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Items: 1 to 50 of 180

1.

Use of busulfan in conditioning for allogeneic hematopoietic stem cell transplantation in adults: a survey by the Transplant Complications Working Party of the EBMT.

Ruutu T, van der Werf S, van Biezen A, Backman JT, Peczynski C, Kröger N, Mohty M, Nagler A, Montoto S, Langebrake C, Niederwieser D, Peric Z, Koenecke C, Duarte RF, Basak G.

Bone Marrow Transplant. 2019 Jun 3. doi: 10.1038/s41409-019-0579-0. [Epub ahead of print]

PMID:
31160806
2.

Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs.

Lilius TO, Blomqvist K, Hauglund NL, Liu G, Stæger FF, Bærentzen S, Du T, Ahlström F, Backman JT, Kalso EA, Rauhala PV, Nedergaard M.

J Control Release. 2019 Jun 28;304:29-38. doi: 10.1016/j.jconrel.2019.05.005. Epub 2019 May 5.

3.

Fluoroquinolone-related adverse events resulting in health service use and costs: A systematic review.

Kuula LSM, Viljemaa KM, Backman JT, Blom M.

PLoS One. 2019 Apr 26;14(4):e0216029. doi: 10.1371/journal.pone.0216029. eCollection 2019.

4.

Enantiospecific Pharmacogenomics of Fluvastatin.

Hirvensalo P, Tornio A, Neuvonen M, Kiander W, Kidron H, Paile-Hyvärinen M, Tapaninen T, Backman JT, Niemi M.

Clin Pharmacol Ther. 2019 Sep;106(3):668-680. doi: 10.1002/cpt.1463. Epub 2019 May 14.

5.

Clinical Studies on Drug-Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation.

Tornio A, Filppula AM, Niemi M, Backman JT.

Clin Pharmacol Ther. 2019 Jun;105(6):1345-1361. doi: 10.1002/cpt.1435. Epub 2019 Apr 20.

6.

Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8.

Kahma H, Filppula AM, Launiainen T, Viinamäki J, Neuvonen M, Evangelista EA, Totah RA, Backman JT.

Drug Metab Dispos. 2019 Apr;47(4):436-443. doi: 10.1124/dmd.118.085498. Epub 2019 Feb 1.

PMID:
30709838
7.

Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2019 Apr;47(4):377-385. doi: 10.1124/dmd.118.084665. Epub 2019 Jan 10.

PMID:
30630815
8.

Response to "Interaction of Dasabuvir With Clopidogrel: Did Predictions by Physiologically Based Pharmacokinetics Modeling Pass the Test?"

Itkonen MK, Tornio A, Lapatto-Reiniluoto O, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2019 Feb;105(2):322. doi: 10.1002/cpt.1195. Epub 2018 Sep 17. No abstract available.

PMID:
30226021
9.

Voriconazole greatly increases the exposure to oral buprenorphine.

Fihlman M, Hemmilä T, Hagelberg NM, Backman JT, Laitila J, Laine K, Neuvonen PJ, Olkkola KT, Saari TI.

Eur J Clin Pharmacol. 2018 Dec;74(12):1615-1622. doi: 10.1007/s00228-018-2548-8. Epub 2018 Aug 30.

PMID:
30167757
10.

CYP3A4*22 Impairs the Elimination of Ticagrelor, But Has No Significant Effect on the Bioactivation of Clopidogrel or Prasugrel.

Holmberg MT, Tornio A, Paile-Hyvärinen M, Tarkiainen EK, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Clin Pharmacol Ther. 2019 Feb;105(2):448-457. doi: 10.1002/cpt.1177. Epub 2018 Aug 20.

PMID:
29998574
11.

In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug-Drug Interactions.

Filppula AM, Mustonen TM, Backman JT.

Basic Clin Pharmacol Toxicol. 2018 Dec;123(6):739-748. doi: 10.1111/bcpt.13088. Epub 2018 Aug 9.

PMID:
29956478
12.

Cytochrome P450 in Pharmacogenetics: An Update.

Tornio A, Backman JT.

