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Items: 1 to 50 of 94

1.

O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart from Failure.

Kronlage M, Dewenter M, Grosso J, Fleming T, Oehl UY, Lehmann LH, Falcão-Pires I, Leite-Moreira AF, Volk N, Gröne HJ, Müller OJ, Sickmann A, Katus HA, Backs J.

Circulation. 2019 Jun 14. doi: 10.1161/CIRCULATIONAHA.117.031942. [Epub ahead of print]

PMID:
31195810
2.

Learned helplessness reveals a population at risk for depressive-like behaviour after myocardial infarction in mice.

Bruns B, Schmitz T, Diemert N, Schwale C, Werhahn SM, Weyrauther F, Gass P, Vogt MA, Katus H, Herzog W, Backs J, Schultz JH.

ESC Heart Fail. 2019 Apr 26. doi: 10.1002/ehf2.12440. [Epub ahead of print]

PMID:
31025825
3.

Heart failure in cardiomyopathies: a position paper from the Heart Failure Association of the European Society of Cardiology.

Seferović PM, Polovina M, Bauersachs J, Arad M, Gal TB, Lund LH, Felix SB, Arbustini E, Caforio ALP, Farmakis D, Filippatos GS, Gialafos E, Kanjuh V, Krljanac G, Limongelli G, Linhart A, Lyon AR, Maksimović R, Miličić D, Milinković I, Noutsias M, Oto A, Oto Ö, Pavlović SU, Piepoli MF, Ristić AD, Rosano GMC, Seggewiss H, Ašanin M, Seferović JP, Ruschitzka F, Čelutkiene J, Jaarsma T, Mueller C, Moura B, Hill L, Volterrani M, Lopatin Y, Metra M, Backs J, Mullens W, Chioncel O, de Boer RA, Anker S, Rapezzi C, Coats AJS, Tschöpe C.

Eur J Heart Fail. 2019 May;21(5):553-576. doi: 10.1002/ejhf.1461. Epub 2019 Apr 16.

PMID:
30989768
4.

The continuous heart failure spectrum: moving beyond an ejection fraction classification.

Triposkiadis F, Butler J, Abboud FM, Armstrong PW, Adamopoulos S, Atherton JJ, Backs J, Bauersachs J, Burkhoff D, Bonow RO, Chopra VK, de Boer RA, de Windt L, Hamdani N, Hasenfuss G, Heymans S, Hulot JS, Konstam M, Lee RT, Linke WA, Lunde IG, Lyon AR, Maack C, Mann DL, Mebazaa A, Mentz RJ, Nihoyannopoulos P, Papp Z, Parissis J, Pedrazzini T, Rosano G, Rouleau J, Seferovic PM, Shah AM, Starling RC, Tocchetti CG, Trochu JN, Thum T, Zannad F, Brutsaert DL, Segers VF, De Keulenaer GW.

Eur Heart J. 2019 Apr 8. pii: ehz158. doi: 10.1093/eurheartj/ehz158. [Epub ahead of print]

PMID:
30957868
5.

CaMKII does not control mitochondrial Ca2+ uptake in cardiac myocytes.

Nickel AG, Kohlhaas M, Bertero E, Wilhelm D, Wagner M, Sequeira V, Kreusser MM, Dewenter M, Kappl R, Hoth M, Dudek J, Backs J, Maack C.

J Physiol. 2019 Feb 16. doi: 10.1113/JP276766. [Epub ahead of print]

PMID:
30770570
6.

Comprehensive plasma and tissue profiling reveals systemic metabolic alterations in cardiac hypertrophy and failure.

Müller OJ, Heckmann MB, Ding L, Rapti K, Rangrez AY, Gerken T, Christiansen N, Rennefahrt UEE, Witt H, Maldonado SG, Ternes P, Schwab DM, Ruf T, Hille S, Remes A, Jungmann A, Weis TM, Kreußer JS, Gröne HJ, Backs J, Schatz P, Katus HA, Frey N.

