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Items: 50

1.

Characterization and optimization of the novel TRPM2 antagonist tatM2NX.

Cruz-Torres I, Backos DS, Herson PS.

Mol Pharmacol. 2019 Nov 26. pii: mol.119.117549. doi: 10.1124/mol.119.117549. [Epub ahead of print]

2.

Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55.

Gifford G, Vu VP, Banda NK, Holers VM, Wang G, Groman EV, Backos D, Scheinman R, Moghimi SM, Simberg D.

J Control Release. 2019 May 28;302:181-189. doi: 10.1016/j.jconrel.2019.04.009. Epub 2019 Apr 8.

PMID:
30974134
3.

Identification and characterization of novel mutations implicated in congenital fibrinogen disorders.

Smith N, Bornikova L, Noetzli L, Guglielmone H, Minoldo S, Backos DS, Jacobson L, Thornburg CD, Escobar M, White-Adams TC, Wolberg AS, Manco-Johnson M, Di Paola J.

Res Pract Thromb Haemost. 2018 Jul 2;2(4):800-811. doi: 10.1002/rth2.12127. eCollection 2018 Oct.

4.

Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4.

Gates C, Backos DS, Reigan P, Kang HJ, Koerner C, Mirzaei J, Natale NR.

Bioorg Med Chem. 2018 Sep 15;26(17):4797-4803. doi: 10.1016/j.bmc.2018.08.012. Epub 2018 Aug 10.

5.

Compensatory Expression of Nur77 and Nurr1 Regulates NF-κB-Dependent Inflammatory Signaling in Astrocytes.

Popichak KA, Hammond SL, Moreno JA, Afzali MF, Backos DS, Slayden RD, Safe S, Tjalkens RB.

Mol Pharmacol. 2018 Oct;94(4):1174-1186. doi: 10.1124/mol.118.112631. Epub 2018 Aug 15.

6.

Development of Potent Pyrazolopyrimidinone-Based WEE1 Inhibitors with Limited Single-Agent Cytotoxicity for Cancer Therapy.

Matheson CJ, Casalvieri KA, Backos DS, Reigan P.

ChemMedChem. 2018 Aug 20;13(16):1681-1694. doi: 10.1002/cmdc.201800188. Epub 2018 Jul 11.

7.

The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism.

Hammond SL, Popichak KA, Li X, Hunt LG, Richman EH, Damale PU, Chong EKP, Backos DS, Safe S, Tjalkens RB.

J Pharmacol Exp Ther. 2018 Jun;365(3):636-651. doi: 10.1124/jpet.117.246389. Epub 2018 Apr 6.

8.

Redox modulation of NQO1.

Siegel D, Dehn DD, Bokatzian SS, Quinn K, Backos DS, Di Francesco A, Bernier M, Reisdorph N, de Cabo R, Ross D.

PLoS One. 2018 Jan 3;13(1):e0190717. doi: 10.1371/journal.pone.0190717. eCollection 2018.

9.

Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.

Assiri MA, Roy SR, Harris PS, Ali H, Liang Y, Shearn CT, Orlicky DJ, Roede JR, Hirschey MD, Backos DS, Fritz KS.

Alcohol Clin Exp Res. 2017 Oct;41(10):1705-1714. doi: 10.1111/acer.13473. Epub 2017 Sep 14.

10.

Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes.

Borghese CM, Herman M, Snell LD, Lawrence KJ, Lee HY, Backos DS, Vanderlinden LA, Harris RA, Roberto M, Hoffman PL, Tabakoff B.

Sci Rep. 2017 Jul 24;7(1):6230. doi: 10.1038/s41598-017-05966-x.

11.

Selective Targeting of RSK Isoforms in Cancer.

Casalvieri KA, Matheson CJ, Backos DS, Reigan P.

Trends Cancer. 2017 Apr;3(4):302-312. doi: 10.1016/j.trecan.2017.03.004. Epub 2017 Apr 3. Review.

