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CYP3A4*22 impairs the elimination of ticagrelor, but has no significant effect on the bioactivation of clopidogrel or prasugrel.

Holmberg MT, Tornio A, Paile-Hyvärinen M, Tarkiainen EK, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Clin Pharmacol Ther. 2018 Jul 11. doi: 10.1002/cpt.1177. [Epub ahead of print]


In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug-Drug Interactions.

Filppula AM, Mustonen TM, Backman JT.

Basic Clin Pharmacol Toxicol. 2018 Jun 28. doi: 10.1111/bcpt.13088. [Epub ahead of print]


Cytochrome P450 in Pharmacogenetics: An Update.

Tornio A, Backman JT.

Adv Pharmacol. 2018;83:3-32. doi: 10.1016/bs.apha.2018.04.007.


Clopidogrel Increases Dasabuvir Exposure With or Without Ritonavir, and Ritonavir Inhibits the Bioactivation of Clopidogrel.

Itkonen MK, Tornio A, Lapatto-Reiniluoto O, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2018 Apr 26. doi: 10.1002/cpt.1099. [Epub ahead of print]


Pulmonary administration of a dry powder formulation of the antifibrotic drug tilorone reduces silica-induced lung fibrosis in mice.

Vartiainen V, Raula J, Bimbo LM, Viinamäki J, Backman JT, Ugur N, Kauppinen E, Sutinen E, Joensuu E, Koli K, Myllärniemi M.

Int J Pharm. 2018 Jun 10;544(1):121-128. doi: 10.1016/j.ijpharm.2018.04.019. Epub 2018 Apr 12.


Implications of intercorrelation between hepatic CYP3A4-CYP2C8 enzymes for the evaluation of drug-drug interactions: a case study with repaglinide.

Doki K, Darwich AS, Achour B, Tornio A, Backman JT, Rostami-Hodjegan A.

Br J Clin Pharmacol. 2018 May;84(5):972-986. doi: 10.1111/bcp.13533. Epub 2018 Mar 6.


Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle.

Hulmi JJ, Nissinen TA, Räsänen M, Degerman J, Lautaoja JH, Hemanthakumar KA, Backman JT, Ritvos O, Silvennoinen M, Kivelä R.

J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):417-432. doi: 10.1002/jcsm.12265. Epub 2017 Dec 11.


Exome-chip meta-analysis identifies association between variation in ANKRD26 and platelet aggregation.

Chen MH, Yanek LR, Backman JD, Eicher JD, Huffman JE, Ben-Shlomo Y, Beswick AD, Yerges-Armstrong LM, Shuldiner AR, O'Connell JR, Mathias RA, Becker DM, Becker LC, Lewis JP, Johnson AD, Faraday N.

Platelets. 2017 Nov 29:1-10. doi: 10.1080/09537104.2017.1384538. [Epub ahead of print]


Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.

Itkonen MK, Tornio A, Filppula AM, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2017 Nov 24. doi: 10.1002/cpt.947. [Epub ahead of print]


Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions.

Kahma H, Filppula AM, Neuvonen M, Tarkiainen EK, Tornio A, Holmberg MT, Itkonen MK, Finel M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2018 Feb;46(2):141-150. doi: 10.1124/dmd.117.078162. Epub 2017 Nov 14.


Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects.

Neuvonen M, Tarkiainen EK, Tornio A, Hirvensalo P, Tapaninen T, Paile-Hyvärinen M, Itkonen MK, Holmberg MT, Kärjä V, Männistö VT, Neuvonen PJ, Pihlajamäki J, Backman JT, Niemi M.

Basic Clin Pharmacol Toxicol. 2018 Mar;122(3):341-345. doi: 10.1111/bcpt.12916. Epub 2017 Nov 17.


Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics.

Hirvensalo P, Tornio A, Neuvonen M, Tapaninen T, Paile-Hyvärinen M, Kärjä V, Männistö VT, Pihlajamäki J, Backman JT, Niemi M.

Clin Pharmacol Ther. 2018 Jul;104(1):158-168. doi: 10.1002/cpt.891. Epub 2017 Nov 6.


Release of mineral-bound water prior to subduction tied to shallow seismogenic slip off Sumatra.

