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Chaperone activity of serine protease HtrA of Helicobacter pylori as a crucial survival factor under stress conditions.

Zarzecka U, Harrer A, Zawilak-Pawlik A, Skorko-Glonek J, Backert S.

Cell Commun Signal. 2019 Dec 3;17(1):161. doi: 10.1186/s12964-019-0481-9.


Establishment of serine protease htrA mutants in Helicobacter pylori is associated with secA mutations.

Zawilak-Pawlik A, Zarzecka U, Żyła-Uklejewicz D, Lach J, Strapagiel D, Tegtmeyer N, Böhm M, Backert S, Skorko-Glonek J.

Sci Rep. 2019 Aug 13;9(1):11794. doi: 10.1038/s41598-019-48030-6.


Specific high affinity interaction of Helicobacter pylori CagL with integrin αV β6 promotes type IV secretion of CagA into human cells.

Buß M, Tegtmeyer N, Schnieder J, Dong X, Li J, Springer TA, Backert S, Niemann HH.

FEBS J. 2019 Oct;286(20):3980-3997. doi: 10.1111/febs.14962. Epub 2019 Jun 27.


The Helicobacter pylori Urease Virulence Factor Is Required for the Induction of Hypoxia-Induced Factor-1α in Gastric Cells.

Valenzuela-Valderrama M, Cerda-Opazo P, Backert S, González MF, Carrasco-Véliz N, Jorquera-Cordero C, Wehinger S, Canales J, Bravo D, Quest AFG.

Cancers (Basel). 2019 Jun 10;11(6). pii: E799. doi: 10.3390/cancers11060799.


Immunopathological properties of the Campylobacter jejuni flagellins and the adhesin CadF as assessed in a clinical murine infection model.

Schmidt AM, Escher U, Mousavi S, Tegtmeyer N, Boehm M, Backert S, Bereswill S, Heimesaat MM.

Gut Pathog. 2019 May 17;11:24. doi: 10.1186/s13099-019-0306-9. eCollection 2019.


Properties of the HtrA Protease From Bacterium Helicobacter pylori Whose Activity Is Indispensable for Growth Under Stress Conditions.

Zarzecka U, Modrak-Wójcik A, Figaj D, Apanowicz M, Lesner A, Bzowska A, Lipinska B, Zawilak-Pawlik A, Backert S, Skorko-Glonek J.

Front Microbiol. 2019 May 3;10:961. doi: 10.3389/fmicb.2019.00961. eCollection 2019.


Classification of Helicobacter pylori Virulence Factors: Is CagA a Toxin or Not?

Knorr J, Ricci V, Hatakeyama M, Backert S.

Trends Microbiol. 2019 Sep;27(9):731-738. doi: 10.1016/j.tim.2019.04.010. Epub 2019 May 23. Review.


Mechanisms of Inflammasome Signaling, microRNA Induction and Resolution of Inflammation by Helicobacter pylori.

Pachathundikandi SK, Blaser N, Backert S.

Curr Top Microbiol Immunol. 2019;421:267-302. doi: 10.1007/978-3-030-15138-6_11.


Genetic Polymorphisms in Inflammatory and Other Regulators in Gastric Cancer: Risks and Clinical Consequences.

Rudnicka K, Backert S, Chmiela M.

Curr Top Microbiol Immunol. 2019;421:53-76. doi: 10.1007/978-3-030-15138-6_3. Review.


Molecular evolution of the VacA p55 binding domain of Helicobacter pylori in mestizos from a high gastric cancer region of Colombia.

Gutiérrez-Escobar AJ, Bravo MM, Acevedo O, Backert S.

PeerJ. 2019 May 6;7:e6634. doi: 10.7717/peerj.6634. eCollection 2019.


Immune Cell Signaling by Helicobacter pylori: Impact on Gastric Pathology.

Blaser N, Backert S, Pachathundikandi SK.

Adv Exp Med Biol. 2019;1149:77-106. doi: 10.1007/5584_2019_360. Review.


Quantification of serine protease HtrA molecules secreted by the foodborne pathogen Campylobacter jejuni.

Neddermann M, Backert S.

Gut Pathog. 2019 Apr 12;11:14. doi: 10.1186/s13099-019-0295-8. eCollection 2019.