PMID:
28718440
12.

Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter.

Steiger SA, Li C, Backos DS, Reigan P, Natale NR.

Bioorg Med Chem. 2017 Jun 15;25(12):3223-3234. doi: 10.1016/j.bmc.2017.04.008. Epub 2017 Apr 8.

13.

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.

Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, Olsen CA, Campbell JE, Muoio DM, Grimsrud PA, Hirschey MD.

Cell Metab. 2017 Apr 4;25(4):838-855.e15. doi: 10.1016/j.cmet.2017.03.003.

14.

A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.

Wagner GR, Bhatt DP, O'Connell TM, Thompson JW, Dubois LG, Backos DS, Yang H, Mitchell GA, Ilkayeva OR, Stevens RD, Grimsrud PA, Hirschey MD.

Cell Metab. 2017 Apr 4;25(4):823-837.e8. doi: 10.1016/j.cmet.2017.03.006.

15.

Characterizing Sirtuin 3 Deacetylase Affinity for Aldehyde Dehydrogenase 2.

Harris PS, Gomez JD, Backos DS, Fritz KS.

Chem Res Toxicol. 2017 Mar 20;30(3):785-793. doi: 10.1021/acs.chemrestox.6b00315. Epub 2017 Mar 1.

16.

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo.

Chen F, Wang G, Griffin JI, Brenneman B, Banda NK, Holers VM, Backos DS, Wu L, Moghimi SM, Simberg D.

Nat Nanotechnol. 2017 May;12(4):387-393. doi: 10.1038/nnano.2016.269. Epub 2016 Dec 19.

17.

Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors.

Furtek SL, Matheson CJ, Backos DS, Reigan P.

Oncotarget. 2016 Nov 22;7(47):77998-78008. doi: 10.18632/oncotarget.12868.

18.

Targeting WEE1 Kinase in Cancer.

Matheson CJ, Backos DS, Reigan P.

Trends Pharmacol Sci. 2016 Oct;37(10):872-881. doi: 10.1016/j.tips.2016.06.006. Epub 2016 Jul 14. Review.

PMID:
27427153
19.

A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization.

Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL.

PLoS One. 2016 Jun 28;11(6):e0158269. doi: 10.1371/journal.pone.0158269. eCollection 2016.

20.

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells.

Matheson CJ, Venkataraman S, Amani V, Harris PS, Backos DS, Donson AM, Wempe MF, Foreman NK, Vibhakar R, Reigan P.

ACS Chem Biol. 2016 Jul 15;11(7):2066-7. doi: 10.1021/acschembio.6b00466. Epub 2016 Jun 15. No abstract available.

PMID:
27304454
21.

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.

Madsen AS, Andersen C, Daoud M, Anderson KA, Laursen JS, Chakladar S, Huynh FK, Colaço AR, Backos DS, Fristrup P, Hirschey MD, Olsen CA.

J Biol Chem. 2016 Mar 25;291(13):7128-41. doi: 10.1074/jbc.M115.668699. Epub 2016 Feb 9.

22.

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells.

Matheson CJ, Venkataraman S, Amani V, Harris PS, Backos DS, Donson AM, Wempe MF, Foreman NK, Vibhakar R, Reigan P.

ACS Chem Biol. 2016 Apr 15;11(4):921-30. doi: 10.1021/acschembio.5b00725. Epub 2016 Jan 8. Erratum in: ACS Chem Biol. 2016 Jul 15;11(7):2066-7.

PMID:
26745241
23.

Strategies and Approaches of Targeting STAT3 for Cancer Treatment.

Furtek SL, Backos DS, Matheson CJ, Reigan P.

ACS Chem Biol. 2016 Feb 19;11(2):308-18. doi: 10.1021/acschembio.5b00945. Epub 2016 Jan 15. Review.

PMID:
26730496
24.

Structure-Based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors.