Hüpers A, Torres ME, Owari S, McNeill LC, Dugan B, Henstock TJ, Milliken KL, Petronotis KE, Backman J, Bourlange S, Chemale F Jr, Chen W, Colson TA, Frederik MCG, Guèrin G, Hamahashi M, House BM, Jeppson TN, Kachovich S, Kenigsberg AR, Kuranaga M, Kutterolf S, Mitchison FL, Mukoyoshi H, Nair N, Pickering KT, Pouderoux HFA, Shan Y, Song I, Vannucchi P, Vrolijk PJ, Yang T, Zhao X.

Science. 2017 May 26;356(6340):841-844. doi: 10.1126/science.aal3429.


Actogram analysis of free-flying migratory birds: new perspectives based on acceleration logging.

Bäckman J, Andersson A, Pedersen L, Sjöberg S, Tøttrup AP, Alerstam T.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017 Jul;203(6-7):543-564. doi: 10.1007/s00359-017-1165-9. Epub 2017 Mar 25. Review.


Using Hilbert-Huang Transform to assess EEG slow wave activity during anesthesia in post-cardiac arrest patients.

Kortelainen J, Vayrynen E, Huuskonen U, Laurila J, Koskenkari J, Backman JT, Alahuhta S, Seppanen T, Ala-Kokko T.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:1850-1853. doi: 10.1109/EMBC.2016.7591080.


Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response.

Backman JD, O'Connell JR, Tanner K, Peer CJ, Figg WD, Spencer SD, Mitchell BD, Shuldiner AR, Yerges-Armstrong LM, Horenstein RB, Lewis JP.

Pharmacogenet Genomics. 2017 Apr;27(4):159-163. doi: 10.1097/FPC.0000000000000272.


Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis.

Morel J, Hargreaves I, Brealey D, Neergheen V, Backman JT, Lindig S, Bläss M, Bauer M, McAuley DF, Singer M.

Clin Sci (Lond). 2017 Apr 25;131(8):747-758. doi: 10.1042/CS20160802. Epub 2017 Feb 15.


Rifampicin decreases exposure to sublingual buprenorphine in healthy subjects.

Hagelberg NM, Fihlman M, Hemmilä T, Backman JT, Laitila J, Neuvonen PJ, Laine K, Olkkola KT, Saari TI.

Pharmacol Res Perspect. 2016 Nov 3;4(6):e00271. doi: 10.1002/prp2.271. eCollection 2016 Dec.


Annual 10-Month Aerial Life Phase in the Common Swift Apus apus.

Hedenström A, Norevik G, Warfvinge K, Andersson A, Bäckman J, Åkesson S.

Curr Biol. 2016 Nov 21;26(22):3066-3070. doi: 10.1016/j.cub.2016.09.014. Epub 2016 Oct 27.


Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin-Dependent Effects on Platelet Aggregation Pathways.

Backman JD, Yerges-Armstrong LM, Horenstein RB, Newcomer S, Shaub S, Morrisey M, Donnelly P, Drolet M, Tanner K, Pavlovich MA, O'Connell JR, Mitchell BD, Lewis JP.

Clin Transl Sci. 2017 Mar;10(2):102-109. doi: 10.1111/cts.12438. Epub 2017 Jan 11.


VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection.

Räsänen M, Degerman J, Nissinen TA, Miinalainen I, Kerkelä R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, Kivelä R, Alitalo K.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13144-13149. Epub 2016 Oct 31.


Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury.

Kortelainen J, Väyrynen E, Huuskonen U, Laurila J, Koskenkari J, Backman JT, Alahuhta S, Seppänen T, Ala-Kokko T.

Anesthesiology. 2017 Jan;126(1):94-103.


Clinical Drug-Drug Interaction Studies: Methods, Pitfalls, and Interpretation.

Backman JT.

Clin Ther. 2016 Oct 6;38(10S):e1-e2. doi: 10.1016/j.clinthera.2016.07.014. No abstract available.


Effect of Two Lipoprotein (a)-Associated Genetic Variants on Plasminogen Levels and Fibrinolysis.

