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Items: 50


Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.

Braun DJ, Bachstetter AD, Sudduth TL, Wilcock DM, Watterson DM, Van Eldik LJ.

Geroscience. 2019 May 19. doi: 10.1007/s11357-019-00072-4. [Epub ahead of print]


Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice.

Duncan MJ, Farlow H, Tirumalaraju C, Yun DH, Wang C, Howard JA, Sanden MN, O'Hara BF, McQuerry KJ, Bachstetter AD.

Alzheimers Dement (N Y). 2019 Feb 28;5:70-80. doi: 10.1016/j.trci.2019.01.003. eCollection 2019.


A Systematic Review of Closed Head Injury Models of Mild Traumatic Brain Injury in Mice and Rats.

Bodnar CN, Roberts KN, Higgins EK, Bachstetter AD.

J Neurotrauma. 2019 Jun;36(11):1683-1706. doi: 10.1089/neu.2018.6127. Epub 2019 Mar 6.


Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model.

Macheda T, Roberts K, Lyons DN, Higgins E, Ritter KJ, Lin AL, Alilain WJ, Bachstetter AD.

Neuroscience. 2019 Feb 1;398:55-63. doi: 10.1016/j.neuroscience.2018.11.040. Epub 2018 Dec 7.


Simulation of P2X-mediated calcium signalling in microglia.

Chun BJ, Stewart BD, Vaughan DD, Bachstetter AD, Kekenes-Huskey PM.

J Physiol. 2019 Feb;597(3):799-818. doi: 10.1113/JP277377. Epub 2018 Dec 17.


Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism.

Bodnar CN, Morganti JM, Bachstetter AD.

Neural Regen Res. 2018 Oct;13(10):1693-1704. doi: 10.4103/1673-5374.238604. Review.


A Mild Traumatic Brain Injury in Mice Produces Lasting Deficits in Brain Metabolism.

Lyons DN, Vekaria H, Macheda T, Bakshi V, Powell DK, Gold BT, Lin AL, Sullivan PG, Bachstetter AD.

J Neurotrauma. 2018 Oct 15;35(20):2435-2447. doi: 10.1089/neu.2018.5663. Epub 2018 Jul 2.


Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury.

Rowe RK, Harrison JL, Zhang H, Bachstetter AD, Hesson DP, O'Hara BF, Greene MI, Lifshitz J.

J Neuroinflammation. 2018 May 22;15(1):154. doi: 10.1186/s12974-018-1200-y.


Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes.

Zhou Z, Bachstetter AD, Späni CB, Roy SM, Watterson DM, Van Eldik LJ.

J Neuroinflammation. 2017 Apr 5;14(1):75. doi: 10.1186/s12974-017-0845-2.


Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi.

Smith VD, Bachstetter AD, Ighodaro E, Roberts K, Abner EL, Fardo DW, Nelson PT.

Brain Pathol. 2018 Mar;28(2):264-273. doi: 10.1111/bpa.12505. Epub 2017 Mar 24.


Rod-shaped microglia morphology is associated with aging in 2 human autopsy series.

Bachstetter AD, Ighodaro ET, Hassoun Y, Aldeiri D, Neltner JH, Patel E, Abner EL, Nelson PT.

Neurobiol Aging. 2017 Apr;52:98-105. doi: 10.1016/j.neurobiolaging.2016.12.028. Epub 2017 Jan 5.


Targeting innate immunity for neurodegenerative disorders of the central nervous system.

Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, Russek-Blum N, Sandusky LA, Selenica ML, Takata K, Teeling J, Town T, Van Eldik LJ.

J Neurochem. 2016 Sep;138(5):653-93. doi: 10.1111/jnc.13667. Review. Erratum in: J Neurochem. 2017 Apr;141(1):151.


Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge.

Rowe RK, Ellis GI, Harrison JL, Bachstetter AD, Corder GF, Van Eldik LJ, Taylor BK, Marti F, Lifshitz J.

Mol Pain. 2016 May 13;12. pii: 1744806916647055. doi: 10.1177/1744806916647055. Print 2016.


Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats after Diffuse Brain Injury.

Liu M, Bachstetter AD, Cass WA, Lifshitz J, Bing G.

J Neurotrauma. 2017 Jan 15;34(2):414-422. doi: 10.1089/neu.2015.4361. Epub 2016 Jun 10.


MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.

Bachstetter AD, Zhou Z, Rowe RK, Xing B, Goulding DS, Conley AN, Sompol P, Meier S, Abisambra JF, Lifshitz J, Watterson DM, Van Eldik LJ.

PLoS One. 2016 Feb 12;11(2):e0149451. doi: 10.1371/journal.pone.0149451. eCollection 2016.


Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals.

Ighodaro ET, Abner EL, Fardo DW, Lin AL, Katsumata Y, Schmitt FA, Kryscio RJ, Jicha GA, Neltner JH, Monsell SE, Kukull WA, Moser DK, Appiah F, Bachstetter AD, Van Eldik LJ; Alzheimer's Disease Neuroimaging Initiative (ADNI), Nelson PT.

J Cereb Blood Flow Metab. 2017 Jan;37(1):201-216. Epub 2016 Jan 6.


Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury.

Febinger HY, Thomasy HE, Pavlova MN, Ringgold KM, Barf PR, George AM, Grillo JN, Bachstetter AD, Garcia JA, Cardona AE, Opp MR, Gemma C.

J Neuroinflammation. 2015 Sep 2;12:154. doi: 10.1186/s12974-015-0386-5.


Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging.

Bachstetter AD, Van Eldik LJ, Schmitt FA, Neltner JH, Ighodaro ET, Webster SJ, Patel E, Abner EL, Kryscio RJ, Nelson PT.

Acta Neuropathol Commun. 2015 May 23;3:32. doi: 10.1186/s40478-015-0209-z.


Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment.

Webster SJ, Van Eldik LJ, Watterson DM, Bachstetter AD.

J Neurosci. 2015 Apr 22;35(16):6554-69. doi: 10.1523/JNEUROSCI.0291-15.2015.


Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic.

Bachstetter AD, Webster SJ, Goulding DS, Morton JE, Watterson DM, Van Eldik LJ.

J Neuroinflammation. 2015 Apr 10;12:69. doi: 10.1186/s12974-015-0289-5.


Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.

Roy SM, Grum-Tokars VL, Schavocky JP, Saeed F, Staniszewski A, Teich AF, Arancio O, Bachstetter AD, Webster SJ, Van Eldik LJ, Minasov G, Anderson WF, Pelletier JC, Watterson DM.

ACS Chem Neurosci. 2015 Apr 15;6(4):666-80. doi: 10.1021/acschemneuro.5b00002. Epub 2015 Feb 23.


Generation and behavior characterization of CaMKIIβ knockout mice.

Bachstetter AD, Webster SJ, Tu T, Goulding DS, Haiech J, Watterson DM, Van Eldik LJ.

PLoS One. 2014 Aug 15;9(8):e105191. doi: 10.1371/journal.pone.0105191. eCollection 2014.


Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults.

Xing B, Bachstetter AD, Van Eldik LJ.

J Mol Neurosci. 2015 Feb;55(2):509-18. doi: 10.1007/s12031-014-0372-x. Epub 2014 Jul 11.


Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models.

Webster SJ, Bachstetter AD, Nelson PT, Schmitt FA, Van Eldik LJ.

Front Genet. 2014 Apr 23;5:88. doi: 10.3389/fgene.2014.00088. eCollection 2014. Review.


Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.

Bachstetter AD, Watterson DM, Van Eldik LJ.

J Neuroimmune Pharmacol. 2014 Sep;9(4):454-60. doi: 10.1007/s11481-014-9543-3. Epub 2014 May 1.


Diffuse brain injury induces acute post-traumatic sleep.

Rowe RK, Striz M, Bachstetter AD, Van Eldik LJ, Donohue KD, O'Hara BF, Lifshitz J.

PLoS One. 2014 Jan 8;9(1):e82507. doi: 10.1371/journal.pone.0082507. eCollection 2014.


The role of microglia in adult hippocampal neurogenesis.

Gemma C, Bachstetter AD.

Front Cell Neurosci. 2013 Nov 22;7:229. doi: 10.3389/fncel.2013.00229. Review.


Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.

Watterson DM, Grum-Tokars VL, Roy SM, Schavocky JP, Bradaric BD, Bachstetter AD, Xing B, Dimayuga E, Saeed F, Zhang H, Staniszewski A, Pelletier JC, Minasov G, Anderson WF, Arancio O, Van Eldik LJ.

PLoS One. 2013 Jun 26;8(6):e66226. doi: 10.1371/journal.pone.0066226. Print 2013.


Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease.

Webster SJ, Bachstetter AD, Van Eldik LJ.

Alzheimers Res Ther. 2013 May 24;5(3):28. doi: 10.1186/alzrt182. eCollection 2013.


The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury.

Bachstetter AD, Rowe RK, Kaneko M, Goulding D, Lifshitz J, Van Eldik LJ.

J Neurosci. 2013 Apr 3;33(14):6143-53. doi: 10.1523/JNEUROSCI.5399-12.2013.


Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models.

Xing B, Bachstetter AD, Van Eldik LJ.