Adv Pharmacol. 2018;83:3-32. doi: 10.1016/bs.apha.2018.04.007. Review.

PMID:
29801580
13.

Clopidogrel Increases Dasabuvir Exposure With or Without Ritonavir, and Ritonavir Inhibits the Bioactivation of Clopidogrel.

Itkonen MK, Tornio A, Lapatto-Reiniluoto O, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2019 Jan;105(1):219-228. doi: 10.1002/cpt.1099. Epub 2018 Aug 9.

14.

Pulmonary administration of a dry powder formulation of the antifibrotic drug tilorone reduces silica-induced lung fibrosis in mice.

Vartiainen V, Raula J, Bimbo LM, Viinamäki J, Backman JT, Ugur N, Kauppinen E, Sutinen E, Joensuu E, Koli K, Myllärniemi M.

Int J Pharm. 2018 Jun 10;544(1):121-128. doi: 10.1016/j.ijpharm.2018.04.019. Epub 2018 Apr 12.

PMID:
29655797
15.

Implications of intercorrelation between hepatic CYP3A4-CYP2C8 enzymes for the evaluation of drug-drug interactions: a case study with repaglinide.

Doki K, Darwich AS, Achour B, Tornio A, Backman JT, Rostami-Hodjegan A.

Br J Clin Pharmacol. 2018 May;84(5):972-986. doi: 10.1111/bcp.13533. Epub 2018 Mar 6.

16.

Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle.

Hulmi JJ, Nissinen TA, Räsänen M, Degerman J, Lautaoja JH, Hemanthakumar KA, Backman JT, Ritvos O, Silvennoinen M, Kivelä R.

J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):417-432. doi: 10.1002/jcsm.12265. Epub 2017 Dec 11.

17.

Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.

Itkonen MK, Tornio A, Filppula AM, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2018 Sep;104(3):495-504. doi: 10.1002/cpt.947. Epub 2017 Dec 23.

18.

Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions.

Kahma H, Filppula AM, Neuvonen M, Tarkiainen EK, Tornio A, Holmberg MT, Itkonen MK, Finel M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2018 Feb;46(2):141-150. doi: 10.1124/dmd.117.078162. Epub 2017 Nov 14.

PMID:
29138287
19.

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects.

Neuvonen M, Tarkiainen EK, Tornio A, Hirvensalo P, Tapaninen T, Paile-Hyvärinen M, Itkonen MK, Holmberg MT, Kärjä V, Männistö VT, Neuvonen PJ, Pihlajamäki J, Backman JT, Niemi M.

Basic Clin Pharmacol Toxicol. 2018 Mar;122(3):341-345. doi: 10.1111/bcpt.12916. Epub 2017 Nov 17.

20.

Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics.

Hirvensalo P, Tornio A, Neuvonen M, Tapaninen T, Paile-Hyvärinen M, Kärjä V, Männistö VT, Pihlajamäki J, Backman JT, Niemi M.

Clin Pharmacol Ther. 2018 Jul;104(1):158-168. doi: 10.1002/cpt.891. Epub 2017 Nov 6.

21.

Using Hilbert-Huang Transform to assess EEG slow wave activity during anesthesia in post-cardiac arrest patients.

Kortelainen J, Vayrynen E, Huuskonen U, Laurila J, Koskenkari J, Backman JT, Alahuhta S, Seppanen T, Ala-Kokko T.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:1850-1853. doi: 10.1109/EMBC.2016.7591080.

PMID:
28268686
22.

Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis.

Morel J, Hargreaves I, Brealey D, Neergheen V, Backman JT, Lindig S, Bläss M, Bauer M, McAuley DF, Singer M.

Clin Sci (Lond). 2017 Apr 25;131(8):747-758. doi: 10.1042/CS20160802. Epub 2017 Feb 15.

PMID:
28202686
23.

Rifampicin decreases exposure to sublingual buprenorphine in healthy subjects.

Hagelberg NM, Fihlman M, Hemmilä T, Backman JT, Laitila J, Neuvonen PJ, Laine K, Olkkola KT, Saari TI.

Pharmacol Res Perspect. 2016 Nov 3;4(6):e00271. doi: 10.1002/prp2.271. eCollection 2016 Dec.