Wang H, Hong CE, Lewis JP, Zhu Y, Wang X, Chu X, Backman J, Hu Z, Yang P, Still CD, Gerhard GS, Fu M.

G3 (Bethesda). 2016 Sep 7. pii: g3.116.034702. doi: 10.1534/g3.116.034702. [Epub ahead of print]


Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters.

Tornio A, Neuvonen PJ, Niemi M, Backman JT.

Expert Opin Drug Metab Toxicol. 2017 Jan;13(1):83-95. Epub 2016 Aug 31. Review.


Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction.

Fihlman M, Hemmilä T, Hagelberg NM, Kuusniemi K, Backman JT, Laitila J, Laine K, Neuvonen PJ, Olkkola KT, Saari TI.

Eur J Clin Pharmacol. 2016 Nov;72(11):1363-1371. Epub 2016 Aug 10.


From Genotype to Phenotype: Nonsense Variants in SLC13A1 Are Associated with Decreased Serum Sulfate and Increased Serum Aminotransferases.

Tise CG, Perry JA, Anforth LE, Pavlovich MA, Backman JD, Ryan KA, Lewis JP, O'Connell JR, Yerges-Armstrong LM, Shuldiner AR.

G3 (Bethesda). 2016 Sep 8;6(9):2909-18. doi: 10.1534/g3.116.032979.


Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2016 Aug;44(8):1364-71. doi: 10.1124/dmd.116.070375. Epub 2016 Jun 3.


The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs.

Heinonen JA, Schramko AA, Skrifvars MB, Litonius E, Backman JT, Mervaala E, Rosenberg PH.

Hum Exp Toxicol. 2017 Apr;36(4):365-375. doi: 10.1177/0960327116650010. Epub 2016 May 24.


Intravenous lipid emulsion for levobupivacaine intoxication in acidotic and hypoxaemic pigs.

Heinonen JA, Skrifvars MB, Haasio J, Backman JT, Rosenberg PH, Litonius E.

Anaesth Intensive Care. 2016 Mar;44(2):270-7.


Evidence for an ice shelf covering the central Arctic Ocean during the penultimate glaciation.

Jakobsson M, Nilsson J, Anderson L, Backman J, Björk G, Cronin TM, Kirchner N, Koshurnikov A, Mayer L, Noormets R, O'Regan M, Stranne C, Ananiev R, Barrientos Macho N, Cherniykh D, Coxall H, Eriksson B, Flodén T, Gemery L, Gustafsson Ö, Jerram K, Johansson C, Khortov A, Mohammad R, Semiletov I.

Nat Commun. 2016 Jan 18;7:10365. doi: 10.1038/ncomms10365.


Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.

Backman JT, Filppula AM, Niemi M, Neuvonen PJ.

Pharmacol Rev. 2016 Jan;68(1):168-241. doi: 10.1124/pr.115.011411. Review.


Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60-year-old Caucasian woman with ovarian carcinoma.

Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K.

Br J Clin Pharmacol. 2016 Feb;81(2):313-5.


Genetic Variation in the Platelet Endothelial Aggregation Receptor 1 Gene Results in Endothelial Dysfunction.

Fisch AS, Yerges-Armstrong LM, Backman JD, Wang H, Donnelly P, Ryan KA, Parihar A, Pavlovich MA, Mitchell BD, O'Connell JR, Herzog W, Harman CR, Wren JD, Lewis JP.

PLoS One. 2015 Sep 25;10(9):e0138795. doi: 10.1371/journal.pone.0138795. eCollection 2015.


Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2015 Nov;43(11):1655-60. doi: 10.1124/dmd.115.065938. Epub 2015 Sep 1.


Detection of flow direction in high-flying insect and songbird migrants.

Chapman JW, Nilsson C, Lim KS, Bäckman J, Reynolds DR, Alerstam T, Reynolds AM.

Curr Biol. 2015 Aug 31;25(17):R751-2. doi: 10.1016/j.cub.2015.07.074.


Adaptive strategies in nocturnally migrating insects and songbirds: contrasting responses to wind.

Chapman JW, Nilsson C, Lim KS, Bäckman J, Reynolds DR, Alerstam T.

J Anim Ecol. 2016 Jan;85(1):115-24. doi: 10.1111/1365-2656.12420. Epub 2015 Aug 17.