Protease Activity of Campylobacter jejuni HtrA Modulates Distinct Intestinal and Systemic Immune Responses in Infected Secondary Abiotic IL-10 Deficient Mice.

Schmidt AM, Escher U, Mousavi S, Boehm M, Backert S, Bereswill S, Heimesaat MM.

Front Cell Infect Microbiol. 2019 Mar 29;9:79. doi: 10.3389/fcimb.2019.00079. eCollection 2019.


How many protein molecules are secreted by single Helicobacter pylori cells: Quantification of serine protease HtrA.

Neddermann M, Backert S.

Cell Microbiol. 2019 Jul;21(7):e13022. doi: 10.1111/cmi.13022. Epub 2019 Mar 19.


Correction: Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence.

Smet A, Yahara K, Rossi M, Tay A, Backert S, Ensser A, Fox JG, Flahou B, Ducatelle R, Haesebrouck F, Corander J.

ISME J. 2019 Jul;13(7):1890. doi: 10.1038/s41396-019-0380-5.


Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA.

Harrer A, Bücker R, Boehm M, Zarzecka U, Tegtmeyer N, Sticht H, Schulzke JD, Backert S.

Gut Pathog. 2019 Feb 13;11:4. doi: 10.1186/s13099-019-0283-z. eCollection 2019.


Function of Serine Protease HtrA in the Lifecycle of the Foodborne Pathogen Campylobacter jejuni.

Boehm M, Simson D, Escher U, Schmidt AM, Bereswill S, Tegtmeyer N, Backert S, Heimesaat MM.

Eur J Microbiol Immunol (Bp). 2018 Jul 17;8(3):70-77. doi: 10.1556/1886.2018.00011. eCollection 2018 Sep 28. Review.


In silico proteomic and phylogenetic analysis of the outer membrane protein repertoire of gastric Helicobacter species.

Bauwens E, Joosten M, Taganna J, Rossi M, Debraekeleer A, Tay A, Peters F, Backert S, Fox J, Ducatelle R, Remaut H, Haesebrouck F, Smet A.

Sci Rep. 2018 Oct 18;8(1):15453. doi: 10.1038/s41598-018-32476-1.


Expression of CEACAM1 or CEACAM5 in AZ-521 cells restores the type IV secretion deficiency for translocation of CagA by Helicobacter pylori.

Tegtmeyer N, Harrer A, Schmitt V, Singer BB, Backert S.

Cell Microbiol. 2019 Jan;21(1):e12965. doi: 10.1111/cmi.12965. Epub 2018 Nov 8.


Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence.

Smet A, Yahara K, Rossi M, Tay A, Backert S, Armin E, Fox JG, Flahou B, Ducatelle R, Haesebrouck F, Corander J.

ISME J. 2018 Oct;12(10):2518-2531. doi: 10.1038/s41396-018-0199-5. Epub 2018 Jun 25. Erratum in: ISME J. 2019 Feb 28;:.


Unusual Manifestation of Live Staphylococcus saprophyticus, Corynebacterium urinapleomorphum, and Helicobacter pylori in the Gallbladder with Cholecystitis.

Backert S, Tegtmeyer N, Oyarzabal OA, Osman D, Rohde M, Grützmann R, Vieth M.

Int J Mol Sci. 2018 Jun 21;19(7). pii: E1826. doi: 10.3390/ijms19071826.


Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs.

Moonens K, Hamway Y, Neddermann M, Reschke M, Tegtmeyer N, Kruse T, Kammerer R, Mejías-Luque R, Singer BB, Backert S, Gerhard M, Remaut H.

EMBO J. 2018 Jul 2;37(13). pii: e98665. doi: 10.15252/embj.201798665. Epub 2018 Jun 1.


Binding of Helicobacter pylori to Human Gastric Mucins Correlates with Binding of TFF1.

Dunne C, Naughton J, Duggan G, Loughrey C, Kilcoyne M, Joshi L, Carrington S, Earley H, Backert S, Robbe Masselot C, May FEB, Clyne M.

Microorganisms. 2018 May 18;6(2). pii: E44. doi: 10.3390/microorganisms6020044.


Amino-Terminal Processing of Helicobacter pylori Serine Protease HtrA: Role in Oligomerization and Activity Regulation.

Albrecht N, Tegtmeyer N, Sticht H, Skórko-Glonek J, Backert S.