24.

VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection.

Räsänen M, Degerman J, Nissinen TA, Miinalainen I, Kerkelä R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, Kivelä R, Alitalo K.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13144-13149. Epub 2016 Oct 31.

25.

Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury.

Kortelainen J, Väyrynen E, Huuskonen U, Laurila J, Koskenkari J, Backman JT, Alahuhta S, Seppänen T, Ala-Kokko T.

Anesthesiology. 2017 Jan;126(1):94-103.

PMID:
27749312
26.

Clinical Drug-Drug Interaction Studies: Methods, Pitfalls, and Interpretation.

Backman JT.

Clin Ther. 2016 Oct 6;38(10S):e1-e2. doi: 10.1016/j.clinthera.2016.07.014. No abstract available.

PMID:
27673600
27.

Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters.

Tornio A, Neuvonen PJ, Niemi M, Backman JT.

Expert Opin Drug Metab Toxicol. 2017 Jan;13(1):83-95. Epub 2016 Aug 31. Review.

PMID:
27548563
28.

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction.

Fihlman M, Hemmilä T, Hagelberg NM, Kuusniemi K, Backman JT, Laitila J, Laine K, Neuvonen PJ, Olkkola KT, Saari TI.

Eur J Clin Pharmacol. 2016 Nov;72(11):1363-1371. Epub 2016 Aug 10.

PMID:
27510521
29.

Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2016 Aug;44(8):1364-71. doi: 10.1124/dmd.116.070375. Epub 2016 Jun 3.

PMID:
27260150
30.

The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs.

Heinonen JA, Schramko AA, Skrifvars MB, Litonius E, Backman JT, Mervaala E, Rosenberg PH.

Hum Exp Toxicol. 2017 Apr;36(4):365-375. doi: 10.1177/0960327116650010. Epub 2016 May 24.

PMID:
27222493
31.

Intravenous lipid emulsion for levobupivacaine intoxication in acidotic and hypoxaemic pigs.

Heinonen JA, Skrifvars MB, Haasio J, Backman JT, Rosenberg PH, Litonius E.

Anaesth Intensive Care. 2016 Mar;44(2):270-7.

32.

Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.

Backman JT, Filppula AM, Niemi M, Neuvonen PJ.

Pharmacol Rev. 2016 Jan;68(1):168-241. doi: 10.1124/pr.115.011411. Review.

PMID:
26721703
33.

Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2015 Nov;43(11):1655-60. doi: 10.1124/dmd.115.065938. Epub 2015 Sep 1.

PMID:
26329790
34.

Drug-Related Inadvertent Deaths in a University Hospital--A Declining Trend.

Lapatto-Reiniluoto O, Patinen L, Niemi M, Backman JT, Neuvonen PJ.

Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):421-6. doi: 10.1111/bcpt.12435. Epub 2015 Jul 21.

35.

SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid.

Tornio A, Vakkilainen J, Neuvonen M, Backman JT, Neuvonen PJ, Niemi M.

Pharmacogenet Genomics. 2015 Aug;25(8):382-7. doi: 10.1097/FPC.0000000000000148.

PMID:
26020121
36.

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril.

Tarkiainen EK, Tornio A, Holmberg MT, Launiainen T, Neuvonen PJ, Backman JT, Niemi M.

Br J Clin Pharmacol. 2015 Nov;80(5):1131-8. doi: 10.1111/bcp.12667. Epub 2015 Jun 11.

37.

Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing.

Fanta S, Kinnunen M, Backman JT, Kalso E.

Eur J Clin Pharmacol. 2015 Apr;71(4):441-7. doi: 10.1007/s00228-015-1826-y. Epub 2015 Mar 1.

PMID:
25724645
38.

Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans.

Tarkiainen EK, Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Clin Pharmacol Ther. 2015 Jun;97(6):650-8. doi: 10.1002/cpt.101. Epub 2015 May 9.

PMID:
25704243
39.

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol.

Saarikoski T, Saari TI, Hagelberg NM, Backman JT, Neuvonen PJ, Scheinin M, Olkkola KT, Laine K.