Drug-Related Inadvertent Deaths in a University Hospital--A Declining Trend.

Lapatto-Reiniluoto O, Patinen L, Niemi M, Backman JT, Neuvonen PJ.

Basic Clin Pharmacol Toxicol. 2015 Dec;117(6):421-6. doi: 10.1111/bcpt.12435. Epub 2015 Jul 21.


SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid.

Tornio A, Vakkilainen J, Neuvonen M, Backman JT, Neuvonen PJ, Niemi M.

Pharmacogenet Genomics. 2015 Aug;25(8):382-7. doi: 10.1097/FPC.0000000000000148.


Targeting matrix metalloproteinases with intravenous doxycycline in severe sepsis--A randomised placebo-controlled pilot trial.

Nukarinen E, Tervahartiala T, Valkonen M, Hynninen M, Kolho E, Pettilä V, Sorsa T, Backman J, Hästbacka J.

Pharmacol Res. 2015 Sep;99:44-51. doi: 10.1016/j.phrs.2015.05.005. Epub 2015 May 22.


Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril.

Tarkiainen EK, Tornio A, Holmberg MT, Launiainen T, Neuvonen PJ, Backman JT, Niemi M.

Br J Clin Pharmacol. 2015 Nov;80(5):1131-8. doi: 10.1111/bcp.12667. Epub 2015 Jun 11.


Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing.

Fanta S, Kinnunen M, Backman JT, Kalso E.

Eur J Clin Pharmacol. 2015 Apr;71(4):441-7. doi: 10.1007/s00228-015-1826-y. Epub 2015 Mar 1.


Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans.

Tarkiainen EK, Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Clin Pharmacol Ther. 2015 Jun;97(6):650-8. doi: 10.1002/cpt.101. Epub 2015 May 9.


Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol.

Saarikoski T, Saari TI, Hagelberg NM, Backman JT, Neuvonen PJ, Scheinin M, Olkkola KT, Laine K.

Eur J Clin Pharmacol. 2015 Mar;71(3):321-7. doi: 10.1007/s00228-014-1799-2. Epub 2015 Jan 6.


Effect of grapefruit juice on the bioactivation of prasugrel.

Holmberg MT, Tornio A, Hyvärinen H, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Br J Clin Pharmacol. 2015 Jul;80(1):139-45. doi: 10.1111/bcp.12581. Epub 2015 Jun 1.


Paroxetine markedly increases plasma concentrations of ophthalmic timolol; CYP2D6 inhibitors may increase the risk of cardiovascular adverse effects of 0.5% timolol eye drops.

Mäenpää J, Volotinen-Maja M, Kautiainen H, Neuvonen M, Niemi M, Neuvonen PJ, Backman JT.

Drug Metab Dispos. 2014 Dec;42(12):2068-76. doi: 10.1124/dmd.114.059576. Epub 2014 Sep 26.


Intravenous lipid emulsion given to volunteers does not affect symptoms of lidocaine brain toxicity.

Heinonen JA, Litonius E, Salmi T, Haasio J, Tarkkila P, Backman JT, Rosenberg PH.

Basic Clin Pharmacol Toxicol. 2015 Apr;116(4):378-83. doi: 10.1111/bcpt.12321. Epub 2014 Oct 7.


Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions.

Tornio A, Filppula AM, Kailari O, Neuvonen M, Nyrönen TH, Tapaninen T, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2014 Oct;96(4):498-507. doi: 10.1038/clpt.2014.141. Epub 2014 Jun 27.


In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors.

Filppula AM, Neuvonen PJ, Backman JT.

Drug Metab Dispos. 2014 Jul;42(7):1202-9. doi: 10.1124/dmd.114.057695. Epub 2014 Apr 8.


Familial aggregation of tobacco use behaviors among Amish men.

Nugent KL, Million-Mrkva A, Backman J, Stephens SH, Reed RM, Kochunov P, Pollin TI, Shuldiner AR, Mitchell BD, Hong LE.

Nicotine Tob Res. 2014 Jul;16(7):923-30. doi: 10.1093/ntr/ntu006. Epub 2014 Feb 28.

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