Front Microbiol. 2018 Apr 16;9:642. doi: 10.3389/fmicb.2018.00642. eCollection 2018.


Extracellular HtrA serine proteases: An emerging new strategy in bacterial pathogenesis.

Backert S, Bernegger S, Skórko-Glonek J, Wessler S.

Cell Microbiol. 2018 Jun;20(6):e12845. doi: 10.1111/cmi.12845. Epub 2018 Apr 30. Review.


A novel basolateral type IV secretion model for the CagA oncoprotein of Helicobacter pylori.

Wessler S, Backert S.

Microb Cell. 2017 Dec 9;5(1):60-62. doi: 10.15698/mic2018.01.611.


Heptose 1,7-Bisphosphate Directed TIFA Oligomerization: A Novel PAMP-Recognizing Signaling Platform in the Control of Bacterial Infections.

Pachathundikandi K, Backert S.

Gastroenterology. 2018 Mar;154(4):778-783. doi: 10.1053/j.gastro.2018.01.009. Epub 2018 Jan 11. No abstract available.


Helicobacter pylori infection of AZ-521 cells reveals a type IV secretion defect and VacA-independent CagA phosphorylation.

Tegtmeyer N, Backert S.

Dis Model Mech. 2017 Dec 19;10(12):1539-1540. doi: 10.1242/dmm.032813. No abstract available.


Type IV secretion in Gram-negative and Gram-positive bacteria.

Grohmann E, Christie PJ, Waksman G, Backert S.

Mol Microbiol. 2018 Feb;107(4):455-471. doi: 10.1111/mmi.13896. Epub 2018 Jan 18. Review. Erratum in: Curr Top Microbiol Immunol. 2017;413:E1.


Biochemical properties of the HtrA homolog from bacterium Stenotrophomonas maltophilia.

Zarzecka U, Modrak-Wojcik A, Bayassi M, Szewczyk M, Gieldon A, Lesner A, Koper T, Bzowska A, Sanguinetti M, Backert S, Lipinska B, Skorko-Glonek J.

Int J Biol Macromol. 2018 Apr 1;109:992-1005. doi: 10.1016/j.ijbiomac.2017.11.086. Epub 2017 Nov 16.


Helicobacter pylori controls NLRP3 expression by regulating hsa-miR-223-3p and IL-10 in cultured and primary human immune cells.

Pachathundikandi SK, Backert S.

Innate Immun. 2018 Jan;24(1):11-23. doi: 10.1177/1753425917738043. Epub 2017 Nov 16.


Helicobacter pylori Employs a Unique Basolateral Type IV Secretion Mechanism for CagA Delivery.

Tegtmeyer N, Wessler S, Necchi V, Rohde M, Harrer A, Rau TT, Asche CI, Boehm M, Loessner H, Figueiredo C, Naumann M, Palmisano R, Solcia E, Ricci V, Backert S.

Cell Host Microbe. 2017 Oct 11;22(4):552-560.e5. doi: 10.1016/j.chom.2017.09.005.


Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori.

Harrer A, Boehm M, Backert S, Tegtmeyer N.

Gut Pathog. 2017 Jul 25;9:40. doi: 10.1186/s13099-017-0189-6. eCollection 2017.


Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-κB and caspase-8-dependent apoptotic cell death.

Lim MCC, Maubach G, Sokolova O, Feige MH, Diezko R, Buchbinder J, Backert S, Schlüter D, Lavrik IN, Naumann M.

Cell Death Differ. 2017 Sep;24(9):1621-1631. doi: 10.1038/cdd.2017.89. Epub 2017 Jun 2.


Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA.

Tegtmeyer N, Neddermann M, Asche CI, Backert S.

Mol Microbiol. 2017 Aug;105(3):358-372. doi: 10.1111/mmi.13707. Epub 2017 May 30. Review.


Type IV Secretion and Signal Transduction of Helicobacter pylori CagA through Interactions with Host Cell Receptors.

Backert S, Tegtmeyer N.

Toxins (Basel). 2017 Mar 24;9(4). pii: E115. doi: 10.3390/toxins9040115. Review.


Exploiting the Gastric Epithelial Barrier: Helicobacter pylori's Attack on Tight and Adherens Junctions.