Eur J Clin Pharmacol. 2015 Mar;71(3):321-7. doi: 10.1007/s00228-014-1799-2. Epub 2015 Jan 6.

PMID:
25560051
40.

Effect of grapefruit juice on the bioactivation of prasugrel.

Holmberg MT, Tornio A, Hyvärinen H, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Br J Clin Pharmacol. 2015 Jul;80(1):139-45. doi: 10.1111/bcp.12581. Epub 2015 Jun 1.

41.

Paroxetine markedly increases plasma concentrations of ophthalmic timolol; CYP2D6 inhibitors may increase the risk of cardiovascular adverse effects of 0.5% timolol eye drops.

Mäenpää J, Volotinen-Maja M, Kautiainen H, Neuvonen M, Niemi M, Neuvonen PJ, Backman JT.

Drug Metab Dispos. 2014 Dec;42(12):2068-76. doi: 10.1124/dmd.114.059576. Epub 2014 Sep 26.

PMID:
25261563
42.

Intravenous lipid emulsion given to volunteers does not affect symptoms of lidocaine brain toxicity.

Heinonen JA, Litonius E, Salmi T, Haasio J, Tarkkila P, Backman JT, Rosenberg PH.

Basic Clin Pharmacol Toxicol. 2015 Apr;116(4):378-83. doi: 10.1111/bcpt.12321. Epub 2014 Oct 7.

43.

Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions.

Tornio A, Filppula AM, Kailari O, Neuvonen M, Nyrönen TH, Tapaninen T, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2014 Oct;96(4):498-507. doi: 10.1038/clpt.2014.141. Epub 2014 Jun 27.

PMID:
24971633
44.

In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors.

Filppula AM, Neuvonen PJ, Backman JT.

Drug Metab Dispos. 2014 Jul;42(7):1202-9. doi: 10.1124/dmd.114.057695. Epub 2014 Apr 8.

PMID:
24713129
45.

Grapefruit juice inhibits the metabolic activation of clopidogrel.

Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Clin Pharmacol Ther. 2014 Mar;95(3):307-13. doi: 10.1038/clpt.2013.192. Epub 2013 Sep 25.

PMID:
24067745
46.

Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial.

Shyamsundar M, McAuley DF, Shields MO, MacSweeney R, Duffy MJ, Johnston JR, McGuigan J, Backman JT, Calfee CS, Matthay MM, Griffiths MJ, McDowell C, Elborn SJ, OʼKane CM.

Ann Surg. 2014 Jan;259(1):26-31. doi: 10.1097/SLA.0b013e31829d686b.

PMID:
23817506
47.

Gemfibrozil impairs imatinib absorption and inhibits the CYP2C8-mediated formation of its main metabolite.

Filppula AM, Tornio A, Niemi M, Neuvonen PJ, Backman JT.

Clin Pharmacol Ther. 2013 Sep;94(3):383-93. doi: 10.1038/clpt.2013.92. Epub 2013 May 8.

PMID:
23657159
48.

Intravenous lipid emulsion entraps amitriptyline into plasma and can lower its brain concentration--an experimental intoxication study in pigs.

Heinonen JA, Litonius E, Backman JT, Neuvonen PJ, Rosenberg PH.

Basic Clin Pharmacol Toxicol. 2013 Sep;113(3):193-200. doi: 10.1111/bcpt.12082. Epub 2013 May 29.

49.

A time-to-event model for acute rejections in paediatric renal transplant recipients treated with ciclosporin A.

Frobel AK, Karlsson MO, Backman JT, Hoppu K, Qvist E, Seikku P, Jalanko H, Holmberg C, Keizer RJ, Fanta S, Jönsson S.

Br J Clin Pharmacol. 2013 Oct;76(4):603-15. doi: 10.1111/bcp.12121.

50.

SLCO2B1 c.935G>A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren.

Tapaninen T, Karonen T, Backman JT, Neuvonen PJ, Niemi M.

Pharmacogenet Genomics. 2013 Jan;23(1):19-24. doi: 10.1097/FPC.0b013e32835bac90.

PMID:
23151832

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