Cardiovasc Res. 2018 Nov 9. doi: 10.1093/cvr/cvy274. [Epub ahead of print]

PMID:
30418544
7.

Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction.

Veltkamp R, Uhlmann S, Marinescu M, Sticht C, Finke D, Gretz N, Gröne HJ, Katus HA, Backs J, Lehmann LH.

J Cachexia Sarcopenia Muscle. 2019 Feb;10(1):54-62. doi: 10.1002/jcsm.12335. Epub 2018 Oct 30.

8.

Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology.

Maack C, Lehrke M, Backs J, Heinzel FR, Hulot JS, Marx N, Paulus WJ, Rossignol P, Taegtmeyer H, Bauersachs J, Bayes-Genis A, Brutsaert D, Bugger H, Clarke K, Cosentino F, De Keulenaer G, Dei Cas A, González A, Huelsmann M, Iaccarino G, Lunde IG, Lyon AR, Pollesello P, Rena G, Riksen NP, Rosano G, Staels B, van Laake LW, Wanner C, Farmakis D, Filippatos G, Ruschitzka F, Seferovic P, de Boer RA, Heymans S.

Eur Heart J. 2018 Dec 21;39(48):4243-4254. doi: 10.1093/eurheartj/ehy596. No abstract available.

9.

Inflammation leads through PGE/EP3 signaling to HDAC5/MEF2-dependent transcription in cardiac myocytes.

Tóth AD, Schell R, Lévay M, Vettel C, Theis P, Haslinger C, Alban F, Werhahn S, Frischbier L, Krebs-Haupenthal J, Thomas D, Gröne HJ, Avkiran M, Katus HA, Wieland T, Backs J.

EMBO Mol Med. 2018 Jul;10(7). pii: e8536. doi: 10.15252/emmm.201708536.

10.

Physiological and unappreciated roles of CaMKII in the heart.

Beckendorf J, van den Hoogenhof MMG, Backs J.

Basic Res Cardiol. 2018 Jun 15;113(4):29. doi: 10.1007/s00395-018-0688-8. Review.

11.

RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling.

van den Hoogenhof MMG, Beqqali A, Amin AS, van der Made I, Aufiero S, Khan MAF, Schumacher CA, Jansweijer JA, van Spaendonck-Zwarts KY, Remme CA, Backs J, Verkerk AO, Baartscheer A, Pinto YM, Creemers EE.

Circulation. 2018 Sep 25;138(13):1330-1342. doi: 10.1161/CIRCULATIONAHA.117.031947.

PMID:
29650543
12.

Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells.

Gomis-Coloma C, Velasco-Aviles S, Gomez-Sanchez JA, Casillas-Bajo A, Backs J, Cabedo H.

J Cell Biol. 2018 Apr 2;217(4):1249-1268. doi: 10.1083/jcb.201611150. Epub 2018 Feb 22.

13.

Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila.

Joos JP, Saadatmand AR, Schnabel C, Viktorinová I, Brand T, Kramer M, Nattel S, Dobrev D, Tomancak P, Backs J, Kleinbongard P, Heusch G, Lorenz K, Koch E, Weber S, El-Armouche A.

Sci Rep. 2018 Feb 13;8(1):2940. doi: 10.1038/s41598-018-21372-3.

14.

Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart.

Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A.

Circulation. 2018 Jun 12;137(24):2592-2608. doi: 10.1161/CIRCULATIONAHA.117.029733. Epub 2018 Jan 20.

PMID:
29353241
15.

A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.

Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J.

Nat Med. 2018 Jan;24(1):62-72. doi: 10.1038/nm.4452. Epub 2017 Dec 11.

PMID:
29227474
16.

In Vivo Quantification of Myocardial Infarction in Mice Using Micro-CT and a Novel Blood Pool Agent.

Sawall S, Franke D, Kirchherr A, Beckendorf J, Kuntz J, Maier J, Kraupner A, Backs J, Briel A, Kachelrieß M.

Contrast Media Mol Imaging. 2017 Oct 16;2017:2617047. doi: 10.1155/2017/2617047. eCollection 2017.