PLoS One. 2013;8(2):e56852. doi: 10.1371/journal.pone.0056852. Epub 2013 Feb 15.


Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.

Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD, Van Eldik LJ, Norris CM.

J Neurosci. 2012 Nov 14;32(46):16129-40. doi: 10.1523/JNEUROSCI.2323-12.2012.


Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology.

Bachstetter AD, Norris CM, Sompol P, Wilcock DM, Goulding D, Neltner JH, St Clair D, Watterson DM, Van Eldik LJ.

J Neurosci. 2012 Jul 25;32(30):10201-10. doi: 10.1523/JNEUROSCI.1496-12.2012.


Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα.

Xing B, Bachstetter AD, Van Eldik LJ.

Mol Neurodegener. 2011 Dec 20;6:84. doi: 10.1186/1750-1326-6-84.


CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity.

Rogers JT, Morganti JM, Bachstetter AD, Hudson CE, Peters MM, Grimmig BA, Weeber EJ, Bickford PC, Gemma C.

J Neurosci. 2011 Nov 9;31(45):16241-50. doi: 10.1523/JNEUROSCI.3667-11.2011.


Neuron-Microglia Dialogue and Hippocampal Neurogenesis in the Aged Brain.

Gemma C, Bachstetter AD, Bickford PC.

Aging Dis. 2010 Dec 1;1(3):232-244.


Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ).

Bachstetter AD, Xing B, de Almeida L, Dimayuga ER, Watterson DM, Van Eldik LJ.

J Neuroinflammation. 2011 Jul 6;8:79. doi: 10.1186/1742-2094-8-79.


CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease.

Pabon MM, Bachstetter AD, Hudson CE, Gemma C, Bickford PC.

J Neuroinflammation. 2011 Jan 25;8:9. doi: 10.1186/1742-2094-8-9.


Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation.

Bachstetter AD, Jernberg J, Schlunk A, Vila JL, Hudson C, Cole MJ, Shytle RD, Tan J, Sanberg PR, Sanberg CD, Borlongan C, Kaneko Y, Tajiri N, Gemma C, Bickford PC.

PLoS One. 2010 May 5;5(5):e10496. doi: 10.1371/journal.pone.0010496.


Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats.

Bachstetter AD, Morganti JM, Jernberg J, Schlunk A, Mitchell SH, Brewster KW, Hudson CE, Cole MJ, Harrison JK, Bickford PC, Gemma C.

Neurobiol Aging. 2011 Nov;32(11):2030-44. doi: 10.1016/j.neurobiolaging.2009.11.022. Epub 2009 Dec 16.


Increased neuronal proliferation in the dentate gyrus of aged rats following neural stem cell implantation.

Park DH, Eve DJ, Sanberg PR, Musso J 3rd, Bachstetter AD, Wolfson A, Schlunk A, Baradez MO, Sinden JD, Gemma C.

Stem Cells Dev. 2010 Feb;19(2):175-80. doi: 10.1089/scd.2009.0172.


Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats.

Yang D, Kim KH, Phimister A, Bachstetter AD, Ward TR, Stackman RW, Mervis RF, Wisniewski AB, Klein SL, Kodavanti PR, Anderson KA, Wayman G, Pessah IN, Lein PJ.

Environ Health Perspect. 2009 Mar;117(3):426-35. doi: 10.1289/ehp.11771. Epub 2008 Sep 12.


Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain.

Bachstetter AD, Pabon MM, Cole MJ, Hudson CE, Sanberg PR, Willing AE, Bickford PC, Gemma C.

BMC Neurosci. 2008 Feb 14;9:22. doi: 10.1186/1471-2202-9-22.


Blockade of caspase-1 increases neurogenesis in the aged hippocampus.

Gemma C, Bachstetter AD, Cole MJ, Fister M, Hudson C, Bickford PC.

Eur J Neurosci. 2007 Nov;26(10):2795-803.


Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls.

Lein PJ, Yang D, Bachstetter AD, Tilson HA, Harry GJ, Mervis RF, Kodavanti PR.

Environ Health Perspect. 2007 Apr;115(4):556-63. Epub 2007 Jan 16.


Influence of predator stress on the consolidation versus retrieval of long-term spatial memory and hippocampal spinogenesis.

Diamond DM, Campbell AM, Park CR, Woodson JC, Conrad CD, Bachstetter AD, Mervis RF.

Hippocampus. 2006;16(7):571-6.


Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms.

Costa DA, Cracchiolo JR, Bachstetter AD, Hughes TF, Bales KR, Paul SM, Mervis RF, Arendash GW, Potter H.

Neurobiol Aging. 2007 Jun;28(6):831-44. Epub 2006 May 26.


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