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Items: 14

1.

Opportunities and challenges for the development of covalent chemical immunomodulators.

Backus KM, Cao J, Maddox SM.

Bioorg Med Chem. 2019 Aug 1;27(15):3421-3439. doi: 10.1016/j.bmc.2019.05.050. Epub 2019 Jun 5. Review.

PMID:
31204229
2.

Applications of Reactive Cysteine Profiling.

Backus KM.

Curr Top Microbiol Immunol. 2019;420:375-417. doi: 10.1007/82_2018_120. Review.

PMID:
30105421
3.

Global profiling of lysine reactivity and ligandability in the human proteome.

Hacker SM, Backus KM, Lazear MR, Forli S, Correia BE, Cravatt BF.

Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.

4.

Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.

Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF.

Cell. 2017 Oct 19;171(3):696-709.e23. doi: 10.1016/j.cell.2017.08.051. Epub 2017 Sep 28.

5.

A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A.

Touchette MH, Van Vlack ER, Bai L, Kim J, Cognetta AB 3rd, Previti ML, Backus KM, Martin DW, Cravatt BF, Seeliger JC.

ACS Infect Dis. 2017 May 12;3(5):336-348. doi: 10.1021/acsinfecdis.6b00179. Epub 2017 Mar 21.

6.

Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases.

Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA.

Cell. 2017 Jan 26;168(3):517-526.e18. doi: 10.1016/j.cell.2016.12.021. Epub 2017 Jan 19.

7.

Covalent Modulators of the Vacuolar ATPase.

Chen YC, Backus KM, Merkulova M, Yang C, Brown D, Cravatt BF, Zhang C.

J Am Chem Soc. 2017 Jan 18;139(2):639-642. doi: 10.1021/jacs.6b12511. Epub 2016 Dec 30.

8.

Chemical Proteomic Profiling of Human Methyltransferases.

Horning BD, Suciu RM, Ghadiri DA, Ulanovskaya OA, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H, Cravatt BF.

J Am Chem Soc. 2016 Oct 12;138(40):13335-13343. Epub 2016 Sep 30.

9.

Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells.

Blewett MM, Xie J, Zaro BW, Backus KM, Altman A, Teijaro JR, Cravatt BF.

Sci Signal. 2016 Sep 13;9(445):rs10. doi: 10.1126/scisignal.aaf7694.

10.

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.

Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG Jr.

Cell. 2016 Jun 30;166(1):126-39. doi: 10.1016/j.cell.2016.05.042.

11.

Proteome-wide covalent ligand discovery in native biological systems.

Backus KM, Correia BE, Lum KM, Forli S, Horning BD, González-Páez GE, Chatterjee S, Lanning BR, Teijaro JR, Olson AJ, Wolan DW, Cravatt BF.

Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.

12.

The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions.

Backus KM, Dolan MA, Barry CS, Joe M, McPhie P, Boshoff HI, Lowary TL, Davis BG, Barry CE 3rd.

J Biol Chem. 2014 Sep 5;289(36):25041-53. doi: 10.1074/jbc.M114.581579. Epub 2014 Jul 14.

13.

ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor.

Barry CS, Backus KM, Barry CE 3rd, Davis BG.

J Am Chem Soc. 2011 Aug 31;133(34):13232-5. doi: 10.1021/ja204249p. Epub 2011 Aug 9.

PMID:
21776980
14.

Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis.

Backus KM, Boshoff HI, Barry CS, Boutureira O, Patel MK, D'Hooge F, Lee SS, Via LE, Tahlan K, Barry CE 3rd, Davis BG.

Nat Chem Biol. 2011 Apr;7(4):228-35. doi: 10.1038/nchembio.539. Epub 2011 Mar 6.

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