17.

Calcium Signaling and Transcriptional Regulation in Cardiomyocytes.

Dewenter M, von der Lieth A, Katus HA, Backs J.

Circ Res. 2017 Sep 29;121(8):1000-1020. doi: 10.1161/CIRCRESAHA.117.310355. Review.

PMID:
28963192
18.

Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and a Novel Class of Biomarkers for Heart Failure.

Meder B, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Frese K, Lai A, Nietsch R, Scheiner C, Mester S, Bordalo DM, Amr A, Dietrich C, Pils D, Siede D, Hund H, Bauer A, Holzer DB, Ruhparwar A, Mueller-Hennessen M, Weichenhan D, Plass C, Weis T, Backs J, Wuerstle M, Keller A, Katus HA, Posch AE.

Circulation. 2017 Oct 17;136(16):1528-1544. doi: 10.1161/CIRCULATIONAHA.117.027355. Epub 2017 Aug 24.

PMID:
28838933
19.

G protein-coupled receptor kinase 2 promotes cardiac hypertrophy.

Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW.

PLoS One. 2017 Jul 31;12(7):e0182110. doi: 10.1371/journal.pone.0182110. eCollection 2017.

20.

Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease.

Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C.

J Mol Cell Cardiol. 2017 Aug;109:48-56. doi: 10.1016/j.yjmcc.2017.06.015. Epub 2017 Jul 1.

PMID:
28676412
21.

Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure.

Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A.

Circ Heart Fail. 2017 May;10(5):e003840. doi: 10.1161/CIRCHEARTFAILURE.117.003840.

22.

Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity.

Neef S, Heijman J, Otte K, Dewenter M, Saadatmand AR, Meyer-Roxlau S, Antos CL, Backs J, Dobrev D, Wagner M, Maier LS, El-Armouche A.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Aug;390(8):857-862. doi: 10.1007/s00210-017-1376-1. Epub 2017 Apr 27.

PMID:
28451724
23.

Role of plasma membrane-associated AKAPs for the regulation of cardiac IK1 current by protein kinase A.

Seyler C, Scherer D, Köpple C, Kulzer M, Korkmaz S, Xynogalos P, Thomas D, Kaya Z, Scholz E, Backs J, Karle C, Katus HA, Zitron E.

Naunyn Schmiedebergs Arch Pharmacol. 2017 May;390(5):493-503. doi: 10.1007/s00210-017-1344-9. Epub 2017 Mar 22.

PMID:
28331977
24.

Facile Modulation of FLP Properties: A Phosphinylvinyl Grignard Reagent and Ga/P- and In/P2 -Based Frustrated Lewis Pairs.

Backs J, Lange M, Possart J, Wollschläger A, Mück-Lichtenfeld C, Uhl W.

Angew Chem Int Ed Engl. 2017 Mar 6;56(11):3094-3097. doi: 10.1002/anie.201612485. Epub 2017 Feb 3.

PMID:
28156031
25.

Evolutionary history and gene flow of an endemic island oak: Quercus pacifica.

Backs JR, Ashley MV.

Am J Bot. 2016 Dec;103(12):2115-2125. doi: 10.3732/ajb.1600259. Epub 2016 Dec 20.

26.

Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure.

Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T.

Circulation. 2017 Feb 28;135(9):881-897. doi: 10.1161/CIRCULATIONAHA.116.022852. Epub 2016 Dec 7.

PMID:
27927712
27.

Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure.

Kreusser MM, Lehmann LH, Wolf N, Keranov S, Jungmann A, Gröne HJ, Müller OJ, Katus HA, Backs J.

Basic Res Cardiol. 2016 Nov;111(6):65. Epub 2016 Sep 28.

PMID:
27683174
28.

Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2.

Scherer D, Seyler C, Xynogalos P, Scholz EP, Thomas D, Backs J, Andrassy M, Völkers M, Karle CA, Katus HA, Zitron E.

PLoS One. 2016 May 23;11(5):e0156181. doi: 10.1371/journal.pone.0156181. eCollection 2016.