Xiong W, Matheson CJ, Xu M, Backos DS, Mills TS, Salian-Mehta S, Kiseljak-Vassiliades K, Reigan P, Wierman ME.

Mol Cancer Ther. 2016 Mar;15(3):412-20. doi: 10.1158/1535-7163.MCT-15-0703. Epub 2015 Dec 31.

25.

AIMing towards improved antitumor efficacy.

Weaver MJ, Kearns AK, Stump S, Li C, Gajewski MP, Rider KC, Backos DS, Reigan PR, Beall HD, Natale NR.

Bioorg Med Chem Lett. 2015 Apr 15;25(8):1765-1770. doi: 10.1016/j.bmcl.2015.02.063. Epub 2015 Mar 3.

26.

ROCK and Rho: Promising therapeutic targets to ameliorate pulmonary fibrosis.

Riches DW, Backos DS, Redente EF.

Am J Pathol. 2015 Apr;185(4):909-12. doi: 10.1016/j.ajpath.2015.01.005. Epub 2015 Feb 14.

27.

Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells.

Lee SO, Li X, Hedrick E, Jin UH, Tjalkens RB, Backos DS, Li L, Zhang Y, Wu Q, Safe S.

Mol Endocrinol. 2014 Oct;28(10):1729-39. doi: 10.1210/me.2014-1102. Epub 2014 Aug 6.

28.

Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.

Galligan JJ, Fritz KS, Backos DS, Shearn CT, Smathers RL, Jiang H, MacLean KN, Reigan PR, Petersen DR.

Free Radic Biol Med. 2014 Aug;73:411-20. doi: 10.1016/j.freeradbiomed.2014.06.002. Epub 2014 Jun 9.

29.

Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.

Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R.

J Biol Chem. 2014 Jun 6;289(23):16349-61. doi: 10.1074/jbc.M114.566729. Epub 2014 Apr 22.

30.

Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.

Shearn CT, Backos DS, Orlicky DJ, Smathers-McCullough RL, Petersen DR.

J Biol Chem. 2014 May 30;289(22):15449-62. doi: 10.1074/jbc.M113.543942. Epub 2014 Apr 10.

31.

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.

Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, Peterson BS, Xu G, Ilkayeva OR, Muehlbauer MJ, Braulke T, Mühlhausen C, Backos DS, Olsen CA, McGuire PJ, Pletcher SD, Lombard DB, Hirschey MD, Zhao Y.

Cell Metab. 2014 Apr 1;19(4):605-17. doi: 10.1016/j.cmet.2014.03.014.

32.

19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity.

Chang CH, Drechsel DA, Kitson RR, Siegel D, You Q, Backos DS, Ju C, Moody CJ, Ross D.

Mol Pharmacol. 2014 Jun;85(6):849-57. doi: 10.1124/mol.113.090654. Epub 2014 Mar 28.

33.

Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis.

Shearn CT, Smathers RL, Backos DS, Reigan P, Orlicky DJ, Petersen DR.

Free Radic Biol Med. 2013 Dec;65:680-692. doi: 10.1016/j.freeradbiomed.2013.07.011. Epub 2013 Jul 17.

34.

Glycation of glutamate cysteine ligase by 2-deoxy-d-ribose and its potential impact on chemoresistance in glioblastoma.

Backos DS, Fritz KS, McArthur DG, Kepa JK, Donson AM, Petersen DR, Foreman NK, Franklin CC, Reigan P.

Neurochem Res. 2013 Sep;38(9):1838-49. doi: 10.1007/s11064-013-1090-4. Epub 2013 Jun 7.

PMID:
23743623
35.

Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activation.

Sun AQ, Luo Y, Backos DS, Xu S, Balasubramaniyan N, Reigan P, Suchy FJ.

Mol Pharmacol. 2013 May;83(5):1078-86. doi: 10.1124/mol.113.084772. Epub 2013 Mar 5.

36.

ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1.