Backert S, Schmidt TP, Harrer A, Wessler S.

Curr Top Microbiol Immunol. 2017;400:195-226. doi: 10.1007/978-3-319-50520-6_9. Review.


Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?

Wessler S, Schneider G, Backert S.

Cell Commun Signal. 2017 Jan 10;15(1):4. doi: 10.1186/s12964-017-0162-5.


Helicobacter pylori: A Paradigm Pathogen for Subverting Host Cell Signal Transmission.

Naumann M, Sokolova O, Tegtmeyer N, Backert S.

Trends Microbiol. 2017 Apr;25(4):316-328. doi: 10.1016/j.tim.2016.12.004. Epub 2017 Jan 3. Review.


Erratum to: Type IV Secretion in Gram-Negative and Gram-Positive Bacteria.

Backert S, Grohmann E.

Curr Top Microbiol Immunol. 2017;413:E1. doi: 10.1007/978-3-319-75241-9_14. No abstract available.


The Helicobacter pylori Type IV Secretion System Encoded by the cag Pathogenicity Island: Architecture, Function, and Signaling.

Backert S, Haas R, Gerhard M, Naumann M.

Curr Top Microbiol Immunol. 2017;413:187-220. doi: 10.1007/978-3-319-75241-9_8. Review.


Erratum: Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.

Javaheri A, Kruse T, Moonens K, Mejías-Luque R, Debraekeleer A, Asche CI, Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Hill DJ, Königer V, Hauck CR, Moskalenko R, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Backert S, Remaut H, Singer BB, Gerhard M.

Nat Microbiol. 2016 Nov 7;2:16243. doi: 10.1038/nmicrobiol.2016.243. No abstract available.


Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.

Javaheri A, Kruse T, Moonens K, Mejías-Luque R, Debraekeleer A, Asche CI, Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Hill DJ, Königer V, Hauck CR, Moskalenko R, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Backert S, Remaut H, Singer BB, Gerhard M.

Nat Microbiol. 2016 Oct 17;2:16189. doi: 10.1038/nmicrobiol.2016.189. Erratum in: Nat Microbiol. 2016 Nov 07;2:16243.


The Role of CagA in the Gastric Biology of Helicobacter pylori.

Backert S, Blaser MJ.

Cancer Res. 2016 Jul 15;76(14):4028-31. doi: 10.1158/0008-5472.CAN-16-1680. No abstract available.


Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains.

Lind J, Backert S, Hoffmann R, Eichler J, Yamaoka Y, Perez-Perez GI, Torres J, Sticht H, Tegtmeyer N.

BMC Microbiol. 2016 Sep 2;16(1):201. doi: 10.1186/s12866-016-0820-6.


Pathogenesis of Helicobacter pylori infection.

Backert S, Neddermann M, Maubach G, Naumann M.

Helicobacter. 2016 Sep;21 Suppl 1:19-25. doi: 10.1111/hel.12335. Review.


Inflammasome Activation by Helicobacter pylori and Its Implications for Persistence and Immunity.

Pachathundikandi SK, Müller A, Backert S.

Curr Top Microbiol Immunol. 2016;397:117-31. doi: 10.1007/978-3-319-41171-2_6. Review.


Differential Expression of Interleukin 1β During Helicobacter pylori Infection of Toll-like Receptor 2 (TLR2)- and TLR10-Expressing HEK293 Cell Lines.

Pachathundikandi SK, Backert S.

J Infect Dis. 2016 Jul 1;214(1):166-7. doi: 10.1093/infdis/jiw154. Epub 2016 Apr 18. No abstract available.


Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA.

Schmidt TP, Perna AM, Fugmann T, Böhm M, Jan Hiss, Haller S, Götz C, Tegtmeyer N, Hoy B, Rau TT, Neri D, Backert S, Schneider G, Wessler S.

Sci Rep. 2016 Mar 17;6:23264. doi: 10.1038/srep23264.


Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA.

Tegtmeyer N, Moodley Y, Yamaoka Y, Pernitzsch SR, Schmidt V, Traverso FR, Schmidt TP, Rad R, Yeoh KG, Bow H, Torres J, Gerhard M, Schneider G, Wessler S, Backert S.

Mol Microbiol. 2016 Mar;99(5):925-44. doi: 10.1111/mmi.13276. Epub 2015 Dec 22.

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