29.

A Significant but Constrained Geometry Pt→Al Interaction: Fixation of CO2 and CS2, Activation of H2 and PhCONH2.

Devillard M, Declercq R, Nicolas E, Ehlers AW, Backs J, Saffon-Merceron N, Bouhadir G, Slootweg JC, Uhl W, Bourissou D.

J Am Chem Soc. 2016 Apr 13;138(14):4917-26. doi: 10.1021/jacs.6b01320. Epub 2016 Mar 30.

PMID:
26977772
30.

Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia.

Schäfer M, Oeing CU, Rohm M, Baysal-Temel E, Lehmann LH, Bauer R, Volz HC, Boutros M, Sohn D, Sticht C, Gretz N, Eichelbaum K, Werner T, Hirt MN, Eschenhagen T, Müller-Decker K, Strobel O, Hackert T, Krijgsveld J, Katus HA, Berriel Diaz M, Backs J, Herzig S.

Mol Metab. 2015 Nov 26;5(2):67-78. doi: 10.1016/j.molmet.2015.11.004. eCollection 2016 Feb.

31.

Landscape genetics and population structure in Valley Oak (Quercus lobata Née).

Ashley MV, Abraham ST, Backs JR, Koenig WD.

Am J Bot. 2015 Dec;102(12):2124-31. doi: 10.3732/ajb.1500182. Epub 2015 Dec 15.

32.

Fibroblast growth factor 23 (FGF-23) is an early predictor of mortality in patients with cardiac arrest.

Spaich S, Zelniker T, Endres P, Stiepak J, Uhlmann L, Bekeredjian R, Chorianopoulos E, Giannitsis E, Backs J, Katus HA, Preusch MR.

Resuscitation. 2016 Jan;98:91-6. doi: 10.1016/j.resuscitation.2015.11.012. Epub 2015 Nov 30.

PMID:
26655587
33.

Ca2+/calmodulin-dependent protein kinase II-γ (CaMKIIγ) negatively regulates vascular smooth muscle cell proliferation and vascular remodeling.

Saddouk FZ, Sun LY, Liu YF, Jiang M, Singer DV, Backs J, Van Riper D, Ginnan R, Schwarz JJ, Singer HA.

FASEB J. 2016 Mar;30(3):1051-64. doi: 10.1096/fj.15-279158. Epub 2015 Nov 13.

34.

Regulation of CaMKII signaling in cardiovascular disease.

Mollova MY, Katus HA, Backs J.

Front Pharmacol. 2015 Aug 25;6:178. doi: 10.3389/fphar.2015.00178. eCollection 2015. Review.

35.

Ongoing controversies surrounding cardiac remodeling: is it black and white-or rather fifty shades of gray?

Spaich S, Katus HA, Backs J.

Front Physiol. 2015 Jul 22;6:202. doi: 10.3389/fphys.2015.00202. eCollection 2015. Review.

36.

Smooth muscle CaMKIIδ promotes allergen-induced airway hyperresponsiveness and inflammation.

Spinelli AM, Liu Y, Sun LY, González-Cobos JC, Backs J, Trebak M, Singer HA.

Pflugers Arch. 2015 Dec;467(12):2541-54. doi: 10.1007/s00424-015-1713-5. Epub 2015 Jun 20.

37.

Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.

Zhang M, Hagenmueller M, Riffel JH, Kreusser MM, Bernhold E, Fan J, Katus HA, Backs J, Hardt SE.

Hypertension. 2015 Feb;65(2):335-44. doi: 10.1161/HYPERTENSIONAHA.114.04467. Epub 2014 Dec 8.

PMID:
25489064
38.

Dative Au→Al interactions: crystallographic characterization and computational analysis.

Devillard M, Nicolas E, Ehlers AW, Backs J, Mallet-Ladeira S, Bouhadir G, Slootweg JC, Uhl W, Bourissou D.

Chemistry. 2015 Jan 2;21(1):74-9. doi: 10.1002/chem.201405610. Epub 2014 Nov 21.