Vasiliou V, Sandoval M, Backos DS, Jackson BC, Chen Y, Reigan P, Lanaspa MA, Johnson RJ, Koppaka V, Thompson DC.

Chem Biol Interact. 2013 Feb 25;202(1-3):22-31. doi: 10.1016/j.cbi.2012.12.018. Epub 2013 Jan 21.

37.

Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2.

Jackson BC, Holmes RS, Backos DS, Reigan P, Thompson DC, Vasiliou V.

Chem Biol Interact. 2013 Feb 25;202(1-3):11-21. doi: 10.1016/j.cbi.2012.11.022. Epub 2012 Dec 13.

38.

Post-translational oxidative modification and inactivation of mitochondrial complex I in epileptogenesis.

Ryan K, Backos DS, Reigan P, Patel M.

J Neurosci. 2012 Aug 15;32(33):11250-8. doi: 10.1523/JNEUROSCI.0907-12.2012.

39.

Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease.

Galligan JJ, Smathers RL, Shearn CT, Fritz KS, Backos DS, Jiang H, Franklin CC, Orlicky DJ, Maclean KN, Petersen DR.

J Toxicol. 2012;2012:207594. doi: 10.1155/2012/207594. Epub 2012 Jul 5.

40.

The role of glutathione in brain tumor drug resistance.

Backos DS, Franklin CC, Reigan P.

Biochem Pharmacol. 2012 Apr 15;83(8):1005-12. doi: 10.1016/j.bcp.2011.11.016. Epub 2011 Nov 28. Review.

PMID:
22138445
41.

2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways.

Kachadourian R, Pugazhenthi S, Velmurugan K, Backos DS, Franklin CC, McCord JM, Day BJ.

Free Radic Biol Med. 2011 Sep 15;51(6):1146-54. doi: 10.1016/j.freeradbiomed.2011.05.041. Epub 2011 Jun 13.

42.

Posttranslational modification and regulation of glutamate-cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal.

Backos DS, Fritz KS, Roede JR, Petersen DR, Franklin CC.

Free Radic Biol Med. 2011 Jan 1;50(1):14-26. doi: 10.1016/j.freeradbiomed.2010.10.694. Epub 2010 Oct 21.

43.
44.

Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase.

Franklin CC, Backos DS, Mohar I, White CC, Forman HJ, Kavanagh TJ.

Mol Aspects Med. 2009 Feb-Apr;30(1-2):86-98. doi: 10.1016/j.mam.2008.08.009. Epub 2008 Sep 6. Review.

45.

Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation.

Correia SS, Bassani S, Brown TC, Lisé MF, Backos DS, El-Husseini A, Passafaro M, Esteban JA.

Nat Neurosci. 2008 Apr;11(4):457-66. doi: 10.1038/nn2063. Epub 2008 Mar 2.

46.

Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons.

Caldeira MV, Melo CV, Pereira DB, Carvalho R, Correia SS, Backos DS, Carvalho AL, Esteban JA, Duarte CB.

J Biol Chem. 2007 Apr 27;282(17):12619-28. Epub 2007 Mar 2. Erratum in: J Biol Chem. 2007 Sep 14;282(37):27556.

47.

Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane.

Gerges NZ, Backos DS, Rupasinghe CN, Spaller MR, Esteban JA.

EMBO J. 2006 Apr 19;25(8):1623-34. Epub 2006 Apr 6.

48.
49.

Local control of AMPA receptor trafficking at the postsynaptic terminal by a small GTPase of the Rab family.

Gerges NZ, Backos DS, Esteban JA.

J Biol Chem. 2004 Oct 15;279(42):43870-8. Epub 2004 Aug 5.

50.

Independent functions of hsp90 in neurotransmitter release and in the continuous synaptic cycling of AMPA receptors.

Gerges NZ, Tran IC, Backos DS, Harrell JM, Chinkers M, Pratt WB, Esteban JA.

J Neurosci. 2004 May 19;24(20):4758-66.

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