Arch. 2014 Jun;466(6):1025-35. doi: 10.1007/s00424-014-1447-9. Epub 2014 Feb 1. Review.


Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smooth muscle cells.

Liang W, Huang L, Zhao D, He JZ, Sharma P, Liu J, Gramolini AO, Ward ME, Cho HC, Backx PH.

J Hypertens. 2014 Feb;32(2):318-30. doi: 10.1097/HJH.0000000000000013.


Congenital heart block maternal sera autoantibodies target an extracellular epitope on the α1G T-type calcium channel in human fetal hearts.

Strandberg LS, Cui X, Rath A, Liu J, Silverman ED, Liu X, Siragam V, Ackerley C, Su BB, Yan JY, Capecchi M, Biavati L, Accorroni A, Yuen W, Quattrone F, Lung K, Jaeggi ET, Backx PH, Deber CM, Hamilton RM.

PLoS One. 2013 Sep 9;8(9):e72668. doi: 10.1371/journal.pone.0072668. eCollection 2013.


Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes.

Nunes SS, Miklas JW, Liu J, Aschar-Sobbi R, Xiao Y, Zhang B, Jiang J, Massé S, Gagliardi M, Hsieh A, Thavandiran N, Laflamme MA, Nanthakumar K, Gross GJ, Backx PH, Keller G, Radisic M.

Nat Methods. 2013 Aug;10(8):781-7. doi: 10.1038/nmeth.2524. Epub 2013 Jun 23.


Mesenchymal stem cell transplantation mitigates electrophysiological remodeling in a rat model of myocardial infarction.

Lai PF, Panama BK, Massé S, Li G, Zhang Y, Kusha M, Farid TA, Asta J, Backx PH, Yau TM, Nanthakumar K.

J Cardiovasc Electrophysiol. 2013 Jul;24(7):813-21. doi: 10.1111/jce.12162. Epub 2013 May 3.


GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure.

Kim M, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, Seino S, Simpson JA, Drucker DJ.

Nat Med. 2013 May;19(5):567-75. doi: 10.1038/nm.3128. Epub 2013 Mar 31.


Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes.

Jadhav A, Liang W, Papageorgiou PC, Shoker A, Kanthan SC, Balsevich J, Levy AS, Heximer S, Backx PH, Gopalakrishnan V.

J Pharmacol Exp Ther. 2013 Jun;345(3):383-92. doi: 10.1124/jpet.112.199661. Epub 2013 Mar 26.


Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heart.

Beca S, Ahmad F, Shen W, Liu J, Makary S, Polidovitch N, Sun J, Hockman S, Chung YW, Movsesian M, Murphy E, Manganiello V, Backx PH.

Circ Res. 2013 Jan 18;112(2):289-97. doi: 10.1161/CIRCRESAHA.111.300003. Epub 2012 Nov 19. Erratum in: Circ Res. 2018 Oct 26;123(10):e33.


Could plugging the oxidation-mediated Ca2+ leak stem the tide of the atrial fibrillation epidemic?

Backx PH.

Circ Res. 2012 Aug 31;111(6):662-5. doi: 10.1161/CIRCRESAHA.112.275453. No abstract available.


α-Crystallin B prevents apoptosis after H2O2 exposure in mouse neonatal cardiomyocytes.

Chis R, Sharma P, Bousette N, Miyake T, Wilson A, Backx PH, Gramolini AO.

Am J Physiol Heart Circ Physiol. 2012 Oct 15;303(8):H967-78. doi: 10.1152/ajpheart.00040.2012. Epub 2012 Aug 17.


Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.

Wu X, Yin J, Simpson J, Kim KH, Gu S, Hong JH, Bayliss P, Backx PH, Neel BG, Araki T.

Mol Cell Biol. 2012 Oct;32(19):3872-90. doi: 10.1128/MCB.00751-12. Epub 2012 Jul 23.


Escape capture bigeminy: phenotypic marker of cardiac sodium channel voltage sensor mutation R222Q.

Nair K, Pekhletski R, Harris L, Care M, Morel C, Farid T, Backx PH, Szabo E, Nanthakumar K.

Heart Rhythm. 2012 Oct;9(10):1681-1688.e1. doi: 10.1016/j.hrthm.2012.06.029. Epub 2012 Jun 16.


Iroquois homeodomain transcription factors in heart development and function.

Kim KH, Rosen A, Bruneau BG, Hui CC, Backx PH.

Circ Res. 2012 May 25;110(11):1513-24. doi: 10.1161/CIRCRESAHA.112.265041. Review.


Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction.

Degousee N, Simpson J, Fazel S, Scholich K, Angoulvant D, Angioni C, Schmidt H, Korotkova M, Stefanski E, Wang XH, Lindsay TF, Ofek E, Pierre S, Butany J, Jakobsson PJ, Keating A, Li RK, Nahrendorf M, Geisslinger G, Backx PH, Rubin BB.

Circulation. 2012 Jun 12;125(23):2904-13. doi: 10.1161/CIRCULATIONAHA.112.099754. Epub 2012 May 15.


A new enzyme-linked immunosorbent assay recognizing both rat and human activated coagulation Factor XII (FXIIa).

Papageorgiou PC, Yeo EL, Backx PH, Floras JS.

J Immunol Methods. 2012 Feb 28;376(1-2):132-8. doi: 10.1016/j.jim.2012.01.002. Epub 2012 Jan 10.


Activated plasma coagulation β-Factor XII-induced vasoconstriction in rats.

Papageorgiou PC, Yeo EL, Backx PH, Floras JS.

Clin Sci (Lond). 2012 Jun;122(12):581-90. doi: 10.1042/CS20110517.


Regulation of murine cardiac function by phosphodiesterases type 3 and 4.

Beca S, Aschars-Sobbi R, Panama BK, Backx PH.

Curr Opin Pharmacol. 2011 Dec;11(6):714-9. doi: 10.1016/j.coph.2011.10.017. Epub 2011 Oct 31. Review.


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