PMID:
25418872
39.

Novel zwitterionic complexes arising from the coordination of an ambiphilic phosphorus-aluminum ligand to gold.

Devillard M, Nicolas E, Appelt C, Backs J, Mallet-Ladeira S, Bouhadir G, Slootweg JC, Uhl W, Bourissou D.

Chem Commun (Camb). 2014 Dec 7;50(94):14805-8. doi: 10.1039/c4cc06992g.

PMID:
25319140
40.

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway.

Fredman G, Ozcan L, Spolitu S, Hellmann J, Spite M, Backs J, Tabas I.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14530-5. doi: 10.1073/pnas.1410851111. Epub 2014 Sep 22.

41.

Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling.

Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13499-504. doi: 10.1073/pnas.1409026111. Epub 2014 Sep 2.

42.

CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury.

Weinreuter M, Kreusser MM, Beckendorf J, Schreiter FC, Leuschner F, Lehmann LH, Hofmann KP, Rostosky JS, Diemert N, Xu C, Volz HC, Jungmann A, Nickel A, Sticht C, Gretz N, Maack C, Schneider MD, Gröne HJ, Müller OJ, Katus HA, Backs J.

EMBO Mol Med. 2014 Oct;6(10):1231-45. doi: 10.15252/emmm.201403848.

43.

Aldosterone augments Na+-induced reduction of cardiac norepinephrine reuptake.

Kreusser MM, Lehmann LH, Riffel JH, Haass M, Maser-Gluth C, Backs J, Katus HA, Buss SJ.

Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1169-77. doi: 10.1152/ajpheart.00193.2014. Epub 2014 Aug 15.

44.

Cardiac CaM Kinase II genes δ and γ contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy.

Kreusser MM, Lehmann LH, Keranov S, Hoting MO, Oehl U, Kohlhaas M, Reil JC, Neumann K, Schneider MD, Hill JA, Dobrev D, Maack C, Maier LS, Gröne HJ, Katus HA, Olson EN, Backs J.

Circulation. 2014 Oct 7;130(15):1262-73. doi: 10.1161/CIRCULATIONAHA.114.006185. Epub 2014 Aug 14.

45.

Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase.

Werfel S, Jungmann A, Lehmann L, Ksienzyk J, Bekeredjian R, Kaya Z, Leuchs B, Nordheim A, Backs J, Engelhardt S, Katus HA, Müller OJ.

Cardiovasc Res. 2014 Oct 1;104(1):15-23. doi: 10.1093/cvr/cvu174. Epub 2014 Jul 31.

PMID:
25082846
46.

Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa.

Dybkova N, Wagner S, Backs J, Hund TJ, Mohler PJ, Sowa T, Nikolaev VO, Maier LS.

Cardiovasc Res. 2014 Jul 1;103(1):168-77. doi: 10.1093/cvr/cvu120. Epub 2014 May 8.

47.

Integrated mechanisms of CaMKII-dependent ventricular remodeling.

Kreusser MM, Backs J.

Front Pharmacol. 2014 Mar 12;5:36. doi: 10.3389/fphar.2014.00036. eCollection 2014. Review.

48.

The role of endothelin-1 in the sympathetic nervous system in the heart.

Lehmann LH, Stanmore DA, Backs J.

Life Sci. 2014 Nov 24;118(2):165-72. doi: 10.1016/j.lfs.2014.03.005. Epub 2014 Mar 13. Review.

PMID:
24632477
49.

Histone deacetylase signaling in cardioprotection.

Lehmann LH, Worst BC, Stanmore DA, Backs J.

Cell Mol Life Sci. 2014 May;71(9):1673-90. doi: 10.1007/s00018-013-1516-9. Epub 2013 Dec 6. Review.

50.

Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.

Ozcan L, Cristina de Souza J, Harari AA, Backs J, Olson EN, Tabas I.

Cell Metab. 2013 Dec 3;18(6):803-15. doi: 10.1016/j.cmet.2013.10.011. Epub 2013 Nov 21.

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